Crystal structure of aurora a kinase and uses thereof

ABSTRACT

The invention provides crystalline forms of a polypeptide corresponding to the catalytic domain of Aurora kinase. The active site ATP binding pocket is defined by its amino acid residues and their atomic coordinates. This structure may be used to select or design chemical modulators of Aurora kinase, particularly Aurora inhibitors. These modulators may be used to treat diseases of cell proliferation, e.g. cancer.

This application is a national stage filing under 35 U.S.C. 371 of International Application No. PCT/GB02/04589, filed Oct. 8, 2002, which claims priority from United Kingdom Patent Application No. 0124299.9, filed Oct. 10, 2001, the specification of which is incorporated by reference herein. International Application No. PCT/GB02/04589 was published under PCT Article 21(2) in English.

FIELD OF THE INVENTION

This invention relates to crystallised Aurora A kinase and the use of its three-dimensional structure to investigate Aurora kinase homologues and to design Aurora kinase modulators.

BACKGROUND OF THE INVENTION

Proteins such as enzymes involved in physiological and pathological processes are important targets in the development of pharmaceutical compounds and treatments. Knowledge of the three dimensional (tertiary) structure of proteins allows the rational design of mimics or modulators of such proteins. By searching structural databases using structural parameters derived from the protein of interest, it is possible to select molecular structures that may mimic or interact with these parameters. It is then possible to synthesise the selected molecular structure and test its activity. Alternatively, the structural parameters derived from the protein of interest may be used to design and synthesise a mimic or modulator with the desired activity. Such mimics or modulators may be useful as therapeutic agents for treating certain diseases. For example, WO98/07835 discloses crystal structures of a protein tyrosine kinase optionally complexed with one or more compounds. The atomic coordinates of the enzyme structures and any of the bound compounds are used to determine the three-dimensional structures of kinases with unknown structure and to identify modulators of kinase functions. As another example, WO99/01476 discloses the crystal structures of anti-Factor IX Fab fragments (antibodies) and their use to identify and design new anticoagulant agents.

Knowledge of the three-dimensional structure of a protein is essential for the rational design of mimics or modulators of that protein. Lack of structural knowledge is a barrier to the development of new mimics or modulators that may have extremely useful pharmaceutical properties.

In Eukaryotes, the cell cycle is largely controlled by an ordered cascade of protein phosphorylation. Several families of protein kinases that play critical roles in this cascade have now been identified. The activity of many of these kinases is increased in human tumours when compared to normal tissue. This can occur by either increased levels of expression of the protein (as a result of gene amplification for example), or by changes in expression of co-activators or inhibitory proteins.

The first identified, and most widely studied of these cell cycle regulators have been the cyclin-dependent kinases (or CDKs). Activity of specific CDKs at specific times is essential for both initiation and coordinated progress through the cell cycle. For example, the CDK4 protein appears to control entry into the cell cycle (the G0-G1-S transition) by phosphorylating the retinoblastoma gene product pRb. This stimulates the release of the transcription factor E2F from pRb, which then acts to increase the transcription of genes necessary for entry into S phase. The catalytic activity of CDK4 is stimulated by binding to a partner protein, Cyclin D1. One of the first demonstrations of a direct link between cancer and the cell cycle was made with the observation that the Cyclin D1 gene was amplified and cyclin D1 protein levels increased (and hence the activity of CDK4 increased) in many human tumours (Reviewed in Sherr, 1996, Science 274: 1672–1677; Pines, 1995, Seminars in Cancer Biology 6: 63–72). Other studies have shown that negative regulators of CDK function are frequently down-regulated or deleted in human tumours, again leading to inappropriate activation of these kinases (Loda et al., 1997, Nature Medicine 3(2): 231–234; Gemma et al., 1996, International Journal of Cancer 68(5): 605–11; Elledge et al. 1996, Trends in Cell Biology 6; 388–392).

More recently, protein kinases that are structurally distinct from the CDK family have been identified which play critical roles in regulating the cell cycle and which also appear to be important in oncogenesis. These include the newly-identified human homologues of the Drosophila Aurora and S. cerevisiae Ipl1 proteins. Drosophila Aurora and S. cerevisiae Ipl1, which are highly homologous at the amino acid sequence level, encode serine/threonine protein kinases. Both Aurora and Ipl1 are known to be involved in controlling the transition from the G2 phase of the cell cycle through mitosis, centrosome function, formation of a mitotic spindle and proper chromosome separation/segregation into daughter cells. The three human homologues of these genes, termed Aurora A, B and C, encode cell cycle regulated protein kinases. These show a peak of expression and kinase activity at the G2/M boundary (Aurora A, C) and in mitosis and cytokinesis (Aurora B). Several observations implicate the involvement of human Aurora proteins, in particular Aurora A in cancer. The Aurora A gene maps to chromosome 20q13, a region that is frequently amplified in human tumours including both breast and colon tumours. Aurora A may be the major target gene of this amplicon, since Aurora A DNA is amplified and Aurora A mRNA over expressed in greater than 50% of primary human colorectal cancers. In these tumours Aurora A protein levels appear greatly elevated compared to adjacent normal tissue. In addition, transfection of rodent fibroblasts with human Aurora A leads to transformation, conferring the ability to grow in soft agar and form tumours in nude mice (Bischoff et al., 1998, The EMBO Journal. 117(11): 3052–3065). Other work has shown that artificial over expression of Aurora A leads to an increase in centrosome number and an increase in aneuploidy (Zhou et al., 1998, Nature Genetics. 20(2): 189–93).

Importantly, it has also been demonstrated that abrogation of Aurora A expression and function by antisense oligonucleotide treatment of human tumour cell lines (Bischoff and Ploughman, 1999, Trends in Cell Biology, 9(11): 454–459 or by a small molecule inhibitor of Aurora A kinase activity (Keen et al. 2001, poster #2455, American Association for Cancer Research annual meeting, New Orleans USA) leads to defects in mitosis, cell cycle arrest and exerts an antiproliferative effect in these tumour cell lines. This indicates that inhibition of the function of Aurora A will have an antiproliferative effect that may be useful in the treatment of human tumours and other hyperproliferative diseases.

In order to design inhibitors of Aurora A kinase, it is necessary to know the three-dimensional structure of Aurora A kinase, in complex with various lead compounds. To date, the three-dimensional structure of Aurora A kinase has not been available. Further, it has not been possible to obtain crystals of any part of Aurora of sufficient quality to allow determination of the structure of the kinase domain including the site of inhibition.

SUMMARY OF THE INVENTION

The present invention relates to the previously unknown three-dimensional structure of human Aurora A kinase. As described herein, the Applicants have overcome the difficulties encountered by others and have produced crystals of the Aurora A kinase catalytic domain that are of sufficient quality to determine the three-dimensional structure of the protein by X-ray diffraction methods. In addition, the Applicants have determined the three-dimensional crystal structure of the kinase catalytic domain of Aurora A kinase in a complex with the ATP analogue AMP-PNP, as well as the three-dimensional crystal structure of the Aurora A kinase catalytic domain in complex with a synthetic inhibitor. There is a clear need for this structural information to enable identification and structure-based design of new Aurora kinase modulators (particularly inhibitors) for the treatment of various diseases or conditions and in particular diseases of cell proliferation such as cancer. The methods described herein allow the determination of the three-dimensional structures of Aurora A kinase, as well as other Aurora kinases, in complex with numerous inhibitors of interest to aid in the rational design of modulators that will treat diseases of cell proliferation.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a schematic representation of the structure of the [T287D] Aurora A complex with AMP-PNP. The inhibitor has 2 conformations.

FIG. 2 a is a schematic representation of the structure of Aurora A in complex with a synthetic inhibitor drawn in approximately the same orientation as FIG. 1.

FIG. 2 b is a schematic representation of Aurora A in complex with a synthetic inhibitor, rotated so as to show the extended inhibitor occupying a long active site binding pocket.

FIG. 3 is a graph of the activity of [T287D]Aurora A as a function of pH.

DETAILED DESCRIPTION OF THE INVENTION

This invention relates to crystals of Aurora A kinase and the use of the three-dimensional structure to investigate Aurora kinase homologues and to design Aurora kinase modulators (preferably inhibitors). It further relates to crystals of Aurora kinase, particularly Aurora A kinase, or the catalytic portion thereof, complexed or uncomplexed as described, of sufficient quality to determine the three dimensional (tertiary) structure of the polypeptide by X-ray diffraction methods.

According to a first aspect of the invention, the Applicants provide two crystalline forms of a polypeptide comprising the catalytic domain of Aurora A kinase. One crystalline form is obtained when we crystallise [T287D]Aurora A(122–396) in the presence of the ATP-analogue AMP-PNP. The second crystalline form is obtained when we crystallise GSHM-[T287D]Aurora A(122–400) in the presence of a synthetic inhibitor. (Amino acid residues in Aurora A are numbered by taking the first amino acid immediately after the initial methionine as amino acid number one). In one embodiment, the first crystalline form has the space group P3₂21. In another embodiment, the first crystalline form has the unit cell dimensions a=b=86.55, c=78.34 Å, α=β=90 and γ=120°. In another embodiment, the second crystalline form has space group P2₁. In another embodiment, the second crystalline form has the unit cell dimensions a=52.6, b=88.4, c=67.8 Å, α=γ=90 and β=90.01°. In another embodiment, these crystalline forms are described by three-dimensional sets of x,y,z-coordinates (Tables 1 and 2) for each atom in the complex representing the unique repeating motif in the crystal. Table 1 contains the coordinates for the complex molecule in the first crystalline form; Table 2 contains the coordinates for two independent complex molecules in the asymmetric unit (smallest unique repeating unit) in the second crystalline form. In another embodiment, these crystalline forms contain a numerical definition of a binding site, approximated by the set of all residues within a 5 Å contact distance from any atom in either inhibitor. The binding site is defined by the x,y,z-coordinates of atoms in the set of amino acid residues (set A) given by the list Arg136, Leu138, Gly139, Lys140, Gly141, Val146, Ala 159, Lys161, Leu163, Val77, Glu180, Val181, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260, Leu262, Ala272, Asp273, Phe274, Gly275, Trp276, Ser277, Val278, and His279, the atomic coordinates being listed in Tables 1 and 2. The binding site is may be defined in any alternate crystalline form, homologue, variant or mutant wherein the binding site has a root mean square deviation from all atoms of the amino acid residues of not more than 1.0 Å from a least-flexible subset (set B) of the binding site that includes the amino acid residues Arg136, Leu138, Gly139, Val146, Ala159, Lys161, Leu163, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260 and Leu262, each having coordinates as described in Tables 1 and 2.

In another embodiment, the first crystalline form comprises a binding site defined by amino acid residues Leu138, Gly139, Val146, Lys161, Val177, Arg178, Arg179, Glu180, Val181, Glu182, Ile183, Gln184, Leu193, Leu209, Tyr211, Ala212, Gly215, Thr216, Glu259, Asn260, Leu262, Ala272, Asp273, Phe274, Gly275, Trp276, Ser277, Val278 and His 279, each having the coordinated listed in Table 1a. An alternative crystalline form, homologue, variant or mutant wherein the binding site has a root mean square deviation from the backbone atoms of the amino acid residues of not more than 1.5 Å, and preferably not more than 1.0 Å is also provided.

In another embodiment, the crystalline forms additionally comprise Aurora kinase inhibitors in complex with the catalytic domain of Aurora kinase including any of the above embodiments of the crystalline form.

Another aspect of the invention relates to a method of designing an Aurora chemical modulator using the atomic coordinates of a crystalline form according to any of the above embodiments.

Another aspect of the invention relates to a method of selecting an Aurora chemical modulator using the atomic coordinates of a crystalline form according to any of the above embodiments.

Another aspect of the invention relates to a method of designing or selecting an Aurora chemical modulator using the atomic coordinates of any other protein, e.g. PKA, which has been shown by this invention to have structural similarity to Aurora.

Another aspect of the invention relates to a method of designing an Aurora protein using the atomic coordinates of a crystalline form according to any of the above embodiments.

Another aspect of the invention relates to a method of designing or selecting an Aurora modulator comprising the steps of:

exploring the atomic coordinates of Aurora (Tables 1 and 2) for information on the three-dimensional characteristics of the protein surface;

arriving at an alternative overlapping or non-overlapping binding pocket to the active site ATP binding pocket; and

selecting or designing an Aurora modulator using the binding pocket information.

Another aspect of the invention relates to a method of determining the three-dimensional structure of a crystal form of Aurora kinase, referred to as a second or new crystal or crystal form of Aurora kinase, comprising the step of applying difference Fourier or molecular replacement methods using the atomic coordinates of an original crystal of Aurora kinase (from Table 1 or 2) to model the structure of a new crystal, wherein the active site ATP binding pocket of the new crystal is equivalent to that in the first crystal. In a specific embodiment, the invention is a method of determining the three-dimensional structure of a crystal form of Aurora kinase A comprising the step of applying difference Fourier or molecular replacement methods using the atomic coordinates of an original (first) crystal of Aurora kinases (from Table 1 or 2) to model the structure of a new crystal or new crystal form of Aurora kinase A, wherein the active site ATP binding pocket of the new crystal is equivalent to that in the original (first) crystal.

In particular provided herein are crystalline forms of a polypeptide including the catalytic domain of an Aurora A protein. The catalytic domain may be found within the complete protein or within a fragment of the protein. The catalytic domain may be also derived from a wild-type Aurora A enzyme or from an Aurora A mutant, homologue or variant. A mutant is a wild type Aurora A protein having one or more changes in its amino acid sequence. An Aurora mutant may have the same activity as the wild type protein, may have modified activity or may be inactive. A variant is a wild type or mutant protein having one or more portions of its sequence removed, or an additional sequence or sequences added, so that the variant is a different length from the wild type or mutant protein. A variant usually has the same activity as the original wild type or mutant protein. A homologue is a related protein in which some parts of the amino acid sequence are the same as in the original protein. Aurora B and Aurora C, for example, are homologues of Aurora A.

The invention relates to crystals of sufficient quality to determine the three dimensional structure to high resolution of any portion, mutant, variant or homologue of Aurora A involving the catalytic domain.

According to a further aspect of the invention, we provide crystalline forms of a polypeptide containing the Aurora A catalytic domain in complex with small molecular weight inhibitor molecules. For example, the inhibitor molecule might be a non-hydrolysable analogue of ATP. Such analogues include, for example, formula I (AMP-PNP). As another example, the inhibitor might be a molecule synthesised chemically. Such molecules include, for example, formula II.

Another aspect of the invention is the unique shape of the active site ATP binding pocket in Aurora. Using X-ray crystallography, we have determined the three-dimensional molecular structure of an Aurora A catalytic domain. Resulting from this, we have determined the unique shape of an Aurora A active site ATP binding pocket (defined by the atomic coordinates of its constituent amino acids). Furthermore, we have determined the spatial arrangement of an Aurora A substrate analogue and an inhibitor molecule relative to the Aurora A active site binding pocket. This structural information can be stored on a computer-readable medium and may be used for rational drug design.

One of the difficulties in studying kinases in general is obtaining active protein. In order to be activated, certain kinases need to be phosphorylated at one or more key amino acid residues. It may be experimentally difficult to obtain 100% pure phosphorylated protein. Different phosphorylation states may have different conformations. Those in the art realise that such heterogeneities in the protein sample can severely impede the ability to form large well-ordered crystals. In Aurora A, phosphorylation of Thr 287 is necessary for activation of the kinase. Replacement of Thr-287 by Asp (an Aurora A mutant called [T287D] Aurora A) provides a mimic of the active protein which can be provided as a homogeneous sample. The [T287D]Aurora A mutant is constitutively active. Thus, preparation of this mutant conveniently addresses both issues of activity and crystallisability.

One of the major hurdles in the crystallisation of multidomain proteins is their flexibility. To increase the chances of crystallising Aurora A, an enzyme construct limited to the catalytic domain was used. This provided a more rigid and compact domain. Catalytic domain constructs can be designed by comparing the amino acid sequence to other kinases of known structure, and defining start and end residues for the polypeptide encompassing the Aurora A catalytic domain by analogy. This gives numerous possible construct variants, which include the catalytic domain. In order to increase further the chances of crystallising Aurora A, experimental evidence was sought as to which catalytic domain construct would be the most compact while retaining integrity as a folding unit. Limited proteolysis was carried out using endoproteinase Glu-C from Staphylococcus aureus V8 on the catalytic domain. This defined the catalytic domain boundaries to be within residues 122 to 396. Other similar constructs may be obtained through similar procedures, using, for example, different proteases for the limited proteolysis experiment. Such a procedure is exemplified by our preparation, crystallisation and determination of the structure of two Aurora A catalytic domain polypeptides. The structure of [T287D]Aurora A(122–396) in complex with the non-hydrolysable ATP analogue AMP-PNP is shown in FIG. 1. The structure of GSHM-[T287D]Aurora A(122–400) in complex with the synthetic Aurora inhibitor of formula II is shown in FIGS. 2 a and 2 b.

The AMP-PNP molecule occupies a cleft between the N-terminal domain (residues 125 to 208) and the C-terminal domain (residues 215 to 374). Comparison with other kinases demonstrates that this cleft represents a portion of the ATP binding site. Therefore, we have identified the active site ATP binding pocket of Aurora. The electron density shows evidence for the AMP-PNP adopting a dual conformation. In both conformations, the adenine ring and ribose moiety occupy similar pockets with the adenine nitrogen atoms N1 and N6 making classical interactions with main chain atoms in the hinge region (residues 209 to 214) of the enzyme. N1 forms a hydrogen bond with the main chain nitrogen of Ala-212 while N6 forms a hydrogen bond to the peptide carbonyl group of Glu-210. However, torsion angle differences elsewhere in the molecule allow the alpha and beta phosphate groups to occupy alternative pockets. No electron density is apparent in either conformation for the gamma phosphate group of the AMP-PNP molecule. In conformation 1, the beta phosphate group makes polar interactions with the O oxygen atoms of Ser 277 and the side-chain of Asn260, while in conformation 2, the beta phosphate makes polar interactions with the amide carbonyl of -Glu-259 and with a water molecule (Wat-542 in this structure).

From the three-dimensional structure that we have determined for [T287D] Aurora A, we establish that the AMP-PNP binding pocket, which is the active site ATP binding pocket, is uniquely defined by the atomic co-ordinates of its constituent amino acid residues, the coordinates being listed in Tables 1 and 2. An equivalent ATP binding pocket may also be defined having the same co-ordinates as detailed in Table 1 and with the same constitutent amino acid residues except that Lys140 and Gly 141 in Table 1 and replaced with Ala 140 and Ala 141, whereby such a table is referred to hereonin as Table 1a.

TABLE 1 coordinates of [T287D] Aurora A (122–396) in complex with AMP-PNP REMARK coordinates from restrained individual B-factor refinement REMARK refinement resolution: 500–2.2 A REMARK starting r = 0.2325 free_r = 0.2841 REMARK final r = 0.2317 free_r = 0.2832 REMARK B rmsd for bonded mainchain atoms = 1.663 target = 1.5 REMARK B rmsd for bonded sidechain atoms = 2.408 target = 2.0 REMARK B rmsd for angle mainchain atoms = 2.759 target = 2.0 REMARK B rmsd for angle sidechain atoms = 3.575 target = 2.5 REMARK wa = 2.95383 REMARK rweight = 9.122374E−02 REMARK target = mlf steps = 40 REMARK sg = P3(2)21 a = 86.551 b = 86.551 c = 78.337 alpha = 90 beta = 90 gamma = 120 REMARK parameter file 1: MSI_CNX_TOPPAR:protein_rep.param REMARK parameter file 2: anp.par REMARK parameter file 3: fra.par REMARK parameter file 4: MSI_CNX_TOPPAR:water_rep.param REMARK parameter file 5: gly.par REMARK molecular structure file: generate.mtf REMARK input coordinates: minimize.pdb REMARK reflection file = aurora-dl.cv REMARK ncs = none REMARK B-correction resolution: 6.0–2.2 REMARK initial B-factor correction applied to fobs: REMARK B11 = −2.797 B22 = −2.797 B33 = 5.593 REMARK B12 = −2.312 B13 = 0.000 B23 = 0.000 REMARK B-factor correction applied to coordinate array B: 0.127 REMARK bulk solvent: (Mask)density level = 0.392672e/A{circumflex over ( )}3, B-factor = 81.6283 A{circumflex over ( )}2 REMARK reflections with |Fobs|/sigma_F < 0.0 rejected REMARK reflections with |Fobs| > 1000 * rms(Fobs) rejected REMARK theoretical total number of refl. in resol. range: 17604 (100.0%) REMARK number of unobserved reflections (no entry or |F| = 0): 841 (4.8%) REMARK number of reflections rejected:    0 (0.0%) REMARK total number of reflections used:   16763 (95.2%) REMARK number of reflections in working set:   15942 (90.6%) REMARK number of reflections in test set:    821 (4.7%) REMARK FILENAME = “bindividual.pdb” REMARK DATE: Jun-18-2001 10:59:05 created by user: mar345 REMARK Written by CNX VERSION: 2000 ATOM 1 CB ALA A 125 45.635 59.219 11.462 1.00 79.31 A C ATOM 2 C ALA A 125 44.028 58.911 13.362 1.00 80.12 A C ATOM 3 O ALA A 125 45.008 59.073 14.092 1.00 81.57 A O ATOM 4 N ALA A 125 43.336 60.097 11.271 1.00 79.55 A N ATOM 5 CA ALA A 125 44.170 59.002 11.840 1.00 80.04 A C ATOM 6 N GLN A 126 42.809 58.655 13.835 1.00 79.21 A N ATOM 7 CA GLN A 126 42.542 58.531 15.272 1.00 77.20 A C ATOM 8 CB GLN A 126 41.980 59.849 15.817 1.00 78.38 A C ATOM 9 CG GLN A 126 42.496 60.222 17.206 1.00 78.91 A C ATOM 10 CD GLN A 126 41.965 59.321 18.304 1.00 79.23 A C ATOM 11 OE1 GLN A 126 42.092 58.098 18.238 1.00 80.18 A O ATOM 12 NE2 GLN A 126 41.372 59.925 19.328 1.00 78.24 A N ATOM 13 C GLN A 126 41.550 57.382 15.510 1.00 74.64 A C ATOM 14 O GLN A 126 41.834 56.234 15.151 1.00 74.20 A O ATOM 15 N TRP A 127 40.402 57.676 16.121 1.00 70.19 A N ATOM 16 CA TRP A 127 39.395 56.640 16.358 1.00 65.92 A C ATOM 17 CB TRP A 127 38.110 57.242 16.943 1.00 67.39 A C ATOM 18 CG TRP A 127 38.032 57.327 18.449 1.00 68.91 A C ATOM 19 CD2 TRP A 127 38.438 56.330 19.399 1.00 69.52 A C ATOM 20 CE2 TRP A 127 38.137 56.832 20.686 1.00 69.28 A C ATOM 21 CE3 TRP A 127 39.028 55.062 19.288 1.00 70.75 A C ATOM 22 CD1 TRP A 127 37.515 58.361 19.182 1.00 68.38 A C ATOM 23 NE1 TRP A 127 37.575 58.070 20.523 1.00 68.76 A N ATOM 24 CZ2 TRP A 127 38.407 56.111 21.855 1.00 70.27 A C ATOM 25 CZ3 TRP A 127 39.299 54.343 20.455 1.00 70.56 A C ATOM 26 CH2 TRP A 127 38.987 54.873 21.719 1.00 71.20 A C ATOM 27 C TRP A 127 39.067 56.021 15.004 1.00 61.91 A C ATOM 28 O TRP A 127 39.034 56.724 14.001 1.00 62.11 A O ATOM 29 N ALA A 128 38.836 54.712 14.975 1.00 57.60 A N ATOM 30 CA ALA A 128 38.491 54.016 13.740 1.00 52.69 A C ATOM 31 CB ALA A 128 39.757 53.556 13.027 1.00 53.72 A C ATOM 32 C ALA A 128 37.597 52.820 14.075 1.00 50.40 A C ATOM 33 O ALA A 128 37.565 52.372 15.220 1.00 48.81 A O ATOM 34 N LEU A 129 36.875 52.308 13.082 1.00 47.90 A N ATOM 35 CA LEU A 129 35.975 51.176 13.293 1.00 47.52 A C ATOM 36 CB LEU A 129 35.235 50.836 11.991 1.00 46.25 A C ATOM 37 CG LEU A 129 34.125 49.775 12.047 1.00 47.39 A C ATOM 38 CD1 LEU A 129 33.068 50.164 13.079 1.00 45.16 A C ATOM 39 CD2 LEU A 129 33.488 49.630 10.671 1.00 48.56 A C ATOM 40 C LEU A 129 36.706 49.936 13.815 1.00 48.62 A C ATOM 41 O LEU A 129 36.170 49.199 14.645 1.00 46.32 A O ATOM 42 N ALA A 130 37.930 49.724 13.333 1.00 49.46 A N ATOM 43 CA ALA A 130 38.750 48.584 13.742 1.00 50.75 A C ATOM 44 CB ALA A 130 40.037 48.538 12.907 1.00 50.42 A C ATOM 45 C ALA A 130 39.098 48.610 15.233 1.00 51.11 A C ATOM 46 O ALA A 130 39.559 47.611 15.782 1.00 51.23 A O ATOM 47 N ASP A 131 38.896 49.752 15.883 1.00 51.02 A N ATOM 48 CA ASP A 131 39.183 49.863 17.310 1.00 51.74 A C ATOM 49 CB ASP A 131 39.353 51.328 17.735 1.00 55.51 A C ATOM 50 CG ASP A 131 40.539 52.012 17.080 1.00 57.37 A C ATOM 51 OD1 ASP A 131 40.515 52.230 15.852 1.00 60.16 A O ATOM 52 OD2 ASP A 131 41.496 52.344 17.804 1.00 60.43 A O ATOM 53 C ASP A 131 38.041 49.282 18.134 1.00 50.19 A C ATOM 54 O ASP A 131 38.147 49.195 19.352 1.00 51.36 A O ATOM 55 N PHE A 132 36.956 48.881 17.474 1.00 48.84 A N ATOM 56 CA PHE A 132 35.779 48.370 18.181 1.00 47.79 A C ATOM 57 CB PHE A 132 34.600 49.327 17.969 1.00 47.00 A C ATOM 58 CG PHE A 132 34.877 50.743 18.370 1.00 45.30 A C ATOM 59 CD1 PHE A 132 34.853 51.119 19.711 1.00 45.44 A C ATOM 60 CD2 PHE A 132 35.148 51.708 17.404 1.00 43.30 A C ATOM 61 CE1 PHE A 132 35.093 52.443 20.087 1.00 41.66 A C ATOM 62 CE2 PHE A 132 35.390 53.034 17.772 1.00 43.84 A C ATOM 63 CZ PHE A 132 35.361 53.399 19.115 1.00 42.35 A C ATOM 64 C PHE A 132 35.278 46.982 17.801 1.00 48.37 A C ATOM 65 O PHE A 132 35.501 46.505 16.689 1.00 49.60 A O ATOM 66 N GLU A 133 34.575 46.350 18.740 1.00 47.46 A N ATOM 67 CA GLU A 133 33.951 45.053 18.501 1.00 45.33 A C ATOM 68 CB GLU A 133 34.214 44.082 19.661 1.00 48.04 A C ATOM 69 CG GLU A 133 34.835 42.759 19.214 1.00 49.09 A C ATOM 70 CD GLU A 133 34.935 41.725 20.325 1.00 49.60 A C ATOM 71 OE1 GLU A 133 33.892 41.172 20.745 1.00 49.55 A O ATOM 72 OE2 GLU A 133 36.064 41.464 20.778 1.00 49.86 A O ATOM 73 C GLU A 133 32.460 45.384 18.418 1.00 44.56 A C ATOM 74 O GLU A 133 31.932 46.080 19.282 1.00 41.15 A O ATOM 75 N ILE A 134 31.785 44.899 17.380 1.00 44.52 A N ATOM 76 CA ILE A 134 30.364 45.180 17.194 1.00 44.87 A C ATOM 77 CB ILE A 134 30.033 45.362 15.700 1.00 43.36 A C ATOM 78 CG2 ILE A 134 28.567 45.739 15.540 1.00 44.27 A C ATOM 79 CG1 ILE A 134 30.968 46.409 15.080 1.00 45.76 A C ATOM 80 CD1 ILE A 134 30.975 47.777 15.776 1.00 43.59 A C ATOM 81 C ILE A 134 29.420 44.119 17.759 1.00 45.96 A C ATOM 82 O ILE A 134 29.603 42.927 17.514 1.00 46.32 A O ATOM 83 N GLY A 135 28.396 44.571 18.487 1.00 44.99 A N ATOM 84 CA GLY A 135 27.425 43.661 19.083 1.00 45.95 A C ATOM 85 C GLY A 135 26.050 43.706 18.438 1.00 44.79 A C ATOM 86 O GLY A 135 25.918 44.096 17.281 1.00 45.37 A O ATOM 87 N ARG A 136 25.014 43.330 19.183 1.00 46.84 A N ATOM 88 CA ARG A 136 23.652 43.314 18.630 1.00 47.11 A C ATOM 89 CB ARG A 136 22.665 42.699 19.629 1.00 47.09 A C ATOM 90 CG ARG A 136 22.462 43.505 20.909 1.00 45.16 A C ATOM 91 CD ARG A 136 21.296 42.979 21.736 1.00 41.59 A C ATOM 92 NE ARG A 136 21.296 43.550 23.080 1.00 41.35 A N ATOM 93 CZ ARG A 136 20.457 44.490 23.507 1.00 41.75 A C ATOM 94 NH1 ARG A 136 19.527 44.978 22.701 1.00 41.10 A N ATOM 95 NH2 ARG A 136 20.553 44.949 24.745 1.00 41.12 A N ATOM 96 C ARG A 136 23.116 44.680 18.205 1.00 47.41 A C ATOM 97 O ARG A 136 23.482 45.710 18.770 1.00 46.21 A O ATOM 98 N PRO A 137 22.231 44.696 17.197 1.00 49.15 A N ATOM 99 CD PRO A 137 21.994 43.557 16.295 1.00 50.53 A C ATOM 100 CA PRO A 137 21.607 45.910 16.659 1.00 50.22 A C ATOM 101 CB PRO A 137 20.948 45.420 15.373 1.00 49.86 A C ATOM 102 CG PRO A 137 21.781 44.245 14.978 1.00 49.74 A C ATOM 103 C PRO A 137 20.580 46.507 17.620 1.00 51.56 A C ATOM 104 O PRO A 137 19.619 45.841 18.007 1.00 52.67 A O ATOM 105 N LEU A 138 20.783 47.760 18.005 1.00 51.44 A N ATOM 106 CA LEU A 138 19.851 48.430 18.908 1.00 52.81 A C ATOM 107 CB LEU A 138 20.589 49.498 19.721 1.00 52.13 A C ATOM 108 CG LEU A 138 21.156 49.087 21.086 1.00 51.35 A C ATOM 109 CD1 LEU A 138 21.737 47.694 21.033 1.00 54.20 A C ATOM 110 CD2 LEU A 138 22.201 50.093 21.516 1.00 50.21 A C ATOM 111 C LEU A 138 18.710 49.064 18.114 1.00 53.48 A C ATOM 112 O LEU A 138 17.604 49.235 18.620 1.00 53.15 A O ATOM 113 N GLY A 139 18.990 49.401 16.860 1.00 55.10 A N ATOM 114 CA GLY A 139 17.992 50.015 16.009 1.00 55.12 A C ATOM 115 C GLY A 139 18.494 50.122 14.586 1.00 57.30 A C ATOM 116 O GLY A 139 19.684 50.365 14.348 1.00 55.60 A O ATOM 117 N LYS A 140 17.585 49.930 13.636 1.00 57.79 A N ATOM 118 CA LYS A 140 17.920 50.004 12.222 1.00 59.68 A C ATOM 119 CB LYS A 140 17.898 48.612 11.604 1.00 60.43 A C ATOM 120 C LYS A 140 16.902 50.897 11.534 1.00 61.09 A C ATOM 121 O LYS A 140 15.735 50.910 11.912 1.00 61.20 A O ATOM 122 N GLY A 141 17.337 51.648 10.530 1.00 62.18 A N ATOM 123 CA GLY A 141 16.413 52.525 9.834 1.00 62.70 A C ATOM 124 CB GLY A 141 15.841 53.534 10.803 1.00 65.14 A C ATOM 125 C GLY A 141 17.012 53.241 8.640 1.00 62.45 A C ATOM 126 O GLY A 141 18.188 53.082 8.325 1.00 61.72 A O ATOM 127 N ALA A 142 16.171 54.048 7.999 1.00 62.55 A N ATOM 128 CA ALA A 142 16.522 54.811 6.806 1.00 61.63 A C ATOM 129 CB ALA A 142 15.351 55.713 6.416 1.00 62.21 A C ATOM 130 C ALA A 142 17.793 55.641 6.903 1.00 60.80 A C ATOM 131 O ALA A 142 18.502 55.816 5.910 1.00 59.56 A O ATOM 132 N PHE A 143 18.088 56.152 8.091 1.00 59.81 A N ATOM 133 CA PHE A 143 19.266 56.986 8.255 1.00 58.87 A C ATOM 134 CB PHE A 143 18.913 58.170 9.153 1.00 61.93 A C ATOM 135 CG PHE A 143 18.150 59.246 8.439 1.00 64.91 A C ATOM 136 CD1 PHE A 143 18.825 60.244 7.739 1.00 65.80 A C ATOM 137 CD2 PHE A 143 16.759 59.225 8.407 1.00 65.92 A C ATOM 138 CE1 PHE A 143 18.125 61.206 7.013 1.00 68.03 A C ATOM 139 CE2 PHE A 143 16.048 60.182 7.683 1.00 67.18 A C ATOM 140 CZ PHE A 143 16.732 61.173 6.984 1.00 67.45 A C ATOM 141 C PHE A 143 20.514 56.275 8.755 1.00 56.62 A C ATOM 142 O PHE A 143 21.614 56.822 8.694 1.00 56.81 A O ATOM 143 N GLY A 144 20.343 55.050 9.235 1.00 54.51 A N ATOM 144 CA GLY A 144 21.472 54.289 9.728 1.00 51.51 A C ATOM 145 C GLY A 144 21.046 53.257 10.748 1.00 50.01 A C ATOM 146 O GLY A 144 19.864 52.914 10.849 1.00 50.62 A O ATOM 147 N ASN A 145 22.011 52.763 11.512 1.00 47.13 A N ATOM 148 CA ASN A 145 21.731 51.769 12.535 1.00 43.41 A C ATOM 149 CB ASN A 145 22.164 50.372 12.065 1.00 44.40 A C ATOM 150 CG ASN A 145 21.861 50.117 10.598 1.00 44.65 A C ATOM 151 OD1 ASN A 145 22.761 50.118 9.761 1.00 46.61 A O ATOM 152 ND2 ASN A 145 20.591 49.900 10.281 1.00 45.75 A N ATOM 153 C ASN A 145 22.517 52.127 13.788 1.00 40.16 A C ATOM 154 O ASN A 145 23.491 52.874 13.722 1.00 38.46 A O ATOM 155 N VAL A 146 22.082 51.599 14.927 1.00 36.92 A N ATOM 156 CA VAL A 146 22.780 51.818 16.188 1.00 35.73 A C ATOM 157 CB VAL A 146 21.908 52.590 17.221 1.00 35.98 A C ATOM 158 CG1 VAL A 146 22.737 52.921 18.440 1.00 35.61 A C ATOM 159 CG2 VAL A 146 21.353 53.868 16.610 1.00 38.31 A C ATOM 160 C VAL A 146 23.082 50.414 16.732 1.00 35.97 A C ATOM 161 O VAL A 146 22.224 49.537 16.688 1.00 35.59 A O ATOM 162 N TYR A 147 24.296 50.197 17.231 1.00 37.55 A N ATOM 163 CA TYR A 147 24.670 48.886 17.763 1.00 37.38 A C ATOM 164 CB TYR A 147 25.674 48.159 16.854 1.00 39.73 A C ATOM 165 CG TYR A 147 25.324 48.027 15.388 1.00 41.31 A C ATOM 166 CD1 TYR A 147 25.614 49.052 14.484 1.00 43.72 A C ATOM 167 CE1 TYR A 147 25.371 48.900 13.119 1.00 41.58 A C ATOM 168 CD2 TYR A 147 24.773 46.847 14.890 1.00 42.29 A C ATOM 169 CE2 TYR A 147 24.528 46.685 13.534 1.00 42.99 A C ATOM 170 CZ TYR A 147 24.832 47.712 12.656 1.00 43.10 A C ATOM 171 OH TYR A 147 24.619 47.533 11.312 1.00 43.57 A O ATOM 172 C TYR A 147 25.352 48.972 19.116 1.00 37.06 A C ATOM 173 O TYR A 147 25.950 49.985 19.466 1.00 36.75 A O ATOM 174 N LEU A 148 25.277 47.879 19.864 1.00 36.10 A N ATOM 175 CA LEU A 148 25.970 47.790 21.133 1.00 35.79 A C ATOM 176 CB LEU A 148 25.466 46.574 21.911 1.00 38.69 A C ATOM 177 CG LEU A 148 25.919 46.357 23.350 1.00 41.70 A C ATOM 178 CD1 LEU A 148 25.512 47.550 24.213 1.00 44.96 A C ATOM 179 CD2 LEU A 148 25.285 45.083 23.876 1.00 41.80 A C ATOM 180 C LEU A 148 27.407 47.562 20.655 1.00 35.72 A C ATOM 181 O LEU A 148 27.606 46.984 19.593 1.00 35.45 A O ATOM 182 N ALA A 149 28.404 48.033 21.395 1.00 36.28 A N ATOM 183 CA ALA A 149 29.791 47.829 20.989 1.00 37.35 A C ATOM 184 CB ALA A 149 30.211 48.870 19.943 1.00 35.81 A C ATOM 185 C ALA A 149 30.728 47.894 22.182 1.00 40.30 A C ATOM 186 O ALA A 149 30.341 48.301 23.278 1.00 39.46 A O ATOM 187 N ARG A 150 31.974 47.498 21.962 1.00 41.71 A N ATOM 188 CA ARG A 150 32.956 47.506 23.026 1.00 45.19 A C ATOM 189 CB ARG A 150 32.946 46.137 23.717 1.00 49.42 A C ATOM 190 CG ARG A 150 33.892 45.984 24.888 1.00 52.01 A C ATOM 191 CD ARG A 150 33.362 44.946 25.885 1.00 54.44 A C ATOM 192 NE ARG A 150 32.854 43.742 25.231 1.00 55.30 A N ATOM 193 CZ ARG A 150 32.082 42.837 25.828 1.00 53.68 A C ATOM 194 NH1 ARG A 150 31.729 42.996 27.095 1.00 54.04 A N ATOM 195 NH2 ARG A 150 31.652 41.781 25.154 1.00 52.52 A N ATOM 196 C ARG A 150 34.322 47.829 22.440 1.00 47.01 A C ATOM 197 O ARG A 150 34.703 47.296 21.397 1.00 47.88 A O ATOM 198 N GLU A 151 35.042 48.730 23.093 1.00 49.42 A N ATOM 199 CA GLU A 151 36.365 49.124 22.632 1.00 54.61 A C ATOM 200 CB GLU A 151 36.848 50.346 23.426 1.00 56.69 A C ATOM 201 CG GLU A 151 37.983 51.140 22.766 1.00 63.91 A C ATOM 202 CD GLU A 151 39.363 50.535 22.995 1.00 66.90 A C ATOM 203 OE1 GLU A 151 39.845 50.581 24.151 1.00 67.65 A O ATOM 204 OE2 GLU A 151 39.967 50.018 22.024 1.00 69.20 A O ATOM 205 C GLU A 151 37.265 47.917 22.871 1.00 56.41 A C ATOM 206 O GLU A 151 37.304 47.384 23.975 1.00 56.29 A O ATOM 207 N LYS A 152 37.963 47.471 21.830 1.00 59.00 A N ATOM 208 CA LYS A 152 38.842 46.305 21.934 1.00 60.50 A C ATOM 209 CB LYS A 152 39.626 46.114 20.630 1.00 61.26 A C ATOM 210 CG LYS A 152 38.765 45.794 19.402 1.00 61.58 A C ATOM 211 CD LYS A 152 39.643 45.531 18.171 1.00 62.51 A C ATOM 212 CE LYS A 152 38.831 45.211 16.916 1.00 61.68 A C ATOM 213 NZ LYS A 152 37.959 44.023 17.075 1.00 63.73 A N ATOM 214 C LYS A 152 39.816 46.390 23.111 1.00 61.70 A C ATOM 215 O LYS A 152 39.759 45.572 24.030 1.00 60.64 A O ATOM 216 N GLN A 153 40.702 47.381 23.083 1.00 63.23 A N ATOM 217 CA GLN A 153 41.689 47.562 24.145 1.00 66.35 A C ATOM 218 CB GLN A 153 42.477 48.859 23.916 1.00 68.76 A C ATOM 219 CG GLN A 153 43.247 48.912 22.597 1.00 72.76 A C ATOM 220 CD GLN A 153 44.497 48.038 22.595 1.00 75.69 A C ATOM 221 OE1 GLN A 153 44.438 46.835 22.872 1.00 75.15 A O ATOM 222 NE2 GLN A 153 45.639 48.644 22.273 1.00 76.04 A N ATOM 223 C GLN A 153 41.055 47.600 25.535 1.00 67.63 A C ATOM 224 O GLN A 153 41.276 46.709 26.360 1.00 67.71 A O ATOM 225 N SER A 154 40.265 48.642 25.776 1.00 67.64 A N ATOM 226 CA SER A 154 39.592 48.858 27.054 1.00 68.46 A C ATOM 227 CB SER A 154 38.963 50.253 27.067 1.00 68.69 A C ATOM 228 OG SER A 154 38.180 50.435 28.231 1.00 72.14 A O ATOM 229 C SER A 154 38.524 47.827 27.413 1.00 67.39 A C ATOM 230 O SER A 154 38.422 47.404 28.562 1.00 66.91 A O ATOM 231 N LYS A 155 37.722 47.447 26.426 1.00 66.94 A N ATOM 232 CA LYS A 155 36.645 46.479 26.602 1.00 65.83 A C ATOM 233 CB LYS A 155 37.166 45.229 27.310 1.00 66.50 A C ATOM 234 CG LYS A 155 38.159 44.456 26.452 1.00 69.74 A C ATOM 235 CD LYS A 155 38.437 43.070 26.992 1.00 70.98 A C ATOM 236 CE LYS A 155 39.396 42.318 26.080 1.00 72.81 A C ATOM 237 NZ LYS A 155 39.663 40.936 26.573 1.00 75.35 A N ATOM 238 C LYS A 155 35.422 47.053 27.326 1.00 64.74 A C ATOM 239 O LYS A 155 34.608 46.318 27.891 1.00 63.21 A O ATOM 240 N PHE A 156 35.289 48.375 27.278 1.00 63.83 A N ATOM 241 CA PHE A 156 34.162 49.061 27.901 1.00 61.40 A C ATOM 242 CB PHE A 156 34.544 50.514 28.194 1.00 63.97 A C ATOM 243 CG PHE A 156 33.478 51.290 28.911 1.00 68.01 A C ATOM 244 CD1 PHE A 156 32.956 50.832 30.121 1.00 69.99 A C ATOM 245 CD2 PHE A 156 33.004 52.490 28.387 1.00 68.86 A C ATOM 246 CE1 PHE A 156 31.975 51.559 30.800 1.00 70.97 A C ATOM 247 CE2 PHE A 156 32.026 53.224 29.055 1.00 69.64 A C ATOM 248 CZ PHE A 156 31.510 52.759 30.264 1.00 70.88 A C ATOM 249 C PHE A 156 32.963 49.013 26.946 1.00 57.88 A C ATOM 250 O PHE A 156 33.127 49.157 25.732 1.00 55.27 A O ATOM 251 N ILE A 157 31.768 48.799 27.498 1.00 53.85 A N ATOM 252 CA ILE A 157 30.542 48.730 26.701 1.00 50.05 A C ATOM 253 CB ILE A 157 29.434 47.949 27.459 1.00 50.70 A C ATOM 254 CG2 ILE A 157 28.097 48.111 26.760 1.00 48.39 A C ATOM 255 CG1 ILE A 157 29.800 46.464 27.545 1.00 51.64 A C ATOM 256 CD1 ILE A 157 29.635 45.707 26.244 1.00 52.26 A C ATOM 257 C ILE A 157 30.020 50.130 26.353 1.00 47.74 A C ATOM 258 O ILE A 157 29.998 51.021 27.203 1.00 45.67 A O ATOM 259 N LEU A 158 29.609 50.308 25.097 1.00 44.24 A N ATOM 260 CA LEU A 158 29.079 51.586 24.618 1.00 43.05 A C ATOM 261 CB LEU A 158 30.229 52.539 24.251 1.00 42.08 A C ATOM 262 CG LEU A 158 31.339 52.029 23.327 1.00 45.57 A C ATOM 263 CD1 LEU A 158 30.844 51.994 21.901 1.00 46.09 A C ATOM 264 CD2 LEU A 158 32.566 52.940 23.435 1.00 46.27 A C ATOM 265 C LEU A 158 28.154 51.392 23.427 1.00 39.34 A C ATOM 266 O LEU A 158 27.861 50.269 23.036 1.00 38.00 A O ATOM 267 N ALA A 159 27.669 52.489 22.858 1.00 39.30 A N ATOM 268 CA ALA A 159 26.789 52.384 21.702 1.00 38.21 A C ATOM 269 CB ALA A 159 25.438 53.007 22.006 1.00 37.68 A C ATOM 270 C ALA A 159 27.443 53.082 20.525 1.00 38.81 A C ATOM 271 O ALA A 159 28.146 54.073 20.694 1.00 38.10 A O ATOM 272 N LEU A 160 27.221 52.556 19.329 1.00 39.75 A N ATOM 273 CA LEU A 160 27.806 53.152 18.145 1.00 39.68 A C ATOM 274 CB LEU A 160 28.793 52.175 17.503 1.00 41.87 A C ATOM 275 CG LEU A 160 29.841 52.748 16.543 1.00 44.90 A C ATOM 276 CD1 LEU A 160 30.807 53.651 17.305 1.00 43.49 A C ATOM 277 CD2 LEU A 160 30.602 51.604 15.885 1.00 44.40 A C ATOM 278 C LEU A 160 26.690 53.496 17.169 1.00 39.67 A C ATOM 279 O LEU A 160 26.005 52.610 16.666 1.00 39.99 A O ATOM 280 N LYS A 161 26.493 54.788 16.921 1.00 38.00 A N ATOM 281 CA LYS A 161 25.461 55.212 15.996 1.00 39.14 A C ATOM 282 CB LYS A 161 24.782 56.501 16.480 1.00 40.21 A C ATOM 283 CG LYS A 161 23.783 57.073 15.485 1.00 43.91 A C ATOM 284 CD LYS A 161 23.120 58.347 15.994 1.00 45.72 A C ATOM 285 CE LYS A 161 22.171 58.060 17.140 1.00 48.13 A C ATOM 286 NZ LYS A 161 21.511 59.299 17.670 1.00 52.12 A N ATOM 287 C LYS A 161 26.102 55.429 14.644 1.00 36.94 A C ATOM 288 O LYS A 161 26.961 56.294 14.485 1.00 35.11 A O ATOM 289 N VAL A 162 25.661 54.631 13.677 1.00 37.87 A N ATOM 290 CA VAL A 162 26.168 54.656 12.311 1.00 37.92 A C ATOM 291 CB VAL A 162 26.400 53.201 11.807 1.00 39.41 A C ATOM 292 CG1 VAL A 162 27.179 53.214 10.506 1.00 37.99 A C ATOM 293 CG2 VAL A 162 27.142 52.382 12.873 1.00 37.26 A C ATOM 294 C VAL A 162 25.180 55.362 11.368 1.00 39.49 A C ATOM 295 O VAL A 162 24.070 54.878 11.141 1.00 40.14 A O ATOM 296 N LEU A 163 25.595 56.500 10.817 1.00 39.18 A N ATOM 297 CA LEU A 163 24.757 57.277 9.907 1.00 42.61 A C ATOM 298 CB LEU A 163 24.659 58.726 10.400 1.00 43.27 A C ATOM 299 CG LEU A 163 23.621 59.124 11.457 1.00 42.79 A C ATOM 300 CD1 LEU A 163 23.227 57.944 12.311 1.00 43.48 A C ATOM 301 CD2 LEU A 163 24.201 60.246 12.313 1.00 43.16 A C ATOM 302 C LEU A 163 25.279 57.278 8.466 1.00 45.56 A C ATOM 303 O LEU A 163 26.462 57.515 8.228 1.00 43.94 A O ATOM 304 N PHE A 164 24.381 57.029 7.513 1.00 48.16 A N ATOM 305 CA PHE A 164 24.733 57.006 6.091 1.00 52.24 A C ATOM 306 CB PHE A 164 23.624 56.332 5.286 1.00 53.67 A C ATOM 307 CG PHE A 164 23.201 55.008 5.831 1.00 55.86 A C ATOM 308 CD1 PHE A 164 21.865 54.625 5.781 1.00 56.34 A C ATOM 309 CD2 PHE A 164 24.133 54.139 6.392 1.00 55.83 A C ATOM 310 CE1 PHE A 164 21.460 53.393 6.286 1.00 58.23 A C ATOM 311 CE2 PHE A 164 23.743 52.907 6.897 1.00 55.86 A C ATOM 312 CZ PHE A 164 22.404 52.530 6.846 1.00 58.79 A C ATOM 313 C PHE A 164 24.919 58.423 5.551 1.00 53.31 A C ATOM 314 O PHE A 164 24.022 59.262 5.676 1.00 51.66 A O ATOM 315 N LYS A 165 26.072 58.682 4.940 1.00 55.24 A N ATOM 316 CA LYS A 165 26.355 60.000 4.372 1.00 57.91 A C ATOM 317 CB LYS A 165 27.751 60.033 3.754 1.00 57.31 A C ATOM 318 CG LYS A 165 28.881 60.126 4.756 1.00 57.21 A C ATOM 319 CD LYS A 165 30.201 60.338 4.040 1.00 57.36 A C ATOM 320 CE LYS A 165 31.340 60.528 5.018 1.00 58.00 A C ATOM 321 NZ LYS A 165 32.638 60.675 4.309 1.00 60.01 A N ATOM 322 C LYS A 165 25.340 60.392 3.306 1.00 59.50 A C ATOM 323 O LYS A 165 24.971 61.559 3.194 1.00 59.56 A O ATOM 324 N ALA A 166 24.894 59.407 2.534 1.00 62.03 A N ATOM 325 CA ALA A 166 23.931 59.628 1.462 1.00 66.28 A C ATOM 326 CB ALA A 166 23.673 58.319 0.728 1.00 65.88 A C ATOM 327 C ALA A 166 22.606 60.229 1.939 1.00 69.38 A C ATOM 328 O ALA A 166 21.706 60.485 1.132 1.00 69.73 A O ATOM 329 N GLN A 167 22.486 60.447 3.246 1.00 70.89 A N ATOM 330 CA GLN A 167 21.272 61.017 3.819 1.00 71.80 A C ATOM 331 CB GLN A 167 20.686 60.063 4.856 1.00 73.19 A C ATOM 332 CG GLN A 167 20.621 58.625 4.388 1.00 76.66 A C ATOM 333 CD GLN A 167 19.769 58.453 3.152 1.00 79.08 A C ATOM 334 OE1 GLN A 167 19.772 57.390 2.527 1.00 80.82 A O ATOM 335 NE2 GLN A 167 19.025 59.497 2.792 1.00 80.53 A N ATOM 336 C GLN A 167 21.597 62.352 4.477 1.00 72.50 A C ATOM 337 O GLN A 167 20.884 63.336 4.298 1.00 71.35 A O ATOM 338 N LEU A 168 22.676 62.379 5.247 1.00 73.59 A N ATOM 339 CA LEU A 168 23.082 63.602 5.912 1.00 76.12 A C ATOM 340 CB LEU A 168 24.460 63.421 6.552 1.00 74.15 A C ATOM 341 CG LEU A 168 24.547 62.317 7.612 1.00 73.50 A C ATOM 342 CD1 LEU A 168 25.979 62.150 8.066 1.00 72.46 A C ATOM 343 CD2 LEU A 168 23.656 62.665 8.789 1.00 72.72 A C ATOM 344 C LEU A 168 23.112 64.728 4.881 1.00 78.84 A C ATOM 345 O LEU A 168 22.254 65.610 4.896 1.00 79.50 A O ATOM 346 N GLU A 169 24.086 64.681 3.976 1.00 81.12 A N ATOM 347 CA GLU A 169 24.228 65.697 2.936 1.00 83.10 A C ATOM 348 CB GLU A 169 25.344 65.296 1.971 1.00 83.78 A C ATOM 349 CG GLU A 169 25.096 63.979 1.255 1.00 85.16 A C ATOM 350 CD GLU A 169 26.298 63.510 0.457 1.00 86.11 A C ATOM 351 OE1 GLU A 169 27.361 63.266 1.068 1.00 85.05 A O ATOM 352 OE2 GLU A 169 26.179 63.387 −0.781 1.00 87.77 A O ATOM 353 C GLU A 169 22.924 65.891 2.164 1.00 83.83 A C ATOM 354 O GLU A 169 22.541 67.018 1.840 1.00 83.53 A O ATOM 355 N LYS A 170 22.250 64.782 1.878 1.00 84.15 A N ATOM 356 CA LYS A 170 20.985 64.794 1.149 1.00 85.24 A C ATOM 357 CB LYS A 170 20.809 63.467 0.411 1.00 84.77 A C ATOM 358 CG LYS A 170 19.407 63.207 −0.112 1.00 84.91 A C ATOM 359 CD LYS A 170 19.271 61.764 −0.560 1.00 84.46 A C ATOM 360 CE LYS A 170 17.863 61.447 −1.022 1.00 84.75 A C ATOM 361 NZ LYS A 170 17.754 60.021 −1.434 1.00 84.95 A N ATOM 362 C LYS A 170 19.797 65.020 2.085 1.00 86.98 A C ATOM 363 O LYS A 170 19.175 64.058 2.547 1.00 88.55 A O ATOM 364 N ALA A 171 19.495 66.291 2.353 1.00 86.65 A N ATOM 365 CA ALA A 171 18.388 66.702 3.222 1.00 86.88 A C ATOM 366 CB ALA A 171 17.388 65.561 3.418 1.00 86.71 A C ATOM 367 C ALA A 171 18.877 67.194 4.577 1.00 86.86 A C ATOM 368 O ALA A 171 19.133 68.386 4.754 1.00 86.68 A O ATOM 369 N GLY A 172 18.993 66.275 5.533 1.00 86.88 A N ATOM 370 CA GLY A 172 19.449 66.635 6.866 1.00 86.26 A C ATOM 371 C GLY A 172 20.858 67.190 6.837 1.00 86.14 A C ATOM 372 O GLY A 172 21.659 66.924 7.735 1.00 86.73 A O ATOM 373 N VAL A 173 21.141 67.967 5.793 1.00 85.19 A N ATOM 374 CA VAL A 173 22.437 68.593 5.564 1.00 83.10 A C ATOM 375 CB VAL A 173 22.280 70.107 5.336 1.00 82.25 A C ATOM 376 CG1 VAL A 173 23.622 70.720 4.988 1.00 79.89 A C ATOM 377 CG2 VAL A 173 21.276 70.355 4.223 1.00 82.16 A C ATOM 378 C VAL A 173 23.450 68.364 6.678 1.00 82.27 A C ATOM 379 O VAL A 173 23.174 68.599 7.857 1.00 82.63 A O ATOM 380 N GLU A 174 24.629 67.897 6.289 1.00 80.75 A N ATOM 381 CA GLU A 174 25.690 67.639 7.242 1.00 79.61 A C ATOM 382 CB GLU A 174 26.984 67.310 6.492 1.00 80.39 A C ATOM 383 CG GLU A 174 28.221 67.233 7.369 1.00 81.70 A C ATOM 384 CD GLU A 174 28.904 68.577 7.535 1.00 83.27 A C ATOM 385 OE1 GLU A 174 29.877 68.658 8.314 1.00 83.32 A O ATOM 386 OE2 GLU A 174 28.474 69.552 6.879 1.00 83.99 A O ATOM 387 C GLU A 174 25.886 68.848 8.151 1.00 78.82 A C ATOM 388 O GLU A 174 26.258 68.701 9.313 1.00 78.22 A O ATOM 389 N HIS A 175 25.618 70.038 7.615 1.00 78.24 A N ATOM 390 CA HIS A 175 25.770 71.285 8.363 1.00 77.47 A C ATOM 391 CB HIS A 175 25.205 72.463 7.562 1.00 76.98 A C ATOM 392 CG HIS A 175 25.859 72.663 6.231 1.00 77.17 A C ATOM 393 CD2 HIS A 175 26.828 71.962 5.597 1.00 76.90 A C ATOM 394 ND1 HIS A 175 25.506 73.687 5.378 1.00 77.46 A N ATOM 395 CE1 HIS A 175 26.229 73.607 4.275 1.00 77.33 A C ATOM 396 NE2 HIS A 175 27.039 72.568 4.382 1.00 77.65 A N ATOM 397 C HIS A 175 25.073 71.223 9.716 1.00 76.86 A C ATOM 398 O HIS A 175 25.709 71.382 10.756 1.00 74.77 A O ATOM 399 N GLN A 176 23.761 70.998 9.684 1.00 77.67 A N ATOM 400 CA GLN A 176 22.946 70.907 10.893 1.00 79.14 A C ATOM 401 CB GLN A 176 21.495 70.583 10.517 1.00 79.88 A C ATOM 402 CG GLN A 176 20.643 70.082 11.673 1.00 81.72 A C ATOM 403 CD GLN A 176 19.203 69.804 11.272 1.00 83.00 A C ATOM 404 OE1 GLN A 176 18.444 69.197 12.028 1.00 82.78 A O ATOM 405 NE2 GLN A 176 18.818 70.257 10.081 1.00 83.25 A N ATOM 406 C GLN A 176 23.459 69.858 11.873 1.00 79.66 A C ATOM 407 O GLN A 176 23.533 70.103 13.079 1.00 78.29 A O ATOM 408 N ALA A 177 23.816 68.689 11.348 1.00 81.28 A N ATOM 409 CA ALA A 177 24.305 67.596 12.178 1.00 82.55 A C ATOM 410 CB ALA A 177 23.604 66.305 11.786 1.00 83.52 A C ATOM 411 C ALA A 177 25.814 67.399 12.113 1.00 83.96 A C ATOM 412 O ALA A 177 26.284 66.312 11.767 1.00 85.89 A O ATOM 413 N ARG A 178 26.575 68.438 12.447 1.00 84.10 A N ATOM 414 CA ARG A 178 28.029 68.327 12.426 1.00 84.25 A C ATOM 415 CB ARG A 178 28.612 68.952 11.160 1.00 83.50 A C ATOM 416 CG ARG A 178 30.132 69.065 11.216 1.00 84.36 A C ATOM 417 CD ARG A 178 30.782 67.748 11.659 1.00 83.46 A C ATOM 418 NE ARG A 178 32.208 67.902 11.948 1.00 81.99 A N ATOM 419 CZ ARG A 178 32.704 68.564 12.990 1.00 79.87 A C ATOM 420 NH1 ARG A 178 31.897 69.144 13.867 1.00 78.59 A N ATOM 421 NH2 ARG A 178 34.017 68.652 13.149 1.00 78.59 A N ATOM 422 C ARG A 178 28.735 68.923 13.639 1.00 83.89 A C ATOM 423 O ARG A 178 29.075 68.199 14.576 1.00 84.19 A O ATOM 424 N ALA A 179 28.971 70.234 13.610 1.00 83.02 A N ATOM 425 CA ALA A 179 29.657 70.913 14.711 1.00 81.63 A C ATOM 426 CB ALA A 179 29.708 72.420 14.457 1.00 82.10 A C ATOM 427 C ALA A 179 28.928 70.622 16.010 1.00 80.48 A C ATOM 428 O ALA A 179 29.497 70.733 17.102 1.00 79.55 A O ATOM 429 N GLU A 180 27.658 70.253 15.869 1.00 79.39 A N ATOM 430 CA GLU A 180 26.815 69.908 17.002 1.00 78.29 A C ATOM 431 CB GLU A 180 25.389 69.647 16.521 1.00 78.71 A C ATOM 432 CG GLU A 180 24.543 70.903 16.382 1.00 81.63 A C ATOM 433 CD GLU A 180 25.322 72.098 15.848 1.00 83.43 A C ATOM 434 OE1 GLU A 180 26.170 72.639 16.591 1.00 84.35 A O ATOM 435 OE2 GLU A 180 25.088 72.499 14.686 1.00 84.07 A O ATOM 436 C GLU A 180 27.382 68.681 17.713 1.00 75.99 A C ATOM 437 O GLU A 180 26.838 68.226 18.720 1.00 75.11 A O ATOM 438 N VAL A 181 28.471 68.146 17.165 1.00 73.03 A N ATOM 439 CA VAL A 181 29.148 66.999 17.757 1.00 70.84 A C ATOM 440 CB VAL A 181 29.938 66.175 16.706 1.00 70.79 A C ATOM 441 CG1 VAL A 181 30.861 65.180 17.409 1.00 69.55 A C ATOM 442 CG2 VAL A 181 28.973 65.433 15.791 1.00 69.51 A C ATOM 443 C VAL A 181 30.128 67.585 18.758 1.00 69.44 A C ATOM 444 O VAL A 181 30.351 67.026 19.831 1.00 69.27 A O ATOM 445 N ALA A 182 30.707 68.724 18.392 1.00 68.30 A N ATOM 446 CA ALA A 182 31.654 69.416 19.259 1.00 66.45 A C ATOM 447 CB ALA A 182 32.419 70.483 18.469 1.00 67.64 A C ATOM 448 C ALA A 182 30.900 70.057 20.425 1.00 64.52 A C ATOM 449 O ALA A 182 31.368 70.013 21.567 1.00 64.11 A O ATOM 450 N ILE A 183 29.737 70.649 20.146 1.00 59.92 A N ATOM 451 CA ILE A 183 28.969 71.262 21.222 1.00 59.47 A C ATOM 452 CB ILE A 183 27.772 72.131 20.710 1.00 60.11 A C ATOM 453 CG2 ILE A 183 28.277 73.193 19.744 1.00 60.37 A C ATOM 454 CG1 ILE A 183 26.705 71.251 20.053 1.00 60.21 A C ATOM 455 CD1 ILE A 183 25.391 71.971 19.783 1.00 60.28 A C ATOM 456 C ILE A 183 28.437 70.164 22.140 1.00 56.99 A C ATOM 457 O ILE A 183 28.617 70.229 23.350 1.00 56.38 A O ATOM 458 N GLN A 184 27.799 69.150 21.562 1.00 56.33 A N ATOM 459 CA GLN A 184 27.264 68.045 22.352 1.00 56.17 A C ATOM 460 CB GLN A 184 26.552 67.026 21.458 1.00 57.52 A C ATOM 461 CG GLN A 184 25.670 66.045 22.228 1.00 61.39 A C ATOM 462 CD GLN A 184 24.324 66.650 22.615 1.00 64.82 A C ATOM 463 OE1 GLN A 184 23.672 66.213 23.570 1.00 62.62 A O ATOM 464 NE2 GLN A 184 23.897 67.654 21.857 1.00 65.33 A N ATOM 465 C GLN A 184 28.381 67.342 23.124 1.00 54.27 A C ATOM 466 O GLN A 184 28.236 67.057 24.308 1.00 53.30 A O ATOM 467 N SER A 185 29.498 67.076 22.458 1.00 53.49 A N ATOM 468 CA SER A 185 30.621 66.401 23.106 1.00 55.92 A C ATOM 469 CB SER A 185 31.786 66.247 22.128 1.00 56.01 A C ATOM 470 OG SER A 185 32.335 67.510 21.797 1.00 55.72 A O ATOM 471 C SER A 185 31.115 67.152 24.342 1.00 56.22 A C ATOM 472 O SER A 185 31.636 66.551 25.281 1.00 55.88 A O ATOM 473 N HIS A 186 30.945 68.467 24.341 1.00 56.92 A N ATOM 474 CA HIS A 186 31.399 69.281 25.460 1.00 58.35 A C ATOM 475 CB HIS A 186 31.765 70.676 24.953 1.00 61.17 A C ATOM 476 CG HIS A 186 32.936 70.683 24.017 1.00 64.95 A C ATOM 477 CD2 HIS A 186 33.986 69.834 23.898 1.00 65.77 A C ATOM 478 ND1 HIS A 186 33.120 71.656 23.056 1.00 66.54 A N ATOM 479 CE1 HIS A 186 34.231 71.404 22.386 1.00 66.45 A C ATOM 480 NE2 HIS A 186 34.775 70.305 22.877 1.00 66.45 A N ATOM 481 C HIS A 186 30.399 69.359 26.610 1.00 56.48 A C ATOM 482 O HIS A 186 30.615 70.079 27.583 1.00 57.86 A O ATOM 483 N LEU A 187 29.304 68.614 26.496 1.00 53.92 A N ATOM 484 CA LEU A 187 28.296 68.580 27.543 1.00 52.14 A C ATOM 485 CB LEU A 187 26.900 68.410 26.935 1.00 51.03 A C ATOM 486 CG LEU A 187 26.067 69.660 26.626 1.00 52.63 A C ATOM 487 CD1 LEU A 187 26.958 70.858 26.344 1.00 52.17 A C ATOM 488 CD2 LEU A 187 25.158 69.365 25.444 1.00 51.26 A C ATOM 489 C LEU A 187 28.619 67.401 28.454 1.00 51.97 A C ATOM 490 O LEU A 187 28.631 66.256 28.010 1.00 51.83 A O ATOM 491 N ARG A 188 28.891 67.682 29.724 1.00 50.85 A N ATOM 492 CA ARG A 188 29.213 66.626 30.676 1.00 49.45 A C ATOM 493 CB ARG A 188 30.703 66.670 31.026 1.00 52.24 A C ATOM 494 CG ARG A 188 31.595 66.327 29.838 1.00 56.65 A C ATOM 495 CD ARG A 188 33.042 66.111 30.252 1.00 61.31 A C ATOM 496 NE ARG A 188 33.881 65.699 29.126 1.00 64.86 A N ATOM 497 CZ ARG A 188 34.195 66.477 28.092 1.00 65.93 A C ATOM 498 NH1 ARG A 188 33.744 67.725 28.028 1.00 67.33 A N ATOM 499 NH2 ARG A 188 34.959 66.007 27.115 1.00 66.11 A N ATOM 500 C ARG A 188 28.356 66.746 31.923 1.00 47.99 A C ATOM 501 O ARG A 188 28.619 67.561 32.813 1.00 47.40 A O ATOM 502 N HIS A 189 27.323 65.913 31.981 1.00 46.41 A N ATOM 503 CA HIS A 189 26.387 65.939 33.095 1.00 43.42 A C ATOM 504 CB HIS A 189 25.288 66.961 32.775 1.00 39.93 A C ATOM 505 CG HIS A 189 24.371 67.255 33.918 1.00 37.78 A C ATOM 506 CD2 HIS A 189 24.342 68.289 34.793 1.00 37.18 A C ATOM 507 ND1 HIS A 189 23.322 66.431 34.261 1.00 38.04 A N ATOM 508 CE1 HIS A 189 22.681 66.948 35.296 1.00 40.74 A C ATOM 509 NE2 HIS A 189 23.281 68.076 35.637 1.00 38.70 A N ATOM 510 C HIS A 189 25.794 64.546 33.314 1.00 42.45 A C ATOM 511 O HIS A 189 25.585 63.799 32.367 1.00 43.83 A O ATOM 512 N PRO A 190 25.539 64.171 34.576 1.00 41.87 A N ATOM 513 CD PRO A 190 25.811 64.893 35.829 1.00 41.35 A C ATOM 514 CA PRO A 190 24.970 62.850 34.851 1.00 40.95 A C ATOM 515 CB PRO A 190 24.878 62.820 36.378 1.00 40.22 A C ATOM 516 CG PRO A 190 24.803 64.267 36.758 1.00 43.23 A C ATOM 517 C PRO A 190 23.626 62.591 34.178 1.00 40.60 A C ATOM 518 O PRO A 190 23.260 61.442 33.931 1.00 40.06 A O ATOM 519 N ASN A 191 22.886 63.650 33.865 1.00 39.67 A N ATOM 520 CA ASN A 191 21.594 63.451 33.237 1.00 37.85 A C ATOM 521 CB ASN A 191 20.532 64.244 34.003 1.00 39.49 A C ATOM 522 CG ASN A 191 20.373 63.762 35.446 1.00 37.64 A C ATOM 523 OD1 ASN A 191 20.013 62.606 35.695 1.00 38.24 A O ATOM 524 ND2 ASN A 191 20.647 64.645 36.397 1.00 35.93 A N ATOM 525 C ASN A 191 21.570 63.766 31.735 1.00 37.60 A C ATOM 526 O ASN A 191 20.518 64.003 31.150 1.00 36.22 A O ATOM 527 N ILE A 192 22.741 63.776 31.112 1.00 37.28 A N ATOM 528 CA ILE A 192 22.829 64.006 29.673 1.00 38.27 A C ATOM 529 CB ILE A 192 23.511 65.351 29.316 1.00 38.46 A C ATOM 530 CG2 ILE A 192 23.623 65.488 27.795 1.00 35.81 A C ATOM 531 CG1 ILE A 192 22.689 66.516 29.867 1.00 41.28 A C ATOM 532 CD1 ILE A 192 23.199 67.881 29.476 1.00 38.83 A C ATOM 533 C ILE A 192 23.672 62.881 29.108 1.00 38.70 A C ATOM 534 O ILE A 192 24.772 62.629 29.597 1.00 38.53 A O ATOM 535 N LEU A 193 23.153 62.195 28.095 1.00 40.02 A N ATOM 536 CA LEU A 193 23.884 61.094 27.477 1.00 39.54 A C ATOM 537 CB LEU A 193 23.099 60.525 26.299 1.00 38.70 A C ATOM 538 CG LEU A 193 23.577 59.164 25.775 1.00 38.41 A C ATOM 539 CD1 LEU A 193 23.122 58.073 26.751 1.00 35.03 A C ATOM 540 CD2 LEU A 193 22.995 58.913 24.380 1.00 34.30 A C ATOM 541 C LEU A 193 25.211 61.630 26.973 1.00 40.55 A C ATOM 542 O LEU A 193 25.245 62.660 26.302 1.00 42.56 A O ATOM 543 N ARG A 194 26.308 60.947 27.282 1.00 40.25 A N ATOM 544 CA ARG A 194 27.593 61.436 26.820 1.00 41.82 A C ATOM 545 CB ARG A 194 28.728 61.018 27.756 1.00 43.59 A C ATOM 546 CG ARG A 194 30.023 61.749 27.418 1.00 49.64 A C ATOM 547 CD ARG A 194 31.216 61.273 28.217 1.00 56.35 A C ATOM 548 NE ARG A 194 32.436 62.006 27.871 1.00 60.72 A N ATOM 549 CZ ARG A 194 33.658 61.677 28.291 1.00 64.00 A C ATOM 550 NH1 ARG A 194 33.834 60.621 29.076 1.00 64.55 A N ATOM 551 NH2 ARG A 194 34.708 62.403 27.924 1.00 65.94 A N ATOM 552 C ARG A 194 27.957 61.023 25.401 1.00 42.36 A C ATOM 553 O ARG A 194 27.723 59.887 24.974 1.00 41.77 A O ATOM 554 N LEU A 195 28.517 61.981 24.671 1.00 41.98 A N ATOM 555 CA LEU A 195 28.981 61.763 23.308 1.00 43.72 A C ATOM 556 CB LEU A 195 28.538 62.912 22.395 1.00 42.46 A C ATOM 557 CG LEU A 195 28.545 62.694 20.878 1.00 46.89 A C ATOM 558 CD1 LEU A 195 28.063 63.967 20.193 1.00 48.66 A C ATOM 559 CD2 LEU A 195 29.926 62.338 20.395 1.00 45.85 A C ATOM 560 C LEU A 195 30.491 61.790 23.493 1.00 43.63 A C ATOM 561 O LEU A 195 31.061 62.851 23.722 1.00 45.28 A O ATOM 562 N TYR A 196 31.123 60.622 23.436 1.00 42.73 A N ATOM 563 CA TYR A 196 32.566 60.518 23.618 1.00 44.78 A C ATOM 564 CB TYR A 196 32.980 59.061 23.844 1.00 46.97 A C ATOM 565 CG TYR A 196 32.399 58.427 25.085 1.00 50.10 A C ATOM 566 CD1 TYR A 196 31.409 57.452 24.996 1.00 50.68 A C ATOM 567 CE1 TYR A 196 30.888 56.846 26.139 1.00 52.33 A C ATOM 568 CD2 TYR A 196 32.853 58.786 26.352 1.00 51.97 A C ATOM 569 CE2 TYR A 196 32.338 58.187 27.504 1.00 52.17 A C ATOM 570 CZ TYR A 196 31.358 57.220 27.389 1.00 54.59 A C ATOM 571 OH TYR A 196 30.844 56.626 28.525 1.00 57.15 A O ATOM 572 C TYR A 196 33.356 61.070 22.443 1.00 44.49 A C ATOM 573 O TYR A 196 34.445 61.604 22.622 1.00 45.61 A O ATOM 574 N GLY A 197 32.819 60.932 21.240 1.00 44.09 A N ATOM 575 CA GLY A 197 33.517 61.441 20.074 1.00 43.41 A C ATOM 576 C GLY A 197 32.913 60.907 18.797 1.00 43.77 A C ATOM 577 O GLY A 197 31.804 60.380 18.802 1.00 43.31 A O ATOM 578 N TYR A 198 33.633 61.044 17.694 1.00 44.25 A N ATOM 579 CA TYR A 198 33.127 60.551 16.425 1.00 45.18 A C ATOM 580 CB TYR A 198 32.041 61.491 15.889 1.00 49.33 A C ATOM 581 CG TYR A 198 32.571 62.592 14.997 1.00 55.20 A C ATOM 582 CD1 TYR A 198 33.310 63.653 15.520 1.00 57.66 A C ATOM 583 CE1 TYR A 198 33.845 64.638 14.688 1.00 59.20 A C ATOM 584 CD2 TYR A 198 32.375 62.543 13.618 1.00 58.31 A C ATOM 585 CE2 TYR A 198 32.904 63.521 12.775 1.00 60.71 A C ATOM 586 CZ TYR A 198 33.640 64.561 13.315 1.00 60.83 A C ATOM 587 OH TYR A 198 34.190 65.505 12.472 1.00 62.06 A O ATOM 588 C TYR A 198 34.235 60.408 15.382 1.00 43.11 A C ATOM 589 O TYR A 198 35.344 60.925 15.553 1.00 39.29 A O ATOM 590 N PHE A 199 33.913 59.695 14.307 1.00 41.05 A N ATOM 591 CA PHE A 199 34.834 59.483 13.194 1.00 42.76 A C ATOM 592 CB PHE A 199 35.884 58.405 13.540 1.00 41.19 A C ATOM 593 CG PHE A 199 35.308 57.040 13.853 1.00 42.02 A C ATOM 594 CD1 PHE A 199 35.100 56.105 12.842 1.00 42.90 A C ATOM 595 CD2 PHE A 199 35.025 56.677 15.162 1.00 40.34 A C ATOM 596 CE1 PHE A 199 34.623 54.822 13.129 1.00 40.61 A C ATOM 597 CE2 PHE A 199 34.545 55.394 15.465 1.00 43.97 A C ATOM 598 CZ PHE A 199 34.347 54.464 14.441 1.00 41.24 A C ATOM 599 C PHE A 199 34.012 59.104 11.964 1.00 42.14 A C ATOM 600 O PHE A 199 32.807 58.881 12.068 1.00 42.73 A O ATOM 601 N HIS A 200 34.647 59.068 10.800 1.00 42.87 A N ATOM 602 CA HIS A 200 33.946 58.732 9.570 1.00 44.89 A C ATOM 603 CB HIS A 200 33.493 60.002 8.856 1.00 46.96 A C ATOM 604 CG HIS A 200 34.610 60.727 8.170 1.00 51.07 A C ATOM 605 CD2 HIS A 200 34.913 60.863 6.856 1.00 52.59 A C ATOM 606 ND1 HIS A 200 35.616 61.370 8.862 1.00 53.07 A N ATOM 607 CE1 HIS A 200 36.489 61.870 8.005 1.00 53.71 A C ATOM 608 NE2 HIS A 200 36.087 61.576 6.781 1.00 52.64 A N ATOM 609 C HIS A 200 34.838 57.969 8.597 1.00 44.12 A C ATOM 610 O HIS A 200 36.041 57.819 8.813 1.00 43.09 A O ATOM 611 N ASP A 201 34.214 57.494 7.525 1.00 42.67 A N ATOM 612 CA ASP A 201 34.910 56.818 6.442 1.00 44.38 A C ATOM 613 CB ASP A 201 34.819 55.281 6.545 1.00 44.11 A C ATOM 614 CG ASP A 201 33.399 54.766 6.553 1.00 43.31 A C ATOM 615 OD1 ASP A 201 32.535 55.361 5.881 1.00 46.12 A O ATOM 616 OD2 ASP A 201 33.152 53.742 7.222 1.00 45.46 A O ATOM 617 C ASP A 201 34.260 57.325 5.153 1.00 44.18 A C ATOM 618 O ASP A 201 33.535 58.322 5.166 1.00 42.40 A O ATOM 619 N ALA A 202 34.515 56.642 4.049 1.00 44.77 A N ATOM 620 CA ALA A 202 33.981 57.044 2.755 1.00 45.80 A C ATOM 621 CB ALA A 202 34.409 56.028 1.687 1.00 44.78 A C ATOM 622 C ALA A 202 32.470 57.227 2.696 1.00 46.73 A C ATOM 623 O ALA A 202 31.982 58.209 2.122 1.00 46.56 A O ATOM 624 N THR A 203 31.736 56.291 3.297 1.00 45.01 A N ATOM 625 CA THR A 203 30.282 56.318 3.245 1.00 45.70 A C ATOM 626 CB THR A 203 29.761 55.004 2.628 1.00 47.92 A C ATOM 627 OG1 THR A 203 29.962 53.934 3.565 1.00 50.55 A O ATOM 628 CG2 THR A 203 30.525 54.669 1.350 1.00 46.84 A C ATOM 629 C THR A 203 29.503 56.536 4.548 1.00 46.72 A C ATOM 630 O THR A 203 28.281 56.715 4.506 1.00 46.89 A O ATOM 631 N ARG A 204 30.170 56.528 5.699 1.00 43.86 A N ATOM 632 CA ARG A 204 29.424 56.680 6.948 1.00 41.61 A C ATOM 633 CB ARG A 204 29.167 55.300 7.577 1.00 42.57 A C ATOM 634 CG ARG A 204 28.645 54.199 6.646 1.00 45.37 A C ATOM 635 CD ARG A 204 28.299 52.983 7.491 1.00 52.00 A C ATOM 636 NE ARG A 204 28.122 51.719 6.769 1.00 59.45 A N ATOM 637 CZ ARG A 204 27.200 51.489 5.838 1.00 60.63 A C ATOM 638 NH1 ARG A 204 26.350 52.439 5.480 1.00 63.62 A N ATOM 639 NH2 ARG A 204 27.106 50.287 5.286 1.00 64.09 A N ATOM 640 C ARG A 204 30.073 57.564 8.010 1.00 39.60 A C ATOM 641 O ARG A 204 31.273 57.839 7.968 1.00 38.12 A O ATOM 642 N VAL A 205 29.249 57.993 8.967 1.00 38.69 A N ATOM 643 CA VAL A 205 29.684 58.807 10.098 1.00 36.15 A C ATOM 644 CB VAL A 205 28.872 60.127 10.202 1.00 39.01 A C ATOM 645 CG1 VAL A 205 29.345 60.924 11.406 1.00 37.93 A C ATOM 646 CG2 VAL A 205 29.031 60.957 8.919 1.00 36.49 A C ATOM 647 C VAL A 205 29.419 57.954 11.344 1.00 36.45 A C ATOM 648 O VAL A 205 28.365 57.331 11.457 1.00 36.62 A O ATOM 649 N TYR A 206 30.367 57.911 12.271 1.00 35.58 A N ATOM 650 CA TYR A 206 30.185 57.100 13.470 1.00 39.37 A C ATOM 651 CB TYR A 206 31.254 55.996 13.533 1.00 40.23 A C ATOM 652 CG TYR A 206 31.301 55.101 12.314 1.00 40.95 A C ATOM 653 CD1 TYR A 206 31.811 55.565 11.101 1.00 43.93 A C ATOM 654 CE1 TYR A 206 31.859 54.741 9.973 1.00 43.38 A C ATOM 655 CD2 TYR A 206 30.836 53.784 12.372 1.00 43.86 A C ATOM 656 CE2 TYR A 206 30.882 52.949 11.252 1.00 42.92 A C ATOM 657 CZ TYR A 206 31.394 53.436 10.057 1.00 43.76 A C ATOM 658 OH TYR A 206 31.433 52.623 8.946 1.00 45.92 A O ATOM 659 C TYR A 206 30.226 57.915 14.760 1.00 38.58 A C ATOM 660 O TYR A 206 31.200 58.604 15.045 1.00 40.46 A O ATOM 661 N LEU A 207 29.163 57.823 15.544 1.00 37.67 A N ATOM 662 CA LEU A 207 29.098 58.545 16.806 1.00 35.63 A C ATOM 663 CB LEU A 207 27.735 59.232 16.928 1.00 35.79 A C ATOM 664 CG LEU A 207 27.388 60.127 15.729 1.00 37.16 A C ATOM 665 CD1 LEU A 207 25.985 60.681 15.899 1.00 37.87 A C ATOM 666 CD2 LEU A 207 28.409 61.256 15.606 1.00 33.68 A C ATOM 667 C LEU A 207 29.314 57.561 17.955 1.00 33.49 A C ATOM 668 O LEU A 207 28.624 56.556 18.044 1.00 32.51 A O ATOM 669 N ILE A 208 30.276 57.858 18.826 1.00 31.11 A N ATOM 670 CA ILE A 208 30.592 56.997 19.961 1.00 32.62 A C ATOM 671 CB ILE A 208 32.094 57.029 20.266 1.00 31.85 A C ATOM 672 CG2 ILE A 208 32.423 55.991 21.298 1.00 29.97 A C ATOM 673 CG1 ILE A 208 32.889 56.759 18.983 1.00 34.87 A C ATOM 674 CD1 ILE A 208 34.370 57.064 19.111 1.00 34.66 A C ATOM 675 C ILE A 208 29.827 57.494 21.185 1.00 33.51 A C ATOM 676 O ILE A 208 30.226 58.470 21.823 1.00 33.57 A O ATOM 677 N LEU A 209 28.747 56.794 21.515 1.00 32.77 A N ATOM 678 CA LEU A 209 27.867 57.173 22.613 1.00 33.70 A C ATOM 679 CB LEU A 209 26.413 57.171 22.104 1.00 31.78 A C ATOM 680 CG LEU A 209 26.089 58.037 20.880 1.00 31.51 A C ATOM 681 CD1 LEU A 209 24.794 57.580 20.244 1.00 32.48 A C ATOM 682 CD2 LEU A 209 26.011 59.504 21.295 1.00 32.98 A C ATOM 683 C LEU A 209 27.933 56.314 23.878 1.00 34.77 A C ATOM 684 O LEU A 209 28.326 55.151 23.842 1.00 35.59 A O ATOM 685 N GLU A 210 27.529 56.917 24.993 1.00 35.23 A N ATOM 686 CA GLU A 210 27.443 56.237 26.282 1.00 34.76 A C ATOM 687 CB GLU A 210 27.107 57.260 27.371 1.00 36.80 A C ATOM 688 CG GLU A 210 26.610 56.678 28.686 1.00 37.86 A C ATOM 689 CD GLU A 210 26.086 57.752 29.637 1.00 39.64 A C ATOM 690 OE1 GLU A 210 25.525 57.394 30.691 1.00 38.77 A O ATOM 691 OE2 GLU A 210 26.237 58.957 29.334 1.00 41.10 A O ATOM 692 C GLU A 210 26.269 55.281 26.102 1.00 34.26 A C ATOM 693 O GLU A 210 25.304 55.624 25.417 1.00 33.07 A O ATOM 694 N TYR A 211 26.334 54.091 26.699 1.00 34.30 A N ATOM 695 CA TYR A 211 25.234 53.126 26.558 1.00 32.97 A C ATOM 696 CB TYR A 211 25.782 51.691 26.439 1.00 33.26 A C ATOM 697 CG TYR A 211 24.709 50.628 26.361 1.00 32.75 A C ATOM 698 CD1 TYR A 211 23.845 50.564 25.266 1.00 34.54 A C ATOM 699 CE1 TYR A 211 22.802 49.649 25.223 1.00 35.34 A C ATOM 700 CD2 TYR A 211 24.507 49.732 27.414 1.00 34.61 A C ATOM 701 CE2 TYR A 211 23.461 48.807 27.385 1.00 35.43 A C ATOM 702 CZ TYR A 211 22.609 48.774 26.288 1.00 38.58 A C ATOM 703 OH TYR A 211 21.538 47.896 26.267 1.00 38.81 A O ATOM 704 C TYR A 211 24.260 53.213 27.735 1.00 33.39 A C ATOM 705 O TYR A 211 24.671 53.179 28.894 1.00 34.96 A O ATOM 706 N ALA A 212 22.972 53.352 27.425 1.00 33.87 A N ATOM 707 CA ALA A 212 21.920 53.438 28.441 1.00 35.11 A C ATOM 708 CB ALA A 212 20.919 54.559 28.080 1.00 34.05 A C ATOM 709 C ALA A 212 21.230 52.071 28.452 1.00 36.01 A C ATOM 710 O ALA A 212 20.408 51.757 27.578 1.00 36.24 A O ATOM 711 N PRO A 213 21.531 51.250 29.471 1.00 37.45 A N ATOM 712 CD PRO A 213 22.357 51.610 30.640 1.00 35.55 A C ATOM 713 CA PRO A 213 20.982 49.900 29.623 1.00 36.93 A C ATOM 714 CB PRO A 213 21.830 49.324 30.754 1.00 36.23 A C ATOM 715 CG PRO A 213 22.033 50.511 31.627 1.00 37.14 A C ATOM 716 C PRO A 213 19.493 49.694 29.857 1.00 37.75 A C ATOM 717 O PRO A 213 18.933 48.701 29.386 1.00 36.37 A O ATOM 718 N LEU A 214 18.837 50.612 30.560 1.00 36.70 A N ATOM 719 CA LEU A 214 17.418 50.415 30.846 1.00 37.91 A C ATOM 720 CB LEU A 214 17.104 50.906 32.266 1.00 36.60 A C ATOM 721 CG LEU A 214 17.399 49.897 33.394 1.00 37.61 A C ATOM 722 CD1 LEU A 214 18.858 49.506 33.397 1.00 37.59 A C ATOM 723 CD2 LEU A 214 17.028 50.497 34.736 1.00 36.22 A C ATOM 724 C LEU A 214 16.371 50.939 29.859 1.00 38.39 A C ATOM 725 O LEU A 214 15.182 50.954 30.173 1.00 38.54 A O ATOM 726 N GLY A 215 16.797 51.355 28.669 1.00 38.88 A N ATOM 727 CA GLY A 215 15.845 51.820 27.671 1.00 39.34 A C ATOM 728 C GLY A 215 15.322 53.244 27.782 1.00 37.48 A C ATOM 729 O GLY A 215 15.892 54.079 28.483 1.00 37.79 A O ATOM 730 N THR A 216 14.226 53.517 27.079 1.00 36.14 A N ATOM 731 CA THR A 216 13.642 54.862 27.066 1.00 36.67 A C ATOM 732 CB THR A 216 13.132 55.254 25.657 1.00 36.78 A C ATOM 733 OG1 THR A 216 11.980 54.461 25.327 1.00 37.06 A O ATOM 734 CG2 THR A 216 14.219 55.026 24.596 1.00 34.73 A C ATOM 735 C THR A 216 12.470 55.056 28.018 1.00 36.30 A C ATOM 736 O THR A 216 11.785 54.106 28.404 1.00 35.69 A O ATOM 737 N VAL A 217 12.254 56.311 28.391 1.00 38.14 A N ATOM 738 CA VAL A 217 11.147 56.686 29.258 1.00 38.24 A C ATOM 739 CB VAL A 217 11.180 58.209 29.559 1.00 38.38 A C ATOM 740 CG1 VAL A 217 9.903 58.642 30.269 1.00 38.16 A C ATOM 741 CG2 VAL A 217 12.394 58.532 30.418 1.00 34.69 A C ATOM 742 C VAL A 217 9.872 56.328 28.497 1.00 38.49 A C ATOM 743 O VAL A 217 8.865 55.949 29.087 1.00 38.84 A O ATOM 744 N TYR A 218 9.934 56.432 27.176 1.00 39.52 A N ATOM 745 CA TYR A 218 8.793 56.105 26.338 1.00 44.49 A C ATOM 746 CB TYR A 218 9.128 56.352 24.868 1.00 47.79 A C ATOM 747 CG TYR A 218 8.037 55.903 23.932 1.00 53.55 A C ATOM 748 CD1 TYR A 218 8.292 54.963 22.934 1.00 55.54 A C ATOM 749 CE1 TYR A 218 7.278 54.518 22.087 1.00 59.77 A C ATOM 750 CD2 TYR A 218 6.738 56.394 24.060 1.00 57.06 A C ATOM 751 CE2 TYR A 218 5.714 55.957 23.219 1.00 59.73 A C ATOM 752 CZ TYR A 218 5.993 55.018 22.235 1.00 61.61 A C ATOM 753 OH TYR A 218 4.986 54.575 21.402 1.00 65.83 A O ATOM 754 C TYR A 218 8.324 54.655 26.523 1.00 45.40 A C ATOM 755 O TYR A 218 7.131 54.409 26.740 1.00 44.19 A O ATOM 756 N ARG A 219 9.248 53.698 26.436 1.00 44.49 A N ATOM 757 CA ARG A 219 8.875 52.290 26.605 1.00 46.38 A C ATOM 758 CB ARG A 219 10.059 51.355 26.324 1.00 47.75 A C ATOM 759 CG ARG A 219 9.690 49.883 26.517 1.00 55.47 A C ATOM 760 CD ARG A 219 10.682 48.919 25.869 1.00 63.31 A C ATOM 761 NE ARG A 219 10.197 47.538 25.933 1.00 68.90 A N ATOM 762 CZ ARG A 219 10.723 46.518 25.260 1.00 70.39 A C ATOM 763 NH1 ARG A 219 11.766 46.714 24.460 1.00 71.45 A N ATOM 764 NH2 ARG A 219 10.199 45.301 25.382 1.00 70.62 A N ATOM 765 C ARG A 219 8.349 52.033 28.015 1.00 44.03 A C ATOM 766 O ARG A 219 7.381 51.297 28.202 1.00 41.33 A O ATOM 767 N GLU A 220 8.991 52.647 29.004 1.00 44.46 A N ATOM 768 CA GLU A 220 8.567 52.505 30.395 1.00 46.08 A C ATOM 769 CB GLU A 220 9.534 53.261 31.315 1.00 47.47 A C ATOM 770 CG GLU A 220 9.059 53.418 32.753 1.00 52.18 A C ATOM 771 CD GLU A 220 10.098 54.084 33.661 1.00 55.45 A C ATOM 772 OE1 GLU A 220 10.628 55.158 33.296 1.00 55.13 A O ATOM 773 OE2 GLU A 220 10.379 53.533 34.751 1.00 56.93 A O ATOM 774 C GLU A 220 7.144 53.050 30.550 1.00 45.87 A C ATOM 775 O GLU A 220 6.367 52.568 31.375 1.00 43.91 A O ATOM 776 N LEU A 221 6.801 54.045 29.737 1.00 44.52 A N ATOM 777 CA LEU A 221 5.473 54.649 29.789 1.00 45.19 A C ATOM 778 CB LEU A 221 5.483 55.989 29.036 1.00 45.91 A C ATOM 779 CG LEU A 221 4.363 57.008 29.278 1.00 47.69 A C ATOM 780 CD1 LEU A 221 4.268 57.346 30.755 1.00 46.44 A C ATOM 781 CD2 LEU A 221 4.646 58.270 28.470 1.00 47.40 A C ATOM 782 C LEU A 221 4.465 53.674 29.170 1.00 46.08 A C ATOM 783 O LEU A 221 3.320 53.580 29.617 1.00 44.50 A O ATOM 784 N GLN A 222 4.893 52.949 28.139 1.00 46.94 A N ATOM 785 CA GLN A 222 4.024 51.960 27.505 1.00 50.56 A C ATOM 786 CB GLN A 222 4.715 51.299 26.313 1.00 52.06 A C ATOM 787 CG GLN A 222 4.828 52.143 25.069 1.00 56.98 A C ATOM 788 CD GLN A 222 5.281 51.318 23.882 1.00 61.40 A C ATOM 789 OE1 GLN A 222 6.287 50.607 23.958 1.00 64.80 A O ATOM 790 NE2 GLN A 222 4.542 51.403 22.776 1.00 61.65 A N ATOM 791 C GLN A 222 3.701 50.872 28.528 1.00 50.28 A C ATOM 792 O GLN A 222 2.572 50.385 28.609 1.00 48.43 A O ATOM 793 N LYS A 223 4.718 50.502 29.301 1.00 51.04 A N ATOM 794 CA LYS A 223 4.604 49.475 30.332 1.00 52.24 A C ATOM 795 CB LYS A 223 5.992 49.146 30.895 1.00 53.80 A C ATOM 796 CG LYS A 223 6.680 47.951 30.261 1.00 57.08 A C ATOM 797 CD LYS A 223 6.939 48.120 28.773 1.00 59.58 A C ATOM 798 CE LYS A 223 7.506 46.821 28.187 1.00 62.45 A C ATOM 799 NZ LYS A 223 7.723 46.877 26.711 1.00 65.10 A N ATOM 800 C LYS A 223 3.680 49.855 31.488 1.00 51.07 A C ATOM 801 O LYS A 223 2.678 49.188 31.731 1.00 51.74 A O ATOM 802 N LEU A 224 4.024 50.927 32.195 1.00 49.30 A N ATOM 803 CA LEU A 224 3.250 51.382 33.347 1.00 47.99 A C ATOM 804 CB LEU A 224 4.153 52.201 34.272 1.00 45.38 A C ATOM 805 CG LEU A 224 5.509 51.562 34.588 1.00 45.90 A C ATOM 806 CD1 LEU A 224 6.327 52.477 35.475 1.00 43.89 A C ATOM 807 CD2 LEU A 224 5.291 50.228 35.263 1.00 47.72 A C ATOM 808 C LEU A 224 1.979 52.183 33.067 1.00 47.57 A C ATOM 809 O LEU A 224 1.198 52.417 33.986 1.00 48.98 A O ATOM 810 N SER A 225 1.770 52.596 31.818 1.00 47.50 A N ATOM 811 CA SER A 225 0.602 53.397 31.432 1.00 46.59 A C ATOM 812 CB SER A 225 −0.682 52.840 32.053 1.00 48.00 A C ATOM 813 OG SER A 225 −1.018 51.593 31.477 1.00 51.00 A O ATOM 814 C SER A 225 0.790 54.850 31.862 1.00 46.78 A C ATOM 815 O SER A 225 0.652 55.771 31.056 1.00 46.17 A O ATOM 816 N LYS A 226 1.113 55.043 33.136 1.00 45.76 A N ATOM 817 CA LYS A 226 1.349 56.371 33.690 1.00 45.69 A C ATOM 818 CB LYS A 226 0.019 57.049 34.025 1.00 48.92 A C ATOM 819 CG LYS A 226 −0.896 56.251 34.937 1.00 50.24 A C ATOM 820 CD LYS A 226 −2.286 56.871 34.944 1.00 55.99 A C ATOM 821 CE LYS A 226 −3.213 56.217 35.960 1.00 56.96 A C ATOM 822 NZ LYS A 226 −4.577 56.820 35.924 1.00 58.58 A N ATOM 823 C LYS A 226 2.211 56.235 34.935 1.00 43.87 A C ATOM 824 O LYS A 226 2.219 55.180 35.563 1.00 43.31 A O ATOM 825 N PHE A 227 2.945 57.291 35.280 1.00 42.51 A N ATOM 826 CA PHE A 227 3.822 57.271 36.446 1.00 41.32 A C ATOM 827 CB PHE A 227 5.136 58.018 36.163 1.00 38.84 A C ATOM 828 CG PHE A 227 5.901 57.493 34.969 1.00 38.42 A C ATOM 829 CD1 PHE A 227 5.793 56.155 34.574 1.00 34.24 A C ATOM 830 CD2 PHE A 227 6.741 58.338 34.242 1.00 37.52 A C ATOM 831 CE1 PHE A 227 6.506 55.673 33.477 1.00 33.25 A C ATOM 832 CE2 PHE A 227 7.460 57.859 33.139 1.00 37.09 A C ATOM 833 CZ PHE A 227 7.340 56.525 32.760 1.00 31.91 A C ATOM 834 C PHE A 227 3.168 57.888 37.669 1.00 44.70 A C ATOM 835 O PHE A 227 2.199 58.644 37.554 1.00 45.27 A O ATOM 836 N ASP A 228 3.708 57.572 38.844 1.00 44.53 A N ATOM 837 CA ASP A 228 3.170 58.115 40.078 1.00 45.73 A C ATOM 838 CB ASP A 228 3.357 57.121 41.234 1.00 47.95 A C ATOM 839 CG ASP A 228 4.797 57.012 41.696 1.00 50.80 A C ATOM 840 OD1 ASP A 228 5.711 57.200 40.871 1.00 55.59 A O ATOM 841 OD2 ASP A 228 5.016 56.718 42.889 1.00 53.57 A O ATOM 842 C ASP A 228 3.873 59.435 40.363 1.00 44.84 A C ATOM 843 O ASP A 228 4.805 59.815 39.655 1.00 42.73 A O ATOM 844 N GLU A 229 3.419 60.130 41.400 1.00 44.06 A N ATOM 845 CA GLU A 229 3.986 61.419 41.769 1.00 44.15 A C ATOM 846 CB GLU A 229 3.176 62.046 42.914 1.00 46.01 A C ATOM 847 CG GLU A 229 1.732 62.358 42.554 1.00 49.15 A C ATOM 848 CD GLU A 229 1.149 63.475 43.398 1.00 53.31 A C ATOM 849 OE1 GLU A 229 1.055 63.311 44.633 1.00 54.33 A O ATOM 850 OE2 GLU A 229 0.785 64.525 42.823 1.00 57.15 A O ATOM 851 C GLU A 229 5.459 61.412 42.146 1.00 42.45 A C ATOM 852 O GLU A 229 6.189 62.330 41.778 1.00 42.84 A O ATOM 853 N GLN A 230 5.904 60.399 42.889 1.00 42.42 A N ATOM 854 CA GLN A 230 7.309 60.355 43.291 1.00 40.75 A C ATOM 855 CB GLN A 230 7.583 59.227 44.302 1.00 43.22 A C ATOM 856 CG GLN A 230 9.034 59.251 44.825 1.00 46.84 A C ATOM 857 CD GLN A 230 9.369 58.120 45.789 1.00 51.94 A C ATOM 858 OE1 GLN A 230 9.463 56.955 45.397 1.00 55.25 A O ATOM 859 NE2 GLN A 230 9.558 58.464 47.059 1.00 53.28 A N ATOM 860 C GLN A 230 8.233 60.171 42.095 1.00 38.22 A C ATOM 861 O GLN A 230 9.274 60.816 42.014 1.00 37.20 A O ATOM 862 N ARG A 231 7.851 59.286 41.176 1.00 36.78 A N ATOM 863 CA ARG A 231 8.663 59.017 39.997 1.00 39.10 A C ATOM 864 CB ARG A 231 8.186 57.749 39.284 1.00 37.47 A C ATOM 865 CG ARG A 231 9.122 57.330 38.158 1.00 39.31 A C ATOM 866 CD ARG A 231 8.420 56.555 37.057 1.00 41.69 A C ATOM 867 NE ARG A 231 8.185 55.146 37.380 1.00 47.47 A N ATOM 868 CZ ARG A 231 9.134 54.213 37.466 1.00 51.32 A C ATOM 869 NH1 ARG A 231 8.799 52.963 37.761 1.00 52.36 A N ATOM 870 NH2 ARG A 231 10.416 54.515 37.266 1.00 48.44 A N ATOM 871 C ARG A 231 8.635 60.192 39.013 1.00 38.58 A C ATOM 872 O ARG A 231 9.640 60.497 38.381 1.00 37.91 A O ATOM 873 N THR A 232 7.477 60.836 38.878 1.00 39.25 A N ATOM 874 CA THR A 232 7.336 61.980 37.980 1.00 36.38 A C ATOM 875 CB THR A 232 5.866 62.434 37.888 1.00 35.78 A C ATOM 876 OG1 THR A 232 5.077 61.377 37.327 1.00 33.52 A O ATOM 877 CG2 THR A 232 5.740 63.684 37.014 1.00 33.99 A C ATOM 878 C THR A 232 8.176 63.157 38.475 1.00 37.94 A C ATOM 879 O THR A 232 8.906 63.780 37.708 1.00 39.65 A O ATOM 880 N ALA A 233 8.085 63.445 39.769 1.00 38.61 A N ATOM 881 CA ALA A 233 8.820 64.556 40.364 1.00 39.65 A C ATOM 882 CB ALA A 233 8.374 64.757 41.810 1.00 39.86 A C ATOM 883 C ALA A 233 10.333 64.359 40.304 1.00 39.68 A C ATOM 884 O ALA A 233 11.085 65.318 40.118 1.00 39.18 A O ATOM 885 N THR A 234 10.783 63.120 40.474 1.00 39.91 A N ATOM 886 CA THR A 234 12.214 62.838 40.421 1.00 39.28 A C ATOM 887 CB THR A 234 12.517 61.360 40.828 1.00 39.65 A C ATOM 888 OG1 THR A 234 11.901 61.073 42.086 1.00 36.77 A O ATOM 889 CG2 THR A 234 14.006 61.131 40.978 1.00 39.65 A C ATOM 890 C THR A 234 12.687 63.096 38.991 1.00 38.18 A C ATOM 891 O THR A 234 13.685 63.780 38.775 1.00 41.05 A O ATOM 892 N TYR A 235 11.953 62.559 38.015 1.00 39.28 A N ATOM 893 CA TYR A 235 12.300 62.737 36.602 1.00 38.40 A C ATOM 894 CB TYR A 235 11.293 62.018 35.700 1.00 38.30 A C ATOM 895 CG TYR A 235 11.446 60.517 35.606 1.00 40.28 A C ATOM 896 CD1 TYR A 235 12.516 59.853 36.209 1.00 41.54 A C ATOM 897 CE1 TYR A 235 12.668 58.463 36.079 1.00 42.34 A C ATOM 898 CD2 TYR A 235 10.532 59.761 34.878 1.00 39.41 A C ATOM 899 CE2 TYR A 235 10.670 58.387 34.746 1.00 40.62 A C ATOM 900 CZ TYR A 235 11.737 57.738 35.344 1.00 42.31 A C ATOM 901 OH TYR A 235 11.866 56.370 35.191 1.00 40.25 A O ATOM 902 C TYR A 235 12.358 64.213 36.207 1.00 38.07 A C ATOM 903 O TYR A 235 13.259 64.629 35.482 1.00 36.19 A O ATOM 904 N ILE A 236 11.392 65.002 36.678 1.00 39.25 A N ATOM 905 CA ILE A 236 11.370 66.434 36.374 1.00 37.44 A C ATOM 906 CB ILE A 236 10.064 67.102 36.872 1.00 37.12 A C ATOM 907 CG2 ILE A 236 10.170 68.627 36.741 1.00 34.15 A C ATOM 908 CG1 ILE A 236 8.878 66.554 36.072 1.00 35.02 A C ATOM 909 CD1 ILE A 236 8.997 66.750 34.561 1.00 36.77 A C ATOM 910 C ILE A 236 12.574 67.115 37.012 1.00 37.57 A C ATOM 911 O ILE A 236 13.172 68.022 36.426 1.00 40.12 A O ATOM 912 N THR A 237 12.941 66.668 38.209 1.00 36.62 A N ATOM 913 CA THR A 237 14.114 67.215 38.891 1.00 36.77 A C ATOM 914 CB THR A 237 14.285 66.590 40.310 1.00 36.70 A C ATOM 915 OG1 THR A 237 13.174 66.970 41.134 1.00 39.88 A O ATOM 916 CG2 THR A 237 15.592 67.072 40.970 1.00 33.73 A C ATOM 917 C THR A 237 15.393 66.931 38.084 1.00 36.40 A C ATOM 918 O THR A 237 16.244 67.808 37.917 1.00 34.72 A O ATOM 919 N GLU A 238 15.531 65.703 37.589 1.00 35.89 A N ATOM 920 CA GLU A 238 16.724 65.343 36.826 1.00 36.31 A C ATOM 921 CB GLU A 238 16.743 63.831 36.584 1.00 37.43 A C ATOM 922 CG GLU A 238 16.699 63.014 37.882 1.00 39.75 A C ATOM 923 CD GLU A 238 16.579 61.516 37.652 1.00 42.37 A C ATOM 924 OE1 GLU A 238 16.240 61.106 36.526 1.00 46.02 A O ATOM 925 OE2 GLU A 238 16.804 60.739 38.605 1.00 44.16 A O ATOM 926 C GLU A 238 16.792 66.124 35.508 1.00 36.97 A C ATOM 927 O GLU A 238 17.875 66.515 35.068 1.00 38.41 A O ATOM 928 N LEU A 239 15.634 66.371 34.898 1.00 37.50 A N ATOM 929 CA LEU A 239 15.551 67.133 33.646 1.00 36.81 A C ATOM 930 CB LEU A 239 14.142 67.020 33.063 1.00 35.68 A C ATOM 931 CG LEU A 239 13.804 65.710 32.362 1.00 39.17 A C ATOM 932 CD1 LEU A 239 12.292 65.600 32.137 1.00 37.66 A C ATOM 933 CD2 LEU A 239 14.575 65.663 31.041 1.00 37.84 A C ATOM 934 C LEU A 239 15.875 68.613 33.852 1.00 35.88 A C ATOM 935 O LEU A 239 16.629 69.219 33.085 1.00 34.18 A O ATOM 936 N ALA A 240 15.294 69.198 34.892 1.00 37.08 A N ATOM 937 CA ALA A 240 15.526 70.613 35.171 1.00 37.40 A C ATOM 938 CB ALA A 240 14.677 71.059 36.375 1.00 35.91 A C ATOM 939 C ALA A 240 17.011 70.863 35.426 1.00 37.09 A C ATOM 940 O ALA A 240 17.558 71.896 35.024 1.00 35.00 A O ATOM 941 N ASN A 241 17.661 69.909 36.092 1.00 38.15 A N ATOM 942 CA ASN A 241 19.092 70.010 36.387 1.00 37.31 A C ATOM 943 CB ASN A 241 19.562 68.864 37.294 1.00 39.88 A C ATOM 944 CG ASN A 241 19.152 69.053 38.733 1.00 44.02 A C ATOM 945 OD1 ASN A 241 19.346 70.125 39.308 1.00 47.57 A O ATOM 946 ND2 ASN A 241 18.588 68.006 39.331 1.00 46.92 A N ATOM 947 C ASN A 241 19.920 69.962 35.119 1.00 36.22 A C ATOM 948 O ASN A 241 20.871 70.724 34.975 1.00 36.76 A O ATOM 949 N ALA A 242 19.585 69.041 34.217 1.00 33.89 A N ATOM 950 CA ALA A 242 20.328 68.916 32.963 1.00 34.20 A C ATOM 951 CB ALA A 242 19.869 67.669 32.178 1.00 31.75 A C ATOM 952 C ALA A 242 20.121 70.173 32.125 1.00 33.01 A C ATOM 953 O ALA A 242 21.073 70.719 31.574 1.00 33.65 A O ATOM 954 N LEU A 243 18.875 70.630 32.043 1.00 33.50 A N ATOM 955 CA LEU A 243 18.554 71.830 31.279 1.00 36.89 A C ATOM 956 CB LEU A 243 17.031 71.999 31.183 1.00 34.36 A C ATOM 957 CG LEU A 243 16.331 70.888 30.385 1.00 35.75 A C ATOM 958 CD1 LEU A 243 14.827 71.111 30.357 1.00 36.43 A C ATOM 959 CD2 LEU A 243 16.884 70.867 28.965 1.00 34.93 A C ATOM 960 C LEU A 243 19.218 73.098 31.848 1.00 38.16 A C ATOM 961 O LEU A 243 19.666 73.956 31.083 1.00 38.31 A O ATOM 962 N SER A 244 19.296 73.219 33.175 1.00 39.80 A N ATOM 963 CA SER A 244 19.945 74.391 33.778 1.00 40.44 A C ATOM 964 CB SER A 244 19.861 74.357 35.308 1.00 43.11 A C ATOM 965 OG SER A 244 18.521 74.198 35.743 1.00 47.97 A O ATOM 966 C SER A 244 21.411 74.365 33.369 1.00 40.05 A C ATOM 967 O SER A 244 22.001 75.396 33.021 1.00 40.00 A O ATOM 968 N TYR A 245 22.005 73.177 33.413 1.00 37.27 A N ATOM 969 CA TYR A 245 23.400 73.053 33.021 1.00 35.82 A C ATOM 970 CB TYR A 245 23.897 71.622 33.252 1.00 35.21 A C ATOM 971 CG TYR A 245 25.202 71.317 32.555 1.00 37.03 A C ATOM 972 CD1 TYR A 245 25.215 70.770 31.274 1.00 36.51 A C ATOM 973 CE1 TYR A 245 26.410 70.511 30.613 1.00 40.47 A C ATOM 974 CD2 TYR A 245 26.426 71.603 33.163 1.00 38.38 A C ATOM 975 CE2 TYR A 245 27.630 71.350 32.507 1.00 41.25 A C ATOM 976 CZ TYR A 245 27.612 70.800 31.231 1.00 40.43 A C ATOM 977 OH TYR A 245 28.788 70.527 30.576 1.00 43.84 A O ATOM 978 C TYR A 245 23.561 73.448 31.550 1.00 35.32 A C ATOM 979 O TYR A 245 24.479 74.176 31.200 1.00 35.27 A O ATOM 980 N CYS A 246 22.661 72.971 30.694 1.00 36.27 A N ATOM 981 CA CYS A 246 22.721 73.295 29.267 1.00 38.83 A C ATOM 982 CB CYS A 246 21.609 72.568 28.498 1.00 38.59 A C ATOM 983 SG CYS A 246 21.897 70.797 28.263 1.00 44.30 A S ATOM 984 C CYS A 246 22.606 74.802 29.031 1.00 39.39 A C ATOM 985 O CYS A 246 23.322 75.358 28.200 1.00 37.11 A O ATOM 986 N HIS A 247 21.704 75.461 29.756 1.00 40.65 A N ATOM 987 CA HIS A 247 21.542 76.903 29.603 1.00 43.91 A C ATOM 988 CB HIS A 247 20.403 77.414 30.493 1.00 44.23 A C ATOM 989 CG HIS A 247 19.038 77.074 29.978 1.00 45.59 A C ATOM 990 CD2 HIS A 247 18.645 76.412 28.862 1.00 45.56 A C ATOM 991 ND1 HIS A 247 17.881 77.447 30.628 1.00 45.85 A N ATOM 992 CE1 HIS A 247 16.834 77.033 29.937 1.00 46.13 A C ATOM 993 NE2 HIS A 247 17.270 76.402 28.861 1.00 48.11 A N ATOM 994 C HIS A 247 22.840 77.642 29.931 1.00 46.24 A C ATOM 995 O HIS A 247 23.223 78.581 29.231 1.00 46.66 A O ATOM 996 N SER A 248 23.527 77.213 30.985 1.00 46.80 A N ATOM 997 CA SER A 248 24.780 77.858 31.359 1.00 47.62 A C ATOM 998 CB SER A 248 25.344 77.247 32.653 1.00 46.92 A C ATOM 999 OG SER A 248 25.872 75.950 32.432 1.00 48.53 A O ATOM 1000 C SER A 248 25.799 77.716 30.223 1.00 47.38 A C ATOM 1001 O SER A 248 26.774 78.469 30.152 1.00 48.22 A O ATOM 1002 N LYS A 249 25.566 76.761 29.328 1.00 45.39 A N ATOM 1003 CA LYS A 249 26.473 76.541 28.209 1.00 46.59 A C ATOM 1004 CB LYS A 249 26.731 75.047 28.021 1.00 44.79 A C ATOM 1005 CG LYS A 249 27.091 74.323 29.300 1.00 49.43 A C ATOM 1006 CD LYS A 249 28.337 74.902 29.951 1.00 52.06 A C ATOM 1007 CE LYS A 249 29.587 74.520 29.183 1.00 56.23 A C ATOM 1008 NZ LYS A 249 29.806 73.040 29.150 1.00 58.63 A N ATOM 1009 C LYS A 249 25.909 77.131 26.919 1.00 48.59 A C ATOM 1010 O LYS A 249 26.490 76.966 25.847 1.00 47.53 A O ATOM 1011 N ARG A 250 24.769 77.808 27.032 1.00 51.35 A N ATOM 1012 CA ARG A 250 24.117 78.434 25.884 1.00 55.46 A C ATOM 1013 CB ARG A 250 25.079 79.425 25.204 1.00 58.41 A C ATOM 1014 CG ARG A 250 25.543 80.543 26.151 1.00 64.68 A C ATOM 1015 CD ARG A 250 26.350 81.658 25.464 1.00 69.77 A C ATOM 1016 NE ARG A 250 27.615 81.204 24.886 1.00 72.33 A N ATOM 1017 CZ ARG A 250 28.584 82.020 24.473 1.00 74.30 A C ATOM 1018 NH1 ARG A 250 28.439 83.338 24.574 1.00 73.90 A N ATOM 1019 NH2 ARG A 250 29.699 81.520 23.951 1.00 74.27 A N ATOM 1020 C ARG A 250 23.606 77.401 24.884 1.00 54.89 A C ATOM 1021 O ARG A 250 23.589 77.635 23.671 1.00 55.10 A O ATOM 1022 N VAL A 251 23.196 76.252 25.413 1.00 53.65 A N ATOM 1023 CA VAL A 251 22.658 75.169 24.605 1.00 51.49 A C ATOM 1024 CB VAL A 251 23.343 73.815 24.924 1.00 51.47 A C ATOM 1025 CG1 VAL A 251 22.550 72.664 24.310 1.00 47.16 A C ATOM 1026 CG2 VAL A 251 24.761 73.809 24.378 1.00 51.44 A C ATOM 1027 C VAL A 251 21.175 75.052 24.927 1.00 52.04 A C ATOM 1028 O VAL A 251 20.793 74.885 26.090 1.00 50.43 A O ATOM 1029 N ILE A 252 20.348 75.158 23.894 1.00 51.36 A N ATOM 1030 CA ILE A 252 18.908 75.050 24.049 1.00 52.79 A C ATOM 1031 CB ILE A 252 18.205 76.372 23.690 1.00 54.02 A C ATOM 1032 CG2 ILE A 252 16.696 76.214 23.823 1.00 54.66 A C ATOM 1033 CG1 ILE A 252 18.709 77.490 24.611 1.00 54.46 A C ATOM 1034 CD1 ILE A 252 18.176 78.868 24.259 1.00 55.53 A C ATOM 1035 C ILE A 252 18.434 73.950 23.113 1.00 53.85 A C ATOM 1036 O ILE A 252 18.911 73.841 21.984 1.00 54.35 A O ATOM 1037 N HIS A 253 17.515 73.124 23.602 1.00 54.36 A N ATOM 1038 CA HIS A 253 16.964 72.021 22.824 1.00 54.56 A C ATOM 1039 CB HIS A 253 16.590 70.840 23.736 1.00 52.75 A C ATOM 1040 CG HIS A 253 17.757 70.216 24.438 1.00 52.00 A C ATOM 1041 CD2 HIS A 253 18.281 68.970 24.359 1.00 52.22 A C ATOM 1042 ND1 HIS A 253 18.546 70.907 25.334 1.00 50.80 A N ATOM 1043 CE1 HIS A 253 19.509 70.115 25.771 1.00 50.65 A C ATOM 1044 NE2 HIS A 253 19.372 68.934 25.195 1.00 52.67 A N ATOM 1045 C HIS A 253 15.715 72.509 22.115 1.00 55.98 A C ATOM 1046 O HIS A 253 15.189 73.579 22.423 1.00 53.17 A O ATOM 1047 N ARG A 254 15.247 71.716 21.161 1.00 59.64 A N ATOM 1048 CA ARG A 254 14.046 72.048 20.412 1.00 63.55 A C ATOM 1049 CB ARG A 254 14.391 72.384 18.956 1.00 67.04 A C ATOM 1050 CG ARG A 254 15.314 73.592 18.803 1.00 72.33 A C ATOM 1051 CD ARG A 254 15.366 74.081 17.357 1.00 76.66 A C ATOM 1052 NE ARG A 254 16.348 75.148 17.165 1.00 79.26 A N ATOM 1053 CZ ARG A 254 16.488 75.840 16.037 1.00 80.83 A C ATOM 1054 NH1 ARG A 254 15.706 75.581 14.997 1.00 81.15 A N ATOM 1055 NH2 ARG A 254 17.413 76.787 15.944 1.00 81.58 A N ATOM 1056 C ARG A 254 13.133 70.831 20.476 1.00 63.27 A C ATOM 1057 O ARG A 254 13.176 69.967 19.607 1.00 65.67 A O ATOM 1058 N ASP A 255 12.327 70.776 21.531 1.00 60.76 A N ATOM 1059 CA ASP A 255 11.391 69.686 21.786 1.00 59.10 A C ATOM 1060 CB ASP A 255 10.512 69.404 20.549 1.00 59.56 A C ATOM 1061 CG ASP A 255 11.108 68.366 19.606 1.00 60.20 A C ATOM 1062 OD1 ASP A 255 11.300 67.208 20.026 1.00 62.58 A O ATOM 1063 OD2 ASP A 255 11.372 68.702 18.433 1.00 60.34 A O ATOM 1064 C ASP A 255 12.099 68.411 22.256 1.00 57.58 A C ATOM 1065 O ASP A 255 13.017 67.901 21.596 1.00 55.18 A O ATOM 1066 N ILE A 256 11.698 67.920 23.426 1.00 54.14 A N ATOM 1067 CA ILE A 256 12.285 66.695 23.948 1.00 52.47 A C ATOM 1068 CB ILE A 256 13.115 66.949 25.237 1.00 54.35 A C ATOM 1069 CG2 ILE A 256 13.581 68.397 25.271 1.00 54.91 A C ATOM 1070 CG1 ILE A 256 12.298 66.652 26.487 1.00 56.23 A C ATOM 1071 CD1 ILE A 256 13.151 66.501 27.717 1.00 58.73 A C ATOM 1072 C ILE A 256 11.150 65.705 24.193 1.00 48.66 A C ATOM 1073 O ILE A 256 10.242 65.957 24.989 1.00 48.97 A O ATOM 1074 N LYS A 257 11.190 64.598 23.461 1.00 44.04 A N ATOM 1075 CA LYS A 257 10.164 63.569 23.551 1.00 42.42 A C ATOM 1076 CB LYS A 257 9.837 63.053 22.146 1.00 42.94 A C ATOM 1077 CG LYS A 257 9.671 64.158 21.119 1.00 47.60 A C ATOM 1078 CD LYS A 257 8.714 63.758 20.008 1.00 50.15 A C ATOM 1079 CE LYS A 257 9.278 62.672 19.115 1.00 54.00 A C ATOM 1080 NZ LYS A 257 8.244 62.166 18.147 1.00 55.95 A N ATOM 1081 C LYS A 257 10.575 62.395 24.446 1.00 40.38 A C ATOM 1082 O LYS A 257 11.761 62.170 24.688 1.00 40.25 A O ATOM 1083 N PRO A 258 9.592 61.631 24.944 1.00 38.26 A N ATOM 1084 CD PRO A 258 8.141 61.822 24.769 1.00 35.77 A C ATOM 1085 CA PRO A 258 9.866 60.479 25.809 1.00 39.42 A C ATOM 1086 CB PRO A 258 8.478 59.868 26.026 1.00 38.99 A C ATOM 1087 CG PRO A 258 7.571 61.051 25.941 1.00 38.85 A C ATOM 1088 C PRO A 258 10.838 59.483 25.173 1.00 38.24 A C ATOM 1089 O PRO A 258 11.621 58.855 25.876 1.00 37.93 A O ATOM 1090 N GLU A 259 10.795 59.352 23.848 1.00 39.21 A N ATOM 1091 CA GLU A 259 11.682 58.421 23.142 1.00 39.84 A C ATOM 1092 CB GLU A 259 11.188 58.155 21.716 1.00 40.55 A C ATOM 1093 CG GLU A 259 9.688 58.072 21.594 1.00 48.83 A C ATOM 1094 CD GLU A 259 9.081 59.411 21.225 1.00 50.31 A C ATOM 1095 OE1 GLU A 259 7.919 59.679 21.604 1.00 51.19 A O ATOM 1096 OE2 GLU A 259 9.776 60.190 20.536 1.00 54.44 A O ATOM 1097 C GLU A 259 13.121 58.909 23.070 1.00 38.93 A C ATOM 1098 O GLU A 259 14.011 58.149 22.694 1.00 36.58 A O ATOM 1099 N ASN A 260 13.347 60.176 23.413 1.00 38.55 A N ATOM 1100 CA ASN A 260 14.690 60.746 23.391 1.00 37.69 A C ATOM 1101 CB ASN A 260 14.694 62.115 22.702 1.00 42.07 A C ATOM 1102 CG ASN A 260 13.986 62.096 21.362 1.00 45.98 A C ATOM 1103 OD1 ASN A 260 14.267 61.258 20.507 1.00 50.60 A O ATOM 1104 ND2 ASN A 260 13.062 63.032 21.171 1.00 50.14 A N ATOM 1105 C ASN A 260 15.222 60.883 24.818 1.00 35.15 A C ATOM 1106 O ASN A 260 16.206 61.578 25.071 1.00 33.57 A O ATOM 1107 N LEU A 261 14.548 60.236 25.754 1.00 32.79 A N ATOM 1108 CA LEU A 261 14.995 60.242 27.146 1.00 35.15 A C ATOM 1109 CB LEU A 261 13.875 60.737 28.075 1.00 30.11 A C ATOM 1110 CG LEU A 261 13.410 62.179 27.822 1.00 29.12 A C ATOM 1111 CD1 LEU A 261 12.459 62.616 28.925 1.00 21.95 A C ATOM 1112 CD2 LEU A 261 14.624 63.110 27.765 1.00 29.74 A C ATOM 1113 C LEU A 261 15.366 58.785 27.462 1.00 35.15 A C ATOM 1114 O LEU A 261 14.499 57.911 27.498 1.00 34.65 A O ATOM 1115 N LEU A 262 16.656 58.528 27.657 1.00 35.80 A N ATOM 1116 CA LEU A 262 17.140 57.180 27.934 1.00 36.00 A C ATOM 1117 CB LEU A 262 18.439 56.923 27.167 1.00 36.54 A C ATOM 1118 CG LEU A 262 18.311 56.713 25.654 1.00 39.58 A C ATOM 1119 CD1 LEU A 262 19.676 56.811 25.001 1.00 37.56 A C ATOM 1120 CD2 LEU A 262 17.678 55.352 25.377 1.00 41.77 A C ATOM 1121 C LEU A 262 17.355 56.958 29.421 1.00 36.91 A C ATOM 1122 O LEU A 262 17.428 57.915 30.189 1.00 38.50 A O ATOM 1123 N LEU A 263 17.467 55.694 29.828 1.00 36.14 A N ATOM 1124 CA LEU A 263 17.640 55.364 31.246 1.00 35.96 A C ATOM 1125 CB LEU A 263 16.472 54.488 31.709 1.00 37.11 A C ATOM 1126 CG LEU A 263 15.116 55.210 31.748 1.00 36.12 A C ATOM 1127 CD1 LEU A 263 14.003 54.231 32.073 1.00 36.15 A C ATOM 1128 CD2 LEU A 263 15.168 56.321 32.782 1.00 32.38 A C ATOM 1129 C LEU A 263 18.965 54.690 31.584 1.00 36.75 A C ATOM 1130 O LEU A 263 19.305 53.648 31.022 1.00 35.94 A O ATOM 1131 N GLY A 264 19.700 55.301 32.512 1.00 36.23 A N ATOM 1132 CA GLY A 264 20.990 54.788 32.933 1.00 38.00 A C ATOM 1133 C GLY A 264 20.941 53.534 33.796 1.00 38.80 A C ATOM 1134 O GLY A 264 19.864 53.026 34.113 1.00 36.95 A O ATOM 1135 N SER A 265 22.122 53.060 34.193 1.00 39.31 A N ATOM 1136 CA SER A 265 22.271 51.844 34.999 1.00 40.86 A C ATOM 1137 CB SER A 265 23.758 51.555 35.232 1.00 40.25 A C ATOM 1138 OG SER A 265 23.942 50.288 35.847 1.00 45.33 A O ATOM 1139 C SER A 265 21.544 51.876 36.337 1.00 41.82 A C ATOM 1140 O SER A 265 21.030 50.852 36.800 1.00 43.16 A O ATOM 1141 N ALA A 266 21.506 53.048 36.962 1.00 43.56 A N ATOM 1142 CA ALA A 266 20.833 53.213 38.248 1.00 43.39 A C ATOM 1143 CB ALA A 266 21.603 54.213 39.126 1.00 41.16 A C ATOM 1144 C ALA A 266 19.402 53.701 38.037 1.00 42.96 A C ATOM 1145 O ALA A 266 18.709 54.053 38.987 1.00 44.36 A O ATOM 1146 N GLY A 267 18.960 53.722 36.787 1.00 43.26 A N ATOM 1147 CA GLY A 267 17.613 54.176 36.510 1.00 43.62 A C ATOM 1148 C GLY A 267 17.464 55.678 36.307 1.00 43.28 A C ATOM 1149 O GLY A 267 16.346 56.156 36.114 1.00 46.43 A O ATOM 1150 N GLU A 268 18.557 56.433 36.350 1.00 42.29 A N ATOM 1151 CA GLU A 268 18.456 57.881 36.147 1.00 42.87 A C ATOM 1152 CB GLU A 268 19.725 58.627 36.592 1.00 44.50 A C ATOM 1153 CG GLU A 268 20.796 57.769 37.220 1.00 50.35 A C ATOM 1154 CD GLU A 268 21.520 56.919 36.204 1.00 49.75 A C ATOM 1155 OE1 GLU A 268 22.583 57.358 35.701 1.00 49.51 A O ATOM 1156 OE2 GLU A 268 21.012 55.817 35.904 1.00 48.21 A O ATOM 1157 C GLU A 268 18.175 58.231 34.689 1.00 41.51 A C ATOM 1158 O GLU A 268 18.505 57.484 33.764 1.00 39.67 A O ATOM 1159 N LEU A 269 17.563 59.390 34.502 1.00 39.23 A N ATOM 1160 CA LEU A 269 17.206 59.881 33.185 1.00 38.66 A C ATOM 1161 CB LEU A 269 16.091 60.912 33.371 1.00 37.44 A C ATOM 1162 CG LEU A 269 15.367 61.562 32.205 1.00 38.26 A C ATOM 1163 CD1 LEU A 269 13.995 62.029 32.680 1.00 32.98 A C ATOM 1164 CD2 LEU A 269 16.203 62.718 31.665 1.00 40.16 A C ATOM 1165 C LEU A 269 18.418 60.480 32.447 1.00 36.13 A C ATOM 1166 O LEU A 269 19.255 61.153 33.050 1.00 34.63 A O ATOM 1167 N LYS A 270 18.507 60.215 31.145 1.00 38.12 A N ATOM 1168 CA LYS A 270 19.589 60.740 30.302 1.00 38.51 A C ATOM 1169 CB LYS A 270 20.511 59.616 29.811 1.00 38.16 A C ATOM 1170 CG LYS A 270 21.125 58.721 30.874 1.00 41.06 A C ATOM 1171 CD LYS A 270 22.288 59.391 31.567 1.00 38.38 A C ATOM 1172 CE LYS A 270 23.088 58.381 32.379 1.00 36.07 A C ATOM 1173 NZ LYS A 270 24.297 59.001 32.993 1.00 29.99 A N ATOM 1174 C LYS A 270 18.977 61.397 29.054 1.00 38.60 A C ATOM 1175 O LYS A 270 18.327 60.714 28.265 1.00 38.86 A O ATOM 1176 N ILE A 271 19.168 62.702 28.870 1.00 36.85 A N ATOM 1177 CA ILE A 271 18.641 63.351 27.671 1.00 38.69 A C ATOM 1178 CB ILE A 271 18.652 64.906 27.752 1.00 38.48 A C ATOM 1179 CG2 ILE A 271 18.141 65.498 26.426 1.00 38.13 A C ATOM 1180 CG1 ILE A 271 17.739 65.390 28.872 1.00 37.28 A C ATOM 1181 CD1 ILE A 271 17.641 66.894 28.965 1.00 41.06 A C ATOM 1182 C ILE A 271 19.579 62.934 26.547 1.00 39.33 A C ATOM 1183 O ILE A 271 20.761 63.273 26.562 1.00 33.34 A O ATOM 1184 N ALA A 272 19.053 62.203 25.575 1.00 43.07 A N ATOM 1185 CA ALA A 272 19.873 61.721 24.474 1.00 50.47 A C ATOM 1186 CB ALA A 272 19.121 60.654 23.687 1.00 46.47 A C ATOM 1187 C ALA A 272 20.320 62.829 23.539 1.00 56.66 A C ATOM 1188 O ALA A 272 19.630 63.837 23.379 1.00 57.25 A O ATOM 1189 N ASP A 273 21.490 62.625 22.935 1.00 61.74 A N ATOM 1190 CA ASP A 273 22.062 63.562 21.979 1.00 65.85 A C ATOM 1191 CB ASP A 273 23.107 62.837 21.120 1.00 66.61 A C ATOM 1192 CG ASP A 273 22.680 61.413 20.754 1.00 65.34 A C ATOM 1193 OD1 ASP A 273 22.571 60.579 21.679 1.00 66.75 A O ATOM 1194 OD2 ASP A 273 22.457 61.118 19.561 1.00 64.24 A O ATOM 1195 C ASP A 273 20.934 64.078 21.095 1.00 69.02 A C ATOM 1196 O ASP A 273 20.500 63.379 20.175 1.00 69.51 A O ATOM 1197 N PHE A 274 20.444 65.287 21.365 1.00 72.26 A N ATOM 1198 CA PHE A 274 19.359 65.784 20.535 1.00 74.92 A C ATOM 1199 CB PHE A 274 18.873 67.185 20.973 1.00 77.06 A C ATOM 1200 CG PHE A 274 19.908 68.278 20.889 1.00 78.54 A C ATOM 1201 CD1 PHE A 274 20.908 68.397 21.850 1.00 78.95 A C ATOM 1202 CD2 PHE A 274 19.819 69.250 19.896 1.00 79.45 A C ATOM 1203 CE1 PHE A 274 21.797 69.480 21.823 1.00 79.11 A C ATOM 1204 CE2 PHE A 274 20.700 70.330 19.861 1.00 80.03 A C ATOM 1205 CZ PHE A 274 21.691 70.448 20.828 1.00 79.54 A C ATOM 1206 C PHE A 274 19.759 65.753 19.067 1.00 76.11 A C ATOM 1207 O PHE A 274 20.857 66.162 18.688 1.00 75.92 A O ATOM 1208 N GLY A 275 18.860 65.208 18.257 1.00 77.26 A N ATOM 1209 CA GLY A 275 19.106 65.096 16.836 1.00 77.96 A C ATOM 1210 C GLY A 275 19.590 63.710 16.471 1.00 79.01 A C ATOM 1211 O GLY A 275 19.492 62.770 17.261 1.00 78.98 A O ATOM 1212 N TRP A 276 20.137 63.595 15.268 1.00 78.75 A N ATOM 1213 CA TRP A 276 20.659 62.336 14.751 1.00 77.92 A C ATOM 1214 CB TRP A 276 21.944 61.930 15.489 1.00 80.84 A C ATOM 1215 CG TRP A 276 22.633 63.003 16.308 1.00 83.68 A C ATOM 1216 CD2 TRP A 276 23.693 63.869 15.877 1.00 84.50 A C ATOM 1217 CE2 TRP A 276 24.079 64.647 16.994 1.00 84.93 A C ATOM 1218 CE3 TRP A 276 24.355 64.063 14.656 1.00 85.10 A C ATOM 1219 CD1 TRP A 276 22.420 63.289 17.627 1.00 84.53 A C ATOM 1220 NE1 TRP A 276 23.287 64.271 18.047 1.00 85.75 A N ATOM 1221 CZ2 TRP A 276 25.100 65.604 16.928 1.00 85.38 A C ATOM 1222 CZ3 TRP A 276 25.373 65.018 14.592 1.00 85.86 A C ATOM 1223 CH2 TRP A 276 25.732 65.774 15.723 1.00 85.40 A C ATOM 1224 C TRP A 276 19.696 61.138 14.777 1.00 75.88 A C ATOM 1225 O TRP A 276 20.148 60.001 14.873 1.00 75.31 A O ATOM 1226 N SER A 277 18.386 61.363 14.692 1.00 73.54 A N ATOM 1227 CA SER A 277 17.470 60.218 14.706 1.00 69.92 A C ATOM 1228 CB SER A 277 16.009 60.656 14.626 1.00 69.39 A C ATOM 1229 OG SER A 277 15.145 59.528 14.690 1.00 68.26 A O ATOM 1230 C SER A 277 17.795 59.324 13.518 1.00 68.61 A C ATOM 1231 O SER A 277 18.330 59.791 12.514 1.00 66.97 A O ATOM 1232 N VAL A 278 17.460 58.042 13.624 1.00 67.80 A N ATOM 1233 CA VAL A 278 17.764 57.094 12.560 1.00 67.75 A C ATOM 1234 CB VAL A 278 18.452 55.830 13.161 1.00 67.67 A C ATOM 1235 CG1 VAL A 278 17.429 54.748 13.454 1.00 66.50 A C ATOM 1236 CG2 VAL A 278 19.530 55.338 12.245 1.00 67.32 A C ATOM 1237 C VAL A 278 16.554 56.679 11.713 1.00 68.01 A C ATOM 1238 O VAL A 278 16.722 56.161 10.606 1.00 66.68 A O ATOM 1239 N ALA A 279 15.351 56.918 12.240 1.00 69.17 A N ATOM 1240 CA ALA A 279 14.076 56.586 11.584 1.00 69.86 A C ATOM 1241 CB ALA A 279 14.174 56.772 10.063 1.00 69.92 A C ATOM 1242 C ALA A 279 13.607 55.167 11.904 1.00 68.92 A C ATOM 1243 O ALA A 279 13.970 54.593 12.929 1.00 69.04 A O ATOM 1244 N GLY A 290 10.838 65.378 16.485 1.00 60.42 A N ATOM 1245 CA GLY A 290 9.748 65.485 17.442 1.00 58.73 A C ATOM 1246 C GLY A 290 8.433 65.948 16.835 1.00 57.18 A C ATOM 1247 O GLY A 290 8.400 66.907 16.063 1.00 56.04 A O ATOM 1248 N THR A 291 7.341 65.281 17.198 1.00 54.45 A N ATOM 1249 CA THR A 291 6.039 65.646 16.665 1.00 49.75 A C ATOM 1250 CB THR A 291 4.985 64.552 16.910 1.00 49.00 A C ATOM 1251 OG1 THR A 291 4.825 64.330 18.315 1.00 49.86 A O ATOM 1252 CG2 THR A 291 5.388 63.284 16.227 1.00 51.10 A C ATOM 1253 C THR A 291 5.471 66.956 17.194 1.00 46.23 A C ATOM 1254 O THR A 291 5.959 67.548 18.163 1.00 42.68 A O ATOM 1255 N LEU A 292 4.419 67.386 16.514 1.00 43.51 A N ATOM 1256 CA LEU A 292 3.696 68.601 16.819 1.00 38.04 A C ATOM 1257 CB LEU A 292 2.460 68.662 15.927 1.00 35.68 A C ATOM 1258 CG LEU A 292 1.624 69.937 15.948 1.00 33.83 A C ATOM 1259 CD1 LEU A 292 2.511 71.150 15.696 1.00 33.10 A C ATOM 1260 CD2 LEU A 292 0.550 69.821 14.881 1.00 35.15 A C ATOM 1261 C LEU A 292 3.275 68.691 18.280 1.00 36.84 A C ATOM 1262 O LEU A 292 3.286 69.771 18.862 1.00 36.40 A O ATOM 1263 N ASP A 293 2.910 67.558 18.878 1.00 36.26 A N ATOM 1264 CA ASP A 293 2.464 67.545 20.270 1.00 33.20 A C ATOM 1265 CB ASP A 293 2.067 66.132 20.701 1.00 36.86 A C ATOM 1266 CG ASP A 293 0.647 65.790 20.328 1.00 37.14 A C ATOM 1267 OD1 ASP A 293 0.417 65.413 19.166 1.00 41.08 A O ATOM 1268 OD2 ASP A 293 −0.240 65.910 21.198 1.00 39.86 A O ATOM 1269 C ASP A 293 3.447 68.091 21.279 1.00 32.18 A C ATOM 1270 O ASP A 293 3.060 68.442 22.388 1.00 32.05 A O ATOM 1271 N TYR A 294 4.719 68.170 20.920 1.00 33.09 A N ATOM 1272 CA TYR A 294 5.692 68.669 21.880 1.00 35.14 A C ATOM 1273 CB TYR A 294 6.837 67.653 22.027 1.00 36.03 A C ATOM 1274 CG TYR A 294 6.352 66.274 22.443 1.00 35.56 A C ATOM 1275 CD1 TYR A 294 5.804 65.389 21.509 1.00 35.20 A C ATOM 1276 CE1 TYR A 294 5.310 64.131 21.905 1.00 37.12 A C ATOM 1277 CD2 TYR A 294 6.397 65.872 23.783 1.00 35.96 A C ATOM 1278 CE2 TYR A 294 5.908 64.628 24.184 1.00 34.99 A C ATOM 1279 CZ TYR A 294 5.369 63.762 23.244 1.00 35.56 A C ATOM 1280 OH TYR A 294 4.917 62.521 23.644 1.00 35.68 A O ATOM 1281 C TYR A 294 6.245 70.064 21.566 1.00 37.52 A C ATOM 1282 O TYR A 294 7.079 70.590 22.303 1.00 39.14 A O ATOM 1283 N LEU A 295 5.758 70.674 20.493 1.00 36.26 A N ATOM 1284 CA LEU A 295 6.232 72.005 20.102 1.00 36.64 A C ATOM 1285 CB LEU A 295 6.135 72.154 18.587 1.00 35.17 A C ATOM 1286 CG LEU A 295 6.953 71.141 17.781 1.00 36.95 A C ATOM 1287 CD1 LEU A 295 6.675 71.328 16.282 1.00 37.45 A C ATOM 1288 CD2 LEU A 295 8.440 71.326 18.097 1.00 36.23 A C ATOM 1289 C LEU A 295 5.480 73.161 20.765 1.00 34.99 A C ATOM 1290 O LEU A 295 4.256 73.170 20.811 1.00 34.10 A O ATOM 1291 N PRO A 296 6.215 74.154 21.293 1.00 35.03 A N ATOM 1292 CD PRO A 296 7.683 74.244 21.374 1.00 32.23 A C ATOM 1293 CA PRO A 296 5.583 75.306 21.939 1.00 34.56 A C ATOM 1294 CB PRO A 296 6.743 75.963 22.686 1.00 32.65 A C ATOM 1295 CG PRO A 296 7.897 75.677 21.801 1.00 35.00 A C ATOM 1296 C PRO A 296 4.980 76.216 20.865 1.00 35.38 A C ATOM 1297 O PRO A 296 5.423 76.210 19.715 1.00 31.51 A O ATOM 1298 N PRO A 297 3.964 77.009 21.231 1.00 35.66 A N ATOM 1299 CD PRO A 297 3.432 77.146 22.597 1.00 35.54 A C ATOM 1300 CA PRO A 297 3.283 77.927 20.313 1.00 36.80 A C ATOM 1301 CB PRO A 297 2.400 78.758 21.245 1.00 37.34 A C ATOM 1302 CG PRO A 297 2.100 77.819 22.358 1.00 38.15 A C ATOM 1303 C PRO A 297 4.182 78.818 19.458 1.00 37.23 A C ATOM 1304 O PRO A 297 3.991 78.920 18.235 1.00 33.75 A O ATOM 1305 N GLU A 298 5.158 79.461 20.095 1.00 37.28 A N ATOM 1306 CA GLU A 298 6.040 80.368 19.375 1.00 39.04 A C ATOM 1307 CB GLU A 298 7.016 81.072 20.335 1.00 40.64 A C ATOM 1308 CG GLU A 298 7.969 80.146 21.080 1.00 41.60 A C ATOM 1309 CD GLU A 298 7.456 79.749 22.453 1.00 41.95 A C ATOM 1310 OE1 GLU A 298 6.216 79.639 22.633 1.00 37.64 A O ATOM 1311 OE2 GLU A 298 8.304 79.536 23.352 1.00 42.68 A O ATOM 1312 C GLU A 298 6.805 79.668 18.266 1.00 40.93 A C ATOM 1313 O GLU A 298 7.175 80.297 17.272 1.00 40.31 A O ATOM 1314 N MET A 299 7.029 78.366 18.415 1.00 41.73 A N ATOM 1315 CA MET A 299 7.759 77.624 17.395 1.00 43.83 A C ATOM 1316 CB MET A 299 8.495 76.437 18.017 1.00 47.01 A C ATOM 1317 CG MET A 299 9.916 76.769 18.440 1.00 50.51 A C ATOM 1318 SD MET A 299 10.859 75.322 18.989 1.00 56.33 A S ATOM 1319 CE MET A 299 10.979 74.398 17.460 1.00 57.30 A C ATOM 1320 C MET A 299 6.907 77.157 16.222 1.00 45.51 A C ATOM 1321 O MET A 299 7.357 77.219 15.078 1.00 46.23 A O ATOM 1322 N ILE A 300 5.686 76.691 16.473 1.00 46.41 A N ATOM 1323 CA ILE A 300 4.857 76.256 15.354 1.00 49.69 A C ATOM 1324 CB ILE A 300 3.667 75.376 15.798 1.00 48.42 A C ATOM 1325 CG2 ILE A 300 4.178 74.162 16.561 1.00 47.80 A C ATOM 1326 CG1 ILE A 300 2.709 76.179 16.675 1.00 49.64 A C ATOM 1327 CD1 ILE A 300 1.559 75.360 17.234 1.00 47.41 A C ATOM 1328 C ILE A 300 4.322 77.478 14.610 1.00 54.06 A C ATOM 1329 O ILE A 300 4.079 77.416 13.399 1.00 54.63 A O ATOM 1330 N GLU A 301 4.153 78.590 15.332 1.00 55.66 A N ATOM 1331 CA GLU A 301 3.646 79.827 14.733 1.00 56.31 A C ATOM 1332 CB GLU A 301 3.129 80.780 15.815 1.00 54.96 A C ATOM 1333 CG GLU A 301 1.744 80.422 16.350 1.00 54.86 A C ATOM 1334 CD GLU A 301 1.408 81.163 17.629 1.00 57.37 A C ATOM 1335 OE1 GLU A 301 2.017 82.225 17.865 1.00 61.01 A O ATOM 1336 OE2 GLU A 301 0.535 80.701 18.397 1.00 57.95 A O ATOM 1337 C GLU A 301 4.684 80.533 13.875 1.00 56.92 A C ATOM 1338 O GLU A 301 4.345 81.438 13.120 1.00 60.15 A O ATOM 1339 N GLY A 302 5.943 80.119 13.988 1.00 58.80 A N ATOM 1340 CA GLY A 302 6.998 80.729 13.191 1.00 59.94 A C ATOM 1341 C GLY A 302 7.683 81.921 13.838 1.00 61.59 A C ATOM 1342 O GLY A 302 8.681 82.429 13.322 1.00 60.55 A O ATOM 1343 N ARG A 303 7.149 82.359 14.974 1.00 62.63 A N ATOM 1344 CA ARG A 303 7.688 83.497 15.712 1.00 63.82 A C ATOM 1345 CB ARG A 303 6.674 83.913 16.778 1.00 64.15 A C ATOM 1346 CG ARG A 303 5.352 84.320 16.161 1.00 65.61 A C ATOM 1347 CD ARG A 303 4.180 84.153 17.100 1.00 69.14 A C ATOM 1348 NE ARG A 303 3.933 85.328 17.925 1.00 72.61 A N ATOM 1349 CZ ARG A 303 2.797 85.543 18.585 1.00 75.65 A C ATOM 1350 NH1 ARG A 303 2.644 86.641 19.318 1.00 75.84 A N ATOM 1351 NH2 ARG A 303 1.806 84.660 18.509 1.00 75.29 A N ATOM 1352 C ARG A 303 9.056 83.212 16.339 1.00 64.35 A C ATOM 1353 O ARG A 303 9.637 82.148 16.122 1.00 65.12 A O ATOM 1354 N MET A 304 9.572 84.173 17.099 1.00 65.05 A N ATOM 1355 CA MET A 304 10.871 84.038 17.756 1.00 66.24 A C ATOM 1356 CB MET A 304 11.377 85.403 18.216 1.00 69.81 A C ATOM 1357 CG MET A 304 11.911 86.312 17.135 1.00 74.75 A C ATOM 1358 SD MET A 304 12.200 87.972 17.807 1.00 80.86 A S ATOM 1359 CE MET A 304 13.387 87.618 19.128 1.00 78.52 A C ATOM 1360 C MET A 304 10.792 83.139 18.981 1.00 65.57 A C ATOM 1361 O MET A 304 9.798 83.164 19.710 1.00 66.01 A O ATOM 1362 N HIS A 305 11.847 82.361 19.216 1.00 64.22 A N ATOM 1363 CA HIS A 305 11.900 81.478 20.381 1.00 63.54 A C ATOM 1364 CB HIS A 305 11.502 80.047 20.005 1.00 62.59 A C ATOM 1365 CG HIS A 305 12.372 79.428 18.958 1.00 63.59 A C ATOM 1366 CD2 HIS A 305 13.509 78.699 19.062 1.00 63.03 A C ATOM 1367 ND1 HIS A 305 12.100 79.524 17.611 1.00 64.03 A N ATOM 1368 CE1 HIS A 305 13.031 78.878 16.930 1.00 64.73 A C ATOM 1369 NE2 HIS A 305 13.897 78.369 17.787 1.00 63.15 A N ATOM 1370 C HIS A 305 13.284 81.470 21.031 1.00 62.77 A C ATOM 1371 O HIS A 305 14.303 81.665 20.359 1.00 61.65 A O ATOM 1372 N ASP A 306 13.307 81.235 22.342 1.00 61.87 A N ATOM 1373 CA ASP A 306 14.553 81.211 23.109 1.00 59.72 A C ATOM 1374 CB ASP A 306 14.722 82.543 23.838 1.00 61.31 A C ATOM 1375 CG ASP A 306 13.804 82.668 25.035 1.00 63.77 A C ATOM 1376 OD1 ASP A 306 12.597 82.368 24.903 1.00 63.61 A O ATOM 1377 OD2 ASP A 306 14.293 83.073 26.111 1.00 67.22 A O ATOM 1378 C ASP A 306 14.614 80.058 24.128 1.00 57.12 A C ATOM 1379 O ASP A 306 13.984 79.014 23.944 1.00 55.04 A O ATOM 1380 N GLU A 307 15.372 80.269 25.202 1.00 53.44 A N ATOM 1381 CA GLU A 307 15.552 79.274 26.253 1.00 50.60 A C ATOM 1382 CB GLU A 307 16.547 79.793 27.298 1.00 52.86 A C ATOM 1383 CG GLU A 307 16.215 81.169 27.862 1.00 56.28 A C ATOM 1384 CD GLU A 307 15.453 81.128 29.175 1.00 58.72 A C ATOM 1385 OE1 GLU A 307 15.048 82.215 29.646 1.00 62.07 A O ATOM 1386 OE2 GLU A 307 15.264 80.027 29.742 1.00 58.85 A O ATOM 1387 C GLU A 307 14.259 78.861 26.935 1.00 48.53 A C ATOM 1388 O GLU A 307 14.153 77.745 27.450 1.00 45.98 A O ATOM 1389 N LYS A 308 13.275 79.756 26.935 1.00 44.46 A N ATOM 1390 CA LYS A 308 11.990 79.460 27.555 1.00 42.65 A C ATOM 1391 CB LYS A 308 11.099 80.706 27.556 1.00 43.53 A C ATOM 1392 CG LYS A 308 11.596 81.812 28.477 1.00 46.71 A C ATOM 1393 CD LYS A 308 11.642 81.330 29.916 1.00 46.09 A C ATOM 1394 CE LYS A 308 12.011 82.458 30.861 1.00 50.52 A C ATOM 1395 NZ LYS A 308 11.941 82.037 32.292 1.00 48.95 A N ATOM 1396 C LYS A 308 11.254 78.301 26.881 1.00 39.37 A C ATOM 1397 O LYS A 308 10.288 77.784 27.439 1.00 38.96 A O ATOM 1398 N VAL A 309 11.691 77.904 25.685 1.00 37.85 A N ATOM 1399 CA VAL A 309 11.055 76.781 24.999 1.00 36.62 A C ATOM 1400 CB VAL A 309 11.665 76.507 23.582 1.00 36.29 A C ATOM 1401 CG1 VAL A 309 11.361 77.654 22.638 1.00 36.56 A C ATOM 1402 CG2 VAL A 309 13.162 76.294 23.680 1.00 36.29 A C ATOM 1403 C VAL A 309 11.238 75.533 25.873 1.00 36.76 A C ATOM 1404 O VAL A 309 10.374 74.666 25.902 1.00 37.91 A O ATOM 1405 N ASP A 310 12.359 75.455 26.594 1.00 36.49 A N ATOM 1406 CA ASP A 310 12.616 74.311 27.467 1.00 37.02 A C ATOM 1407 CB ASP A 310 14.048 74.340 28.005 1.00 36.24 A C ATOM 1408 CG ASP A 310 15.080 74.031 26.947 1.00 39.49 A C ATOM 1409 OD1 ASP A 310 14.820 73.177 26.074 1.00 42.74 A O ATOM 1410 OD2 ASP A 310 16.172 74.629 26.994 1.00 43.52 A O ATOM 1411 C ASP A 310 11.633 74.227 28.645 1.00 36.95 A C ATOM 1412 O ASP A 310 11.342 73.133 29.140 1.00 37.49 A O ATOM 1413 N LEU A 311 11.122 75.365 29.109 1.00 35.08 A N ATOM 1414 CA LEU A 311 10.166 75.333 30.211 1.00 32.22 A C ATOM 1415 CB LEU A 311 9.951 76.736 30.790 1.00 34.39 A C ATOM 1416 CG LEU A 311 10.913 77.158 31.909 1.00 33.96 A C ATOM 1417 CD1 LEU A 311 10.809 76.178 33.064 1.00 35.22 A C ATOM 1418 CD2 LEU A 311 12.334 77.210 31.389 1.00 33.80 A C ATOM 1419 C LEU A 311 8.833 74.752 29.743 1.00 31.56 A C ATOM 1420 O LEU A 311 8.139 74.050 30.488 1.00 31.74 A O ATOM 1421 N TRP A 312 8.466 75.048 28.503 1.00 30.35 A N ATOM 1422 CA TRP A 312 7.220 74.520 27.960 1.00 29.50 A C ATOM 1423 CB TRP A 312 6.948 75.139 26.585 1.00 28.53 A C ATOM 1424 CG TRP A 312 5.759 74.557 25.875 1.00 28.80 A C ATOM 1425 CD2 TRP A 312 4.431 75.100 25.843 1.00 30.03 A C ATOM 1426 CE2 TRP A 312 3.648 74.251 25.027 1.00 29.38 A C ATOM 1427 CE3 TRP A 312 3.830 76.225 26.421 1.00 29.90 A C ATOM 1428 CD1 TRP A 312 5.730 73.429 25.103 1.00 26.36 A C ATOM 1429 NE1 TRP A 312 4.460 73.237 24.589 1.00 30.47 A N ATOM 1430 CZ2 TRP A 312 2.299 74.495 24.775 1.00 32.48 A C ATOM 1431 CZ3 TRP A 312 2.488 76.465 26.171 1.00 31.78 A C ATOM 1432 CH2 TRP A 312 1.739 75.604 25.354 1.00 33.00 A C ATOM 1433 C TRP A 312 7.319 72.991 27.855 1.00 28.16 A C ATOM 1434 O TRP A 312 6.371 72.272 28.190 1.00 30.23 A O ATOM 1435 N SER A 313 8.467 72.503 27.389 1.00 27.71 A N ATOM 1436 CA SER A 313 8.699 71.066 27.248 1.00 29.31 A C ATOM 1437 CB SER A 313 10.120 70.803 26.715 1.00 30.43 A C ATOM 1438 OG SER A 313 10.265 71.217 25.364 1.00 31.34 A O ATOM 1439 C SER A 313 8.540 70.373 28.605 1.00 30.79 A C ATOM 1440 O SER A 313 7.926 69.314 28.729 1.00 31.14 A O ATOM 1441 N LEU A 314 9.101 70.994 29.628 1.00 32.96 A N ATOM 1442 CA LEU A 314 9.026 70.455 30.966 1.00 33.68 A C ATOM 1443 CB LEU A 314 9.746 71.412 31.921 1.00 35.73 A C ATOM 1444 CG LEU A 314 10.693 70.816 32.958 1.00 39.36 A C ATOM 1445 CD1 LEU A 314 11.611 69.795 32.312 1.00 37.79 A C ATOM 1446 CD2 LEU A 314 11.494 71.940 33.611 1.00 39.93 A C ATOM 1447 C LEU A 314 7.567 70.265 31.368 1.00 34.08 A C ATOM 1448 O LEU A 314 7.213 69.270 32.002 1.00 35.54 A O ATOM 1449 N GLY A 315 6.715 71.212 30.974 1.00 34.46 A N ATOM 1450 CA GLY A 315 5.302 71.129 31.311 1.00 32.61 A C ATOM 1451 C GLY A 315 4.533 70.037 30.580 1.00 32.40 A C ATOM 1452 O GLY A 315 3.653 69.393 31.156 1.00 31.59 A O ATOM 1453 N VAL A 316 4.848 69.839 29.305 1.00 30.85 A N ATOM 1454 CA VAL A 316 4.191 68.812 28.500 1.00 30.81 A C ATOM 1455 CB VAL A 316 4.675 68.870 27.019 1.00 31.13 A C ATOM 1456 CG1 VAL A 316 4.091 67.703 26.225 1.00 31.52 A C ATOM 1457 CG2 VAL A 316 4.268 70.206 26.381 1.00 31.54 A C ATOM 1458 C VAL A 316 4.541 67.431 29.076 1.00 30.12 A C ATOM 1459 O VAL A 316 3.694 66.547 29.151 1.00 28.42 A O ATOM 1460 N LEU A 317 5.800 67.269 29.472 1.00 30.58 A N ATOM 1461 CA LEU A 317 6.307 66.018 30.041 1.00 32.76 A C ATOM 1462 CB LEU A 317 7.834 66.091 30.182 1.00 33.36 A C ATOM 1463 CG LEU A 317 8.741 65.504 29.091 1.00 37.19 A C ATOM 1464 CD1 LEU A 317 7.959 65.186 27.838 1.00 34.20 A C ATOM 1465 CD2 LEU A 317 9.868 66.471 28.805 1.00 29.92 A C ATOM 1466 C LEU A 317 5.700 65.710 31.408 1.00 32.08 A C ATOM 1467 O LEU A 317 5.249 64.587 31.656 1.00 34.68 A O ATOM 1468 N CYS A 318 5.702 66.697 32.298 1.00 31.11 A N ATOM 1469 CA CYS A 318 5.151 66.491 33.629 1.00 33.57 A C ATOM 1470 CB CYS A 318 5.156 67.798 34.432 1.00 33.30 A C ATOM 1471 SG CYS A 318 4.864 67.562 36.226 1.00 37.22 A S ATOM 1472 C CYS A 318 3.725 65.973 33.468 1.00 35.37 A C ATOM 1473 O CYS A 318 3.326 64.971 34.075 1.00 33.70 A O ATOM 1474 N TYR A 319 2.969 66.645 32.613 1.00 32.86 A N ATOM 1475 CA TYR A 319 1.598 66.244 32.364 1.00 33.70 A C ATOM 1476 CB TYR A 319 0.927 67.239 31.395 1.00 29.85 A C ATOM 1477 CG TYR A 319 −0.525 66.932 31.098 1.00 30.41 A C ATOM 1478 CD1 TYR A 319 −0.877 65.857 30.276 1.00 28.02 A C ATOM 1479 CE1 TYR A 319 −2.207 65.545 30.022 1.00 29.18 A C ATOM 1480 CD2 TYR A 319 −1.557 67.696 31.667 1.00 28.95 A C ATOM 1481 CE2 TYR A 319 −2.902 67.387 31.424 1.00 27.56 A C ATOM 1482 CZ TYR A 319 −3.217 66.318 30.599 1.00 30.05 A C ATOM 1483 OH TYR A 319 −4.530 66.032 30.309 1.00 30.26 A O ATOM 1484 C TYR A 319 1.550 64.825 31.796 1.00 33.79 A C ATOM 1485 O TYR A 319 0.804 63.970 32.286 1.00 34.68 A O ATOM 1486 N GLU A 320 2.343 64.562 30.764 1.00 34.53 A N ATOM 1487 CA GLU A 320 2.317 63.236 30.153 1.00 34.32 A C ATOM 1488 CB GLU A 320 3.228 63.166 28.927 1.00 31.06 A C ATOM 1489 CG GLU A 320 3.005 61.857 28.188 1.00 40.04 A C ATOM 1490 CD GLU A 320 3.781 61.719 26.906 1.00 42.41 A C ATOM 1491 OE1 GLU A 320 3.546 60.713 26.203 1.00 44.86 A O ATOM 1492 OE2 GLU A 320 4.618 62.591 26.600 1.00 43.17 A O ATOM 1493 C GLU A 320 2.688 62.104 31.116 1.00 32.80 A C ATOM 1494 O GLU A 320 2.109 61.018 31.045 1.00 32.14 A O ATOM 1495 N PHE A 321 3.651 62.357 32.003 1.00 32.51 A N ATOM 1496 CA PHE A 321 4.071 61.343 32.973 1.00 33.85 A C ATOM 1497 CB PHE A 321 5.235 61.833 33.829 1.00 29.43 A C ATOM 1498 CG PHE A 321 6.517 62.054 33.070 1.00 30.26 A C ATOM 1499 CD1 PHE A 321 6.711 61.505 31.816 1.00 28.99 A C ATOM 1500 CD2 PHE A 321 7.556 62.764 33.655 1.00 25.23 A C ATOM 1501 CE1 PHE A 321 7.932 61.654 31.156 1.00 32.51 A C ATOM 1502 CE2 PHE A 321 8.782 62.919 33.007 1.00 30.02 A C ATOM 1503 CZ PHE A 321 8.969 62.356 31.750 1.00 28.27 A C ATOM 1504 C PHE A 321 2.933 60.969 33.916 1.00 36.33 A C ATOM 1505 O PHE A 321 2.740 59.800 34.239 1.00 34.14 A O ATOM 1506 N LEU A 322 2.191 61.976 34.367 1.00 37.42 A N ATOM 1507 CA LEU A 322 1.085 61.755 35.296 1.00 37.42 A C ATOM 1508 CB LEU A 322 0.811 63.030 36.085 1.00 38.07 A C ATOM 1509 CG LEU A 322 1.884 63.502 37.050 1.00 37.46 A C ATOM 1510 CD1 LEU A 322 1.563 64.921 37.490 1.00 41.27 A C ATOM 1511 CD2 LEU A 322 1.939 62.557 38.246 1.00 40.08 A C ATOM 1512 C LEU A 322 −0.214 61.302 34.658 1.00 37.12 A C ATOM 1513 O LEU A 322 −1.004 60.596 35.281 1.00 38.55 A O ATOM 1514 N VAL A 323 −0.435 61.692 33.410 1.00 38.25 A N ATOM 1515 CA VAL A 323 −1.686 61.356 32.743 1.00 37.24 A C ATOM 1516 CB VAL A 323 −2.283 62.634 32.058 1.00 35.89 A C ATOM 1517 CG1 VAL A 323 −3.556 62.300 31.285 1.00 35.08 A C ATOM 1518 CG2 VAL A 323 −2.587 63.683 33.123 1.00 33.83 A C ATOM 1519 C VAL A 323 −1.609 60.209 31.746 1.00 37.69 A C ATOM 1520 O VAL A 323 −2.620 59.538 31.493 1.00 38.39 A O ATOM 1521 N GLY A 324 −0.429 59.972 31.177 1.00 36.52 A N ATOM 1522 CA GLY A 324 −0.310 58.887 30.215 1.00 38.42 A C ATOM 1523 C GLY A 324 −0.333 59.333 28.759 1.00 39.62 A C ATOM 1524 O GLY A 324 −0.077 58.536 27.855 1.00 36.81 A O ATOM 1525 N LYS A 325 −0.652 60.606 28.527 1.00 40.00 A N ATOM 1526 CA LYS A 325 −0.682 61.165 27.173 1.00 37.45 A C ATOM 1527 CB LYS A 325 −2.002 60.824 26.477 1.00 39.47 A C ATOM 1528 CG LYS A 325 −3.252 61.105 27.288 1.00 42.40 A C ATOM 1529 CD LYS A 325 −4.497 60.695 26.509 1.00 45.48 A C ATOM 1530 CE LYS A 325 −5.785 61.028 27.265 1.00 49.79 A C ATOM 1531 NZ LYS A 325 −5.968 60.179 28.489 1.00 55.16 A N ATOM 1532 C LYS A 325 −0.449 62.675 27.230 1.00 33.68 A C ATOM 1533 O LYS A 325 −0.751 63.318 28.236 1.00 31.87 A O ATOM 1534 N PRO A 326 0.121 63.256 26.158 1.00 31.60 A N ATOM 1535 CD PRO A 326 0.475 62.618 24.876 1.00 32.20 A C ATOM 1536 CA PRO A 326 0.390 64.697 26.133 1.00 31.72 A C ATOM 1537 CB PRO A 326 1.174 64.879 24.832 1.00 31.00 A C ATOM 1538 CG PRO A 326 0.629 63.796 23.948 1.00 32.88 A C ATOM 1539 C PRO A 326 −0.903 65.527 26.234 1.00 29.94 A C ATOM 1540 O PRO A 326 −1.946 65.112 25.753 1.00 30.57 A O ATOM 1541 N PRO A 327 −0.836 66.715 26.857 1.00 27.73 A N ATOM 1542 CD PRO A 327 0.377 67.360 27.400 1.00 27.90 A C ATOM 1543 CA PRO A 327 −2.024 67.570 27.025 1.00 29.32 A C ATOM 1544 CB PRO A 327 −1.517 68.695 27.933 1.00 25.30 A C ATOM 1545 CG PRO A 327 −0.039 68.828 27.530 1.00 27.21 A C ATOM 1546 C PRO A 327 −2.821 68.110 25.831 1.00 30.82 A C ATOM 1547 O PRO A 327 −3.998 68.441 25.988 1.00 33.12 A O ATOM 1548 N PHE A 328 −2.218 68.177 24.649 1.00 31.39 A N ATOM 1549 CA PHE A 328 −2.901 68.742 23.486 1.00 33.88 A C ATOM 1550 CB PHE A 328 −2.041 69.869 22.890 1.00 33.58 A C ATOM 1551 CG PHE A 328 −1.601 70.894 23.899 1.00 33.55 A C ATOM 1552 CD1 PHE A 328 −2.531 71.726 24.522 1.00 33.79 A C ATOM 1553 CD2 PHE A 328 −0.257 71.002 24.256 1.00 33.06 A C ATOM 1554 CE1 PHE A 328 −2.133 72.647 25.490 1.00 33.48 A C ATOM 1555 CE2 PHE A 328 0.160 71.923 25.226 1.00 34.56 A C ATOM 1556 CZ PHE A 328 −0.781 72.748 25.846 1.00 36.22 A C ATOM 1557 C PHE A 328 −3.240 67.739 22.390 1.00 36.41 A C ATOM 1558 O PHE A 328 −3.555 68.125 21.260 1.00 36.68 A O ATOM 1559 N GLU A 329 −3.189 66.457 22.728 1.00 39.55 A N ATOM 1560 CA GLU A 329 −3.457 65.388 21.771 1.00 42.10 A C ATOM 1561 CB GLU A 329 −3.331 64.037 22.474 1.00 44.65 A C ATOM 1562 CG GLU A 329 −3.295 62.852 21.537 1.00 51.26 A C ATOM 1563 CD GLU A 329 −2.954 61.571 22.264 1.00 54.01 A C ATOM 1564 OE1 GLU A 329 −3.729 61.174 23.160 1.00 56.26 A O ATOM 1565 OE2 GLU A 329 −1.907 60.966 21.943 1.00 57.24 A O ATOM 1566 C GLU A 329 −4.820 65.498 21.089 1.00 41.21 A C ATOM 1567 O GLU A 329 −5.827 65.795 21.731 1.00 38.95 A O ATOM 1568 N ALA A 330 −4.842 65.248 19.783 1.00 41.49 A N ATOM 1569 CA ALA A 330 −6.077 65.330 19.014 1.00 44.78 A C ATOM 1570 CB ALA A 330 −6.345 66.782 18.609 1.00 45.23 A C ATOM 1571 C ALA A 330 −6.059 64.438 17.775 1.00 45.72 A C ATOM 1572 O ALA A 330 −5.013 63.941 17.363 1.00 45.07 A O ATOM 1573 N ASN A 331 −7.234 64.252 17.185 1.00 47.77 A N ATOM 1574 CA ASN A 331 −7.386 63.413 16.006 1.00 50.88 A C ATOM 1575 CB ASN A 331 −8.875 63.131 15.755 1.00 54.96 A C ATOM 1576 CG ASN A 331 −9.508 62.298 16.865 1.00 60.45 A C ATOM 1577 OD1 ASN A 331 −9.016 61.216 17.202 1.00 64.11 A O ATOM 1578 ND2 ASN A 331 −10.608 62.795 17.433 1.00 63.29 A N ATOM 1579 C ASN A 331 −6.749 63.980 14.741 1.00 49.91 A C ATOM 1580 O ASN A 331 −6.409 63.229 13.833 1.00 51.49 A O ATOM 1581 N THR A 332 −6.586 65.296 14.675 1.00 48.66 A N ATOM 1582 CA THR A 332 −5.982 65.917 13.496 1.00 46.76 A C ATOM 1583 CB THR A 332 −7.050 66.648 12.650 1.00 47.96 A C ATOM 1584 OG1 THR A 332 −7.648 67.696 13.424 1.00 45.93 A O ATOM 1585 CG2 THR A 332 −8.131 65.675 12.217 1.00 46.55 A C ATOM 1586 C THR A 332 −4.886 66.914 13.864 1.00 44.80 A C ATOM 1587 O THR A 332 −4.875 67.444 14.973 1.00 41.95 A O ATOM 1588 N TYR A 333 −3.954 67.155 12.940 1.00 43.86 A N ATOM 1589 CA TYR A 333 −2.885 68.115 13.199 1.00 43.43 A C ATOM 1590 CB TYR A 333 −1.938 68.232 11.999 1.00 47.91 A C ATOM 1591 CG TYR A 333 −1.084 67.015 11.710 1.00 50.72 A C ATOM 1592 CD1 TYR A 333 −1.606 65.916 11.033 1.00 53.76 A C ATOM 1593 CE1 TYR A 333 −0.816 64.803 10.748 1.00 54.63 A C ATOM 1594 CD2 TYR A 333 0.254 66.973 12.099 1.00 50.61 A C ATOM 1595 CE2 TYR A 333 1.053 65.868 11.821 1.00 51.32 A C ATOM 1596 CZ TYR A 333 0.515 64.786 11.142 1.00 53.90 A C ATOM 1597 OH TYR A 333 1.305 63.696 10.836 1.00 52.72 A O ATOM 1598 C TYR A 333 −3.561 69.470 13.416 1.00 42.37 A C ATOM 1599 O TYR A 333 −3.083 70.317 14.169 1.00 39.21 A O ATOM 1600 N GLN A 334 −4.688 69.643 12.734 1.00 41.68 A N ATOM 1601 CA GLN A 334 −5.479 70.865 12.790 1.00 41.47 A C ATOM 1602 CB GLN A 334 −6.709 70.733 11.885 1.00 42.29 A C ATOM 1603 CG GLN A 334 −7.485 72.011 11.777 1.00 45.81 A C ATOM 1604 CD GLN A 334 −6.550 73.173 11.567 1.00 51.49 A C ATOM 1605 OE1 GLN A 334 −5.725 73.152 10.653 1.00 52.23 A O ATOM 1606 NE2 GLN A 334 −6.655 74.192 12.420 1.00 52.56 A N ATOM 1607 C GLN A 334 −5.933 71.195 14.202 1.00 37.45 A C ATOM 1608 O GLN A 334 −5.690 72.291 14.706 1.00 33.84 A O ATOM 1609 N GLU A 335 −6.599 70.231 14.821 1.00 35.59 A N ATOM 1610 CA GLU A 335 −7.113 70.385 16.164 1.00 37.26 A C ATOM 1611 CB GLU A 335 −8.091 69.243 16.458 1.00 39.04 A C ATOM 1612 CG GLU A 335 −8.854 69.370 17.767 1.00 44.38 A C ATOM 1613 CD GLU A 335 −9.901 70.478 17.746 1.00 49.56 A C ATOM 1614 OE1 GLU A 335 −10.579 70.666 18.784 1.00 48.54 A O ATOM 1615 OE2 GLU A 335 −10.042 71.159 16.699 1.00 49.52 A O ATOM 1616 C GLU A 335 −5.967 70.416 17.189 1.00 36.13 A C ATOM 1617 O GLU A 335 −6.083 71.062 18.232 1.00 35.59 A O ATOM 1618 N THR A 336 −4.864 69.723 16.900 1.00 33.83 A N ATOM 1619 CA THR A 336 −3.721 69.727 17.819 1.00 32.60 A C ATOM 1620 CB THR A 336 −2.606 68.755 17.357 1.00 31.68 A C ATOM 1621 OG1 THR A 336 −3.126 67.422 17.292 1.00 34.29 A O ATOM 1622 CG2 THR A 336 −1.443 68.771 18.331 1.00 29.91 A C ATOM 1623 C THR A 336 −3.143 71.145 17.889 1.00 31.31 A C ATOM 1624 O THR A 336 −2.914 71.686 18.971 1.00 28.38 A O ATOM 1625 N TYR A 337 −2.911 71.732 16.717 1.00 31.54 A N ATOM 1626 CA TYR A 337 −2.381 73.094 16.597 1.00 33.23 A C ATOM 1627 CB TYR A 337 −2.339 73.489 15.120 1.00 38.97 A C ATOM 1628 CG TYR A 337 −1.770 74.861 14.855 1.00 43.55 A C ATOM 1629 CD1 TYR A 337 −0.414 75.030 14.589 1.00 50.62 A C ATOM 1630 CE1 TYR A 337 0.123 76.290 14.343 1.00 53.16 A C ATOM 1631 CD2 TYR A 337 −2.584 75.991 14.872 1.00 43.59 A C ATOM 1632 CE2 TYR A 337 −2.062 77.254 14.632 1.00 47.84 A C ATOM 1633 CZ TYR A 337 −0.704 77.397 14.364 1.00 53.57 A C ATOM 1634 OH TYR A 337 −0.170 78.637 14.096 1.00 56.75 A O ATOM 1635 C TYR A 337 −3.290 74.070 17.359 1.00 32.20 A C ATOM 1636 O TYR A 337 −2.823 74.890 18.159 1.00 30.91 A O ATOM 1637 N LYS A 338 −4.592 73.966 17.103 1.00 30.03 A N ATOM 1638 CA LYS A 338 −5.580 74.809 17.771 1.00 30.11 A C ATOM 1639 CB LYS A 338 −7.008 74.344 17.421 1.00 31.44 A C ATOM 1640 CG LYS A 338 −8.107 75.329 17.852 1.00 34.97 A C ATOM 1641 CD LYS A 338 −9.521 74.720 17.889 1.00 38.62 A C ATOM 1642 CE LYS A 338 −10.082 74.415 16.504 1.00 43.83 A C ATOM 1643 NZ LYS A 338 −11.532 74.025 16.552 1.00 43.82 A N ATOM 1644 C LYS A 338 −5.387 74.764 19.289 1.00 30.09 A C ATOM 1645 O LYS A 338 −5.257 75.804 19.942 1.00 29.38 A O ATOM 1646 N ARG A 339 −5.356 73.554 19.846 1.00 29.91 A N ATOM 1647 CA ARG A 339 −5.200 73.370 21.288 1.00 29.88 A C ATOM 1648 CB ARG A 339 −5.376 71.880 21.642 1.00 32.35 A C ATOM 1649 CG ARG A 339 −6.790 71.364 21.347 1.00 37.87 A C ATOM 1650 CD ARG A 339 −6.962 69.849 21.524 1.00 43.23 A C ATOM 1651 NE ARG A 339 −8.337 69.455 21.193 1.00 48.20 A N ATOM 1652 CZ ARG A 339 −8.845 68.223 21.287 1.00 50.25 A C ATOM 1653 NH1 ARG A 339 −8.107 67.202 21.712 1.00 48.72 A N ATOM 1654 NH2 ARG A 339 −10.111 68.010 20.940 1.00 51.23 A N ATOM 1655 C ARG A 339 −3.883 73.906 21.850 1.00 28.91 A C ATOM 1656 O ARG A 339 −3.853 74.491 22.930 1.00 31.71 A O ATOM 1657 N ILE A 340 −2.792 73.700 21.125 1.00 28.62 A N ATOM 1658 CA ILE A 340 −1.487 74.180 21.565 1.00 30.14 A C ATOM 1659 CB ILE A 340 −0.366 73.660 20.631 1.00 28.04 A C ATOM 1660 CG2 ILE A 340 0.932 74.397 20.925 1.00 25.58 A C ATOM 1661 CG1 ILE A 340 −0.190 72.142 20.807 1.00 26.16 A C ATOM 1662 CD1 ILE A 340 0.830 71.531 19.845 1.00 27.76 A C ATOM 1663 C ILE A 340 −1.462 75.712 21.526 1.00 32.65 A C ATOM 1664 O ILE A 340 −1.024 76.377 22.470 1.00 33.37 A O ATOM 1665 N SER A 341 −1.935 76.243 20.404 1.00 33.83 A N ATOM 1666 CA SER A 341 −2.000 77.676 20.138 1.00 35.56 A C ATOM 1667 CB SER A 341 −2.644 77.892 18.772 1.00 35.09 A C ATOM 1668 OG SER A 341 −1.991 78.931 18.084 1.00 39.44 A O ATOM 1669 C SER A 341 −2.794 78.436 21.185 1.00 35.59 A C ATOM 1670 O SER A 341 −2.367 79.478 21.673 1.00 37.28 A O ATOM 1671 N ARG A 342 −3.952 77.893 21.530 1.00 34.73 A N ATOM 1672 CA ARG A 342 −4.851 78.508 22.493 1.00 34.53 A C ATOM 1673 CB ARG A 342 −6.296 78.295 22.016 1.00 35.36 A C ATOM 1674 CG ARG A 342 −6.539 78.913 20.641 1.00 33.27 A C ATOM 1675 CD ARG A 342 −7.836 78.460 19.969 1.00 38.01 A C ATOM 1676 NE ARG A 342 −8.038 79.214 18.730 1.00 41.54 A N ATOM 1677 CZ ARG A 342 −9.135 79.184 17.974 1.00 41.67 A C ATOM 1678 NH1 ARG A 342 −9.187 79.922 16.870 1.00 44.15 A N ATOM 1679 NH2 ARG A 342 −10.176 78.435 18.315 1.00 37.28 A N ATOM 1680 C ARG A 342 −4.652 77.962 23.900 1.00 36.18 A C ATOM 1681 O ARG A 342 −5.446 78.252 24.802 1.00 34.08 A O ATOM 1682 N VAL A 343 −3.582 77.178 24.072 1.00 35.22 A N ATOM 1683 CA VAL A 343 −3.221 76.575 25.355 1.00 34.16 A C ATOM 1684 CB VAL A 343 −2.613 77.622 26.315 1.00 34.38 A C ATOM 1685 CG1 VAL A 343 −2.081 76.935 27.561 1.00 36.51 A C ATOM 1686 CG2 VAL A 343 −1.500 78.391 25.632 1.00 31.25 A C ATOM 1687 C VAL A 343 −4.441 75.952 26.018 1.00 34.20 A C ATOM 1688 O VAL A 343 −4.782 76.284 27.153 1.00 31.68 A O ATOM 1689 N GLU A 344 −5.097 75.050 25.294 1.00 33.81 A N ATOM 1690 CA GLU A 344 −6.292 74.369 25.783 1.00 34.08 A C ATOM 1691 CB GLU A 344 −7.340 74.265 24.658 1.00 34.89 A C ATOM 1692 CG GLU A 344 −8.047 75.572 24.334 1.00 38.33 A C ATOM 1693 CD GLU A 344 −8.665 75.594 22.944 1.00 40.26 A C ATOM 1694 OE1 GLU A 344 −9.402 76.553 22.636 1.00 39.02 A O ATOM 1695 OE2 GLU A 344 −8.406 74.665 22.154 1.00 41.41 A O ATOM 1696 C GLU A 344 −6.022 72.972 26.337 1.00 33.90 A C ATOM 1697 O GLU A 344 −5.887 72.020 25.575 1.00 35.23 A O ATOM 1698 N PHE A 345 −5.958 72.851 27.661 1.00 35.80 A N ATOM 1699 CA PHE A 345 −5.736 71.558 28.314 1.00 37.65 A C ATOM 1700 CB PHE A 345 −4.247 71.370 28.643 1.00 35.66 A C ATOM 1701 CG PHE A 345 −3.731 72.296 29.714 1.00 38.52 A C ATOM 1702 CD1 PHE A 345 −3.768 71.924 31.052 1.00 40.34 A C ATOM 1703 CD2 PHE A 345 −3.212 73.545 29.382 1.00 38.83 A C ATOM 1704 CE1 PHE A 345 −3.294 72.786 32.049 1.00 41.72 A C ATOM 1705 CE2 PHE A 345 −2.737 74.414 30.361 1.00 39.94 A C ATOM 1706 CZ PHE A 345 −2.778 74.034 31.701 1.00 43.18 A C ATOM 1707 C PHE A 345 −6.559 71.455 29.595 1.00 39.42 A C ATOM 1708 O PHE A 345 −6.876 72.478 30.211 1.00 40.64 A O ATOM 1709 N THR A 346 −6.905 70.225 29.985 1.00 38.79 A N ATOM 1710 CA THR A 346 −7.669 69.967 31.209 1.00 38.83 A C ATOM 1711 CB THR A 346 −9.177 69.732 30.906 1.00 38.24 A C ATOM 1712 OG1 THR A 346 −9.324 68.712 29.912 1.00 35.72 A O ATOM 1713 CG2 THR A 346 −9.831 71.024 30.411 1.00 38.59 A C ATOM 1714 C THR A 346 −7.103 68.743 31.957 1.00 40.45 A C ATOM 1715 O THR A 346 −6.477 67.872 31.350 1.00 40.52 A O ATOM 1716 N PHE A 347 −7.337 68.684 33.267 1.00 38.41 A N ATOM 1717 CA PHE A 347 −6.832 67.602 34.117 1.00 38.01 A C ATOM 1718 CB PHE A 347 −6.299 68.175 35.430 1.00 33.25 A C ATOM 1719 CG PHE A 347 −5.179 69.157 35.272 1.00 37.35 A C ATOM 1720 CD1 PHE A 347 −3.910 68.736 34.870 1.00 36.75 A C ATOM 1721 CD2 PHE A 347 −5.377 70.507 35.570 1.00 35.58 A C ATOM 1722 CE1 PHE A 347 −2.854 69.647 34.773 1.00 37.99 A C ATOM 1723 CE2 PHE A 347 −4.334 71.420 35.477 1.00 36.58 A C ATOM 1724 CZ PHE A 347 −3.064 70.993 35.077 1.00 36.04 A C ATOM 1725 C PHE A 347 −7.829 66.501 34.502 1.00 40.55 A C ATOM 1726 O PHE A 347 −8.996 66.775 34.800 1.00 40.32 A O ATOM 1727 N PRO A 348 −7.381 65.230 34.493 1.00 42.22 A N ATOM 1728 CD PRO A 348 −6.184 64.654 33.855 1.00 40.80 A C ATOM 1729 CA PRO A 348 −8.326 64.177 34.887 1.00 43.29 A C ATOM 1730 CB PRO A 348 −7.552 62.888 34.612 1.00 41.59 A C ATOM 1731 CG PRO A 348 −6.671 63.267 33.455 1.00 41.69 A C ATOM 1732 C PRO A 348 −8.540 64.420 36.380 1.00 43.20 A C ATOM 1733 O PRO A 348 −7.758 65.136 37.003 1.00 42.10 A O ATOM 1734 N ASP A 349 −9.574 63.832 36.963 1.00 46.66 A N ATOM 1735 CA ASP A 349 −9.842 64.058 38.380 1.00 49.33 A C ATOM 1736 CB ASP A 349 −11.171 63.396 38.774 1.00 52.46 A C ATOM 1737 CG ASP A 349 −12.363 64.001 38.043 1.00 56.47 A C ATOM 1738 OD1 ASP A 349 −12.403 65.242 37.898 1.00 56.97 A O ATOM 1739 OD2 ASP A 349 −13.265 63.240 37.623 1.00 59.92 A O ATOM 1740 C ASP A 349 −8.747 63.646 39.375 1.00 49.27 A C ATOM 1741 O ASP A 349 −8.651 64.225 40.454 1.00 48.92 A O ATOM 1742 N PHE A 350 −7.908 62.675 39.020 1.00 49.30 A N ATOM 1743 CA PHE A 350 −6.863 62.219 39.946 1.00 47.22 A C ATOM 1744 CB PHE A 350 −6.440 60.781 39.598 1.00 46.74 A C ATOM 1745 CG PHE A 350 −5.715 60.649 38.287 1.00 43.91 A C ATOM 1746 CD1 PHE A 350 −4.417 61.141 38.135 1.00 44.25 A C ATOM 1747 CD2 PHE A 350 −6.330 60.039 37.202 1.00 40.16 A C ATOM 1748 CE1 PHE A 350 −3.748 61.025 36.915 1.00 42.32 A C ATOM 1749 CE2 PHE A 350 −5.674 59.919 35.984 1.00 39.67 A C ATOM 1750 CZ PHE A 350 −4.382 60.413 35.839 1.00 40.57 A C ATOM 1751 C PHE A 350 −5.614 63.085 40.109 1.00 47.01 A C ATOM 1752 O PHE A 350 −4.843 62.876 41.041 1.00 46.65 A O ATOM 1753 N VAL A 351 −5.395 64.051 39.222 1.00 46.50 A N ATOM 1754 CA VAL A 351 −4.211 64.893 39.355 1.00 45.42 A C ATOM 1755 CB VAL A 351 −3.936 65.695 38.057 1.00 44.39 A C ATOM 1756 CG1 VAL A 351 −2.726 66.586 38.236 1.00 40.46 A C ATOM 1757 CG2 VAL A 351 −3.705 64.745 36.909 1.00 42.44 A C ATOM 1758 C VAL A 351 −4.356 65.847 40.542 1.00 48.95 A C ATOM 1759 O VAL A 351 −5.391 66.498 40.709 1.00 49.11 A O ATOM 1760 N THR A 352 −3.304 65.913 41.355 1.00 48.97 A N ATOM 1761 CA THR A 352 −3.246 66.739 42.557 1.00 50.49 A C ATOM 1762 CB THR A 352 −2.058 66.288 43.442 1.00 51.76 A C ATOM 1763 OG1 THR A 352 −2.329 64.978 43.962 1.00 54.65 A O ATOM 1764 CG2 THR A 352 −1.839 67.249 44.600 1.00 55.96 A C ATOM 1765 C THR A 352 −3.127 68.239 42.291 1.00 51.36 A C ATOM 1766 O THR A 352 −2.633 68.655 41.240 1.00 51.12 A O ATOM 1767 N GLU A 353 −3.574 69.044 43.256 1.00 49.74 A N ATOM 1768 CA GLU A 353 −3.519 70.499 43.132 1.00 51.27 A C ATOM 1769 CB GLU A 353 −4.131 71.177 44.363 1.00 53.88 A C ATOM 1770 CG GLU A 353 −5.636 70.993 44.533 1.00 60.04 A C ATOM 1771 CD GLU A 353 −6.446 71.598 43.397 1.00 64.09 A C ATOM 1772 OE1 GLU A 353 −6.082 72.700 42.921 1.00 64.63 A O ATOM 1773 OE2 GLU A 353 −7.457 70.975 42.991 1.00 65.02 A O ATOM 1774 C GLU A 353 −2.088 70.989 42.969 1.00 49.88 A C ATOM 1775 O GLU A 353 −1.838 71.970 42.268 1.00 50.18 A O ATOM 1776 N GLY A 354 −1.154 70.319 43.635 1.00 47.30 A N ATOM 1777 CA GLY A 354 0.238 70.709 43.529 1.00 47.27 A C ATOM 1778 C GLY A 354 0.764 70.481 42.123 1.00 46.09 A C ATOM 1779 O GLY A 354 1.525 71.292 41.594 1.00 46.49 A O ATOM 1780 N ALA A 355 0.360 69.367 41.523 1.00 45.69 A N ATOM 1781 CA ALA A 355 0.764 69.018 40.164 1.00 45.85 A C ATOM 1782 CB ALA A 355 0.304 67.604 39.841 1.00 43.96 A C ATOM 1783 C ALA A 355 0.115 70.011 39.194 1.00 45.34 A C ATOM 1784 O ALA A 355 0.774 70.582 38.318 1.00 43.69 A O ATOM 1785 N ARG A 356 −1.188 70.210 39.374 1.00 44.80 A N ATOM 1786 CA ARG A 356 −1.964 71.121 38.547 1.00 43.64 A C ATOM 1787 CB ARG A 356 −3.429 71.110 39.008 1.00 43.97 A C ATOM 1788 CG ARG A 356 −4.084 69.742 38.844 1.00 44.00 A C ATOM 1789 CD ARG A 356 −5.299 69.539 39.760 1.00 46.78 A C ATOM 1790 NE ARG A 356 −6.562 69.930 39.146 1.00 46.50 A N ATOM 1791 CZ ARG A 356 −7.545 69.088 38.835 1.00 48.09 A C ATOM 1792 NH1 ARG A 356 −7.423 67.793 39.078 1.00 45.87 A N ATOM 1793 NH2 ARG A 356 −8.660 69.545 38.276 1.00 47.73 A N ATOM 1794 C ARG A 356 −1.387 72.534 38.584 1.00 42.30 A C ATOM 1795 O ARG A 356 −1.404 73.242 37.579 1.00 42.77 A O ATOM 1796 N ASP A 357 −0.850 72.938 39.728 1.00 39.68 A N ATOM 1797 CA ASP A 357 −0.273 74.267 39.836 1.00 41.20 A C ATOM 1798 CB ASP A 357 −0.047 74.645 41.305 1.00 45.03 A C ATOM 1799 CG ASP A 357 0.628 76.002 41.454 1.00 45.48 A C ATOM 1800 OD1 ASP A 357 −0.080 77.030 41.454 1.00 49.20 A O ATOM 1801 OD2 ASP A 357 1.872 76.046 41.544 1.00 46.68 A O ATOM 1802 C ASP A 357 1.054 74.381 39.081 1.00 41.64 A C ATOM 1803 O ASP A 357 1.326 75.406 38.448 1.00 41.73 A O ATOM 1804 N LEU A 358 1.888 73.343 39.153 1.00 41.39 A N ATOM 1805 CA LEU A 358 3.179 73.381 38.461 1.00 40.21 A C ATOM 1806 CB LEU A 358 4.060 72.189 38.858 1.00 40.82 A C ATOM 1807 CG LEU A 358 5.351 71.990 38.038 1.00 39.19 A C ATOM 1808 CD1 LEU A 358 6.262 73.211 38.156 1.00 35.41 A C ATOM 1809 CD2 LEU A 358 6.082 70.757 38.534 1.00 35.10 A C ATOM 1810 C LEU A 358 2.989 73.376 36.949 1.00 38.71 A C ATOM 1811 O LEU A 358 3.548 74.210 36.240 1.00 36.97 A O ATOM 1812 N ILE A 359 2.205 72.425 36.463 1.00 37.63 A N ATOM 1813 CA ILE A 359 1.958 72.318 35.036 1.00 37.27 A C ATOM 1814 CB ILE A 359 1.024 71.129 34.739 1.00 35.58 A C ATOM 1815 CG2 ILE A 359 0.616 71.125 33.257 1.00 33.52 A C ATOM 1816 CG1 ILE A 359 1.740 69.822 35.123 1.00 33.71 A C ATOM 1817 CD1 ILE A 359 0.904 68.556 34.965 1.00 27.32 A C ATOM 1818 C ILE A 359 1.367 73.619 34.490 1.00 39.28 A C ATOM 1819 O ILE A 359 1.756 74.080 33.419 1.00 40.17 A O ATOM 1820 N SER A 360 0.448 74.219 35.243 1.00 39.65 A N ATOM 1821 CA SER A 360 −0.178 75.468 34.828 1.00 39.78 A C ATOM 1822 CB SER A 360 −1.326 75.824 35.774 1.00 38.05 A C ATOM 1823 OG SER A 360 −2.421 74.949 35.570 1.00 41.59 A O ATOM 1824 C SER A 360 0.803 76.634 34.732 1.00 38.08 A C ATOM 1825 O SER A 360 0.648 77.505 33.881 1.00 37.97 A O ATOM 1826 N ARG A 361 1.809 76.655 35.600 1.00 37.99 A N ATOM 1827 CA ARG A 361 2.809 77.722 35.568 1.00 38.96 A C ATOM 1828 CB ARG A 361 3.667 77.702 36.834 1.00 42.54 A C ATOM 1829 CG ARG A 361 2.988 78.154 38.121 1.00 50.26 A C ATOM 1830 CD ARG A 361 3.971 78.022 39.287 1.00 54.77 A C ATOM 1831 NE ARG A 361 3.358 78.286 40.586 1.00 60.68 A N ATOM 1832 CZ ARG A 361 2.987 79.490 41.010 1.00 63.56 A C ATOM 1833 NH1 ARG A 361 2.435 79.631 42.211 1.00 65.68 A N ATOM 1834 NH2 ARG A 361 3.171 80.554 40.238 1.00 63.46 A N ATOM 1835 C ARG A 361 3.745 77.560 34.371 1.00 36.65 A C ATOM 1836 O ARG A 361 4.273 78.537 33.838 1.00 34.66 A O ATOM 1837 N LEU A 362 3.956 76.314 33.966 1.00 34.75 A N ATOM 1838 CA LEU A 362 4.865 76.004 32.871 1.00 33.58 A C ATOM 1839 CB LEU A 362 5.370 74.563 33.019 1.00 33.55 A C ATOM 1840 CG LEU A 362 6.321 74.331 34.198 1.00 33.17 A C ATOM 1841 CD1 LEU A 362 6.561 72.852 34.402 1.00 32.66 A C ATOM 1842 CD2 LEU A 362 7.624 75.058 33.936 1.00 28.23 A C ATOM 1843 C LEU A 362 4.275 76.199 31.479 1.00 32.52 A C ATOM 1844 O LEU A 362 4.965 76.657 30.580 1.00 33.69 A O ATOM 1845 N LEU A 363 3.010 75.848 31.302 1.00 29.78 A N ATOM 1846 CA LEU A 363 2.369 75.985 29.997 1.00 33.86 A C ATOM 1847 CB LEU A 363 1.323 74.870 29.814 1.00 29.15 A C ATOM 1848 CG LEU A 363 1.817 73.401 29.868 1.00 31.05 A C ATOM 1849 CD1 LEU A 363 0.631 72.468 29.746 1.00 24.51 A C ATOM 1850 CD2 LEU A 363 2.837 73.123 28.748 1.00 24.89 A C ATOM 1851 C LEU A 363 1.726 77.371 29.798 1.00 34.25 A C ATOM 1852 O LEU A 363 0.508 77.505 29.740 1.00 36.86 A O ATOM 1853 N LYS A 364 2.565 78.396 29.710 1.00 38.02 A N ATOM 1854 CA LYS A 364 2.117 79.773 29.510 1.00 39.26 A C ATOM 1855 CB LYS A 364 2.907 80.735 30.407 1.00 40.63 A C ATOM 1856 CG LYS A 364 2.650 80.605 31.901 1.00 42.73 A C ATOM 1857 CD LYS A 364 1.227 81.004 32.237 1.00 45.77 A C ATOM 1858 CE LYS A 364 1.046 81.228 33.725 1.00 50.52 A C ATOM 1859 NZ LYS A 364 −0.323 81.742 34.024 1.00 54.71 A N ATOM 1860 C LYS A 364 2.372 80.145 28.057 1.00 39.30 A C ATOM 1861 O LYS A 364 3.496 79.997 27.569 1.00 38.57 A O ATOM 1862 N HIS A 365 1.335 80.616 27.368 1.00 39.57 A N ATOM 1863 CA HIS A 365 1.476 81.020 25.970 1.00 40.20 A C ATOM 1864 CB HIS A 365 0.187 81.659 25.451 1.00 40.44 A C ATOM 1865 CG HIS A 365 0.276 82.111 24.027 1.00 37.64 A C ATOM 1866 CD2 HIS A 365 0.827 83.219 23.477 1.00 40.32 A C ATOM 1867 ND1 HIS A 365 −0.179 81.349 22.974 1.00 38.59 A N ATOM 1868 CE1 HIS A 365 0.088 81.963 21.836 1.00 36.60 A C ATOM 1869 NE2 HIS A 365 0.699 83.101 22.113 1.00 41.15 A N ATOM 1870 C HIS A 365 2.606 82.031 25.839 1.00 40.73 A C ATOM 1871 O HIS A 365 3.430 81.948 24.925 1.00 41.73 A O ATOM 1872 N ASN A 366 2.637 82.997 26.753 1.00 42.45 A N ATOM 1873 CA ASN A 366 3.681 84.024 26.737 1.00 44.24 A C ATOM 1874 CB ASN A 366 3.183 85.272 27.477 1.00 44.55 A C ATOM 1875 CG ASN A 366 4.149 86.454 27.384 1.00 47.76 A C ATOM 1876 OD1 ASN A 366 3.772 87.591 27.682 1.00 51.08 A O ATOM 1877 ND2 ASN A 366 5.388 86.194 26.985 1.00 43.49 A N ATOM 1878 C ASN A 366 4.922 83.443 27.415 1.00 42.19 A C ATOM 1879 O ASN A 366 4.885 83.105 28.594 1.00 39.81 A O ATOM 1880 N PRO A 367 6.036 83.321 26.668 1.00 44.23 A N ATOM 1881 CD PRO A 367 6.151 83.761 25.267 1.00 43.04 A C ATOM 1882 CA PRO A 367 7.319 82.778 27.145 1.00 45.24 A C ATOM 1883 CB PRO A 367 8.252 82.989 25.953 1.00 44.30 A C ATOM 1884 CG PRO A 367 7.320 82.944 24.778 1.00 45.18 A C ATOM 1885 C PRO A 367 7.851 83.444 28.413 1.00 47.56 A C ATOM 1886 O PRO A 367 8.370 82.764 29.312 1.00 46.80 A O ATOM 1887 N SER A 368 7.716 84.770 28.470 1.00 47.18 A N ATOM 1888 CA SER A 368 8.162 85.579 29.607 1.00 47.72 A C ATOM 1889 CB SER A 368 7.926 87.076 29.334 1.00 48.23 A C ATOM 1890 OG SER A 368 8.681 87.537 28.227 1.00 51.49 A O ATOM 1891 C SER A 368 7.447 85.211 30.897 1.00 46.18 A C ATOM 1892 O SER A 368 7.988 85.406 31.989 1.00 48.13 A O ATOM 1893 N GLN A 369 6.228 84.699 30.787 1.00 45.87 A N ATOM 1894 CA GLN A 369 5.481 84.329 31.984 1.00 47.80 A C ATOM 1895 CB GLN A 369 3.973 84.295 31.697 1.00 51.34 A C ATOM 1896 CG GLN A 369 3.343 85.642 31.358 1.00 53.45 A C ATOM 1897 CD GLN A 369 1.840 85.530 31.120 1.00 57.46 A C ATOM 1898 OE1 GLN A 369 1.061 85.287 32.048 1.00 60.02 A O ATOM 1899 NE2 GLN A 369 1.430 85.698 29.872 1.00 58.61 A N ATOM 1900 C GLN A 369 5.916 82.983 32.561 1.00 47.67 A C ATOM 1901 O GLN A 369 5.606 82.668 33.715 1.00 46.25 A O ATOM 1902 N ARG A 370 6.628 82.188 31.765 1.00 46.58 A N ATOM 1903 CA ARG A 370 7.095 80.881 32.229 1.00 47.27 A C ATOM 1904 CB ARG A 370 7.596 80.040 31.042 1.00 43.84 A C ATOM 1905 CG ARG A 370 6.520 79.778 29.989 1.00 41.08 A C ATOM 1906 CD ARG A 370 7.094 79.136 28.732 1.00 42.55 A C ATOM 1907 NE ARG A 370 6.191 79.264 27.585 1.00 38.83 A N ATOM 1908 CZ ARG A 370 6.563 79.083 26.324 1.00 36.60 A C ATOM 1909 NH1 ARG A 370 7.816 78.757 26.039 1.00 35.02 A N ATOM 1910 NH2 ARG A 370 5.692 79.264 25.343 1.00 37.82 A N ATOM 1911 C ARG A 370 8.209 81.119 33.247 1.00 47.29 A C ATOM 1912 O ARG A 370 8.995 82.057 33.102 1.00 48.42 A O ATOM 1913 N PRO A 371 8.284 80.277 34.296 1.00 47.54 A N ATOM 1914 CD PRO A 371 7.383 79.135 34.552 1.00 46.07 A C ATOM 1915 CA PRO A 371 9.291 80.382 35.359 1.00 46.72 A C ATOM 1916 CB PRO A 371 8.772 79.410 36.415 1.00 45.48 A C ATOM 1917 CG PRO A 371 8.160 78.338 35.581 1.00 47.78 A C ATOM 1918 C PRO A 371 10.734 80.076 34.980 1.00 47.35 A C ATOM 1919 O PRO A 371 11.026 79.618 33.877 1.00 47.37 A O ATOM 1920 N MET A 372 11.642 80.357 35.911 1.00 48.69 A N ATOM 1921 CA MET A 372 13.055 80.067 35.713 1.00 47.91 A C ATOM 1922 CB MET A 372 13.923 80.961 36.598 1.00 51.73 A C ATOM 1923 CG MET A 372 13.788 82.444 36.324 1.00 56.54 A C ATOM 1924 SD MET A 372 14.948 83.405 37.339 1.00 60.67 A S ATOM 1925 CE MET A 372 16.321 83.556 36.190 1.00 59.45 A C ATOM 1926 C MET A 372 13.178 78.618 36.164 1.00 45.14 A C ATOM 1927 O MET A 372 12.344 78.139 36.929 1.00 44.11 A O ATOM 1928 N LEU A 373 14.204 77.917 35.703 1.00 44.75 A N ATOM 1929 CA LEU A 373 14.354 76.522 36.086 1.00 44.46 A C ATOM 1930 CB LEU A 373 15.526 75.893 35.325 1.00 42.40 A C ATOM 1931 CG LEU A 373 15.209 75.530 33.861 1.00 41.97 A C ATOM 1932 CD1 LEU A 373 16.493 75.194 33.117 1.00 37.82 A C ATOM 1933 CD2 LEU A 373 14.223 74.352 33.808 1.00 38.88 A C ATOM 1934 C LEU A 373 14.507 76.353 37.597 1.00 44.43 A C ATOM 1935 O LEU A 373 14.051 75.364 38.164 1.00 43.69 A O ATOM 1936 N ALA A 374 15.121 77.336 38.249 1.00 47.31 A N ATOM 1937 CA ALA A 374 15.310 77.289 39.699 1.00 48.80 A C ATOM 1938 CB ALA A 374 16.126 78.496 40.152 1.00 49.01 A C ATOM 1939 C ALA A 374 13.967 77.239 40.446 1.00 49.34 A C ATOM 1940 O ALA A 374 13.825 76.527 41.444 1.00 50.65 A O ATOM 1941 N GLU A 375 12.981 77.986 39.960 1.00 50.02 A N ATOM 1942 CA GLU A 375 11.662 78.006 40.582 1.00 50.79 A C ATOM 1943 CB GLU A 375 10.785 79.070 39.925 1.00 53.29 A C ATOM 1944 CG GLU A 375 11.341 80.477 39.993 1.00 58.36 A C ATOM 1945 CD GLU A 375 10.491 81.460 39.207 1.00 60.16 A C ATOM 1946 OE1 GLU A 375 9.294 81.606 39.540 1.00 62.91 A O ATOM 1947 OE2 GLU A 375 11.015 82.078 38.255 1.00 59.36 A O ATOM 1948 C GLU A 375 10.954 76.653 40.485 1.00 50.97 A C ATOM 1949 O GLU A 375 10.032 76.373 41.253 1.00 50.08 A O ATOM 1950 N VAL A 376 11.363 75.826 39.526 1.00 50.81 A N ATOM 1951 CA VAL A 376 10.765 74.502 39.358 1.00 50.86 A C ATOM 1952 CB VAL A 376 10.995 73.942 37.927 1.00 51.95 A C ATOM 1953 CG1 VAL A 376 10.460 72.511 37.836 1.00 49.77 A C ATOM 1954 CG2 VAL A 376 10.306 74.834 36.895 1.00 50.95 A C ATOM 1955 C VAL A 376 11.379 73.524 40.360 1.00 50.64 A C ATOM 1956 O VAL A 376 10.682 72.682 40.928 1.00 51.15 A O ATOM 1957 N LEU A 377 12.687 73.642 40.564 1.00 50.28 A N ATOM 1958 CA LEU A 377 13.413 72.782 41.492 1.00 52.39 A C ATOM 1959 CB LEU A 377 14.921 72.951 41.294 1.00 50.30 A C ATOM 1960 CG LEU A 377 15.497 72.434 39.973 1.00 49.77 A C ATOM 1961 CD1 LEU A 377 16.942 72.875 39.830 1.00 47.65 A C ATOM 1962 CD2 LEU A 377 15.393 70.919 39.931 1.00 48.67 A C ATOM 1963 C LEU A 377 13.054 73.091 42.944 1.00 54.42 A C ATOM 1964 O LEU A 377 13.302 72.283 43.841 1.00 55.25 A O ATOM 1965 N GLU A 378 12.467 74.263 43.169 1.00 55.92 A N ATOM 1966 CA GLU A 378 12.075 74.676 44.510 1.00 56.51 A C ATOM 1967 CB GLU A 378 12.597 76.079 44.791 1.00 57.88 A C ATOM 1968 CG GLU A 378 14.102 76.137 44.929 1.00 61.78 A C ATOM 1969 CD GLU A 378 14.631 77.545 44.819 1.00 65.68 A C ATOM 1970 OE1 GLU A 378 15.846 77.741 45.039 1.00 68.31 A O ATOM 1971 OE2 GLU A 378 13.834 78.456 44.502 1.00 67.56 A O ATOM 1972 C GLU A 378 10.569 74.639 44.721 1.00 55.69 A C ATOM 1973 O GLU A 378 10.081 75.016 45.784 1.00 57.50 A O ATOM 1974 N HIS A 379 9.832 74.183 43.715 1.00 52.52 A N ATOM 1975 CA HIS A 379 8.381 74.103 43.824 1.00 50.30 A C ATOM 1976 CB HIS A 379 7.773 73.684 42.484 1.00 46.98 A C ATOM 1977 CG HIS A 379 6.276 73.759 42.441 1.00 45.89 A C ATOM 1978 CD2 HIS A 379 5.446 74.721 41.969 1.00 43.25 A C ATOM 1979 ND1 HIS A 379 5.463 72.753 42.922 1.00 44.60 A N ATOM 1980 CE1 HIS A 379 4.197 73.090 42.746 1.00 42.55 A C ATOM 1981 NE2 HIS A 379 4.159 74.279 42.170 1.00 45.42 A N ATOM 1982 C HIS A 379 8.002 73.108 44.918 1.00 51.08 A C ATOM 1983 O HIS A 379 8.526 71.992 44.975 1.00 50.77 A O ATOM 1984 N PRO A 380 7.076 73.506 45.804 1.00 52.09 A N ATOM 1985 CD PRO A 380 6.283 74.747 45.721 1.00 52.19 A C ATOM 1986 CA PRO A 380 6.612 72.669 46.913 1.00 50.97 A C ATOM 1987 CB PRO A 380 5.502 73.519 47.546 1.00 51.57 A C ATOM 1988 CG PRO A 380 5.003 74.343 46.401 1.00 53.46 A C ATOM 1989 C PRO A 380 6.146 71.257 46.549 1.00 49.66 A C ATOM 1990 O PRO A 380 6.253 70.340 47.361 1.00 48.94 A O ATOM 1991 N TRP A 381 5.626 71.074 45.341 1.00 47.98 A N ATOM 1992 CA TRP A 381 5.169 69.751 44.936 1.00 46.47 A C ATOM 1993 CB TRP A 381 4.188 69.854 43.774 1.00 45.54 A C ATOM 1994 CG TRP A 381 3.631 68.527 43.346 1.00 40.93 A C ATOM 1995 CD2 TRP A 381 4.049 67.743 42.222 1.00 40.08 A C ATOM 1996 CE2 TRP A 381 3.226 66.595 42.185 1.00 38.42 A C ATOM 1997 CE3 TRP A 381 5.036 67.900 41.238 1.00 40.44 A C ATOM 1998 CD1 TRP A 381 2.606 67.840 43.932 1.00 41.28 A C ATOM 1999 NE1 TRP A 381 2.356 66.681 43.240 1.00 40.02 A N ATOM 2000 CZ2 TRP A 381 3.359 65.605 41.200 1.00 38.16 A C ATOM 2001 CZ3 TRP A 381 5.167 66.914 40.257 1.00 39.27 A C ATOM 2002 CH2 TRP A 381 4.332 65.783 40.248 1.00 35.86 A C ATOM 2003 C TRP A 381 6.362 68.898 44.516 1.00 46.87 A C ATOM 2004 O TRP A 381 6.373 67.683 44.718 1.00 46.53 A O ATOM 2005 N ILE A 382 7.362 69.539 43.917 1.00 48.95 A N ATOM 2006 CA ILE A 382 8.566 68.835 43.485 1.00 50.95 A C ATOM 2007 CB ILE A 382 9.489 69.749 42.634 1.00 49.30 A C ATOM 2008 CG2 ILE A 382 10.821 69.053 42.398 1.00 48.74 A C ATOM 2009 CG1 ILE A 382 8.822 70.098 41.294 1.00 49.61 A C ATOM 2010 CD1 ILE A 382 8.619 68.907 40.358 1.00 42.81 A C ATOM 2011 C ILE A 382 9.341 68.384 44.725 1.00 53.01 A C ATOM 2012 O ILE A 382 9.651 67.203 44.889 1.00 51.75 A O ATOM 2013 N THR A 383 9.643 69.340 45.596 1.00 56.54 A N ATOM 2014 CA THR A 383 10.384 69.069 46.827 1.00 60.42 A C ATOM 2015 CB THR A 383 10.615 70.364 47.629 1.00 60.63 A C ATOM 2016 OG1 THR A 383 11.390 71.279 46.844 1.00 62.34 A O ATOM 2017 CG2 THR A 383 11.360 70.067 48.923 1.00 64.67 A C ATOM 2018 C THR A 383 9.667 68.070 47.726 1.00 61.26 A C ATOM 2019 O THR A 383 10.303 67.355 48.501 1.00 62.87 A O ATOM 2020 N ALA A 384 8.346 68.010 47.609 1.00 61.81 A N ATOM 2021 CA ALA A 384 7.554 67.104 48.427 1.00 62.66 A C ATOM 2022 CB ALA A 384 6.140 67.656 48.585 1.00 63.07 A C ATOM 2023 C ALA A 384 7.493 65.668 47.909 1.00 63.07 A C ATOM 2024 O ALA A 384 7.337 64.735 48.695 1.00 63.72 A O ATOM 2025 N ASN A 385 7.612 65.482 46.597 1.00 62.18 A N ATOM 2026 CA ASN A 385 7.550 64.140 46.025 1.00 62.42 A C ATOM 2027 CB ASN A 385 6.466 64.083 44.946 1.00 61.14 A C ATOM 2028 CG ASN A 385 5.078 64.372 45.491 1.00 60.33 A C ATOM 2029 OD1 ASN A 385 4.427 63.499 46.065 1.00 57.45 A O ATOM 2030 ND2 ASN A 385 4.623 65.610 45.317 1.00 56.76 A N ATOM 2031 C ASN A 385 8.871 63.653 45.430 1.00 63.75 A C ATOM 2032 O ASN A 385 9.030 62.466 45.154 1.00 63.17 A O ATOM 2033 N SER A 386 9.814 64.565 45.234 1.00 66.08 A N ATOM 2034 CA SER A 386 11.103 64.211 44.651 1.00 69.04 A C ATOM 2035 CB SER A 386 11.731 65.441 43.990 1.00 70.22 A C ATOM 2036 OG SER A 386 13.032 65.159 43.503 1.00 70.59 A O ATOM 2037 C SER A 386 12.093 63.626 45.654 1.00 72.01 A C ATOM 2038 O SER A 386 12.098 63.989 46.833 1.00 73.11 A O ATOM 2039 N SER A 387 12.931 62.717 45.169 1.00 73.40 A N ATOM 2040 CA SER A 387 13.951 62.088 45.995 1.00 75.94 A C ATOM 2041 CB SER A 387 14.024 60.589 45.695 1.00 75.91 A C ATOM 2042 OG SER A 387 12.754 59.981 45.840 1.00 76.94 A O ATOM 2043 C SER A 387 15.284 62.751 45.650 1.00 77.73 A C ATOM 2044 O SER A 387 16.348 62.280 46.058 1.00 78.06 A O ATOM 2045 N LYS A 388 15.194 63.843 44.886 1.00 78.26 A N ATOM 2046 CA LYS A 388 16.339 64.635 44.428 1.00 79.08 A C ATOM 2047 CB LYS A 388 17.409 64.724 45.525 1.00 79.44 A C ATOM 2048 CG LYS A 388 16.974 65.500 46.763 1.00 79.33 A C ATOM 2049 CD LYS A 388 18.062 65.484 47.824 1.00 79.09 A C ATOM 2050 CE LYS A 388 17.695 66.350 49.018 1.00 79.02 A C ATOM 2051 NZ LYS A 388 17.530 67.782 48.641 1.00 78.19 A N ATOM 2052 C LYS A 388 16.959 64.102 43.130 1.00 78.82 A C ATOM 2053 O LYS A 388 16.481 63.074 42.619 1.00 78.44 A O ATOM 2054 OXT LYS A 388 17.916 64.723 42.618 1.00 79.61 A O ATOM 2056 PB AANP Z 379 15.037 57.738 17.969 0.50 47.69 Z P ATOM 2057 PB BANP Z 379 17.785 58.350 20.389 0.50 50.58 Z P ATOM 2058 O1B AANP Z 379 15.506 57.453 19.308 0.50 49.57 Z O ATOM 2059 O1B BANP Z 379 18.803 57.539 21.023 0.50 51.23 Z O ATOM 2060 O2B AANP Z 379 14.617 59.160 17.829 0.50 48.87 Z O ATOM 2061 O2B BANP Z 379 18.020 59.811 20.601 0.50 52.85 Z O ATOM 2062 O3B AANP Z 379 13.854 56.738 17.611 0.50 47.44 Z O ATOM 2063 O3B BANP Z 379 16.375 57.916 20.971 0.50 53.88 Z O ATOM 2064 PA AANP Z 379 17.533 56.644 17.115 0.50 51.30 Z P ATOM 2065 PA BANP Z 379 18.302 56.815 17.978 0.50 49.99 Z P ATOM 2066 O1A AANP Z 379 18.137 56.443 15.785 0.50 52.19 Z O ATOM 2067 O1A BANP Z 379 17.740 56.898 16.602 0.50 51.27 Z O ATOM 2068 O2A AANP Z 379 18.354 57.484 18.041 0.50 51.52 Z O ATOM 2069 O2A BANP Z 379 19.779 56.935 18.073 0.50 51.64 Z O ATOM 2070 O3A AANP Z 379 16.105 57.302 16.924 0.50 51.44 Z O ATOM 2071 O3A BANP Z 379 17.600 57.938 18.878 0.50 50.89 Z O ATOM 2072 O5* AANP Z 379 17.177 55.295 17.877 0.50 50.92 Z O ATOM 2073 O5* BANP Z 379 17.867 55.497 18.751 0.50 47.15 Z O ATOM 2074 C5* AANP Z 379 17.877 54.090 17.490 0.50 47.94 Z C ATOM 2075 C5* BANP Z 379 17.722 54.257 18.009 0.50 40.88 Z C ATOM 2076 C4* AANP Z 379 17.460 52.862 18.318 0.50 47.92 Z C ATOM 2077 C4* BANP Z 379 17.263 53.099 18.926 0.50 36.96 Z C ATOM 2078 O4* AANP Z 379 18.576 52.400 19.179 0.50 47.21 Z O ATOM 2079 O4* BANP Z 379 18.369 52.549 19.752 0.50 33.82 Z O ATOM 2080 C3* AANP Z 379 16.328 53.019 19.359 0.50 47.98 Z C ATOM 2081 C3* BANP Z 379 16.203 53.417 20.009 0.50 33.98 Z C ATOM 2082 O3* AANP Z 379 15.560 51.846 19.588 0.50 48.47 Z O ATOM 2083 O3* BANP Z 379 15.320 52.350 20.339 0.50 32.96 Z O ATOM 2084 C2* AANP Z 379 17.076 53.566 20.584 0.50 47.21 Z C ATOM 2085 C2* BANP Z 379 17.064 53.934 21.164 0.50 32.17 Z C ATOM 2086 O2* AANP Z 379 16.398 53.519 21.825 0.50 48.99 Z O ATOM 2087 O2* BANP Z 379 16.446 54.056 22.437 0.50 30.71 Z O ATOM 2088 C1* AANP Z 379 18.369 52.807 20.558 0.50 46.20 Z C ATOM 2089 C1* BANP Z 379 18.273 53.024 21.121 0.50 31.00 Z C ATOM 2090 N9 AANP Z 379 19.533 53.632 21.081 0.50 44.22 Z N ATOM 2091 N9 BANP Z 379 19.537 53.738 21.552 0.50 27.84 Z N ATOM 2092 C8 AANP Z 379 20.137 54.688 20.410 0.50 43.51 Z C ATOM 2093 C8 BANP Z 379 20.190 54.721 20.820 0.50 26.21 Z C ATOM 2094 N7 AANP Z 379 21.138 55.258 21.064 0.50 43.16 Z N ATOM 2095 N7 BANP Z 379 21.273 55.211 21.389 0.50 27.05 Z N ATOM 2096 C5 AANP Z 379 21.222 54.563 22.228 0.50 43.37 Z C ATOM 2097 C5 BANP Z 379 21.372 54.538 22.561 0.50 27.46 Z C ATOM 2098 C6 AANP Z 379 22.077 54.630 23.408 0.50 41.80 Z C ATOM 2099 C6 BANP Z 379 22.300 54.555 23.675 0.50 26.76 Z C ATOM 2100 N6 AANP Z 379 23.058 55.506 23.571 0.50 41.70 Z N ATOM 2101 N6 BANP Z 379 23.356 55.348 23.750 0.50 26.20 Z N ATOM 2102 N1 AANP Z 379 21.858 53.706 24.460 0.50 43.30 Z N ATOM 2103 N1 BANP Z 379 22.075 53.675 24.765 0.50 29.25 Z N ATOM 2104 C2 AANP Z 379 20.844 52.746 24.372 0.50 42.75 Z C ATOM 2105 C2 BANP Z 379 20.979 52.806 24.765 0.50 27.75 Z C ATOM 2106 N3 AANP Z 379 19.992 52.607 23.302 0.50 43.98 Z N ATOM 2107 N3 BANP Z 379 20.052 52.720 23.761 0.50 28.35 Z N ATOM 2108 C4 AANP Z 379 20.223 53.538 22.258 0.50 43.59 Z C ATOM 2109 C4 BANP Z 379 20.292 53.604 22.682 0.50 27.97 Z C ATOM 2110 P1 FRA Z 379 26.094 48.843 31.713 1.00 52.95 Z P ATOM 2111 O2 FRA Z 379 27.446 48.301 31.747 1.00 53.45 Z O ATOM 2112 O3 FRA Z 379 25.842 49.670 32.927 1.00 57.52 Z O ATOM 2113 O4 FRA Z 379 25.079 47.640 31.660 1.00 53.32 Z O ATOM 2114 O5 FRA Z 379 25.925 49.788 30.418 1.00 54.94 Z O TER 2115 FRAG Z 1 Z ATOM 2116 O HOH W 379 0.331 67.542 23.164 1.00 33.20 W O ATOM 2117 O HOH W 380 28.844 46.119 11.651 1.00 48.79 W O ATOM 2118 O HOH W 381 23.007 73.689 19.317 1.00 39.02 W O ATOM 2119 O HOH W 382 10.568 41.141 28.154 1.00 49.97 W O ATOM 2120 O HOH W 383 12.722 71.913 24.732 1.00 38.33 W O ATOM 2121 O HOH W 384 27.119 63.991 29.594 1.00 34.78 W O ATOM 2122 O HOH W 385 25.822 60.889 31.761 1.00 35.64 W O ATOM 2123 O HOH W 386 12.649 51.436 29.438 1.00 30.54 W O ATOM 2124 O HOH W 387 −1.136 77.886 32.084 1.00 58.06 W O ATOM 2125 O HOH W 388 −5.994 68.177 27.794 1.00 32.43 W O ATOM 2126 O HOH W 389 30.025 50.004 9.061 1.00 46.99 W O ATOM 2127 O HOH W 390 −3.566 81.854 26.459 1.00 55.28 W O ATOM 2128 O HOH W 391 30.646 47.521 34.093 1.00 60.01 W O ATOM 2129 O HOH W 392 −1.097 85.911 26.783 1.00 47.89 W O ATOM 2130 O HOH W 393 0.595 65.227 46.406 1.00 53.88 W O ATOM 2131 O HOH W 394 6.207 71.002 50.031 1.00 52.47 W O ATOM 2132 O HOH W 395 5.278 55.170 38.782 1.00 41.90 W O ATOM 2133 O HOH W 396 −12.360 69.423 40.011 1.00 62.19 W O ATOM 2134 O HOH W 397 10.584 80.817 23.752 1.00 42.95 W O ATOM 2135 O HOH W 398 20.285 61.152 38.189 1.00 57.76 W O ATOM 2136 O HOH W 399 38.138 63.320 28.926 1.00 63.01 W O ATOM 2137 O HOH W 400 36.205 63.417 18.017 1.00 42.85 W O ATOM 2138 O HOH W 401 10.940 46.826 29.244 1.00 66.42 W O ATOM 2139 O HOH W 402 28.740 45.402 31.083 1.00 57.98 W O ATOM 2140 O HOH W 403 16.667 51.609 23.943 1.00 49.28 W O ATOM 2141 O HOH W 404 0.650 83.566 28.516 1.00 48.67 W O ATOM 2142 O HOH W 405 23.052 81.277 32.597 1.00 79.68 W O ATOM 2143 O HOH W 406 21.015 66.488 25.190 1.00 51.11 W O ATOM 2144 O HOH W 407 29.555 78.569 17.681 1.00 72.97 W O ATOM 2145 O HOH W 408 23.196 68.069 19.434 1.00 38.38 W O ATOM 2146 O HOH W 409 −7.313 65.296 29.334 1.00 66.68 W O ATOM 2147 O HOH W 410 24.377 54.450 33.733 1.00 39.04 W O ATOM 2148 O HOH W 411 18.676 56.503 40.201 1.00 43.61 W O ATOM 2149 O HOH W 412 19.799 63.234 10.818 1.00 60.37 W O ATOM 2150 O HOH W 413 4.227 81.623 22.473 1.00 45.07 W O ATOM 2151 O HOH W 414 35.586 63.256 25.029 1.00 58.40 W O ATOM 2152 O HOH W 415 26.042 47.904 6.604 1.00 63.98 W O ATOM 2153 O HOH W 416 0.125 61.540 20.664 1.00 58.49 W O ATOM 2154 O HOH W 417 15.750 58.426 38.595 1.00 51.37 W O ATOM 2155 O HOH W 418 8.114 48.760 24.263 1.00 66.46 W O ATOM 2156 O HOH W 419 −13.534 60.538 36.389 1.00 56.48 W O ATOM 2157 O HOH W 420 37.492 60.906 4.499 1.00 56.53 W O ATOM 2158 O HOH W 421 11.597 49.198 40.125 1.00 55.46 W O ATOM 2159 O HOH W 422 29.535 40.480 27.301 1.00 39.07 W O ATOM 2160 O HOH W 423 −9.419 60.202 32.744 1.00 49.49 W O ATOM 2161 O HOH W 424 −3.387 80.285 33.001 1.00 53.18 W O ATOM 2162 O HOH W 425 22.854 68.702 38.913 1.00 56.31 W O ATOM 2163 O HOH W 426 5.516 90.168 27.801 1.00 57.26 W O ATOM 2164 O HOH W 427 42.341 62.424 13.295 1.00 70.57 W O ATOM 2165 O HOH W 428 50.104 46.432 21.896 1.00 59.70 W O ATOM 2166 O HOH W 429 19.133 50.530 8.236 1.00 38.20 W O ATOM 2167 O HOH W 430 14.218 90.460 15.295 1.00 59.43 W O ATOM 2168 O HOH W 431 20.996 76.724 18.128 1.00 68.02 W O ATOM 2169 O HOH W 432 28.748 65.408 11.519 1.00 55.89 W O ATOM 2170 O HOH W 433 33.109 52.617 3.045 1.00 66.13 W O ATOM 2171 O HOH W 434 −0.097 51.530 27.181 1.00 62.48 W O ATOM 2172 O HOH W 435 34.328 49.913 33.453 1.00 80.02 W O ATOM 2173 O HOH W 436 16.321 46.597 36.609 1.00 55.74 W O ATOM 2174 O HOH W 437 15.506 88.823 36.550 1.00 60.31 W O ATOM 2175 O HOH W 438 −10.288 68.090 36.659 1.00 43.23 W O ATOM 2176 O HOH W 439 35.236 49.316 7.956 1.00 47.01 W O ATOM 2177 O HOH W 440 −2.382 64.267 14.669 1.00 54.31 W O ATOM 2178 O HOH W 441 3.145 71.184 22.878 1.00 32.15 W O ATOM 2179 O HOH W 442 13.920 51.205 25.014 1.00 47.83 W O ATOM 2180 O HOH W 443 −0.162 59.596 37.808 1.00 46.99 W O ATOM 2181 O HOH W 444 21.993 67.937 15.891 1.00 41.38 W O ATOM 2182 O HOH W 445 18.406 49.826 26.693 1.00 48.92 W O ATOM 2183 O HOH W 446 27.317 49.713 35.324 1.00 50.93 W O ATOM 2184 O HOH W 447 32.044 55.554 32.480 1.00 59.20 W O ATOM 2185 O HOH W 448 15.585 66.847 22.965 1.00 66.60 W O ATOM 2186 O HOH W 449 28.577 85.371 20.089 1.00 61.69 W O ATOM 2187 O HOH W 450 19.255 74.406 43.569 1.00 78.23 W O ATOM 2188 O HOH W 451 46.877 44.566 20.648 1.00 63.82 W O ATOM 2189 O HOH W 452 18.724 77.353 37.945 1.00 74.74 W O ATOM 2190 O HOH W 453 32.145 68.599 9.155 1.00 80.54 W O ATOM 2191 O HOH W 454 4.355 81.219 35.183 1.00 34.92 W O ATOM 2192 O HOH W 455 25.635 56.901 34.614 1.00 47.34 W O ATOM 2193 O HOH W 456 42.338 49.434 11.100 1.00 72.43 W O ATOM 2194 O HOH W 457 −2.051 65.103 18.494 1.00 39.83 W O ATOM 2195 O HOH W 458 −9.591 72.598 44.168 1.00 64.69 W O ATOM 2196 O HOH W 459 20.373 46.614 27.914 1.00 38.68 W O ATOM 2197 O HOH W 460 0.659 55.516 18.515 1.00 58.39 W O ATOM 2198 O HOH W 461 21.076 80.510 26.713 1.00 61.17 W O ATOM 2199 O HOH W 462 32.155 47.583 8.094 1.00 70.56 W O ATOM 2200 O HOH W 463 4.044 58.878 44.996 1.00 51.08 W O ATOM 2201 O HOH W 464 41.005 53.749 30.770 1.00 75.59 W O ATOM 2202 O HOH W 465 26.371 63.533 −4.679 1.00 74.46 W O ATOM 2203 O HOH W 466 18.683 73.320 26.848 1.00 53.79 W O ATOM 2204 O HOH W 467 31.520 71.009 32.011 1.00 56.96 W O ATOM 2205 O HOH W 468 17.101 44.021 28.295 1.00 65.42 W O ATOM 2206 O HOH W 469 39.280 50.487 10.873 1.00 71.08 W O ATOM 2207 O HOH W 470 37.290 42.352 23.513 1.00 70.13 W O ATOM 2208 O HOH W 471 5.578 77.441 49.897 1.00 69.56 W O ATOM 2209 O HOH W 472 7.437 83.010 37.688 1.00 69.84 W O ATOM 2210 O HOH W 473 26.352 64.806 24.911 1.00 54.06 W O ATOM 2211 O HOH W 474 11.127 50.403 42.491 1.00 74.19 W O ATOM 2212 O HOH W 475 13.078 66.605 47.781 1.00 64.41 W O ATOM 2213 O HOH W 476 33.069 47.485 4.075 1.00 73.62 W O ATOM 2214 O HOH W 477 16.310 47.636 28.660 1.00 60.28 W O ATOM 2215 O HOH W 478 10.526 56.684 48.949 1.00 65.54 W O ATOM 2216 O HOH W 479 8.120 87.653 17.142 1.00 54.25 W O ATOM 2217 O HOH W 480 8.395 84.399 35.638 1.00 53.58 W O ATOM 2218 O HOH W 481 37.470 55.653 9.464 1.00 46.07 W O ATOM 2219 O HOH W 482 26.702 61.295 39.749 1.00 63.14 W O ATOM 2220 O HOH W 483 45.743 51.322 22.505 1.00 64.82 W O ATOM 2221 O HOH W 484 26.243 53.676 32.375 1.00 76.35 W O ATOM 2222 O HOH W 485 28.613 53.324 28.097 1.00 38.88 W O ATOM 2223 O HOH W 486 4.244 65.989 13.927 1.00 36.47 W O ATOM 2224 O HOH W 487 24.103 54.829 31.073 1.00 48.23 W O ATOM 2225 O HOH W 488 16.440 64.104 14.517 1.00 46.59 W O ATOM 2226 O HOH W 489 37.058 53.211 10.107 1.00 41.19 W O ATOM 2227 O HOH W 490 1.626 58.930 43.465 1.00 56.15 W O ATOM 2228 O HOH W 491 5.404 80.824 37.937 1.00 49.30 W O ATOM 2229 O HOH W 492 3.696 83.191 19.871 1.00 55.84 W O ATOM 2230 O HOH W 493 9.216 69.339 23.781 1.00 49.12 W O ATOM 2231 O HOH W 494 36.460 55.040 25.386 1.00 61.90 W O ATOM 2232 O HOH W 495 29.035 64.618 25.993 1.00 44.19 W O ATOM 2233 O HOH W 496 −1.211 81.253 28.481 1.00 49.42 W O ATOM 2234 O HOH W 497 −13.349 74.056 40.995 1.00 57.64 W O ATOM 2235 O HOH W 498 22.952 75.394 20.894 1.00 54.51 W O ATOM 2236 O HOH W 499 8.061 54.650 41.586 1.00 49.70 W O ATOM 2237 O HOH W 500 −4.078 73.918 41.599 1.00 51.57 W O ATOM 2238 O HOH W 501 26.284 56.747 2.127 1.00 52.08 W O ATOM 2239 O HOH W 502 30.005 48.619 30.666 1.00 72.19 W O ATOM 2240 O HOH W 503 20.159 65.366 13.420 1.00 51.24 W O ATOM 2241 O HOH W 504 −5.361 63.850 28.736 1.00 60.73 W O ATOM 2242 O HOH W 505 26.955 52.505 30.145 1.00 52.17 W O ATOM 2243 O HOH W 506 0.745 55.925 28.349 1.00 47.50 W O ATOM 2244 O HOH W 507 13.465 63.276 17.023 1.00 63.56 W O ATOM 2245 O HOH W 508 −0.920 64.629 40.572 1.00 40.57 W O ATOM 2246 O HOH W 509 −8.382 72.769 39.661 1.00 58.85 W O ATOM 2247 O HOH W 510 19.488 70.756 41.864 1.00 49.15 W O ATOM 2248 O HOH W 511 14.101 54.714 36.057 1.00 57.27 W O ATOM 2249 O HOH W 512 31.885 61.378 38.523 1.00 62.27 W O ATOM 2250 O HOH W 513 35.755 51.839 8.257 1.00 47.13 W O ATOM 2251 O HOH W 514 17.069 82.457 25.470 1.00 55.98 W O ATOM 2252 O HOH W 515 −4.640 64.734 26.208 1.00 35.90 W O ATOM 2253 O HOH W 516 28.342 79.720 28.289 1.00 51.97 W O ATOM 2254 O HOH W 517 28.930 63.693 33.886 1.00 47.21 W O ATOM 2255 O HOH W 518 14.019 51.336 17.356 1.00 74.59 W O ATOM 2256 O HOH W 519 16.446 79.651 42.696 1.00 66.23 W O ATOM 2257 O HOH W 520 32.520 63.699 25.738 1.00 57.23 W O ATOM 2258 O HOH W 521 −11.168 62.126 35.907 1.00 65.36 W O ATOM 2259 O HOH W 522 13.702 76.196 48.300 1.00 61.59 W O ATOM 2260 O HOH W 523 1.241 58.718 25.331 1.00 64.44 W O ATOM 2261 O HOH W 524 14.477 78.178 21.588 1.00 64.83 W O ATOM 2262 O HOH W 525 12.372 54.887 20.646 1.00 60.88 W O ATOM 2263 O HOH W 526 7.266 74.256 14.263 1.00 39.73 W O ATOM 2264 O HOH W 527 20.091 44.006 35.105 1.00 50.82 W O ATOM 2265 O HOH W 528 1.165 69.375 46.475 1.00 57.89 W O ATOM 2266 O HOH W 529 19.142 46.127 35.660 1.00 45.19 W O ATOM 2267 O HOH W 530 42.086 55.304 19.791 1.00 71.79 W O ATOM 2268 O HOH W 531 25.087 50.111 39.148 1.00 63.76 W O ATOM 2269 O HOH W 532 5.318 61.373 18.508 1.00 62.59 W O ATOM 2270 O HOH W 533 29.675 78.586 23.627 1.00 58.56 W O ATOM 2271 O HOH W 534 19.557 76.701 12.869 1.00 68.72 W O ATOM 2272 O HOH W 535 42.115 57.119 21.522 1.00 71.32 W O ATOM 2273 O HOH W 536 0.634 77.003 19.831 1.00 100.00 W O ATOM 2274 O HOH W 537 19.709 88.994 42.992 1.00 58.23 W O ATOM 2275 O HOH W 538 13.524 50.624 47.508 1.00 75.63 W O ATOM 2276 O HOH W 539 11.617 86.001 30.094 1.00 68.80 W O ATOM 2277 O HOH W 540 −7.680 59.135 43.088 1.00 61.92 W O TER 2278 HOH W 205 W ATOM 2279 C1 FRA V 541 18.019 80.374 32.848 1.00 57.37 V C ATOM 2280 C2 FRA V 541 17.378 79.416 33.865 1.00 55.67 V C ATOM 2281 C3 FRA V 541 17.724 79.837 35.320 1.00 57.54 V C ATOM 2282 O4 FRA V 541 17.702 79.994 31.523 1.00 54.83 V O ATOM 2283 O5 FRA V 541 15.964 79.445 33.671 1.00 53.75 V O ATOM 2284 O6 FRA V 541 16.818 79.285 36.284 1.00 58.10 V O ATOM 2285 O HOH V 542 21.116 58.251 20.758 1.00 34.64 V O TER 2286 HOH V 2 V END

TABLE 2 coordinates for the two molecules in the asymmetric unit of [T287] Aurora A (122–396) in complex with an inhibitor of formula II in space group P2₁ REMARK [No title given] REMARK [No title given] REMARK [No title given] REMARK Aurora complex with M535136. Refined structure. Solved by REMARK molecular replacement using a partly refined aurora structure REMARK from the trigonal crystal form. Original MR model derived REMARK from a PKA alignment. Inhibitor occupies much of active site REMARK cleft and usual interactions at adenine site. Superposition REMARK with PKA shows a very wide, open active site cleft. REMARK coordinates from restrained individual B-factor refinement REMARK refinement resolution: 500.0–2.1 A REMARK starting r = 0.2306 free_r = 0.2716 REMARK final r = 0.2256 free_r = 0.2677 REMARK B rmsd for bonded mainchain atoms = 1.521 target = 1.5 REMARK B rmsd for bonded sidechain atoms = 2.205 target = 2.0 REMARK B rmsd for angle mainchain atoms = 2.492 target = 2.0 REMARK B rmsd for angle sidechain atoms = 3.350 target = 2.5 REMARK rweight = 0.1000 (with wa = 3.00741) REMARK target = mlf steps = 30 REMARK sg = P2(1)a = 52.603 b = 88.421 c = 67.832 alpha = 90 beta = 90.013 gamma = 90 REMARK parameter file 1: MSI_CNX_TOPPAR:protein_rep.param REMARK parameter file 2: fra.par REMARK parameter file 3: MSI_CNX_TOPPAR:water_rep.param REMARK molecular structure file: reb9.mtf REMARK input coordinates: anneal_reb_1.pdb REMARK reflection file = aurora-p21.cv REMARK ncs = none REMARK B-correction resolution: 6.0–2.1 REMARK initial B-factor correction applied to fobs: REMARK B11 = 1.629 B22 = −1.218 B33 = −0.411 REMARK B12 = 0.000 B13 = 0.000 B23 = 0.000 REMARK B-factor correction applied to coordinate array B: −0.233 REMARK bulk solvent: (Mask)density level = 0.31769 e/A{circumflex over ( )}3, B-factor = 51.8227 A{circumflex over ( )}2 REMARK reflections with |Fobs|/sigma_F < 0.0 rejected REMARK reflections with |Fobs| > 10000 * rms(Fobs) rejected REMARK theoretical total number of refl. in resol. range:  36279(100.0%) REMARK number of unobserved reflections (no entry or |F| = 0): 9992 (27.5%) REMARK number of reflections rejected:   0 (0.0%) REMARK total number of reflections used:   26287 (72.5%) REMARK number of reflections in working set:   25018 (69.0%) REMARK number of reflections in test set:   1269 (3.5%) REMARK FILENAME = “bindividual.pdb” REMARK DATE: Feb-12-2001 13:11:17  created by user: mar345 REMARK Written by CNX VERSION: 2000.1 CRYST1 52.603 88.421 67.832 90.00 90.01 90.00 P 1 21 1 SCALE1  0.019010 0.000000 0.000003  0.00000 SCALE2  0.000000 0.011310 0.000000  0.00000 SCALE3  0.000000 0.000000 0.014742  0.00000 ATOM 1 CB GLN A 126 32.162 112.290 73.232 1.00 49.44 A C ATOM 2 CG GLN A 126 32.015 113.484 72.284 1.00 51.02 A C ATOM 3 CD GLN A 126 32.563 113.219 70.887 1.00 51.57 A C ATOM 4 OE1 GLN A 126 31.961 112.499 70.089 1.00 51.89 A O ATOM 5 NE2 GLN A 126 33.717 113.803 70.589 1.00 52.45 A N ATOM 6 C GLN A 126 31.499 110.010 73.975 1.00 46.32 A C ATOM 7 O GLN A 126 31.745 110.223 75.161 1.00 48.00 A O ATOM 8 N GLN A 126 29.765 111.655 73.328 1.00 47.98 A N ATOM 9 CA GLN A 126 31.143 111.162 73.040 1.00 47.45 A C ATOM 10 N TRP A 127 31.523 108.792 73.443 1.00 43.51 A N ATOM 11 CA TRP A 127 31.864 107.618 74.238 1.00 40.38 A C ATOM 12 CB TRP A 127 30.998 106.418 73.836 1.00 40.28 A C ATOM 13 CG TRP A 127 29.528 106.692 73.786 1.00 37.53 A C ATOM 14 CD2 TRP A 127 28.575 106.442 74.826 1.00 36.46 A C ATOM 15 CE2 TRP A 127 27.309 106.835 74.335 1.00 36.39 A C ATOM 16 CE3 TRP A 127 28.669 105.924 76.123 1.00 34.75 A C ATOM 17 CD1 TRP A 127 28.827 107.215 72.740 1.00 37.84 A C ATOM 18 NE1 TRP A 127 27.490 107.302 73.060 1.00 36.81 A N ATOM 19 CZ2 TRP A 127 26.142 106.725 75.097 1.00 36.10 A C ATOM 20 CZ3 TRP A 127 27.507 105.814 76.884 1.00 37.35 A C ATOM 21 CH2 TRP A 127 26.260 106.214 76.366 1.00 37.47 A C ATOM 22 C TRP A 127 33.329 107.249 74.024 1.00 38.84 A C ATOM 23 O TRP A 127 33.984 107.765 73.117 1.00 37.85 A O ATOM 24 N ALA A 128 33.835 106.349 74.858 1.00 36.22 A N ATOM 25 CA ALA A 128 35.212 105.891 74.741 1.00 35.97 A C ATOM 26 CB ALA A 128 36.136 106.763 75.582 1.00 35.91 A C ATOM 27 C ALA A 128 35.289 104.441 75.200 1.00 35.31 A C ATOM 28 O ALA A 128 34.514 104.015 76.056 1.00 34.64 A O ATOM 29 N LEU A 129 36.221 103.688 74.626 1.00 33.98 A N ATOM 30 CA LEU A 129 36.385 102.283 74.976 1.00 34.14 A C ATOM 31 CB LEU A 129 37.556 101.681 74.191 1.00 33.48 A C ATOM 32 CG LEU A 129 37.816 100.175 74.339 1.00 35.39 A C ATOM 33 CD1 LEU A 129 36.514 99.396 74.175 1.00 34.09 A C ATOM 34 CD2 LEU A 129 38.841 99.729 73.300 1.00 33.75 A C ATOM 35 C LEU A 129 36.596 102.092 76.476 1.00 33.77 A C ATOM 36 O LEU A 129 36.028 101.182 77.083 1.00 33.18 A O ATOM 37 N ALA A 130 37.389 102.974 77.072 1.00 34.08 A N ATOM 38 CA ALA A 130 37.691 102.918 78.500 1.00 33.53 A C ATOM 39 CB ALA A 130 38.757 103.954 78.836 1.00 33.52 A C ATOM 40 C ALA A 130 36.483 103.112 79.415 1.00 33.70 A C ATOM 41 O ALA A 130 36.615 103.026 80.633 1.00 35.42 A O ATOM 42 N ASP A 131 35.315 103.380 78.841 1.00 33.03 A N ATOM 43 CA ASP A 131 34.092 103.588 79.632 1.00 31.53 A C ATOM 44 CB ASP A 131 33.094 104.444 78.849 1.00 35.30 A C ATOM 45 CG ASP A 131 33.415 105.919 78.898 1.00 37.25 A C ATOM 46 OD1 ASP A 131 32.854 106.665 78.066 1.00 40.43 A O ATOM 47 OD2 ASP A 131 34.209 106.335 79.770 1.00 39.65 A O ATOM 48 C ASP A 131 33.404 102.274 79.970 1.00 29.88 A C ATOM 49 O ASP A 131 32.510 102.223 80.816 1.00 27.49 A O ATOM 50 N PHE A 132 33.836 101.211 79.305 1.00 28.87 A N ATOM 51 CA PHE A 132 33.232 99.906 79.487 1.00 27.75 A C ATOM 52 CB PHE A 132 32.617 99.450 78.168 1.00 25.08 A C ATOM 53 CG PHE A 132 31.820 100.504 77.478 1.00 24.75 A C ATOM 54 CD1 PHE A 132 30.535 100.808 77.899 1.00 22.62 A C ATOM 55 CD2 PHE A 132 32.356 101.195 76.403 1.00 22.91 A C ATOM 56 CE1 PHE A 132 29.794 101.788 77.249 1.00 26.12 A C ATOM 57 CE2 PHE A 132 31.626 102.174 75.749 1.00 25.55 A C ATOM 58 CZ PHE A 132 30.340 102.471 76.173 1.00 23.27 A C ATOM 59 C PHE A 132 34.164 98.801 79.947 1.00 27.73 A C ATOM 60 O PHE A 132 35.375 98.852 79.736 1.00 27.55 A O ATOM 61 N GLU A 133 33.560 97.798 80.575 1.00 27.29 A N ATOM 62 CA GLU A 133 34.254 96.596 81.004 1.00 26.91 A C ATOM 63 CB GLU A 133 33.863 96.187 82.415 1.00 29.96 A C ATOM 64 CG GLU A 133 34.290 97.120 83.506 1.00 35.88 A C ATOM 65 CD GLU A 133 33.945 96.546 84.858 1.00 39.31 A C ATOM 66 OE1 GLU A 133 34.491 95.469 85.189 1.00 40.33 A O ATOM 67 OE2 GLU A 133 33.120 97.153 85.576 1.00 40.57 A O ATOM 68 C GLU A 133 33.665 95.582 80.034 1.00 24.82 A C ATOM 69 O GLU A 133 32.444 95.536 79.854 1.00 21.66 A O ATOM 70 N ILE A 134 34.523 94.787 79.410 1.00 22.94 A N ATOM 71 CA ILE A 134 34.091 93.784 78.443 1.00 22.52 A C ATOM 72 CB ILE A 134 35.115 93.688 77.286 1.00 23.20 A C ATOM 73 CG2 ILE A 134 34.652 92.704 76.240 1.00 23.57 A C ATOM 74 CG1 ILE A 134 35.317 95.073 76.668 1.00 26.34 A C ATOM 75 CD1 ILE A 134 34.059 95.709 76.121 1.00 27.45 A C ATOM 76 C ILE A 134 33.935 92.413 79.093 1.00 23.10 A C ATOM 77 O ILE A 134 34.737 92.024 79.941 1.00 24.84 A O ATOM 78 N GLY A 135 32.904 91.679 78.681 1.00 24.78 A N ATOM 79 CA GLY A 135 32.648 90.355 79.231 1.00 22.02 A C ATOM 80 C GLY A 135 32.677 89.246 78.193 1.00 20.46 A C ATOM 81 O GLY A 135 33.404 89.330 77.212 1.00 18.06 A O ATOM 82 N ARG A 136 31.867 88.212 78.391 1.00 23.35 A N ATOM 83 CA ARG A 136 31.852 87.077 77.464 1.00 25.21 A C ATOM 84 CB ARG A 136 31.078 85.902 78.064 1.00 26.99 A C ATOM 85 CG ARG A 136 29.601 86.174 78.284 1.00 28.67 A C ATOM 86 CD ARG A 136 28.870 84.914 78.725 1.00 29.20 A C ATOM 87 NE ARG A 136 27.497 85.201 79.121 1.00 31.23 A N ATOM 88 CZ ARG A 136 26.417 84.687 78.532 1.00 34.58 A C ATOM 89 NH1 ARG A 136 26.546 83.847 77.512 1.00 33.49 A N ATOM 90 NH2 ARG A 136 25.204 85.028 78.958 1.00 34.12 A N ATOM 91 C ARG A 136 31.285 87.369 76.084 1.00 26.22 A C ATOM 92 O ARG A 136 30.450 88.260 75.916 1.00 24.47 A O ATOM 93 N PRO A 137 31.749 86.620 75.070 1.00 26.55 A N ATOM 94 CD PRO A 137 32.907 85.714 75.122 1.00 27.27 A C ATOM 95 CA PRO A 137 31.285 86.786 73.690 1.00 26.49 A C ATOM 96 CB PRO A 137 32.236 85.898 72.887 1.00 25.92 A C ATOM 97 CG PRO A 137 33.477 85.858 73.729 1.00 25.14 A C ATOM 98 C PRO A 137 29.856 86.276 73.609 1.00 27.01 A C ATOM 99 O PRO A 137 29.538 85.226 74.169 1.00 26.92 A O ATOM 100 N LEU A 138 28.995 87.018 72.924 1.00 27.88 A N ATOM 101 CA LEU A 138 27.602 86.615 72.779 1.00 29.09 A C ATOM 102 CB LEU A 138 26.691 87.843 72.865 1.00 27.78 A C ATOM 103 CG LEU A 138 26.450 88.473 74.240 1.00 26.22 A C ATOM 104 CD1 LEU A 138 27.758 88.636 74.965 1.00 29.17 A C ATOM 105 CD2 LEU A 138 25.771 89.816 74.075 1.00 20.07 A C ATOM 106 C LEU A 138 27.403 85.907 71.438 1.00 30.81 A C ATOM 107 O LEU A 138 26.619 84.964 71.329 1.00 32.24 A O ATOM 108 N GLY A 139 28.124 86.367 70.424 1.00 32.34 A N ATOM 109 CA GLY A 139 28.014 85.773 69.109 1.00 35.00 A C ATOM 110 C GLY A 139 29.136 86.215 68.190 1.00 38.07 A C ATOM 111 O GLY A 139 29.859 87.166 68.488 1.00 38.60 A O ATOM 112 N LYS A 140 29.281 85.519 67.066 1.00 41.32 A N ATOM 113 CA LYS A 140 30.320 85.831 66.092 1.00 43.10 A C ATOM 114 CB LYS A 140 31.244 84.633 65.917 1.00 44.15 A C ATOM 115 C LYS A 140 29.703 86.216 64.751 1.00 44.25 A C ATOM 116 O LYS A 140 28.615 85.755 64.403 1.00 43.38 A O ATOM 117 N GLY A 141 30.406 87.066 64.007 1.00 45.98 A N ATOM 118 CA GLY A 141 29.939 87.527 62.705 1.00 47.85 A C ATOM 119 CB GLY A 141 29.270 88.895 62.842 1.00 49.28 A C ATOM 120 C GLY A 141 31.109 87.613 61.731 1.00 48.68 A C ATOM 121 O GLY A 141 32.235 87.245 62.073 1.00 48.92 A O ATOM 122 N ALA A 142 30.842 88.111 60.525 1.00 48.78 A N ATOM 123 CA ALA A 142 31.877 88.226 59.502 1.00 47.65 A C ATOM 124 CB ALA A 142 31.247 88.156 58.115 1.00 48.08 A C ATOM 125 C ALA A 142 32.730 89.488 59.620 1.00 46.86 A C ATOM 126 O ALA A 142 33.828 89.550 59.063 1.00 46.94 A O ATOM 127 N PHE A 143 32.242 90.492 60.343 1.00 45.34 A N ATOM 128 CA PHE A 143 33.004 91.731 60.477 1.00 43.93 A C ATOM 129 CB PHE A 143 32.193 92.907 59.920 1.00 43.56 A C ATOM 130 CG PHE A 143 31.628 92.653 58.550 1.00 43.95 A C ATOM 131 CD1 PHE A 143 30.352 92.118 58.397 1.00 44.56 A C ATOM 132 CD2 PHE A 143 32.385 92.915 57.413 1.00 44.21 A C ATOM 133 CE1 PHE A 143 29.836 91.845 57.129 1.00 44.68 A C ATOM 134 CE2 PHE A 143 31.881 92.645 56.141 1.00 44.72 A C ATOM 135 CZ PHE A 143 30.604 92.109 55.999 1.00 44.72 A C ATOM 136 C PHE A 143 33.456 92.045 61.901 1.00 42.13 A C ATOM 137 O PHE A 143 34.137 93.043 62.132 1.00 41.48 A O ATOM 138 N GLY A 144 33.085 91.183 62.846 1.00 40.73 A N ATOM 139 CA GLY A 144 33.452 91.396 64.235 1.00 37.57 A C ATOM 140 C GLY A 144 32.537 90.631 65.171 1.00 36.23 A C ATOM 141 O GLY A 144 31.625 89.938 64.721 1.00 35.58 A O ATOM 142 N ASN A 145 32.763 90.763 66.474 1.00 34.55 A N ATOM 143 CA ASN A 145 31.947 90.052 67.453 1.00 32.65 A C ATOM 144 CB ASN A 145 32.842 89.187 68.341 1.00 34.14 A C ATOM 145 CG ASN A 145 33.913 88.458 67.549 1.00 36.27 A C ATOM 146 OD1 ASN A 145 35.068 88.893 67.489 1.00 36.74 A O ATOM 147 ND2 ASN A 145 33.531 87.352 66.924 1.00 35.73 A N ATOM 148 C ASN A 145 31.096 90.959 68.331 1.00 30.37 A C ATOM 149 O ASN A 145 31.232 92.183 68.308 1.00 31.36 A O ATOM 150 N VAL A 146 30.214 90.337 69.107 1.00 27.53 A N ATOM 151 CA VAL A 146 29.326 91.051 70.013 1.00 24.74 A C ATOM 152 CB VAL A 146 27.836 90.769 69.684 1.00 26.28 A C ATOM 153 CG1 VAL A 146 26.932 91.644 70.548 1.00 24.90 A C ATOM 154 CG2 VAL A 146 27.573 91.006 68.211 1.00 28.46 A C ATOM 155 C VAL A 146 29.605 90.546 71.424 1.00 22.82 A C ATOM 156 O VAL A 146 29.599 89.341 71.660 1.00 24.33 A O ATOM 157 N TYR A 147 29.836 91.461 72.357 1.00 20.11 A N ATOM 158 CA TYR A 147 30.125 91.081 73.738 1.00 18.69 A C ATOM 159 CB TYR A 147 31.530 91.523 74.145 1.00 16.30 A C ATOM 160 CG TYR A 147 32.646 91.083 73.231 1.00 20.13 A C ATOM 161 CD1 TYR A 147 32.849 91.701 71.997 1.00 19.62 A C ATOM 162 CE1 TYR A 147 33.898 91.318 71.162 1.00 22.76 A C ATOM 163 CD2 TYR A 147 33.519 90.059 73.610 1.00 19.37 A C ATOM 164 CE2 TYR A 147 34.574 89.661 72.777 1.00 20.22 A C ATOM 165 CZ TYR A 147 34.755 90.298 71.559 1.00 23.88 A C ATOM 166 OH TYR A 147 35.788 89.925 70.727 1.00 27.07 A O ATOM 167 C TYR A 147 29.177 91.690 74.757 1.00 17.31 A C ATOM 168 O TYR A 147 28.568 92.731 74.521 1.00 16.25 A O ATOM 169 N LEU A 148 29.071 91.026 75.903 1.00 17.91 A N ATOM 170 CA LEU A 148 28.283 91.544 76.996 1.00 16.28 A C ATOM 171 CB LEU A 148 28.040 90.472 78.054 1.00 19.47 A C ATOM 172 CG LEU A 148 27.148 90.939 79.205 1.00 19.54 A C ATOM 173 CD1 LEU A 148 25.844 90.198 79.117 1.00 23.07 A C ATOM 174 CD2 LEU A 148 27.809 90.695 80.561 1.00 21.88 A C ATOM 175 C LEU A 148 29.230 92.599 77.555 1.00 16.81 A C ATOM 176 O LEU A 148 30.449 92.387 77.604 1.00 17.66 A O ATOM 177 N ALA A 149 28.693 93.740 77.962 1.00 17.06 A N ATOM 178 CA ALA A 149 29.529 94.794 78.504 1.00 15.77 A C ATOM 179 CB ALA A 149 29.953 95.744 77.400 1.00 16.74 A C ATOM 180 C ALA A 149 28.778 95.540 79.591 1.00 19.32 A C ATOM 181 O ALA A 149 27.585 95.302 79.815 1.00 17.25 A O ATOM 182 N ARG A 150 29.483 96.442 80.262 1.00 18.18 A N ATOM 183 CA ARG A 150 28.903 97.215 81.338 1.00 20.87 A C ATOM 184 CB ARG A 150 29.073 96.435 82.651 1.00 24.33 A C ATOM 185 CG ARG A 150 28.543 97.119 83.890 1.00 30.19 A C ATOM 186 CD ARG A 150 28.265 96.096 84.995 1.00 32.40 A C ATOM 187 NE ARG A 150 29.370 95.162 85.167 1.00 33.70 A N ATOM 188 CZ ARG A 150 29.308 94.053 85.897 1.00 35.11 A C ATOM 189 NH1 ARG A 150 28.186 93.735 86.533 1.00 36.02 A N ATOM 190 NH2 ARG A 150 30.365 93.252 85.983 1.00 32.01 A N ATOM 191 C ARG A 150 29.593 98.574 81.422 1.00 22.84 A C ATOM 192 O ARG A 150 30.808 98.675 81.180 1.00 18.77 A O ATOM 193 N GLU A 151 28.819 99.618 81.727 1.00 23.89 A N ATOM 194 CA GLU A 151 29.383 100.958 81.874 1.00 26.53 A C ATOM 195 CB GLU A 151 28.286 102.033 81.883 1.00 26.52 A C ATOM 196 CG GLU A 151 27.420 102.099 80.629 1.00 28.40 A C ATOM 197 CD GLU A 151 26.365 103.198 80.704 1.00 29.97 A C ATOM 198 OE1 GLU A 151 25.724 103.337 81.765 1.00 29.43 A O ATOM 199 OE2 GLU A 151 26.164 103.917 79.704 1.00 31.53 A O ATOM 200 C GLU A 151 30.049 100.897 83.242 1.00 27.68 A C ATOM 201 O GLU A 151 29.390 100.577 84.230 1.00 28.40 A O ATOM 202 N LYS A 152 31.346 101.195 83.288 1.00 30.73 A N ATOM 203 CA LYS A 152 32.135 101.140 84.523 1.00 33.53 A C ATOM 204 CB LYS A 152 33.545 101.691 84.288 1.00 34.64 A C ATOM 205 CG LYS A 152 34.458 100.758 83.531 1.00 37.25 A C ATOM 206 CD LYS A 152 35.836 101.367 83.353 1.00 39.94 A C ATOM 207 CE LYS A 152 36.759 100.408 82.629 1.00 40.54 A C ATOM 208 NZ LYS A 152 38.093 101.012 82.399 1.00 41.98 A N ATOM 209 C LYS A 152 31.548 101.842 85.727 1.00 33.54 A C ATOM 210 O LYS A 152 31.401 101.239 86.790 1.00 35.42 A O ATOM 211 N GLN A 153 31.222 103.117 85.564 1.00 33.48 A N ATOM 212 CA GLN A 153 30.669 103.904 86.655 1.00 34.22 A C ATOM 213 CB GLN A 153 30.568 105.370 86.231 1.00 36.43 A C ATOM 214 CG GLN A 153 31.890 105.975 85.797 1.00 39.77 A C ATOM 215 CD GLN A 153 32.954 105.939 86.889 1.00 42.68 A C ATOM 216 OE1 GLN A 153 34.107 106.304 86.657 1.00 46.22 A O ATOM 217 NE2 GLN A 153 32.572 105.503 88.082 1.00 43.83 A N ATOM 218 C GLN A 153 29.316 103.424 87.182 1.00 33.78 A C ATOM 219 O GLN A 153 29.226 102.938 88.314 1.00 34.62 A O ATOM 220 N SER A 154 28.268 103.555 86.371 1.00 32.03 A N ATOM 221 CA SER A 154 26.929 103.156 86.794 1.00 29.99 A C ATOM 222 CB SER A 154 25.868 103.831 85.914 1.00 29.69 A C ATOM 223 OG SER A 154 26.050 103.510 84.551 1.00 29.28 A O ATOM 224 C SER A 154 26.661 101.657 86.845 1.00 29.81 A C ATOM 225 O SER A 154 25.646 101.236 87.398 1.00 29.38 A O ATOM 226 N LYS A 155 27.550 100.855 86.261 1.00 29.05 A N ATOM 227 CA LYS A 155 27.389 99.401 86.276 1.00 30.67 A C ATOM 228 CB LYS A 155 27.185 98.936 87.725 1.00 32.82 A C ATOM 229 CG LYS A 155 27.059 97.435 87.912 1.00 39.02 A C ATOM 230 CD LYS A 155 26.671 97.066 89.342 1.00 43.54 A C ATOM 231 CE LYS A 155 25.205 97.386 89.669 1.00 47.18 A C ATOM 232 NZ LYS A 155 24.902 98.848 89.800 1.00 49.30 A N ATOM 233 C LYS A 155 26.223 98.913 85.398 1.00 28.46 A C ATOM 234 O LYS A 155 25.706 97.812 85.590 1.00 27.89 A O ATOM 235 N PHE A 156 25.831 99.727 84.424 1.00 26.49 A N ATOM 236 CA PHE A 156 24.716 99.403 83.536 1.00 23.82 A C ATOM 237 CB PHE A 156 24.185 100.698 82.905 1.00 24.31 A C ATOM 238 CG PHE A 156 23.043 100.492 81.955 1.00 24.97 A C ATOM 239 CD1 PHE A 156 21.771 100.187 82.428 1.00 24.81 A C ATOM 240 CD2 PHE A 156 23.244 100.592 80.580 1.00 24.41 A C ATOM 241 CE1 PHE A 156 20.705 99.982 81.537 1.00 27.89 A C ATOM 242 CE2 PHE A 156 22.195 100.390 79.685 1.00 24.55 A C ATOM 243 CZ PHE A 156 20.920 100.084 80.163 1.00 25.32 A C ATOM 244 C PHE A 156 25.082 98.381 82.445 1.00 21.90 A C ATOM 245 O PHE A 156 26.019 98.582 81.676 1.00 21.26 A O ATOM 246 N ILE A 157 24.321 97.294 82.388 1.00 19.42 A N ATOM 247 CA ILE A 157 24.535 96.219 81.418 1.00 19.66 A C ATOM 248 CB ILE A 157 23.863 94.906 81.878 1.00 20.30 A C ATOM 249 CG2 ILE A 157 23.931 93.876 80.759 1.00 18.66 A C ATOM 250 CG1 ILE A 157 24.541 94.373 83.143 1.00 20.54 A C ATOM 251 CD1 ILE A 157 25.994 93.979 82.929 1.00 23.70 A C ATOM 252 C ILE A 157 23.996 96.515 80.018 1.00 20.08 A C ATOM 253 O ILE A 157 22.851 96.955 79.859 1.00 18.61 A O ATOM 254 N LEU A 158 24.819 96.239 79.011 1.00 18.01 A N ATOM 255 CA LEU A 158 24.445 96.436 77.616 1.00 19.34 A C ATOM 256 CB LEU A 158 24.651 97.900 77.220 1.00 20.73 A C ATOM 257 CG LEU A 158 25.882 98.644 77.734 1.00 22.83 A C ATOM 258 CD1 LEU A 158 27.125 98.226 76.965 1.00 23.65 A C ATOM 259 CD2 LEU A 158 25.633 100.139 77.576 1.00 24.53 A C ATOM 260 C LEU A 158 25.231 95.498 76.688 1.00 19.24 A C ATOM 261 O LEU A 158 25.944 94.623 77.153 1.00 20.32 A O ATOM 262 N ALA A 159 25.077 95.654 75.379 1.00 19.56 A N ATOM 263 CA ALA A 159 25.790 94.803 74.431 1.00 19.83 A C ATOM 264 CB ALA A 159 24.809 94.009 73.579 1.00 19.54 A C ATOM 265 C ALA A 159 26.673 95.672 73.553 1.00 20.25 A C ATOM 266 O ALA A 159 26.274 96.766 73.143 1.00 19.23 A O ATOM 267 N LEU A 160 27.878 95.190 73.274 1.00 20.17 A N ATOM 268 CA LEU A 160 28.820 95.944 72.459 1.00 22.21 A C ATOM 269 CB LEU A 160 30.019 96.360 73.326 1.00 23.33 A C ATOM 270 CG LEU A 160 31.194 97.129 72.715 1.00 27.33 A C ATOM 271 CD1 LEU A 160 30.789 98.572 72.410 1.00 27.43 A C ATOM 272 CD2 LEU A 160 32.359 97.112 73.699 1.00 26.63 A C ATOM 273 C LEU A 160 29.298 95.146 71.249 1.00 22.33 A C ATOM 274 O LEU A 160 29.772 94.021 71.379 1.00 21.48 A O ATOM 275 N LYS A 161 29.170 95.738 70.067 1.00 23.83 A N ATOM 276 CA LYS A 161 29.612 95.082 68.840 1.00 24.70 A C ATOM 277 CB LYS A 161 28.502 95.107 67.792 1.00 24.56 A C ATOM 278 CG LYS A 161 28.735 94.154 66.635 1.00 26.78 A C ATOM 279 CD LYS A 161 27.431 93.891 65.887 1.00 25.97 A C ATOM 280 CE LYS A 161 27.612 92.863 64.792 1.00 23.17 A C ATOM 281 NZ LYS A 161 26.293 92.377 64.315 1.00 22.83 A N ATOM 282 C LYS A 161 30.850 95.798 68.314 1.00 25.61 A C ATOM 283 O LYS A 161 30.850 97.014 68.146 1.00 25.29 A O ATOM 284 N VAL A 162 31.907 95.031 68.072 1.00 27.06 A N ATOM 285 CA VAL A 162 33.172 95.568 67.585 1.00 28.41 A C ATOM 286 CB VAL A 162 34.346 95.050 68.456 1.00 31.04 A C ATOM 287 CG1 VAL A 162 35.678 95.617 67.957 1.00 31.63 A C ATOM 288 CG2 VAL A 162 34.113 95.427 69.914 1.00 30.41 A C ATOM 289 C VAL A 162 33.387 95.132 66.139 1.00 28.72 A C ATOM 290 O VAL A 162 33.387 93.942 65.844 1.00 28.91 A O ATOM 291 N LEU A 163 33.561 96.096 65.241 1.00 30.09 A N ATOM 292 CA LEU A 163 33.760 95.801 63.823 1.00 31.38 A C ATOM 293 CB LEU A 163 32.670 96.479 62.987 1.00 30.68 A C ATOM 294 CG LEU A 163 31.207 96.151 63.295 1.00 31.65 A C ATOM 295 CD1 LEU A 163 30.343 97.379 63.035 1.00 33.15 A C ATOM 296 CD2 LEU A 163 30.747 94.985 62.452 1.00 31.46 A C ATOM 297 C LEU A 163 35.116 96.333 63.393 1.00 32.77 A C ATOM 298 O LEU A 163 35.541 97.386 63.865 1.00 33.03 A O ATOM 299 N PHE A 164 35.793 95.610 62.503 1.00 34.61 A N ATOM 300 CA PHE A 164 37.107 96.043 62.018 1.00 36.93 A C ATOM 301 CB PHE A 164 38.068 94.849 61.878 1.00 38.68 A C ATOM 302 CG PHE A 164 38.406 94.181 63.180 1.00 40.41 A C ATOM 303 CD1 PHE A 164 37.659 93.101 63.639 1.00 41.41 A C ATOM 304 CD2 PHE A 164 39.464 94.645 63.960 1.00 41.14 A C ATOM 305 CE1 PHE A 164 37.959 92.489 64.857 1.00 41.57 A C ATOM 306 CE2 PHE A 164 39.774 94.041 65.182 1.00 42.28 A C ATOM 307 CZ PHE A 164 39.020 92.960 65.630 1.00 41.55 A C ATOM 308 C PHE A 164 37.000 96.759 60.674 1.00 36.27 A C ATOM 309 O PHE A 164 36.489 96.203 59.701 1.00 34.52 A O ATOM 310 N LYS A 165 37.495 97.993 60.632 1.00 37.51 A N ATOM 311 CA LYS A 165 37.461 98.809 59.422 1.00 39.00 A C ATOM 312 CB LYS A 165 38.248 100.103 59.635 1.00 39.41 A C ATOM 313 CG LYS A 165 37.700 100.988 60.738 1.00 41.43 A C ATOM 314 CD LYS A 165 38.473 102.292 60.820 1.00 43.19 A C ATOM 315 CE LYS A 165 37.957 103.175 61.941 1.00 43.06 A C ATOM 316 NZ LYS A 165 38.712 104.452 62.007 1.00 45.01 A N ATOM 317 C LYS A 165 38.016 98.092 58.200 1.00 39.84 A C ATOM 318 O LYS A 165 37.332 97.966 57.183 1.00 40.35 A O ATOM 319 N ALA A 166 39.259 97.629 58.309 1.00 40.50 A N ATOM 320 CA ALA A 166 39.930 96.930 57.218 1.00 41.24 A C ATOM 321 CB ALA A 166 41.230 96.314 57.717 1.00 40.66 A C ATOM 322 C ALA A 166 39.039 95.850 56.622 1.00 42.45 A C ATOM 323 O ALA A 166 39.143 95.524 55.439 1.00 42.34 A O ATOM 324 N GLN A 167 38.160 95.298 57.448 1.00 42.58 A N ATOM 325 CA GLN A 167 37.256 94.255 56.995 1.00 44.47 A C ATOM 326 CB GLN A 167 36.814 93.405 58.189 1.00 47.08 A C ATOM 327 CG GLN A 167 36.076 92.133 57.818 1.00 49.82 A C ATOM 328 CD GLN A 167 36.382 90.991 58.772 1.00 51.86 A C ATOM 329 OE1 GLN A 167 36.182 91.105 59.985 1.00 52.31 A O ATOM 330 NE2 GLN A 167 36.873 89.880 58.226 1.00 52.20 A N ATOM 331 C GLN A 167 36.044 94.856 56.288 1.00 44.78 A C ATOM 332 O GLN A 167 35.580 94.329 55.277 1.00 44.92 A O ATOM 333 N LEU A 168 35.539 95.965 56.818 1.00 45.62 A N ATOM 334 CA LEU A 168 34.379 96.635 56.232 1.00 47.56 A C ATOM 335 CB LEU A 168 33.899 97.775 57.146 1.00 46.01 A C ATOM 336 CG LEU A 168 33.222 97.423 58.476 1.00 43.92 A C ATOM 337 CD1 LEU A 168 33.079 98.664 59.335 1.00 42.28 A C ATOM 338 CD2 LEU A 168 31.866 96.802 58.209 1.00 44.54 A C ATOM 339 C LEU A 168 34.702 97.200 54.851 1.00 49.49 A C ATOM 340 O LEU A 168 33.974 96.973 53.884 1.00 49.80 A O ATOM 341 N GLU A 169 35.806 97.930 54.756 1.00 51.68 A N ATOM 342 CA GLU A 169 36.185 98.536 53.490 1.00 53.42 A C ATOM 343 CB GLU A 169 37.063 99.751 53.749 1.00 53.84 A C ATOM 344 CG GLU A 169 38.381 99.423 54.394 1.00 54.96 A C ATOM 345 CD GLU A 169 39.178 100.665 54.697 1.00 55.82 A C ATOM 346 OE1 GLU A 169 38.781 101.410 55.619 1.00 55.83 A O ATOM 347 OE2 GLU A 169 40.193 100.901 54.006 1.00 57.62 A O ATOM 348 C GLU A 169 36.886 97.589 52.523 1.00 53.75 A C ATOM 349 O GLU A 169 37.892 97.947 51.922 1.00 54.54 A O ATOM 350 N LYS A 170 36.352 96.382 52.375 1.00 54.68 A N ATOM 351 CA LYS A 170 36.923 95.398 51.464 1.00 55.27 A C ATOM 352 CB LYS A 170 38.040 94.603 52.151 1.00 56.80 A C ATOM 353 CG LYS A 170 37.588 93.641 53.249 1.00 59.09 A C ATOM 354 CD LYS A 170 37.396 92.216 52.725 1.00 59.63 A C ATOM 355 CE LYS A 170 37.133 91.239 53.873 1.00 60.14 A C ATOM 356 NZ LYS A 170 37.117 89.809 53.437 1.00 59.19 A N ATOM 357 C LYS A 170 35.815 94.469 50.997 1.00 55.75 A C ATOM 358 O LYS A 170 35.765 94.086 49.830 1.00 56.27 A O ATOM 359 N ALA A 171 34.921 94.116 51.915 1.00 55.93 A N ATOM 360 CA ALA A 171 33.792 93.250 51.590 1.00 56.64 A C ATOM 361 CB ALA A 171 33.064 92.823 52.866 1.00 56.68 A C ATOM 362 C ALA A 171 32.872 94.088 50.719 1.00 56.98 A C ATOM 363 O ALA A 171 31.899 93.599 50.139 1.00 55.93 A O ATOM 364 N GLY A 172 33.207 95.369 50.642 1.00 56.93 A N ATOM 365 CA GLY A 172 32.429 96.297 49.856 1.00 58.46 A C ATOM 366 C GLY A 172 32.681 97.681 50.397 1.00 59.30 A C ATOM 367 O GLY A 172 33.629 97.892 51.156 1.00 60.21 A O ATOM 368 N VAL A 173 31.840 98.626 50.003 1.00 59.95 A N ATOM 369 CA VAL A 173 31.970 99.998 50.459 1.00 60.15 A C ATOM 370 CB VAL A 173 31.642 100.992 49.328 1.00 61.54 A C ATOM 371 CG1 VAL A 173 31.817 102.420 49.825 1.00 62.43 A C ATOM 372 CG2 VAL A 173 32.538 100.720 48.118 1.00 61.17 A C ATOM 373 C VAL A 173 30.955 100.142 51.574 1.00 59.92 A C ATOM 374 O VAL A 173 29.860 100.673 51.369 1.00 60.94 A O ATOM 375 N GLU A 174 31.327 99.652 52.756 1.00 58.81 A N ATOM 376 CA GLU A 174 30.452 99.681 53.921 1.00 55.71 A C ATOM 377 CB GLU A 174 31.091 98.900 55.067 1.00 56.69 A C ATOM 378 CG GLU A 174 31.360 97.440 54.731 1.00 57.20 A C ATOM 379 CD GLU A 174 30.135 96.717 54.197 1.00 57.78 A C ATOM 380 OE1 GLU A 174 29.580 97.156 53.166 1.00 56.65 A O ATOM 381 OE2 GLU A 174 29.733 95.705 54.808 1.00 57.97 A O ATOM 382 C GLU A 174 29.985 101.040 54.428 1.00 54.20 A C ATOM 383 O GLU A 174 29.998 101.302 55.634 1.00 53.74 A O ATOM 384 N HIS A 175 29.587 101.913 53.506 1.00 51.35 A N ATOM 385 CA HIS A 175 29.040 103.199 53.896 1.00 47.97 A C ATOM 386 CB HIS A 175 29.047 104.184 52.726 1.00 50.39 A C ATOM 387 CG HIS A 175 30.391 104.788 52.460 1.00 54.57 A C ATOM 388 CD2 HIS A 175 30.998 105.144 51.303 1.00 55.04 A C ATOM 389 ND1 HIS A 175 31.266 105.127 53.472 1.00 55.47 A N ATOM 390 CE1 HIS A 175 32.354 105.664 52.949 1.00 55.64 A C ATOM 391 NE2 HIS A 175 32.216 105.687 51.635 1.00 55.68 A N ATOM 392 C HIS A 175 27.615 102.794 54.253 1.00 44.77 A C ATOM 393 O HIS A 175 26.842 103.562 54.817 1.00 43.37 A O ATOM 394 N GLN A 176 27.299 101.550 53.902 1.00 41.61 A N ATOM 395 CA GLN A 176 26.010 100.942 54.178 1.00 39.54 A C ATOM 396 CB GLN A 176 25.982 99.524 53.604 1.00 40.25 A C ATOM 397 CG GLN A 176 24.822 98.672 54.086 1.00 42.14 A C ATOM 398 CD GLN A 176 23.480 99.184 53.606 1.00 44.16 A C ATOM 399 OE1 GLN A 176 22.431 98.673 54.002 1.00 45.91 A O ATOM 400 NE2 GLN A 176 23.505 100.193 52.745 1.00 43.65 A N ATOM 401 C GLN A 176 25.817 100.891 55.696 1.00 37.68 A C ATOM 402 O GLN A 176 24.727 101.142 56.205 1.00 36.70 A O ATOM 403 N LEU A 177 26.887 100.559 56.408 1.00 34.73 A N ATOM 404 CA LEU A 177 26.842 100.495 57.862 1.00 33.53 A C ATOM 405 CB LEU A 177 28.236 100.230 58.427 1.00 32.47 A C ATOM 406 CG LEU A 177 28.307 100.187 59.957 1.00 32.80 A C ATOM 407 CD1 LEU A 177 27.773 98.844 60.439 1.00 33.65 A C ATOM 408 CD2 LEU A 177 29.742 100.380 60.431 1.00 31.75 A C ATOM 409 C LEU A 177 26.357 101.842 58.380 1.00 33.15 A C ATOM 410 O LEU A 177 25.411 101.920 59.168 1.00 30.88 A O ATOM 411 N ARG A 178 27.021 102.898 57.916 1.00 31.91 A N ATOM 412 CA ARG A 178 26.709 104.261 58.317 1.00 31.40 A C ATOM 413 CB ARG A 178 27.661 105.238 57.618 1.00 33.75 A C ATOM 414 CG ARG A 178 27.658 106.625 58.226 1.00 36.73 A C ATOM 415 CD ARG A 178 28.681 107.531 57.562 1.00 43.53 A C ATOM 416 NE ARG A 178 28.822 108.809 58.262 1.00 46.96 A N ATOM 417 CZ ARG A 178 29.674 109.770 57.909 1.00 48.25 A C ATOM 418 NH1 ARG A 178 30.466 109.604 56.857 1.00 48.99 A N ATOM 419 NH2 ARG A 178 29.741 110.895 58.613 1.00 47.98 A N ATOM 420 C ARG A 178 25.254 104.669 58.065 1.00 29.09 A C ATOM 421 O ARG A 178 24.642 105.327 58.902 1.00 28.32 A O ATOM 422 N ARG A 179 24.694 104.289 56.924 1.00 28.97 A N ATOM 423 CA ARG A 179 23.301 104.633 56.624 1.00 27.69 A C ATOM 424 CB ARG A 179 22.927 104.220 55.194 1.00 29.53 A C ATOM 425 CG ARG A 179 23.091 105.294 54.131 1.00 33.34 A C ATOM 426 CD ARG A 179 22.514 104.813 52.800 1.00 34.69 A C ATOM 427 NE ARG A 179 21.091 104.473 52.896 1.00 38.29 A N ATOM 428 CZ ARG A 179 20.103 105.367 52.916 1.00 39.89 A C ATOM 429 NH1 ARG A 179 20.377 106.665 52.842 1.00 41.81 A N ATOM 430 NH2 ARG A 179 18.840 104.966 53.011 1.00 39.44 A N ATOM 431 C ARG A 179 22.377 103.900 57.589 1.00 25.80 A C ATOM 432 O ARG A 179 21.421 104.465 58.121 1.00 24.65 A O ATOM 433 N GLU A 180 22.689 102.628 57.795 1.00 24.97 A N ATOM 434 CA GLU A 180 21.924 101.746 58.655 1.00 24.64 A C ATOM 435 CB GLU A 180 22.475 100.329 58.512 1.00 25.95 A C ATOM 436 CG GLU A 180 21.507 99.239 58.900 1.00 30.77 A C ATOM 437 CD GLU A 180 20.238 99.256 58.073 1.00 32.75 A C ATOM 438 OE1 GLU A 180 20.336 99.283 56.830 1.00 33.51 A O ATOM 439 OE2 GLU A 180 19.138 99.233 58.669 1.00 36.77 A O ATOM 440 C GLU A 180 21.962 102.206 60.110 1.00 24.56 A C ATOM 441 O GLU A 180 20.965 102.116 60.831 1.00 23.69 A O ATOM 442 N VAL A 181 23.109 102.715 60.541 1.00 23.97 A N ATOM 443 CA VAL A 181 23.235 103.191 61.905 1.00 25.68 A C ATOM 444 CB VAL A 181 24.709 103.469 62.244 1.00 24.65 A C ATOM 445 CG1 VAL A 181 24.806 104.314 63.499 1.00 21.02 A C ATOM 446 CG2 VAL A 181 25.440 102.142 62.440 1.00 23.99 A C ATOM 447 C VAL A 181 22.403 104.459 62.100 1.00 27.42 A C ATOM 448 O VAL A 181 21.771 104.653 63.144 1.00 28.13 A O ATOM 449 N GLU A 182 22.406 105.307 61.079 1.00 28.83 A N ATOM 450 CA GLU A 182 21.667 106.563 61.092 1.00 31.06 A C ATOM 451 CB GLU A 182 21.938 107.314 59.779 1.00 34.99 A C ATOM 452 CG GLU A 182 21.403 108.753 59.671 1.00 41.26 A C ATOM 453 CD GLU A 182 21.846 109.429 58.359 1.00 45.14 A C ATOM 454 OE1 GLU A 182 21.502 110.617 58.122 1.00 42.54 A O ATOM 455 OE2 GLU A 182 22.548 108.757 57.561 1.00 46.92 A O ATOM 456 C GLU A 182 20.182 106.239 61.235 1.00 29.45 A C ATOM 457 O GLU A 182 19.488 106.798 62.080 1.00 26.72 A O ATOM 458 N ILE A 183 19.717 105.306 60.412 1.00 28.76 A N ATOM 459 CA ILE A 183 18.323 104.890 60.411 1.00 28.45 A C ATOM 460 CB ILE A 183 18.055 103.892 59.265 1.00 28.73 A C ATOM 461 CG2 ILE A 183 16.618 103.413 59.318 1.00 28.72 A C ATOM 462 CG1 ILE A 183 18.344 104.554 57.916 1.00 27.67 A C ATOM 463 CD1 ILE A 183 18.250 103.605 56.728 1.00 26.58 A C ATOM 464 C ILE A 183 17.886 104.235 61.716 1.00 29.83 A C ATOM 465 O ILE A 183 16.870 104.605 62.302 1.00 27.93 A O ATOM 466 N GLN A 184 18.668 103.261 62.168 1.00 29.56 A N ATOM 467 CA GLN A 184 18.349 102.519 63.373 1.00 30.04 A C ATOM 468 CB GLN A 184 19.315 101.345 63.495 1.00 30.32 A C ATOM 469 CG GLN A 184 18.801 100.235 64.369 1.00 34.52 A C ATOM 470 CD GLN A 184 17.721 99.403 63.709 1.00 32.90 A C ATOM 471 OE1 GLN A 184 16.988 98.695 64.388 1.00 36.44 A O ATOM 472 NE2 GLN A 184 17.628 99.470 62.386 1.00 32.19 A N ATOM 473 C GLN A 184 18.335 103.318 64.679 1.00 31.00 A C ATOM 474 O GLN A 184 17.593 102.988 65.606 1.00 29.21 A O ATOM 475 N SER A 185 19.139 104.375 64.752 1.00 32.70 A N ATOM 476 CA SER A 185 19.219 105.179 65.968 1.00 33.38 A C ATOM 477 CB SER A 185 20.512 105.985 65.976 1.00 34.25 A C ATOM 478 OG SER A 185 20.460 107.001 64.996 1.00 35.32 A O ATOM 479 C SER A 185 18.051 106.134 66.192 1.00 34.71 A C ATOM 480 O SER A 185 17.989 106.797 67.221 1.00 34.82 A O ATOM 481 N HIS A 186 17.131 106.212 65.237 1.00 35.78 A N ATOM 482 CA HIS A 186 15.974 107.098 65.366 1.00 36.17 A C ATOM 483 CB HIS A 186 15.875 108.002 64.133 1.00 38.62 A C ATOM 484 CG HIS A 186 17.044 108.925 63.970 1.00 42.07 A C ATOM 485 CD2 HIS A 186 17.816 109.557 64.886 1.00 42.75 A C ATOM 486 ND1 HIS A 186 17.538 109.290 62.736 1.00 42.17 A N ATOM 487 CE1 HIS A 186 18.566 110.104 62.899 1.00 42.82 A C ATOM 488 NE2 HIS A 186 18.755 110.283 64.194 1.00 43.03 A N ATOM 489 C HIS A 186 14.673 106.310 65.545 1.00 35.02 A C ATOM 490 O HIS A 186 13.580 106.868 65.449 1.00 36.65 A O ATOM 491 N LEU A 187 14.796 105.011 65.793 1.00 31.62 A N ATOM 492 CA LEU A 187 13.631 104.161 65.994 1.00 29.84 A C ATOM 493 CB LEU A 187 13.791 102.828 65.253 1.00 28.15 A C ATOM 494 CG LEU A 187 13.577 102.778 63.743 1.00 28.01 A C ATOM 495 CD1 LEU A 187 14.398 103.855 63.066 1.00 31.70 A C ATOM 496 CD2 LEU A 187 13.973 101.410 63.226 1.00 25.23 A C ATOM 497 C LEU A 187 13.480 103.886 67.479 1.00 28.25 A C ATOM 498 O LEU A 187 14.397 103.359 68.110 1.00 28.90 A O ATOM 499 N ALA A 188 12.333 104.254 68.038 1.00 25.67 A N ATOM 500 CA ALA A 188 12.074 104.024 69.451 1.00 23.28 A C ATOM 501 CB ALA A 188 11.981 105.355 70.201 1.00 22.40 A C ATOM 502 C ALA A 188 10.782 103.241 69.612 1.00 21.56 A C ATOM 503 O ALA A 188 9.695 103.793 69.488 1.00 21.09 A O ATOM 504 N HIS A 189 10.906 101.944 69.859 1.00 21.04 A N ATOM 505 CA HIS A 189 9.736 101.088 70.048 1.00 22.71 A C ATOM 506 CB HIS A 189 9.299 100.458 68.720 1.00 22.11 A C ATOM 507 CG HIS A 189 7.961 99.784 68.774 1.00 23.56 A C ATOM 508 CD2 HIS A 189 7.621 98.494 69.014 1.00 23.56 A C ATOM 509 ND1 HIS A 189 6.775 100.456 68.562 1.00 26.00 A N ATOM 510 CE1 HIS A 189 5.765 99.612 68.666 1.00 23.68 A C ATOM 511 NE2 HIS A 189 6.251 98.414 68.941 1.00 25.80 A N ATOM 512 C HIS A 189 10.122 99.999 71.045 1.00 22.46 A C ATOM 513 O HIS A 189 11.254 99.509 71.041 1.00 22.66 A O ATOM 514 N PRO A 190 9.185 99.615 71.919 1.00 22.08 A N ATOM 515 CD PRO A 190 7.823 100.159 72.076 1.00 22.50 A C ATOM 516 CA PRO A 190 9.458 98.584 72.915 1.00 22.42 A C ATOM 517 CB PRO A 190 8.238 98.659 73.837 1.00 22.67 A C ATOM 518 CG PRO A 190 7.149 99.106 72.925 1.00 23.94 A C ATOM 519 C PRO A 190 9.688 97.190 72.341 1.00 23.17 A C ATOM 520 O PRO A 190 10.091 96.282 73.070 1.00 21.69 A O ATOM 521 N ASN A 191 9.445 97.015 71.043 1.00 21.27 A N ATOM 522 CA ASN A 191 9.657 95.711 70.422 1.00 19.49 A C ATOM 523 CB ASN A 191 8.361 95.170 69.831 1.00 19.45 A C ATOM 524 CG ASN A 191 7.320 94.880 70.884 1.00 19.61 A C ATOM 525 OD1 ASN A 191 7.495 93.995 71.715 1.00 22.06 A O ATOM 526 ND2 ASN A 191 6.227 95.628 70.855 1.00 20.03 A N ATOM 527 C ASN A 191 10.732 95.753 69.345 1.00 19.88 A C ATOM 528 O ASN A 191 10.813 94.857 68.497 1.00 19.36 A O ATOM 529 N ILE A 192 11.542 96.807 69.380 1.00 18.73 A N ATOM 530 CA ILE A 192 12.652 96.973 68.454 1.00 18.72 A C ATOM 531 CB ILE A 192 12.412 98.160 67.491 1.00 18.58 A C ATOM 532 CG2 ILE A 192 13.676 98.453 66.697 1.00 15.53 A C ATOM 533 CG1 ILE A 192 11.252 97.824 66.543 1.00 20.81 A C ATOM 534 CD1 ILE A 192 10.965 98.892 65.507 1.00 22.29 A C ATOM 535 C ILE A 192 13.904 97.224 69.300 1.00 19.43 A C ATOM 536 O ILE A 192 13.909 98.111 70.157 1.00 21.71 A O ATOM 537 N LEU A 193 14.957 96.441 69.075 1.00 18.98 A N ATOM 538 CA LEU A 193 16.188 96.588 69.860 1.00 20.69 A C ATOM 539 CB LEU A 193 17.214 95.514 69.467 1.00 19.99 A C ATOM 540 CG LEU A 193 18.234 95.145 70.558 1.00 21.41 A C ATOM 541 CD1 LEU A 193 17.560 94.248 71.601 1.00 18.84 A C ATOM 542 CD2 LEU A 193 19.431 94.424 69.942 1.00 20.29 A C ATOM 543 C LEU A 193 16.799 97.985 69.693 1.00 19.95 A C ATOM 544 O LEU A 193 17.020 98.455 68.578 1.00 21.40 A O ATOM 545 N ARG A 194 17.060 98.647 70.811 1.00 19.34 A N ATOM 546 CA ARG A 194 17.628 99.988 70.805 1.00 18.88 A C ATOM 547 CB ARG A 194 17.376 100.662 72.154 1.00 23.30 A C ATOM 548 CG ARG A 194 16.092 101.460 72.259 1.00 29.13 A C ATOM 549 CD ARG A 194 16.164 102.728 71.425 1.00 36.10 A C ATOM 550 NE ARG A 194 15.089 103.659 71.763 1.00 41.78 A N ATOM 551 CZ ARG A 194 14.999 104.308 72.922 1.00 44.56 A C ATOM 552 NH1 ARG A 194 15.925 104.131 73.860 1.00 45.72 A N ATOM 553 NH2 ARG A 194 13.983 105.132 73.147 1.00 45.18 A N ATOM 554 C ARG A 194 19.126 100.073 70.513 1.00 18.39 A C ATOM 555 O ARG A 194 19.919 99.292 71.031 1.00 15.95 A O ATOM 556 N LEU A 195 19.493 101.035 69.673 1.00 18.46 A N ATOM 557 CA LEU A 195 20.887 101.311 69.355 1.00 22.13 A C ATOM 558 CB LEU A 195 21.056 101.650 67.869 1.00 23.02 A C ATOM 559 CG LEU A 195 22.400 101.369 67.180 1.00 25.45 A C ATOM 560 CD1 LEU A 195 22.513 102.259 65.948 1.00 24.91 A C ATOM 561 CD2 LEU A 195 23.570 101.636 68.111 1.00 25.90 A C ATOM 562 C LEU A 195 21.116 102.573 70.196 1.00 22.63 A C ATOM 563 O LEU A 195 20.599 103.633 69.862 1.00 24.54 A O ATOM 564 N TYR A 196 21.851 102.456 71.294 1.00 22.66 A N ATOM 565 CA TYR A 196 22.095 103.605 72.168 1.00 23.33 A C ATOM 566 CB TYR A 196 22.619 103.141 73.534 1.00 22.65 A C ATOM 567 CG TYR A 196 21.702 102.221 74.310 1.00 21.37 A C ATOM 568 CD1 TYR A 196 22.190 101.040 74.879 1.00 22.83 A C ATOM 569 CE1 TYR A 196 21.387 100.235 75.677 1.00 22.12 A C ATOM 570 CD2 TYR A 196 20.379 102.565 74.551 1.00 22.29 A C ATOM 571 CE2 TYR A 196 19.561 101.765 75.348 1.00 23.98 A C ATOM 572 CZ TYR A 196 20.075 100.603 75.911 1.00 25.61 A C ATOM 573 OH TYR A 196 19.277 99.825 76.725 1.00 27.32 A O ATOM 574 C TYR A 196 23.088 104.603 71.574 1.00 23.97 A C ATOM 575 O TYR A 196 23.028 105.794 71.867 1.00 24.83 A O ATOM 576 N GLY A 197 24.008 104.114 70.750 1.00 25.27 A N ATOM 577 CA GLY A 197 24.985 104.999 70.141 1.00 23.65 A C ATOM 578 C GLY A 197 26.091 104.230 69.457 1.00 24.59 A C ATOM 579 O GLY A 197 25.990 103.019 69.276 1.00 24.07 A O ATOM 580 N TYR A 198 27.147 104.934 69.070 1.00 26.73 A N ATOM 581 CA TYR A 198 28.282 104.307 68.413 1.00 29.46 A C ATOM 582 CB TYR A 198 27.894 103.881 66.994 1.00 33.22 A C ATOM 583 CG TYR A 198 27.914 104.997 65.981 1.00 38.83 A C ATOM 584 CD1 TYR A 198 29.029 105.197 65.165 1.00 40.36 A C ATOM 585 CE1 TYR A 198 29.066 106.235 64.237 1.00 44.11 A C ATOM 586 CD2 TYR A 198 26.830 105.865 65.846 1.00 41.61 A C ATOM 587 CE2 TYR A 198 26.856 106.912 64.917 1.00 44.45 A C ATOM 588 CZ TYR A 198 27.978 107.088 64.118 1.00 45.02 A C ATOM 589 OH TYR A 198 28.016 108.112 63.195 1.00 48.52 A O ATOM 590 C TYR A 198 29.462 105.272 68.366 1.00 29.09 A C ATOM 591 O TYR A 198 29.286 106.475 68.477 1.00 28.17 A O ATOM 592 N PHE A 199 30.664 104.729 68.218 1.00 30.25 A N ATOM 593 CA PHE A 199 31.880 105.533 68.134 1.00 31.17 A C ATOM 594 CB PHE A 199 32.356 105.961 69.529 1.00 29.63 A C ATOM 595 CG PHE A 199 32.650 104.819 70.462 1.00 28.60 A C ATOM 596 CD1 PHE A 199 33.957 104.372 70.648 1.00 29.19 A C ATOM 597 CD2 PHE A 199 31.624 104.210 71.181 1.00 27.35 A C ATOM 598 CE1 PHE A 199 34.242 103.335 71.541 1.00 28.83 A C ATOM 599 CE2 PHE A 199 31.894 103.171 72.076 1.00 28.14 A C ATOM 600 CZ PHE A 199 33.208 102.732 72.258 1.00 28.52 A C ATOM 601 C PHE A 199 32.946 104.707 67.435 1.00 32.80 A C ATOM 602 O PHE A 199 32.689 103.574 67.032 1.00 31.66 A O ATOM 603 N HIS A 200 34.137 105.269 67.277 1.00 35.04 A N ATOM 604 CA HIS A 200 35.204 104.542 66.604 1.00 37.23 A C ATOM 605 CB HIS A 200 35.033 104.644 65.082 1.00 38.99 A C ATOM 606 CG HIS A 200 35.193 106.036 64.552 1.00 41.96 A C ATOM 607 CD2 HIS A 200 36.210 106.620 63.875 1.00 43.26 A C ATOM 608 ND1 HIS A 200 34.257 107.027 64.763 1.00 44.18 A N ATOM 609 CE1 HIS A 200 34.691 108.160 64.240 1.00 43.73 A C ATOM 610 NE2 HIS A 200 35.875 107.940 63.697 1.00 43.65 A N ATOM 611 C HIS A 200 36.570 105.083 66.987 1.00 36.48 A C ATOM 612 O HIS A 200 36.679 106.156 67.574 1.00 37.25 A O ATOM 613 N ASP A 201 37.607 104.315 66.673 1.00 36.48 A N ATOM 614 CA ASP A 201 38.981 104.730 66.930 1.00 35.68 A C ATOM 615 CB ASP A 201 39.662 103.861 68.007 1.00 34.18 A C ATOM 616 CG ASP A 201 39.533 102.371 67.745 1.00 33.78 A C ATOM 617 OD1 ASP A 201 39.597 101.946 66.574 1.00 33.96 A O ATOM 618 OD2 ASP A 201 39.386 101.616 68.731 1.00 35.77 A O ATOM 619 C ASP A 201 39.717 104.633 65.599 1.00 35.73 A C ATOM 620 O ASP A 201 39.136 104.924 64.556 1.00 36.16 A O ATOM 621 N ALA A 202 40.977 104.215 65.614 1.00 36.60 A N ATOM 622 CA ALA A 202 41.738 104.124 64.372 1.00 35.67 A C ATOM 623 CB ALA A 202 43.228 104.205 64.676 1.00 34.98 A C ATOM 624 C ALA A 202 41.444 102.881 63.530 1.00 36.02 A C ATOM 625 O ALA A 202 41.396 102.960 62.302 1.00 36.18 A O ATOM 626 N ALA A 203 41.234 101.741 64.182 1.00 35.91 A N ATOM 627 CA ALA A 203 40.983 100.499 63.455 1.00 35.99 A C ATOM 628 CB ALA A 203 42.056 99.474 63.822 1.00 35.92 A C ATOM 629 C ALA A 203 39.599 99.881 63.642 1.00 35.06 A C ATOM 630 O ALA A 203 39.167 99.058 62.833 1.00 35.70 A O ATOM 631 N ARG A 204 38.896 100.275 64.697 1.00 34.43 A N ATOM 632 CA ARG A 204 37.580 99.700 64.962 1.00 32.43 A C ATOM 633 CB ARG A 204 37.648 98.895 66.267 1.00 32.75 A C ATOM 634 CG ARG A 204 38.506 97.632 66.175 1.00 35.06 A C ATOM 635 CD ARG A 204 39.131 97.280 67.516 1.00 35.42 A C ATOM 636 NE ARG A 204 40.124 98.281 67.891 1.00 39.37 A N ATOM 637 CZ ARG A 204 40.829 98.271 69.020 1.00 39.97 A C ATOM 638 NH1 ARG A 204 40.664 97.303 69.915 1.00 41.24 A N ATOM 639 NH2 ARG A 204 41.691 99.249 69.259 1.00 42.09 A N ATOM 640 C ARG A 204 36.397 100.675 65.019 1.00 29.51 A C ATOM 641 O ARG A 204 36.563 101.873 65.235 1.00 27.71 A O ATOM 642 N VAL A 205 35.203 100.124 64.810 1.00 27.67 A N ATOM 643 CA VAL A 205 33.945 100.864 64.873 1.00 26.35 A C ATOM 644 CB VAL A 205 33.203 100.843 63.514 1.00 27.17 A C ATOM 645 CG1 VAL A 205 31.863 101.555 63.639 1.00 28.86 A C ATOM 646 CG2 VAL A 205 34.049 101.521 62.446 1.00 28.26 A C ATOM 647 C VAL A 205 33.103 100.127 65.919 1.00 24.01 A C ATOM 648 O VAL A 205 32.992 98.892 65.876 1.00 22.92 A O ATOM 649 N TYR A 206 32.516 100.868 66.852 1.00 22.11 A N ATOM 650 CA TYR A 206 31.723 100.254 67.919 1.00 21.58 A C ATOM 651 CB TYR A 206 32.341 100.574 69.286 1.00 24.51 A C ATOM 652 CG TYR A 206 33.832 100.308 69.398 1.00 28.74 A C ATOM 653 CD1 TYR A 206 34.768 101.282 69.043 1.00 30.43 A C ATOM 654 CE1 TYR A 206 36.148 101.040 69.156 1.00 33.31 A C ATOM 655 CD2 TYR A 206 34.304 99.084 69.862 1.00 30.70 A C ATOM 656 CE2 TYR A 206 35.672 98.832 69.974 1.00 33.27 A C ATOM 657 CZ TYR A 206 36.587 99.810 69.624 1.00 33.23 A C ATOM 658 OH TYR A 206 37.934 99.555 69.755 1.00 33.76 A O ATOM 659 C TYR A 206 30.245 100.650 67.964 1.00 20.45 A C ATOM 660 O TYR A 206 29.898 101.825 67.828 1.00 20.51 A O ATOM 661 N LEU A 207 29.385 99.659 68.179 1.00 19.23 A N ATOM 662 CA LEU A 207 27.943 99.883 68.290 1.00 20.53 A C ATOM 663 CB LEU A 207 27.183 99.001 67.288 1.00 21.53 A C ATOM 664 CG LEU A 207 27.574 99.160 65.814 1.00 21.15 A C ATOM 665 CD1 LEU A 207 26.675 98.309 64.950 1.00 23.10 A C ATOM 666 CD2 LEU A 207 27.462 100.624 65.412 1.00 23.96 A C ATOM 667 C LEU A 207 27.495 99.542 69.712 1.00 20.27 A C ATOM 668 O LEU A 207 27.760 98.443 70.204 1.00 22.20 A O ATOM 669 N ILE A 208 26.825 100.480 70.375 1.00 18.68 A N ATOM 670 CA ILE A 208 26.350 100.256 71.736 1.00 18.33 A C ATOM 671 CB ILE A 208 26.514 101.518 72.599 1.00 17.78 A C ATOM 672 CG2 ILE A 208 26.331 101.161 74.075 1.00 18.29 A C ATOM 673 CG1 ILE A 208 27.896 102.138 72.365 1.00 21.18 A C ATOM 674 CD1 ILE A 208 28.100 103.468 73.086 1.00 19.74 A C ATOM 675 C ILE A 208 24.864 99.895 71.650 1.00 19.02 A C ATOM 676 O ILE A 208 24.025 100.749 71.332 1.00 20.96 A O ATOM 677 N LEU A 209 24.554 98.639 71.963 1.00 18.23 A N ATOM 678 CA LEU A 209 23.200 98.100 71.868 1.00 17.67 A C ATOM 679 CB LEU A 209 23.216 96.893 70.941 1.00 17.32 A C ATOM 680 CG LEU A 209 23.871 97.022 69.564 1.00 19.38 A C ATOM 681 CD1 LEU A 209 24.381 95.647 69.117 1.00 20.09 A C ATOM 682 CD2 LEU A 209 22.877 97.587 68.571 1.00 19.54 A C ATOM 683 C LEU A 209 22.519 97.668 73.160 1.00 19.32 A C ATOM 684 O LEU A 209 23.169 97.322 74.149 1.00 18.62 A O ATOM 685 N GLU A 210 21.190 97.682 73.124 1.00 17.29 A N ATOM 686 CA GLU A 210 20.373 97.235 74.240 1.00 17.08 A C ATOM 687 CB GLU A 210 18.892 97.490 73.922 1.00 17.25 A C ATOM 688 CG GLU A 210 17.915 97.005 74.971 1.00 14.08 A C ATOM 689 CD GLU A 210 16.466 97.056 74.493 1.00 16.64 A C ATOM 690 OE1 GLU A 210 15.579 96.672 75.275 1.00 16.48 A O ATOM 691 OE2 GLU A 210 16.210 97.470 73.338 1.00 18.70 A O ATOM 692 C GLU A 210 20.625 95.724 74.369 1.00 17.70 A C ATOM 693 O GLU A 210 20.722 95.018 73.367 1.00 16.33 A O ATOM 694 N TYR A 211 20.737 95.230 75.596 1.00 18.29 A N ATOM 695 CA TYR A 211 20.992 93.811 75.817 1.00 18.22 A C ATOM 696 CB TYR A 211 21.889 93.644 77.045 1.00 21.03 A C ATOM 697 CG TYR A 211 22.150 92.216 77.474 1.00 21.77 A C ATOM 698 CD1 TYR A 211 22.898 91.347 76.681 1.00 22.50 A C ATOM 699 CE1 TYR A 211 23.160 90.036 77.103 1.00 23.40 A C ATOM 700 CD2 TYR A 211 21.671 91.743 78.696 1.00 22.56 A C ATOM 701 CE2 TYR A 211 21.928 90.443 79.124 1.00 21.84 A C ATOM 702 CZ TYR A 211 22.666 89.598 78.328 1.00 22.93 A C ATOM 703 OH TYR A 211 22.902 88.314 78.757 1.00 24.56 A O ATOM 704 C TYR A 211 19.704 93.011 75.996 1.00 17.77 A C ATOM 705 O TYR A 211 18.791 93.444 76.694 1.00 16.95 A O ATOM 706 N ALA A 212 19.642 91.845 75.353 1.00 18.77 A N ATOM 707 CA ALA A 212 18.477 90.952 75.439 1.00 18.90 A C ATOM 708 CB ALA A 212 18.090 90.485 74.040 1.00 16.75 A C ATOM 709 C ALA A 212 18.873 89.755 76.325 1.00 19.85 A C ATOM 710 O ALA A 212 19.551 88.837 75.872 1.00 20.40 A O ATOM 711 N PRO A 213 18.444 89.757 77.602 1.00 21.83 A N ATOM 712 CD PRO A 213 17.600 90.806 78.190 1.00 22.17 A C ATOM 713 CA PRO A 213 18.727 88.726 78.609 1.00 22.10 A C ATOM 714 CB PRO A 213 18.026 89.258 79.865 1.00 23.45 A C ATOM 715 CG PRO A 213 17.976 90.713 79.651 1.00 24.12 A C ATOM 716 C PRO A 213 18.318 87.295 78.320 1.00 22.31 A C ATOM 717 O PRO A 213 19.019 86.360 78.703 1.00 22.54 A O ATOM 718 N LEU A 214 17.184 87.111 77.656 1.00 22.59 A N ATOM 719 CA LEU A 214 16.715 85.765 77.375 1.00 20.79 A C ATOM 720 CB LEU A 214 15.181 85.716 77.499 1.00 21.06 A C ATOM 721 CG LEU A 214 14.680 85.611 78.950 1.00 22.27 A C ATOM 722 CD1 LEU A 214 15.249 86.752 79.769 1.00 25.21 A C ATOM 723 CD2 LEU A 214 13.160 85.633 79.001 1.00 21.90 A C ATOM 724 C LEU A 214 17.189 85.117 76.075 1.00 20.41 A C ATOM 725 O LEU A 214 16.846 83.975 75.805 1.00 21.99 A O ATOM 726 N GLY A 215 17.986 85.823 75.276 1.00 20.34 A N ATOM 727 CA GLY A 215 18.503 85.227 74.047 1.00 22.43 A C ATOM 728 C GLY A 215 17.611 85.190 72.813 1.00 21.59 A C ATOM 729 O GLY A 215 16.679 85.976 72.696 1.00 23.24 A O ATOM 730 N THR A 216 17.892 84.273 71.889 1.00 22.02 A N ATOM 731 CA THR A 216 17.112 84.172 70.652 1.00 23.73 A C ATOM 732 CB THR A 216 17.960 83.626 69.487 1.00 24.78 A C ATOM 733 OG1 THR A 216 18.233 82.238 69.706 1.00 25.51 A O ATOM 734 CG2 THR A 216 19.270 84.397 69.369 1.00 25.01 A C ATOM 735 C THR A 216 15.851 83.314 70.720 1.00 23.31 A C ATOM 736 O THR A 216 15.750 82.382 71.513 1.00 21.80 A O ATOM 737 N VAL A 217 14.886 83.645 69.867 1.00 25.09 A N ATOM 738 CA VAL A 217 13.626 82.904 69.797 1.00 25.79 A C ATOM 739 CB VAL A 217 12.604 83.633 68.902 1.00 23.02 A C ATOM 740 CG1 VAL A 217 11.368 82.773 68.703 1.00 24.17 A C ATOM 741 CG2 VAL A 217 12.234 84.961 69.533 1.00 22.94 A C ATOM 742 C VAL A 217 13.921 81.530 69.196 1.00 26.14 A C ATOM 743 O VAL A 217 13.278 80.534 69.525 1.00 25.55 A O ATOM 744 N TYR A 218 14.909 81.501 68.314 1.00 26.45 A N ATOM 745 CA TYR A 218 15.327 80.283 67.655 1.00 30.04 A C ATOM 746 CB TYR A 218 16.464 80.624 66.690 1.00 34.58 A C ATOM 747 CG TYR A 218 17.201 79.443 66.113 1.00 40.28 A C ATOM 748 CD1 TYR A 218 18.240 78.834 66.818 1.00 43.24 A C ATOM 749 CE1 TYR A 218 18.945 77.765 66.277 1.00 44.89 A C ATOM 750 CD2 TYR A 218 16.882 78.949 64.854 1.00 42.24 A C ATOM 751 CE2 TYR A 218 17.579 77.879 64.304 1.00 44.73 A C ATOM 752 CZ TYR A 218 18.608 77.292 65.019 1.00 46.29 A C ATOM 753 OH TYR A 218 19.304 76.235 64.475 1.00 48.71 A O ATOM 754 C TYR A 218 15.759 79.241 68.684 1.00 30.04 A C ATOM 755 O TYR A 218 15.383 78.075 68.607 1.00 29.65 A O ATOM 756 N ARG A 219 16.534 79.675 69.668 1.00 31.08 A N ATOM 757 CA ARG A 219 17.011 78.778 70.702 1.00 30.24 A C ATOM 758 CB ARG A 219 18.047 79.502 71.555 1.00 34.57 A C ATOM 759 CG ARG A 219 18.660 78.657 72.634 1.00 39.81 A C ATOM 760 CD ARG A 219 19.723 79.443 73.374 1.00 45.90 A C ATOM 761 NE ARG A 219 20.255 78.683 74.501 1.00 51.60 A N ATOM 762 CZ ARG A 219 21.250 79.097 75.276 1.00 52.82 A C ATOM 763 NH1 ARG A 219 21.826 80.273 75.041 1.00 53.30 A N ATOM 764 NH2 ARG A 219 21.658 78.338 76.289 1.00 53.23 A N ATOM 765 C ARG A 219 15.855 78.267 71.556 1.00 29.44 A C ATOM 766 O ARG A 219 15.829 77.101 71.941 1.00 28.48 A O ATOM 767 N GLU A 220 14.892 79.138 71.840 1.00 29.18 A N ATOM 768 CA GLU A 220 13.721 78.765 72.627 1.00 29.90 A C ATOM 769 CB GLU A 220 12.873 80.011 72.924 1.00 30.93 A C ATOM 770 CG GLU A 220 11.570 79.737 73.653 1.00 35.19 A C ATOM 771 CD GLU A 220 10.684 80.975 73.765 1.00 38.55 A C ATOM 772 OE1 GLU A 220 10.619 81.754 72.789 1.00 41.41 A O ATOM 773 OE2 GLU A 220 10.036 81.165 74.816 1.00 38.75 A O ATOM 774 C GLU A 220 12.890 77.730 71.852 1.00 29.28 A C ATOM 775 O GLU A 220 12.319 76.813 72.434 1.00 29.27 A O ATOM 776 N LEU A 221 12.846 77.882 70.533 1.00 29.01 A N ATOM 777 CA LEU A 221 12.096 76.981 69.661 1.00 29.41 A C ATOM 778 CB LEU A 221 12.087 77.547 68.234 1.00 29.75 A C ATOM 779 CG LEU A 221 11.135 76.947 67.198 1.00 27.34 A C ATOM 780 CD1 LEU A 221 9.691 77.040 67.681 1.00 26.36 A C ATOM 781 CD2 LEU A 221 11.298 77.707 65.902 1.00 28.29 A C ATOM 782 C LEU A 221 12.691 75.570 69.655 1.00 31.02 A C ATOM 783 O LEU A 221 11.958 74.579 69.659 1.00 30.54 A O ATOM 784 N GLN A 222 14.022 75.487 69.636 1.00 32.15 A N ATOM 785 CA GLN A 222 14.718 74.204 69.644 1.00 33.38 A C ATOM 786 CB GLN A 222 16.224 74.405 69.478 1.00 36.12 A C ATOM 787 CG GLN A 222 16.624 75.120 68.206 1.00 40.81 A C ATOM 788 CD GLN A 222 18.126 75.279 68.092 1.00 44.96 A C ATOM 789 OE1 GLN A 222 18.787 75.722 69.033 1.00 46.46 A O ATOM 790 NE2 GLN A 222 18.675 74.924 66.933 1.00 47.81 A N ATOM 791 C GLN A 222 14.467 73.437 70.937 1.00 33.08 A C ATOM 792 O GLN A 222 14.435 72.212 70.933 1.00 33.65 A O ATOM 793 N LYS A 223 14.288 74.160 72.038 1.00 32.99 A N ATOM 794 CA LYS A 223 14.045 73.539 73.336 1.00 32.56 A C ATOM 795 CB LYS A 223 14.314 74.541 74.464 1.00 35.07 A C ATOM 796 CG LYS A 223 15.780 74.660 74.873 1.00 38.94 A C ATOM 797 CD LYS A 223 16.682 74.938 73.680 1.00 42.58 A C ATOM 798 CE LYS A 223 18.143 75.049 74.084 1.00 45.75 A C ATOM 799 NZ LYS A 223 19.012 75.377 72.910 1.00 47.32 A N ATOM 800 C LYS A 223 12.629 72.992 73.480 1.00 31.92 A C ATOM 801 O LYS A 223 12.444 71.840 73.869 1.00 31.63 A O ATOM 802 N LEU A 224 11.635 73.815 73.159 1.00 29.58 A N ATOM 803 CA LEU A 224 10.235 73.413 73.272 1.00 27.04 A C ATOM 804 CB LEU A 224 9.355 74.651 73.488 1.00 27.41 A C ATOM 805 CG LEU A 224 9.626 75.554 74.703 1.00 26.07 A C ATOM 806 CD1 LEU A 224 8.545 76.626 74.805 1.00 23.48 A C ATOM 807 CD2 LEU A 224 9.632 74.717 75.968 1.00 26.95 A C ATOM 808 C LEU A 224 9.698 72.613 72.080 1.00 26.87 A C ATOM 809 O LEU A 224 8.653 71.977 72.187 1.00 27.46 A O ATOM 810 N SER A 225 10.410 72.650 70.954 1.00 26.55 A N ATOM 811 CA SER A 225 10.009 71.944 69.730 1.00 28.34 A C ATOM 812 CB SER A 225 9.473 70.549 70.062 1.00 30.23 A C ATOM 813 OG SER A 225 9.605 69.698 68.941 1.00 33.93 A O ATOM 814 C SER A 225 8.964 72.732 68.920 1.00 26.55 A C ATOM 815 O SER A 225 9.046 72.810 67.697 1.00 26.63 A O ATOM 816 N LYS A 226 7.977 73.296 69.607 1.00 25.84 A N ATOM 817 CA LYS A 226 6.958 74.129 68.976 1.00 25.88 A C ATOM 818 CB LYS A 226 6.012 73.304 68.087 1.00 28.21 A C ATOM 819 CG LYS A 226 5.184 72.259 68.790 1.00 28.88 A C ATOM 820 CD LYS A 226 4.409 71.443 67.770 1.00 34.11 A C ATOM 821 CE LYS A 226 3.483 70.427 68.435 1.00 34.70 A C ATOM 822 NZ LYS A 226 4.240 69.444 69.261 1.00 37.81 A N ATOM 823 C LYS A 226 6.191 74.851 70.073 1.00 25.27 A C ATOM 824 O LYS A 226 6.124 74.373 71.202 1.00 26.71 A O ATOM 825 N PHE A 227 5.637 76.016 69.749 1.00 24.65 A N ATOM 826 CA PHE A 227 4.891 76.808 70.722 1.00 22.54 A C ATOM 827 CB PHE A 227 5.085 78.312 70.463 1.00 23.44 A C ATOM 828 CG PHE A 227 6.527 78.753 70.359 1.00 20.95 A C ATOM 829 CD1 PHE A 227 7.523 78.135 71.106 1.00 21.88 A C ATOM 830 CD2 PHE A 227 6.868 79.847 69.561 1.00 19.95 A C ATOM 831 CE1 PHE A 227 8.850 78.606 71.065 1.00 23.78 A C ATOM 832 CE2 PHE A 227 8.183 80.326 69.511 1.00 21.33 A C ATOM 833 CZ PHE A 227 9.176 79.706 70.265 1.00 21.20 A C ATOM 834 C PHE A 227 3.397 76.514 70.673 1.00 22.04 A C ATOM 835 O PHE A 227 2.882 76.035 69.660 1.00 21.17 A O ATOM 836 N ASP A 228 2.707 76.813 71.768 1.00 19.93 A N ATOM 837 CA ASP A 228 1.269 76.617 71.842 1.00 21.17 A C ATOM 838 CB ASP A 228 0.840 76.388 73.294 1.00 22.28 A C ATOM 839 CG ASP A 228 1.204 77.547 74.203 1.00 24.14 A C ATOM 840 OD1 ASP A 228 1.715 77.288 75.307 1.00 25.83 A O ATOM 841 OD2 ASP A 228 0.968 78.718 73.829 1.00 24.66 A O ATOM 842 C ASP A 228 0.607 77.876 71.259 1.00 21.29 A C ATOM 843 O ASP A 228 1.287 78.878 70.977 1.00 20.58 A O ATOM 844 N GLU A 229 −0.707 77.829 71.086 1.00 19.93 A N ATOM 845 CA GLU A 229 −1.441 78.947 70.498 1.00 20.43 A C ATOM 846 CB GLU A 229 −2.919 78.586 70.333 1.00 22.25 A C ATOM 847 CG GLU A 229 −3.177 77.435 69.383 1.00 22.96 A C ATOM 848 CD GLU A 229 −4.657 77.151 69.227 1.00 23.72 A C ATOM 849 OE1 GLU A 229 −5.276 76.655 70.185 1.00 27.47 A O ATOM 850 OE2 GLU A 229 −5.203 77.437 68.152 1.00 23.78 A O ATOM 851 C GLU A 229 −1.330 80.270 71.237 1.00 20.15 A C ATOM 852 O GLU A 229 −1.247 81.320 70.598 1.00 19.16 A O ATOM 853 N GLN A 230 −1.337 80.238 72.569 1.00 17.98 A N ATOM 854 CA GLN A 230 −1.233 81.480 73.319 1.00 17.46 A C ATOM 855 CB GLN A 230 −1.412 81.246 74.833 1.00 16.42 A C ATOM 856 CG GLN A 230 −1.448 82.560 75.641 1.00 18.34 A C ATOM 857 CD GLN A 230 −1.683 82.377 77.140 1.00 18.98 A C ATOM 858 OE1 GLN A 230 −0.744 82.430 77.933 1.00 21.19 A O ATOM 859 NE2 GLN A 230 −2.932 82.167 77.529 1.00 16.82 A N ATOM 860 C GLN A 230 0.107 82.173 73.040 1.00 16.75 A C ATOM 861 O GLN A 230 0.136 83.359 72.679 1.00 17.29 A O ATOM 862 N ARG A 231 1.210 81.443 73.179 1.00 14.85 A N ATOM 863 CA ARG A 231 2.519 82.045 72.939 1.00 16.59 A C ATOM 864 CB ARG A 231 3.657 81.051 73.227 1.00 18.36 A C ATOM 865 CG ARG A 231 5.042 81.728 73.190 1.00 22.57 A C ATOM 866 CD ARG A 231 6.185 80.747 73.258 1.00 27.11 A C ATOM 867 NE ARG A 231 6.191 79.991 74.503 1.00 33.40 A N ATOM 868 CZ ARG A 231 6.654 80.446 75.664 1.00 35.76 A C ATOM 869 NH1 ARG A 231 6.605 79.675 76.738 1.00 36.21 A N ATOM 870 NH2 ARG A 231 7.176 81.660 75.752 1.00 38.74 A N ATOM 871 C ARG A 231 2.671 82.581 71.513 1.00 14.93 A C ATOM 872 O ARG A 231 3.151 83.700 71.311 1.00 14.16 A O ATOM 873 N THR A 232 2.276 81.776 70.531 1.00 15.57 A N ATOM 874 CA THR A 232 2.366 82.160 69.121 1.00 17.08 A C ATOM 875 CB THR A 232 1.859 81.030 68.188 1.00 18.02 A C ATOM 876 OG1 THR A 232 2.656 79.856 68.382 1.00 18.40 A O ATOM 877 CG2 THR A 232 1.953 81.451 66.718 1.00 15.83 A C ATOM 878 C THR A 232 1.553 83.420 68.821 1.00 17.13 A C ATOM 879 O THR A 232 2.061 84.359 68.204 1.00 18.70 A O ATOM 880 N ALA A 233 0.296 83.433 69.258 1.00 16.14 A N ATOM 881 CA ALA A 233 −0.590 84.568 69.025 1.00 16.30 A C ATOM 882 CB ALA A 233 −1.982 84.246 69.529 1.00 16.62 A C ATOM 883 C ALA A 233 −0.076 85.846 69.687 1.00 17.07 A C ATOM 884 O ALA A 233 −0.259 86.944 69.166 1.00 16.10 A O ATOM 885 N THR A 234 0.552 85.699 70.849 1.00 17.52 A N ATOM 886 CA THR A 234 1.092 86.845 71.552 1.00 16.78 A C ATOM 887 CB THR A 234 1.494 86.467 73.014 1.00 17.54 A C ATOM 888 OG1 THR A 234 0.314 86.125 73.759 1.00 12.72 A O ATOM 889 CG2 THR A 234 2.184 87.633 73.706 1.00 17.21 A C ATOM 890 C THR A 234 2.297 87.362 70.766 1.00 16.02 A C ATOM 891 O THR A 234 2.471 88.564 70.621 1.00 18.24 A O ATOM 892 N TYR A 235 3.116 86.459 70.239 1.00 15.74 A N ATOM 893 CA TYR A 235 4.275 86.879 69.456 1.00 18.00 A C ATOM 894 CB TYR A 235 5.180 85.694 69.117 1.00 18.40 A C ATOM 895 CG TYR A 235 6.016 85.167 70.264 1.00 22.59 A C ATOM 896 CD1 TYR A 235 6.142 85.880 71.459 1.00 19.60 A C ATOM 897 CE1 TYR A 235 6.943 85.413 72.490 1.00 23.79 A C ATOM 898 CD2 TYR A 235 6.718 83.968 70.133 1.00 22.03 A C ATOM 899 CE2 TYR A 235 7.530 83.492 71.158 1.00 25.06 A C ATOM 900 CZ TYR A 235 7.639 84.217 72.331 1.00 24.79 A C ATOM 901 OH TYR A 235 8.449 83.748 73.332 1.00 27.52 A O ATOM 902 C TYR A 235 3.882 87.574 68.148 1.00 17.48 A C ATOM 903 O TYR A 235 4.498 88.570 67.760 1.00 18.14 A O ATOM 904 N ILE A 236 2.869 87.050 67.463 1.00 15.10 A N ATOM 905 CA ILE A 236 2.443 87.655 66.207 1.00 15.95 A C ATOM 906 CB ILE A 236 1.374 86.784 65.505 1.00 15.91 A C ATOM 907 CG2 ILE A 236 0.944 87.425 64.184 1.00 14.22 A C ATOM 908 CG1 ILE A 236 1.950 85.393 65.225 1.00 13.58 A C ATOM 909 CD1 ILE A 236 3.140 85.396 64.289 1.00 15.33 A C ATOM 910 C ILE A 236 1.905 89.070 66.425 1.00 16.93 A C ATOM 911 O ILE A 236 2.064 89.935 65.560 1.00 16.24 A O ATOM 912 N THR A 237 1.281 89.301 67.584 1.00 18.11 A N ATOM 913 CA THR A 237 0.727 90.613 67.937 1.00 19.28 A C ATOM 914 CB THR A 237 −0.107 90.545 69.255 1.00 22.99 A C ATOM 915 OG1 THR A 237 −1.306 89.787 69.035 1.00 23.64 A O ATOM 916 CG2 THR A 237 −0.470 91.953 69.741 1.00 21.39 A C ATOM 917 C THR A 237 1.863 91.610 68.152 1.00 19.31 A C ATOM 918 O THR A 237 1.787 92.763 67.726 1.00 20.31 A O ATOM 919 N GLU A 238 2.912 91.164 68.836 1.00 18.54 A N ATOM 920 CA GLU A 238 4.063 92.011 69.097 1.00 18.15 A C ATOM 921 CB GLU A 238 5.052 91.280 70.025 1.00 20.31 A C ATOM 922 CG GLU A 238 4.684 91.396 71.511 1.00 23.11 A C ATOM 923 CD1 GLU A 238 5.394 90.392 72.410 1.00 24.67 A C ATOM 924 OE1 GLU A 238 6.516 89.946 72.079 1.00 24.03 A O ATOM 925 OE2 GLU A 238 4.825 90.057 73.473 1.00 28.40 A O ATOM 926 C GLU A 238 4.746 92.432 67.794 1.00 17.67 A C ATOM 927 O GLU A 238 5.101 93.601 67.629 1.00 16.64 A O ATOM 928 N LEU A 239 4.917 91.487 66.869 1.00 18.93 A N ATOM 929 CA LEU A 239 5.555 91.769 65.573 1.00 19.50 A C ATOM 930 CB LEU A 239 5.822 90.469 64.813 1.00 18.18 A C ATOM 931 CG LEU A 239 6.841 89.501 65.407 1.00 23.44 A C ATOM 932 CD1 LEU A 239 6.766 88.159 64.674 1.00 22.23 A C ATOM 933 CD2 LEU A 239 8.236 90.107 65.314 1.00 21.26 A C ATOM 934 C LEU A 239 4.727 92.703 64.675 1.00 19.61 A C ATOM 935 O LEU A 239 5.279 93.583 64.024 1.00 17.80 A O ATOM 936 N ALA A 240 3.412 92.502 64.631 1.00 18.94 A N ATOM 937 CA ALA A 240 2.548 93.351 63.802 1.00 19.51 A C ATOM 938 CB ALA A 240 1.079 92.853 63.841 1.00 18.09 A C ATOM 939 C ALA A 240 2.633 94.787 64.288 1.00 18.99 A C ATOM 940 O ALA A 240 2.721 95.706 63.482 1.00 22.48 A O ATOM 941 N ASN A 241 2.610 94.992 65.603 1.00 21.18 A N ATOM 942 CA ASN A 241 2.736 96.347 66.135 1.00 21.65 A C ATOM 943 CB ASN A 241 2.687 96.365 67.663 1.00 23.20 A C ATOM 944 CG ASN A 241 1.299 96.153 68.203 1.00 24.44 A C ATOM 945 OD1 ASN A 241 0.325 96.621 67.626 1.00 27.47 A O ATOM 946 ND2 ASN A 241 1.198 95.462 69.326 1.00 27.36 A N ATOM 947 C ASN A 241 4.069 96.935 65.685 1.00 22.55 A C ATOM 948 O ASN A 241 4.111 98.035 65.129 1.00 24.99 A O ATOM 949 N ALA A 242 5.159 96.200 65.909 1.00 21.61 A N ATOM 950 CA ALA A 242 6.483 96.684 65.525 1.00 20.55 A C ATOM 951 CB ALA A 242 7.557 95.687 65.959 1.00 20.38 A C ATOM 952 C ALA A 242 6.607 96.967 64.026 1.00 21.10 A C ATOM 953 O ALA A 242 7.207 97.969 63.627 1.00 20.03 A O ATOM 954 N LEU A 243 6.050 96.088 63.195 1.00 21.54 A N ATOM 955 CA LEU A 243 6.111 96.281 61.742 1.00 23.33 A C ATOM 956 CB LEU A 243 5.617 95.029 61.014 1.00 21.31 A C ATOM 957 CG LEU A 243 6.556 93.828 61.128 1.00 21.88 A C ATOM 958 CD1 LEU A 243 5.843 92.565 60.657 1.00 20.10 A C ATOM 959 CD2 LEU A 243 7.802 94.085 60.305 1.00 18.75 A C ATOM 960 C LEU A 243 5.284 97.489 61.306 1.00 23.69 A C ATOM 961 O LEU A 243 5.627 98.171 60.344 1.00 22.16 A O ATOM 962 N SER A 244 4.191 97.741 62.021 1.00 25.47 A N ATOM 963 CA SER A 244 3.315 98.872 61.724 1.00 27.54 A C ATOM 964 CB SER A 244 2.053 98.784 62.584 1.00 28.75 A C ATOM 965 OG SER A 244 1.177 99.856 62.312 1.00 33.33 A O ATOM 966 C SER A 244 4.053 100.190 61.992 1.00 27.13 A C ATOM 967 O SER A 244 3.987 101.131 61.197 1.00 25.34 A O ATOM 968 N TYR A 245 4.757 100.253 63.117 1.00 27.39 A N ATOM 969 CA TYR A 245 5.518 101.444 63.455 1.00 26.91 A C ATOM 970 CB TYR A 245 6.122 101.303 64.862 1.00 26.66 A C ATOM 971 CG TYR A 245 7.181 102.328 65.192 1.00 26.43 A C ATOM 972 CD1 TYR A 245 8.530 102.058 64.966 1.00 26.18 A C ATOM 973 CE1 TYR A 245 9.517 103.008 65.248 1.00 27.41 A C ATOM 974 CD2 TYR A 245 6.836 103.580 65.709 1.00 28.15 A C ATOM 975 CE2 TYR A 245 7.815 104.539 65.994 1.00 27.61 A C ATOM 976 CZ TYR A 245 9.153 104.243 65.762 1.00 28.05 A C ATOM 977 OH TYR A 245 10.130 105.171 66.056 1.00 29.74 A O ATOM 978 C TYR A 245 6.612 101.653 62.402 1.00 26.52 A C ATOM 979 O TYR A 245 6.864 102.780 61.975 1.00 28.22 A O ATOM 980 N CYS A 246 7.254 100.573 61.970 1.00 26.10 A N ATOM 981 CA CYS A 246 8.305 100.683 60.957 1.00 27.26 A C ATOM 982 CB CYS A 246 8.973 99.320 60.703 1.00 25.76 A C ATOM 983 SG CYS A 246 10.111 98.729 62.011 1.00 25.61 A S ATOM 984 C CYS A 246 7.766 101.234 59.630 1.00 28.04 A C ATOM 985 O CYS A 246 8.357 102.139 59.041 1.00 28.18 A O ATOM 986 N HIS A 247 6.649 100.685 59.159 1.00 28.72 A N ATOM 987 CA HIS A 247 6.063 101.135 57.900 1.00 28.83 A C ATOM 988 CB HIS A 247 4.807 100.321 57.565 1.00 27.01 A C ATOM 989 CG HIS A 247 5.100 98.935 57.074 1.00 28.45 A C ATOM 990 CD2 HIS A 247 6.274 98.296 56.851 1.00 29.49 A C ATOM 991 ND1 HIS A 247 4.108 98.032 56.751 1.00 28.49 A N ATOM 992 CE1 HIS A 247 4.658 96.898 56.354 1.00 27.81 A C ATOM 993 NE2 HIS A 247 5.971 97.032 56.404 1.00 27.61 A N ATOM 994 C HIS A 247 5.757 102.627 57.921 1.00 28.03 A C ATOM 995 O HIS A 247 5.962 103.312 56.926 1.00 27.03 A O ATOM 996 N SER A 248 5.289 103.135 59.055 1.00 29.96 A N ATOM 997 CA SER A 248 4.996 104.568 59.172 1.00 31.71 A C ATOM 998 CB SER A 248 4.209 104.862 60.460 1.00 31.45 A C ATOM 999 OG SER A 248 4.988 104.617 61.622 1.00 32.11 A O ATOM 1000 C SER A 248 6.296 105.381 59.167 1.00 32.32 A C ATOM 1001 O SER A 248 6.276 106.604 59.039 1.00 33.26 A O ATOM 1002 N LYS A 249 7.426 104.694 59.310 1.00 33.45 A N ATOM 1003 CA LYS A 249 8.727 105.351 59.312 1.00 34.06 A C ATOM 1004 CB LYS A 249 9.572 104.883 60.506 1.00 35.23 A C ATOM 1005 CG LYS A 249 9.108 105.420 61.849 1.00 36.16 A C ATOM 1006 CD LYS A 249 9.142 106.947 61.870 1.00 38.50 A C ATOM 1007 CE LYS A 249 8.754 107.506 63.231 1.00 39.69 A C ATOM 1008 NZ LYS A 249 7.384 107.080 63.656 1.00 42.72 A N ATOM 1009 C LYS A 249 9.457 105.048 58.012 1.00 34.43 A C ATOM 1010 O LYS A 249 10.640 105.364 57.861 1.00 32.18 A O ATOM 1011 N ARG A 250 8.738 104.430 57.078 1.00 35.69 A N ATOM 1012 CA ARG A 250 9.288 104.081 55.778 1.00 37.56 A C ATOM 1013 CB ARG A 250 9.696 105.359 55.038 1.00 39.76 A C ATOM 1014 CG ARG A 250 8.501 106.132 54.453 1.00 41.59 A C ATOM 1015 CD ARG A 250 8.894 107.524 53.945 1.00 45.10 A C ATOM 1016 NE ARG A 250 8.232 107.855 52.679 1.00 47.20 A N ATOM 1017 CZ ARG A 250 8.713 107.536 51.478 1.00 47.18 A C ATOM 1018 NH1 ARG A 250 9.865 106.884 51.374 1.00 46.33 A N ATOM 1019 NH2 ARG A 250 8.042 107.863 50.381 1.00 45.77 A N ATOM 1020 C ARG A 250 10.465 103.118 55.890 1.00 39.53 A C ATOM 1021 O ARG A 250 11.451 103.225 55.162 1.00 38.88 A O ATOM 1022 N VAL A 251 10.348 102.169 56.813 1.00 41.36 A N ATOM 1023 CA VAL A 251 11.384 101.171 57.031 1.00 43.61 A C ATOM 1024 CB VAL A 251 11.846 101.171 58.500 1.00 43.34 A C ATOM 1025 CG1 VAL A 251 12.834 100.031 58.745 1.00 42.55 A C ATOM 1026 CG2 VAL A 251 12.479 102.512 58.834 1.00 41.90 A C ATOM 1027 C VAL A 251 10.864 99.782 56.672 1.00 45.77 A C ATOM 1028 O VAL A 251 9.773 99.393 57.087 1.00 45.19 A O ATOM 1029 N ILE A 252 11.013 98.979 55.608 1.00 48.92 A N ATOM 1030 CA ILE A 252 10.490 97.678 55.184 1.00 51.87 A C ATOM 1031 CB ILE A 252 10.035 97.701 53.702 1.00 51.65 A C ATOM 1032 CG2 ILE A 252 9.532 96.322 53.292 1.00 52.57 A C ATOM 1033 CG1 ILE A 252 8.929 98.741 53.511 1.00 50.23 A C ATOM 1034 CD1 ILE A 252 9.375 100.169 53.722 1.00 48.71 A C ATOM 1035 C ILE A 252 11.630 96.682 55.358 1.00 53.81 A C ATOM 1036 O ILE A 252 12.743 96.924 54.895 1.00 53.23 A O ATOM 1037 N HIS A 253 11.359 95.564 56.019 1.00 57.15 A N ATOM 1038 CA HIS A 253 12.415 94.593 56.281 1.00 60.73 A C ATOM 1039 CB HIS A 253 12.150 93.878 57.606 1.00 61.57 A C ATOM 1040 CG HIS A 253 12.383 94.743 58.805 1.00 63.18 A C ATOM 1041 CD2 HIS A 253 11.736 94.819 59.992 1.00 62.71 A C ATOM 1042 ND1 HIS A 253 13.419 95.651 58.873 1.00 63.35 A N ATOM 1043 CE1 HIS A 253 13.400 96.248 60.051 1.00 63.74 A C ATOM 1044 NE2 HIS A 253 12.389 95.762 60.749 1.00 63.77 A N ATOM 1045 C HIS A 253 12.749 93.565 55.217 1.00 62.30 A C ATOM 1046 O HIS A 253 13.885 93.514 54.744 1.00 61.97 A O ATOM 1047 N ARG A 254 11.774 92.742 54.849 1.00 64.77 A N ATOM 1048 CA ARG A 254 12.004 91.700 53.855 1.00 66.63 A C ATOM 1049 CB ARG A 254 12.719 92.304 52.639 1.00 67.76 A C ATOM 1050 CG ARG A 254 11.948 93.473 52.021 1.00 69.83 A C ATOM 1051 CD ARG A 254 12.846 94.466 51.288 1.00 71.13 A C ATOM 1052 NE ARG A 254 13.615 93.863 50.203 1.00 71.83 A N ATOM 1053 CZ ARG A 254 14.438 94.543 49.410 1.00 72.27 A C ATOM 1054 NH1 ARG A 254 14.596 95.850 49.580 1.00 72.84 A N ATOM 1055 NH2 ARG A 254 15.107 93.917 48.450 1.00 72.64 A N ATOM 1056 C ARG A 254 12.858 90.603 54.507 1.00 67.14 A C ATOM 1057 O ARG A 254 13.356 89.699 53.830 1.00 67.13 A O ATOM 1058 N ASP A 255 13.002 90.694 55.832 1.00 67.58 A N ATOM 1059 CA ASP A 255 13.789 89.744 56.630 1.00 66.56 A C ATOM 1060 CB ASP A 255 15.286 90.046 56.458 1.00 67.69 A C ATOM 1061 CG ASP A 255 16.113 89.642 57.669 1.00 68.95 A C ATOM 1062 OD1 ASP A 255 16.108 88.448 58.041 1.00 69.89 A O ATOM 1063 OD2 ASP A 255 16.772 90.529 58.249 1.00 69.16 A O ATOM 1064 C ASP A 255 13.413 89.809 58.122 1.00 64.41 A C ATOM 1065 O ASP A 255 13.261 90.904 58.674 1.00 64.57 A O ATOM 1066 N ILE A 256 13.265 88.644 58.763 1.00 60.26 A N ATOM 1067 CA ILE A 256 12.918 88.587 60.186 1.00 56.43 A C ATOM 1068 CB ILE A 256 11.560 89.297 60.443 1.00 56.10 A C ATOM 1069 CG2 ILE A 256 10.406 88.449 59.934 1.00 55.25 A C ATOM 1070 CG1 ILE A 256 11.386 89.571 61.931 1.00 55.17 A C ATOM 1071 CD1 ILE A 256 10.193 90.444 62.235 1.00 56.51 A C ATOM 1072 C ILE A 256 12.877 87.163 60.782 1.00 53.68 A C ATOM 1073 O ILE A 256 11.950 86.803 61.505 1.00 53.90 A O ATOM 1074 N LYS A 257 13.904 86.370 60.492 1.00 49.81 A N ATOM 1075 CA LYS A 257 14.008 84.992 60.975 1.00 46.01 A C ATOM 1076 CB LYS A 257 15.248 84.327 60.369 1.00 45.90 A C ATOM 1077 CG LYS A 257 15.162 84.086 58.880 1.00 48.40 A C ATOM 1078 CD LYS A 257 16.403 83.366 58.365 1.00 49.60 A C ATOM 1079 CE LYS A 257 17.628 84.250 58.442 1.00 49.74 A C ATOM 1080 NZ LYS A 257 17.476 85.429 57.544 1.00 51.45 A N ATOM 1081 C LYS A 257 14.070 84.838 62.498 1.00 42.23 A C ATOM 1082 O LYS A 257 14.379 85.783 63.218 1.00 42.43 A O ATOM 1083 N PRO A 258 13.822 84.410 63.074 1.00 38.37 A N ATOM 1084 CD PRO A 258 13.620 83.540 61.908 1.00 37.81 A C ATOM 1085 CA PRO A 258 13.838 83.621 64.315 1.00 36.58 A C ATOM 1086 CB PRO A 258 13.569 82.193 63.834 1.00 35.41 A C ATOM 1087 CG PRO A 258 12.869 82.383 62.514 1.00 35.75 A C ATOM 1088 C PRO A 258 15.216 83.756 64.962 1.00 35.92 A C ATOM 1089 O PRO A 258 15.333 84.057 66.151 1.00 32.14 A O ATOM 1090 N GLU A 259 16.249 83.523 64.155 1.00 35.08 A N ATOM 1091 CA GLU A 259 17.626 83.652 64.601 1.00 36.22 A C ATOM 1092 CB GLU A 259 18.607 83.198 63.506 1.00 37.23 A C ATOM 1093 CG GLU A 259 18.795 81.688 63.340 1.00 40.19 A C ATOM 1094 CD GLU A 259 17.713 81.010 62.496 1.00 42.23 A C ATOM 1095 OE1 GLU A 259 17.915 79.827 62.142 1.00 41.52 A O ATOM 1096 OE2 GLU A 259 16.670 81.642 62.192 1.00 40.30 A O ATOM 1097 C GLU A 259 17.863 85.132 64.870 1.00 35.71 A C ATOM 1098 O GLU A 259 18.700 85.499 65.688 1.00 35.67 A O ATOM 1099 N ASN A 260 17.114 85.980 64.171 1.00 35.37 A N ATOM 1100 CA ASN A 260 17.264 87.423 64.308 1.00 33.13 A C ATOM 1101 CB ASN A 260 17.209 88.081 62.927 1.00 34.73 A C ATOM 1102 CG ASN A 260 18.037 87.335 61.893 1.00 35.58 A C ATOM 1103 OD1 ASN A 260 19.087 86.773 62.205 1.00 37.11 A O ATOM 1104 ND2 ASN A 260 17.573 87.340 60.653 1.00 37.65 A N ATOM 1105 C ASN A 260 16.236 88.073 65.229 1.00 31.26 A C ATOM 1106 O ASN A 260 16.106 89.300 65.261 1.00 34.44 A O ATOM 1107 N LEU A 261 15.494 87.255 65.963 1.00 27.11 A N ATOM 1108 CA LEU A 261 14.501 87.762 66.902 1.00 24.52 A C ATOM 1109 CB LEU A 261 13.147 87.089 66.648 1.00 24.18 A C ATOM 1110 CG LEU A 261 12.432 87.443 65.340 1.00 22.90 A C ATOM 1111 CD1 LEU A 261 11.116 86.685 65.252 1.00 24.50 A C ATOM 1112 CD2 LEU A 261 12.172 88.923 65.296 1.00 21.37 A C ATOM 1113 C LEU A 261 14.986 87.476 68.329 1.00 22.38 A C ATOM 1114 O LEU A 261 15.179 86.321 68.694 1.00 23.95 A O ATOM 1115 N LEU A 262 15.182 88.524 69.126 1.00 20.79 A N ATOM 1116 CA LEU A 262 15.670 88.370 70.499 1.00 20.67 A C ATOM 1117 CB LEU A 262 16.810 89.376 70.758 1.00 18.51 A C ATOM 1118 CG LEU A 262 17.955 89.381 69.723 1.00 21.77 A C ATOM 1119 CD1 LEU A 262 18.955 90.499 70.035 1.00 21.55 A C ATOM 1120 CD2 LEU A 262 18.672 88.033 69.723 1.00 20.67 A C ATOM 1121 C LEU A 262 14.556 88.538 71.543 1.00 20.45 A C ATOM 1122 O LEU A 262 13.484 89.054 71.232 1.00 21.30 A O ATOM 1123 N LEU A 263 14.820 88.095 72.775 1.00 19.96 A N ATOM 1124 CA LEU A 263 13.855 88.172 73.875 1.00 20.52 A C ATOM 1125 CB LEU A 263 13.556 86.769 74.407 1.00 20.43 A C ATOM 1126 CG LEU A 263 12.804 85.816 73.471 1.00 22.66 A C ATOM 1127 CD1 LEU A 263 12.979 84.366 73.956 1.00 21.47 A C ATOM 1128 CD2 LEU A 263 11.330 86.219 73.415 1.00 19.52 A C ATOM 1129 C LEU A 263 14.307 89.045 75.046 1.00 22.38 A C ATOM 1130 O LEU A 263 15.389 88.848 75.603 1.00 22.70 A O ATOM 1131 N GLY A 264 13.456 89.992 75.429 1.00 21.30 A N ATOM 1132 CA GLY A 264 13.765 90.882 76.530 1.00 23.34 A C ATOM 1133 C GLY A 264 13.574 90.251 77.902 1.00 25.78 A C ATOM 1134 O GLY A 264 13.277 89.061 78.025 1.00 24.77 A O ATOM 1135 N SER A 265 13.732 91.067 78.939 1.00 27.28 A N ATOM 1136 CA SER A 265 13.618 90.609 80.321 1.00 28.82 A C ATOM 1137 CB SER A 265 13.959 91.758 81.270 1.00 29.98 A C ATOM 1138 OG SER A 265 14.174 91.285 82.583 1.00 31.27 A O ATOM 1139 C SER A 265 12.253 90.039 80.684 1.00 29.23 A C ATOM 1140 O SER A 265 12.158 89.086 81.449 1.00 30.53 A O ATOM 1141 N ALA A 266 11.193 90.623 80.140 1.00 29.57 A N ATOM 1142 CA ALA A 266 9.845 90.156 80.432 1.00 28.18 A C ATOM 1143 CB ALA A 266 8.889 91.338 80.475 1.00 28.62 A C ATOM 1144 C ALA A 266 9.373 89.141 79.399 1.00 27.11 A C ATOM 1145 O ALA A 266 8.211 88.749 79.393 1.00 29.47 A O ATOM 1146 N GLY A 267 10.274 88.717 78.524 1.00 25.83 A N ATOM 1147 CA GLY A 267 9.900 87.759 77.502 1.00 24.74 A C ATOM 1148 C GLY A 267 9.343 88.414 76.249 1.00 24.20 A C ATOM 1149 O GLY A 267 8.829 87.729 75.365 1.00 22.75 A O ATOM 1150 N GLU A 268 9.435 89.740 76.167 1.00 24.05 A N ATOM 1151 CA GLU A 268 8.942 90.468 74.993 1.00 25.88 A C ATOM 1152 CB GLU A 268 8.748 91.951 75.328 1.00 27.62 A C ATOM 1153 CG GLU A 268 8.880 92.266 76.803 1.00 33.71 A C ATOM 1154 CD GLU A 268 10.323 92.434 77.243 1.00 35.40 A C ATOM 1155 OE1 GLU A 268 10.874 93.537 77.049 1.00 36.57 A O ATOM 1156 OE2 GLU A 268 10.909 91.465 77.773 1.00 36.25 A O ATOM 1157 C GLU A 268 9.920 90.327 73.820 1.00 24.17 A C ATOM 1158 O GLU A 268 11.138 90.213 74.021 1.00 23.37 A O ATOM 1159 N LEU A 269 9.380 90.317 72.603 1.00 22.43 A N ATOM 1160 CA LEU A 269 10.185 90.189 71.388 1.00 22.74 A C ATOM 1161 CB LEU A 269 9.291 89.793 70.204 1.00 27.41 A C ATOM 1162 CG LEU A 269 8.740 88.370 70.198 1.00 30.77 A C ATOM 1163 CD1 LEU A 269 7.689 88.219 69.115 1.00 32.33 A C ATOM 1164 CD2 LEU A 269 9.893 87.387 69.981 1.00 30.69 A C ATOM 1165 C LEU A 269 10.941 91.466 71.024 1.00 20.79 A C ATOM 1166 O LEU A 269 10.427 92.569 71.176 1.00 20.86 A O ATOM 1167 N LYS A 270 12.164 91.310 70.536 1.00 19.07 A N ATOM 1168 CA LYS A 270 12.968 92.453 70.123 1.00 19.86 A C ATOM 1169 CB LYS A 270 14.179 92.628 71.046 1.00 19.41 A C ATOM 1170 CG LYS A 270 13.839 92.907 72.512 1.00 21.56 A C ATOM 1171 CD LYS A 270 13.368 94.336 72.739 1.00 21.90 A C ATOM 1172 CE LYS A 270 13.083 94.578 74.222 1.00 19.95 A C ATOM 1173 NZ LYS A 270 12.812 96.006 74.509 1.00 19.75 A N ATOM 1174 C LYS A 270 13.459 92.201 68.703 1.00 19.52 A C ATOM 1175 O LYS A 270 14.126 91.199 68.458 1.00 19.94 A O ATOM 1176 N ILE A 271 13.122 93.092 67.768 1.00 20.30 A N ATOM 1177 CA ILE A 271 13.581 92.946 66.388 1.00 19.95 A C ATOM 1178 CB ILE A 271 12.637 93.645 65.375 1.00 21.57 A C ATOM 1179 CG2 ILE A 271 13.245 93.602 63.959 1.00 22.31 A C ATOM 1180 CG1 ILE A 271 11.275 92.952 65.349 1.00 23.31 A C ATOM 1181 CD1 ILE A 271 10.313 93.557 64.325 1.00 23.77 A C ATOM 1182 C ILE A 271 14.966 93.584 66.273 1.00 20.17 A C ATOM 1183 O ILE A 271 15.139 94.761 66.590 1.00 19.60 A O ATOM 1184 N ALA A 272 15.945 92.805 65.822 1.00 20.80 A N ATOM 1185 CA ALA A 272 17.318 93.291 65.675 1.00 22.55 A C ATOM 1186 CB ALA A 272 18.278 92.307 66.319 1.00 22.63 A C ATOM 1187 C ALA A 272 17.671 93.477 64.199 1.00 23.77 A C ATOM 1188 O ALA A 272 16.967 92.985 63.335 1.00 27.69 A O ATOM 1189 N ASP A 273 18.770 94.166 63.914 1.00 25.21 A N ATOM 1190 CA ASP A 273 19.179 94.423 62.535 1.00 26.15 A C ATOM 1191 CB ASP A 273 19.470 95.919 62.371 1.00 26.59 A C ATOM 1192 CG ASP A 273 19.481 96.364 60.922 1.00 28.71 A C ATOM 1193 OD1 ASP A 273 19.921 97.503 60.662 1.00 27.94 A O ATOM 1194 OD2 ASP A 273 19.042 95.587 60.048 1.00 26.80 A O ATOM 1195 C ASP A 273 20.409 93.608 62.114 1.00 28.69 A C ATOM 1196 O ASP A 273 21.513 94.134 62.036 1.00 31.16 A O ATOM 1197 N PHE A 274 20.212 92.325 61.825 1.00 31.46 A N ATOM 1198 CA PHE A 274 21.309 91.445 61.410 1.00 34.17 A C ATOM 1199 CB PHE A 274 21.014 90.005 61.826 1.00 34.86 A C ATOM 1200 CG PHE A 274 21.126 89.762 63.298 1.00 34.01 A C ATOM 1201 CD1 PHE A 274 22.369 89.593 63.891 1.00 35.57 A C ATOM 1202 CD2 PHE A 274 19.986 89.690 64.091 1.00 33.84 A C ATOM 1203 CE1 PHE A 274 22.478 89.352 65.255 1.00 34.13 A C ATOM 1204 CE2 PHE A 274 20.075 89.449 65.458 1.00 33.04 A C ATOM 1205 CZ PHE A 274 21.315 89.279 66.043 1.00 35.67 A C ATOM 1206 C PHE A 274 21.610 91.465 59.908 1.00 35.98 A C ATOM 1207 O PHE A 274 22.769 91.357 59.508 1.00 37.36 A O ATOM 1208 N GLY A 275 20.591 91.607 59.065 1.00 36.77 A N ATOM 1209 CA GLY A 275 20.872 91.613 57.640 1.00 38.21 A C ATOM 1210 C GLY A 275 21.125 93.012 57.108 1.00 39.96 A C ATOM 1211 O GLY A 275 20.645 93.371 56.030 1.00 40.54 A O ATOM 1212 N TRP A 276 21.894 93.801 57.850 1.00 40.99 A N ATOM 1213 CA TRP A 276 22.180 95.178 57.454 1.00 41.46 A C ATOM 1214 CB TRP A 276 22.767 95.958 58.633 1.00 39.82 A C ATOM 1215 CG TRP A 276 24.099 95.435 59.065 1.00 39.01 A C ATOM 1216 CD2 TRP A 276 25.376 95.801 58.523 1.00 38.81 A C ATOM 1217 CE2 TRP A 276 26.350 95.024 59.190 1.00 38.69 A C ATOM 1218 CE3 TRP A 276 25.790 96.707 57.538 1.00 38.86 A C ATOM 1219 CD1 TRP A 276 24.344 94.481 60.014 1.00 37.17 A C ATOM 1220 NE1 TRP A 276 25.692 94.231 60.092 1.00 36.72 A N ATOM 1221 CZ2 TRP A 276 27.717 95.125 58.905 1.00 39.22 A C ATOM 1222 CZ3 TRP A 276 27.154 96.809 57.249 1.00 40.49 A C ATOM 1223 CH2 TRP A 276 28.101 96.018 57.934 1.00 39.41 A C ATOM 1224 C TRP A 276 23.152 95.244 56.289 1.00 42.15 A C ATOM 1225 O TRP A 276 23.334 96.307 55.686 1.00 43.44 A O ATOM 1226 N SER A 277 23.790 94.119 55.982 1.00 42.35 A N ATOM 1227 CA SER A 277 24.750 94.058 54.887 1.00 43.23 A C ATOM 1228 CB SER A 277 26.063 93.415 55.360 1.00 42.06 A C ATOM 1229 OG SER A 277 25.810 92.188 56.032 1.00 41.30 A O ATOM 1230 C SER A 277 24.171 93.244 53.736 1.00 44.99 A C ATOM 1231 O SER A 277 24.709 93.259 52.619 1.00 46.90 A O ATOM 1232 N GLY A 290 19.559 85.906 54.593 1.00 50.58 A N ATOM 1233 CA GLY A 290 18.167 85.530 54.418 1.00 50.41 A C ATOM 1234 C GLY A 290 17.976 84.405 53.413 1.00 49.78 A C ATOM 1235 O GLY A 290 17.787 84.652 52.215 1.00 49.58 A O ATOM 1236 N THR A 291 18.024 83.166 53.899 1.00 47.99 A N ATOM 1237 CA THR A 291 17.855 82.001 53.036 1.00 45.67 A C ATOM 1238 CB THR A 291 17.993 80.671 53.833 1.00 46.93 A C ATOM 1239 OG1 THR A 291 17.389 80.818 55.127 1.00 47.18 A O ATOM 1240 CG2 THR A 291 19.460 80.279 53.988 1.00 45.73 A C ATOM 1241 C THR A 291 16.504 82.009 52.318 1.00 43.16 A C ATOM 1242 O THR A 291 15.604 82.783 52.650 1.00 42.03 A O ATOM 1243 N LEU A 292 16.385 81.119 51.340 1.00 41.25 A N ATOM 1244 CA LEU A 292 15.194 80.972 50.514 1.00 39.15 A C ATOM 1245 CB LEU A 292 15.417 79.814 49.540 1.00 41.13 A C ATOM 1246 CG LEU A 292 14.653 79.815 48.220 1.00 41.33 A C ATOM 1247 CD1 LEU A 292 14.961 81.085 47.436 1.00 40.19 A C ATOM 1248 CD2 LEU A 292 15.069 78.592 47.423 1.00 43.53 A C ATOM 1249 C LEU A 292 13.887 80.750 51.280 1.00 36.22 A C ATOM 1250 O LEU A 292 12.847 81.287 50.909 1.00 35.72 A O ATOM 1251 N ASP A 293 13.949 79.964 52.346 1.00 32.89 A N ATOM 1252 CA ASP A 293 12.771 79.647 53.150 1.00 31.62 A C ATOM 1253 CB ASP A 293 13.211 78.945 54.437 1.00 31.49 A C ATOM 1254 CG ASP A 293 13.399 77.452 54.253 1.00 33.23 A C ATOM 1255 OD1 ASP A 293 14.114 76.838 55.076 1.00 35.49 A O ATOM 1256 OD2 ASP A 293 12.818 76.886 53.299 1.00 31.43 A O ATOM 1257 C ASP A 293 11.805 80.779 53.503 1.00 29.72 A C ATOM 1258 O ASP A 293 10.595 80.563 53.556 1.00 28.20 A O ATOM 1259 N TYR A 294 12.327 81.977 53.748 1.00 28.61 A N ATOM 1260 CA TYR A 294 11.476 83.101 54.128 1.00 27.28 A C ATOM 1261 CB TYR A 294 12.064 83.814 55.357 1.00 28.14 A C ATOM 1262 CG TYR A 294 12.451 82.871 56.472 1.00 29.60 A C ATOM 1263 CD1 TYR A 294 13.669 82.192 56.442 1.00 31.65 A C ATOM 1264 CE1 TYR A 294 14.003 81.264 57.423 1.00 33.54 A C ATOM 1265 CD2 TYR A 294 11.574 82.601 57.522 1.00 31.90 A C ATOM 1266 CE2 TYR A 294 11.897 81.669 58.514 1.00 32.48 A C ATOM 1267 CZ TYR A 294 13.112 81.005 58.454 1.00 35.17 A C ATOM 1268 OH TYR A 294 13.437 80.065 59.406 1.00 37.45 A O ATOM 1269 C TYR A 294 11.211 84.126 53.032 1.00 26.29 A C ATOM 1270 O TYR A 294 10.530 85.117 53.276 1.00 27.19 A O ATOM 1271 N LEU A 295 11.732 83.888 51.830 1.00 25.16 A N ATOM 1272 CA LEU A 295 11.540 84.809 50.709 1.00 24.82 A C ATOM 1273 CB LEU A 295 12.643 84.607 49.669 1.00 24.50 A C ATOM 1274 CG LEU A 295 14.052 85.044 50.075 1.00 25.62 A C ATOM 1275 CD1 LEU A 295 15.019 84.731 48.952 1.00 21.99 A C ATOM 1276 CD2 LEU A 295 14.053 86.535 50.391 1.00 25.81 A C ATOM 1277 C LEU A 295 10.181 84.671 50.019 1.00 22.65 A C ATOM 1278 O LEU A 295 9.736 83.565 49.730 1.00 22.45 A O ATOM 1279 N PRO A 296 9.515 85.800 49.730 1.00 21.47 A N ATOM 1280 CD PRO A 296 9.864 87.159 50.187 1.00 22.06 A C ATOM 1281 CA PRO A 296 8.202 85.782 49.066 1.00 21.33 A C ATOM 1282 CB PRO A 296 7.634 87.169 49.380 1.00 20.33 A C ATOM 1283 CG PRO A 296 8.848 88.033 49.450 1.00 21.76 A C ATOM 1284 C PRO A 296 8.260 85.479 47.561 1.00 22.16 A C ATOM 1285 O PRO A 296 9.292 85.652 46.917 1.00 19.11 A O ATOM 1286 N PRO A 297 7.137 85.032 46.976 1.00 23.42 A N ATOM 1287 CD PRO A 297 5.799 84.826 47.557 1.00 21.93 A C ATOM 1288 CA PRO A 297 7.141 84.720 45.542 1.00 24.58 A C ATOM 1289 CB PRO A 297 5.693 84.315 45.271 1.00 24.85 A C ATOM 1290 CG PRO A 297 5.220 83.791 46.629 1.00 22.35 A C ATOM 1291 C PRO A 297 7.602 85.869 44.641 1.00 26.51 A C ATOM 1292 O PRO A 297 8.425 85.667 43.749 1.00 24.25 A O ATOM 1293 N GLU A 298 7.081 87.070 44.884 1.00 28.74 A N ATOM 1294 CA GLU A 298 7.435 88.231 44.070 1.00 32.43 A C ATOM 1295 CB GLU A 298 6.792 89.508 44.625 1.00 31.92 A C ATOM 1296 CG GLU A 298 7.073 89.780 46.093 1.00 31.41 A C ATOM 1297 CD GLU A 298 5.970 89.259 46.993 1.00 31.60 A C ATOM 1298 OE1 GLU A 298 5.566 88.089 46.835 1.00 32.77 A O ATOM 1299 OE2 GLU A 298 5.504 90.017 47.864 1.00 32.41 A O ATOM 1300 C GLU A 298 8.937 88.440 43.934 1.00 34.76 A C ATOM 1301 O GLU A 298 9.420 88.836 42.872 1.00 34.79 A O ATOM 1302 N MET A 299 9.679 88.167 45.003 1.00 37.58 A N ATOM 1303 CA MET A 299 11.121 88.348 44.966 1.00 39.94 A C ATOM 1304 CB MET A 299 11.676 88.481 46.391 1.00 40.17 A C ATOM 1305 CG MET A 299 11.251 89.800 47.055 1.00 40.44 A C ATOM 1306 SD MET A 299 11.866 90.123 48.737 1.00 42.44 A S ATOM 1307 CE MET A 299 13.408 90.986 48.365 1.00 41.54 A C ATOM 1308 C MET A 299 11.857 87.268 44.179 1.00 41.00 A C ATOM 1309 O MET A 299 12.582 87.589 43.237 1.00 42.71 A O ATOM 1310 N ILE A 300 11.674 85.998 44.525 1.00 42.03 A N ATOM 1311 CA ILE A 300 12.363 84.941 43.784 1.00 43.81 A C ATOM 1312 CB ILE A 300 12.140 83.535 44.407 1.00 44.39 A C ATOM 1313 CG2 ILE A 300 12.690 83.497 45.829 1.00 45.06 A C ATOM 1314 CG1 ILE A 300 10.656 83.172 44.378 1.00 44.10 A C ATOM 1315 CD1 ILE A 300 10.379 81.745 44.804 1.00 44.41 A C ATOM 1316 C ILE A 300 11.906 84.908 42.323 1.00 44.98 A C ATOM 1317 O ILE A 300 12.573 84.322 41.472 1.00 45.46 A O ATOM 1318 N GLU A 301 10.762 85.529 42.042 1.00 45.85 A N ATOM 1319 CA GLU A 301 10.232 85.592 40.682 1.00 46.66 A C ATOM 1320 CB GLU A 301 8.709 85.477 40.687 1.00 47.45 A C ATOM 1321 CG GLU A 301 8.189 84.054 40.721 1.00 48.05 A C ATOM 1322 CD GLU A 301 6.688 83.997 40.916 1.00 49.14 A C ATOM 1323 OE1 GLU A 301 5.979 84.782 40.253 1.00 50.01 A O ATOM 1324 OE2 GLU A 301 6.218 83.166 41.724 1.00 48.90 A O ATOM 1325 C GLU A 301 10.643 86.904 40.026 1.00 47.81 A C ATOM 1326 O GLU A 301 10.048 87.326 39.035 1.00 47.15 A O ATOM 1327 N GLY A 302 11.650 87.547 40.613 1.00 49.04 A N ATOM 1328 CA GLY A 302 12.193 88.792 40.094 1.00 50.61 A C ATOM 1329 C GLY A 302 11.296 89.991 39.844 1.00 51.92 A C ATOM 1330 O GLY A 302 11.642 90.841 39.025 1.00 52.54 A O ATOM 1331 N ARG A 303 10.167 90.087 40.542 1.00 52.91 A N ATOM 1332 CA ARG A 303 9.259 91.219 40.356 1.00 53.57 A C ATOM 1333 CB ARG A 303 7.812 90.753 40.529 1.00 55.04 A C ATOM 1334 CG ARG A 303 7.494 89.500 39.724 1.00 58.17 A C ATOM 1335 CD ARG A 303 6.011 89.149 39.750 1.00 60.28 A C ATOM 1336 NE ARG A 303 5.212 90.072 38.947 1.00 62.73 A N ATOM 1337 CZ ARG A 303 3.919 89.903 38.680 1.00 63.00 A C ATOM 1338 NH1 ARG A 303 3.271 90.794 37.941 1.00 62.86 A N ATOM 1339 NH2 ARG A 303 3.275 88.842 39.150 1.00 62.02 A N ATOM 1340 C ARG A 303 9.571 92.371 41.320 1.00 52.69 A C ATOM 1341 O ARG A 303 10.582 92.344 42.020 1.00 52.06 A O ATOM 1342 N MET A 304 8.710 93.385 41.344 1.00 52.57 A N ATOM 1343 CA MET A 304 8.907 94.539 42.223 1.00 52.97 A C ATOM 1344 CB MET A 304 8.395 95.820 41.542 1.00 55.47 A C ATOM 1345 CG MET A 304 8.972 97.135 42.103 1.00 59.08 A C ATOM 1346 SD MET A 304 7.948 98.022 43.326 1.00 62.23 A S ATOM 1347 CE MET A 304 7.208 99.317 42.301 1.00 60.78 A C ATOM 1348 C MET A 304 8.153 94.299 43.526 1.00 51.89 A C ATOM 1349 O MET A 304 7.026 93.809 43.511 1.00 51.02 A O ATOM 1350 N HIS A 305 8.775 94.645 44.651 1.00 50.91 A N ATOM 1351 CA HIS A 305 8.149 94.441 45.953 1.00 49.66 A C ATOM 1352 CB HIS A 305 8.944 93.415 46.762 1.00 51.52 A C ATOM 1353 CG HIS A 305 10.392 93.763 46.926 1.00 54.62 A C ATOM 1354 CD2 HIS A 305 11.085 94.211 48.000 1.00 54.89 A C ATOM 1355 ND1 HIS A 305 11.304 93.665 45.897 1.00 55.05 A N ATOM 1356 CE1 HIS A 305 12.496 94.034 46.330 1.00 55.54 A C ATOM 1357 NE2 HIS A 305 12.391 94.371 47.603 1.00 55.94 A N ATOM 1358 C HIS A 305 7.996 95.712 46.778 1.00 47.80 A C ATOM 1359 O HIS A 305 8.620 96.730 46.491 1.00 47.81 A O ATOM 1360 N ASP A 306 7.150 95.635 47.802 1.00 45.38 A N ATOM 1361 CA ASP A 306 6.903 96.746 48.713 1.00 43.84 A C ATOM 1362 CB ASP A 306 5.667 97.548 48.278 1.00 44.46 A C ATOM 1363 CG ASP A 306 4.424 96.691 48.154 1.00 45.21 A C ATOM 1364 OD1 ASP A 306 4.281 95.727 48.935 1.00 45.61 A O ATOM 1365 OD2 ASP A 306 3.579 96.992 47.285 1.00 45.96 A O ATOM 1366 C ASP A 306 6.714 96.213 50.141 1.00 42.01 A C ATOM 1367 O ASP A 306 7.276 95.181 50.498 1.00 40.43 A O ATOM 1368 N GLU A 307 5.917 96.910 50.948 1.00 41.41 A N ATOM 1369 CA GLU A 307 5.684 96.503 52.334 1.00 40.47 A C ATOM 1370 CB GLU A 307 5.047 97.658 53.116 1.00 43.34 A C ATOM 1371 CG GLU A 307 3.673 98.084 52.624 1.00 49.09 A C ATOM 1372 CD GLU A 307 2.543 97.317 53.287 1.00 53.33 A C ATOM 1373 OE1 GLU A 307 1.369 97.561 52.933 1.00 56.15 A O ATOM 1374 OE2 GLU A 307 2.822 96.475 54.168 1.00 56.15 A O ATOM 1375 C GLU A 307 4.838 95.236 52.486 1.00 37.15 A C ATOM 1376 O GLU A 307 4.595 94.774 53.603 1.00 36.77 A O ATOM 1377 N LYS A 308 4.402 94.668 51.367 1.00 33.66 A N ATOM 1378 CA LYS A 308 3.599 93.455 51.411 1.00 29.96 A C ATOM 1379 CB LYS A 308 2.842 93.262 50.095 1.00 31.75 A C ATOM 1380 CG LYS A 308 1.668 94.214 49.908 1.00 30.26 A C ATOM 1381 CD LYS A 308 0.631 94.005 50.994 1.00 30.93 A C ATOM 1382 CE LYS A 308 −0.590 94.881 50.766 1.00 33.18 A C ATOM 1383 NZ LYS A 308 −1.687 94.574 51.722 1.00 31.42 A N ATOM 1384 C LYS A 308 4.452 92.227 51.704 1.00 28.16 A C ATOM 1385 O LYS A 308 3.918 91.178 52.055 1.00 26.90 A O ATOM 1386 N VAL A 309 5.772 92.354 51.566 1.00 26.12 A N ATOM 1387 CA VAL A 309 6.666 91.230 51.849 1.00 27.15 A C ATOM 1388 CB VAL A 309 8.147 91.546 51.483 1.00 28.50 A C ATOM 1389 CG1 VAL A 309 8.273 91.828 49.988 1.00 28.82 A C ATOM 1390 CG2 VAL A 309 8.648 92.728 52.299 1.00 28.83 A C ATOM 1391 C VAL A 309 6.608 90.885 53.339 1.00 27.51 A C ATOM 1392 O VAL A 309 6.748 89.720 53.725 1.00 28.44 A O ATOM 1393 N ASP A 310 6.382 91.905 54.167 1.00 25.49 A N ATOM 1394 CA ASP A 310 6.308 91.715 55.607 1.00 23.57 A C ATOM 1395 CB ASP A 310 6.281 93.069 56.332 1.00 23.42 A C ATOM 1396 CG ASP A 310 7.564 93.858 56.139 1.00 26.52 A C ATOM 1397 OD1 ASP A 310 8.657 93.249 56.164 1.00 26.12 A O ATOM 1398 OD2 ASP A 310 7.489 95.095 55.974 1.00 28.59 A O ATOM 1399 C ASP A 310 5.106 90.878 56.012 1.00 21.40 A C ATOM 1400 O ASP A 310 5.147 90.193 57.038 1.00 21.03 A O ATOM 1401 N LEU A 311 4.032 90.932 55.228 1.00 20.72 A N ATOM 1402 CA LEU A 311 2.848 90.126 55.541 1.00 20.20 A C ATOM 1403 CB LEU A 311 1.628 90.564 54.713 1.00 19.65 A C ATOM 1404 CG LEU A 311 0.794 91.785 55.141 1.00 21.99 A C ATOM 1405 CD1 LEU A 311 0.255 91.575 56.547 1.00 23.33 A C ATOM 1406 CD2 LEU A 311 1.635 93.047 55.092 1.00 23.76 A C ATOM 1407 C LEU A 311 3.171 88.658 55.238 1.00 18.99 A C ATOM 1408 O LEU A 311 2.764 87.760 55.960 1.00 16.87 A O ATOM 1409 N TRP A 312 3.892 88.424 54.148 1.00 19.04 A N ATOM 1410 CA TRP A 312 4.284 87.069 53.786 1.00 19.16 A C ATOM 1411 CB TRP A 312 5.094 87.083 52.482 1.00 19.35 A C ATOM 1412 CG TRP A 312 5.628 85.742 52.102 1.00 18.58 A C ATOM 1413 CD2 TRP A 312 4.970 84.762 51.294 1.00 17.19 A C ATOM 1414 CE2 TRP A 312 5.813 83.629 51.242 1.00 16.50 A C ATOM 1415 CE3 TRP A 312 3.747 84.730 50.607 1.00 17.90 A C ATOM 1416 CD1 TRP A 312 6.815 85.184 52.496 1.00 19.08 A C ATOM 1417 NE1 TRP A 312 6.933 83.911 51.983 1.00 18.08 A N ATOM 1418 CZ2 TRP A 312 5.473 82.478 50.533 1.00 17.00 A C ATOM 1419 CZ3 TRP A 312 3.409 83.580 49.899 1.00 14.87 A C ATOM 1420 CH2 TRP A 312 4.271 82.470 49.870 1.00 19.28 A C ATOM 1421 C TRP A 312 5.142 86.497 54.923 1.00 18.64 A C ATOM 1422 O TRP A 312 4.883 85.396 55.424 1.00 16.66 A O ATOM 1423 N SER A 313 6.154 87.259 55.333 1.00 15.99 A N ATOM 1424 CA SER A 313 7.043 86.823 56.408 1.00 18.14 A C ATOM 1425 CB SER A 313 8.034 87.931 56.760 1.00 18.03 A C ATOM 1426 OG SER A 313 8.746 88.320 55.604 1.00 20.11 A O ATOM 1427 C SER A 313 6.254 86.450 57.650 1.00 15.82 A C ATOM 1428 O SER A 313 6.538 85.460 58.303 1.00 16.33 A O ATOM 1429 N LEU A 314 5.251 87.249 57.967 1.00 17.05 A N ATOM 1430 CA LEU A 314 4.429 86.997 59.137 1.00 18.31 A C ATOM 1431 CB LEU A 314 3.408 88.136 59.273 1.00 21.36 A C ATOM 1432 CG LEU A 314 3.115 88.707 60.664 1.00 25.08 A C ATOM 1433 CD1 LEU A 314 4.403 89.035 61.393 1.00 26.53 A C ATOM 1434 CD2 LEU A 314 2.258 89.954 60.524 1.00 26.95 A C ATOM 1435 C LEU A 314 3.736 85.627 59.044 1.00 17.43 A C ATOM 1436 O LEU A 314 3.565 84.928 60.046 1.00 16.65 A O ATOM 1437 N GLY A 315 3.348 85.242 57.835 1.00 17.42 A N ATOM 1438 CA GLY A 315 2.682 83.961 57.646 1.00 16.42 A C ATOM 1439 C GLY A 315 3.623 82.781 57.799 1.00 13.19 A C ATOM 1440 O GLY A 315 3.275 81.775 58.411 1.00 12.24 A O ATOM 1441 N VAL A 316 4.816 82.900 57.231 1.00 11.93 A N ATOM 1442 CA VAL A 316 5.810 81.844 57.322 1.00 12.52 A C ATOM 1443 CB VAL A 316 7.085 82.225 56.521 1.00 14.29 A C ATOM 1444 CG1 VAL A 316 8.233 81.270 56.858 1.00 9.03 A C ATOM 1445 CG2 VAL A 316 6.779 82.186 55.011 1.00 11.86 A C ATOM 1446 C VAL A 316 6.182 81.591 58.784 1.00 15.03 A C ATOM 1447 O VAL A 316 6.310 80.446 59.213 1.00 17.62 A O ATOM 1448 N LEU A 317 6.343 82.679 59.534 1.00 14.58 A N ATOM 1449 CA LEU A 317 6.709 82.651 60.945 1.00 16.47 A C ATOM 1450 CB LEU A 317 7.011 84.077 61.402 1.00 19.62 A C ATOM 1451 CG LEU A 317 8.077 84.260 62.478 1.00 23.94 A C ATOM 1452 CD1 LEU A 317 9.386 83.649 61.992 1.00 23.88 A C ATOM 1453 CD2 LEU A 317 8.256 85.742 62.782 1.00 25.46 A C ATOM 1454 C LEU A 317 5.618 82.058 61.837 1.00 17.53 A C ATOM 1455 O LEU A 317 5.897 81.270 62.752 1.00 16.69 A O ATOM 1456 N CYS A 318 4.371 82.444 61.578 1.00 15.98 A N ATOM 1457 CA CYS A 318 3.272 81.937 62.380 1.00 15.13 A C ATOM 1458 CB CYS A 318 1.940 82.520 61.898 1.00 13.25 A C ATOM 1459 SG CYS A 318 0.563 82.056 62.970 1.00 20.95 A S ATOM 1460 C CYS A 318 3.253 80.420 62.263 1.00 14.70 A C ATOM 1461 O CYS A 318 3.087 79.710 63.245 1.00 13.83 A O ATOM 1462 N TYR A 319 3.421 79.942 61.038 1.00 15.03 A N ATOM 1463 CA TYR A 319 3.444 78.518 60.742 1.00 15.40 A C ATOM 1464 CB TYR A 319 3.583 78.317 59.226 1.00 14.02 A C ATOM 1465 CG TYR A 319 3.545 76.875 58.766 1.00 14.42 A C ATOM 1466 CD1 TYR A 319 4.651 76.036 58.902 1.00 13.77 A C ATOM 1467 CE1 TYR A 319 4.612 74.713 58.446 1.00 16.09 A C ATOM 1468 CD2 TYR A 319 2.396 76.357 58.167 1.00 17.16 A C ATOM 1469 CE2 TYR A 319 2.345 75.047 57.710 1.00 15.61 A C ATOM 1470 CZ TYR A 319 3.445 74.231 57.849 1.00 16.40 A C ATOM 1471 OH TYR A 319 3.363 72.937 57.385 1.00 15.59 A O ATOM 1472 C TYR A 319 4.610 77.831 61.462 1.00 15.16 A C ATOM 1473 O TYR A 319 4.407 76.869 62.193 1.00 14.51 A O ATOM 1474 N GLU A 320 5.828 78.330 61.246 1.00 17.29 A N ATOM 1475 CA GLU A 320 7.000 77.734 61.880 1.00 17.27 A C ATOM 1476 CB GLU A 320 8.281 78.487 61.507 1.00 18.78 A C ATOM 1477 CG GLU A 320 9.537 77.819 62.068 1.00 22.31 A C ATOM 1478 CD GLU A 320 10.838 78.346 61.469 1.00 26.99 A C ATOM 1479 OE1 GLU A 320 11.904 77.777 61.784 1.00 27.38 A O ATOM 1480 OE2 GLU A 320 10.807 79.319 60.692 1.00 26.89 A O ATOM 1481 C GLU A 320 6.845 77.672 63.404 1.00 17.31 A C ATOM 1482 O GLU A 320 7.234 76.689 64.019 1.00 16.67 A O ATOM 1483 N PHE A 321 6.259 78.702 64.006 1.00 17.96 A N ATOM 1484 CA PHE A 321 6.057 78.697 65.458 1.00 18.82 A C ATOM 1485 CB PHE A 321 5.387 79.993 65.948 1.00 18.10 A C ATOM 1486 CG PHE A 321 6.318 81.180 66.061 1.00 20.78 A C ATOM 1487 CD1 PHE A 321 7.705 81.017 66.064 1.00 21.45 A C ATOM 1488 CD2 PHE A 321 5.796 82.472 66.152 1.00 20.42 A C ATOM 1489 CE1 PHE A 321 8.554 82.127 66.150 1.00 21.67 A C ATOM 1490 CE2 PHE A 321 6.632 83.587 66.238 1.00 21.82 A C ATOM 1491 CZ PHE A 321 8.013 83.417 66.236 1.00 21.08 A C ATOM 1492 C PHE A 321 5.174 77.530 65.896 1.00 19.26 A C ATOM 1493 O PHE A 321 5.466 76.848 66.878 1.00 18.07 A O ATOM 1494 N LEU A 322 4.089 77.309 65.159 1.00 18.30 A N ATOM 1495 CA LEU A 322 3.134 76.258 65.498 1.00 18.16 A C ATOM 1496 CB LEU A 322 1.777 76.572 64.859 1.00 17.23 A C ATOM 1497 CG LEU A 322 1.016 77.755 65.455 1.00 16.28 A C ATOM 1498 CD1 LEU A 322 −0.128 78.162 64.528 1.00 20.13 A C ATOM 1499 CD2 LEU A 322 0.490 77.372 66.833 1.00 14.25 A C ATOM 1500 C LEU A 322 3.530 74.833 65.136 1.00 17.66 A C ATOM 1501 O LEU A 322 3.286 73.908 65.908 1.00 15.88 A O ATOM 1502 N VAL A 323 4.138 74.670 63.963 1.00 17.86 A N ATOM 1503 CA VAL A 323 4.531 73.360 63.462 1.00 19.30 A C ATOM 1504 CB VAL A 323 4.441 73.318 61.909 1.00 19.49 A C ATOM 1505 CG1 VAL A 323 4.742 71.915 61.399 1.00 21.44 A C ATOM 1506 CG2 VAL A 323 3.069 73.746 61.462 1.00 18.47 A C ATOM 1507 C VAL A 323 5.934 72.926 63.890 1.00 19.76 A C ATOM 1508 O VAL A 323 6.164 71.746 64.148 1.00 18.74 A O ATOM 1509 N GLY A 324 6.865 73.873 63.975 1.00 18.78 A N ATOM 1510 CA GLY A 324 8.218 73.524 64.380 1.00 19.81 A C ATOM 1511 C GLY A 324 9.219 73.717 63.257 1.00 21.90 A C ATOM 1512 O GLY A 324 10.429 73.731 63.486 1.00 23.85 A O ATOM 1513 N LYS A 325 8.715 73.851 62.034 1.00 23.08 A N ATOM 1514 CA LYS A 325 9.560 74.078 60.873 1.00 23.18 A C ATOM 1515 CB LYS A 325 10.035 72.748 60.282 1.00 25.82 A C ATOM 1516 CG LYS A 325 8.940 71.860 59.738 1.00 28.72 A C ATOM 1517 CD LYS A 325 9.550 70.690 58.988 1.00 31.14 A C ATOM 1518 CE LYS A 325 8.492 69.716 58.508 1.00 32.54 A C ATOM 1519 NZ LYS A 325 7.811 69.057 59.655 1.00 36.73 A N ATOM 1520 C LYS A 325 8.775 74.886 59.838 1.00 22.65 A C ATOM 1521 O LYS A 325 7.546 74.928 59.884 1.00 20.82 A O ATOM 1522 N PRO A 326 9.480 75.543 58.897 1.00 21.36 A N ATOM 1523 CD PRO A 326 10.936 75.420 58.702 1.00 22.88 A C ATOM 1524 CA PRO A 326 8.891 76.368 57.836 1.00 21.28 A C ATOM 1525 CB PRO A 326 10.118 76.980 57.165 1.00 23.22 A C ATOM 1526 CG PRO A 326 11.115 75.882 57.275 1.00 22.99 A C ATOM 1527 C PRO A 326 8.000 75.589 56.865 1.00 19.59 A C ATOM 1528 O PRO A 326 8.191 74.391 56.637 1.00 17.62 A O ATOM 1529 N PRO A 327 7.015 76.272 56.266 1.00 19.54 A N ATOM 1530 CD PRO A 327 6.590 77.659 56.535 1.00 18.59 A C ATOM 1531 CA PRO A 327 6.105 75.600 55.336 1.00 19.17 A C ATOM 1532 CB PRO A 327 4.946 76.594 55.212 1.00 19.31 A C ATOM 1533 CG PRO A 327 5.603 77.918 55.424 1.00 21.80 A C ATOM 1534 C PRO A 327 6.612 75.105 53.976 1.00 20.25 A C ATOM 1535 O PRO A 327 6.025 74.185 53.412 1.00 22.68 A O ATOM 1536 N PHE A 328 7.692 75.672 53.449 1.00 19.21 A N ATOM 1537 CA PHE A 328 8.179 75.244 52.134 1.00 21.50 A C ATOM 1538 CB PHE A 328 8.344 76.469 51.220 1.00 20.17 A C ATOM 1539 CG PHE A 328 7.108 77.331 51.119 1.00 19.02 A C ATOM 1540 CD1 PHE A 328 5.995 76.903 50.385 1.00 19.37 A C ATOM 1541 CD2 PHE A 328 7.048 78.561 51.776 1.00 17.08 A C ATOM 1542 CE1 PHE A 328 4.840 77.688 50.307 1.00 16.91 A C ATOM 1543 CE2 PHE A 328 5.900 79.354 51.709 1.00 20.03 A C ATOM 1544 CZ PHE A 328 4.788 78.912 50.967 1.00 18.39 A C ATOM 1545 C PHE A 328 9.501 74.466 52.163 1.00 24.45 A C ATOM 1546 O PHE A 328 10.149 74.296 51.131 1.00 24.06 A O ATOM 1547 N GLU A 329 9.902 73.992 53.337 1.00 26.19 A N ATOM 1548 CA GLU A 329 11.159 73.255 53.465 1.00 28.35 A C ATOM 1549 CB GLU A 329 11.410 72.938 54.936 1.00 31.29 A C ATOM 1550 CG GLU A 329 12.815 72.478 55.236 1.00 37.80 A C ATOM 1551 CD GLU A 329 12.954 71.963 56.648 1.00 41.63 A C ATOM 1552 OE1 GLU A 329 12.396 70.880 56.938 1.00 41.71 A O ATOM 1553 OE2 GLU A 329 13.614 72.646 57.468 1.00 44.04 A O ATOM 1554 C GLU A 329 11.195 71.955 52.647 1.00 27.64 A C ATOM 1555 O GLU A 329 10.230 71.193 52.639 1.00 25.94 A O ATOM 1556 N ALA A 330 12.313 71.714 51.962 1.00 26.33 A N ATOM 1557 CA ALA A 330 12.498 70.507 51.149 1.00 28.04 A C ATOM 1558 CB ALA A 330 11.948 70.731 49.731 1.00 25.92 A C ATOM 1559 C ALA A 330 13.982 70.099 51.084 1.00 28.74 A C ATOM 1560 O ALA A 330 14.856 70.838 51.537 1.00 29.37 A O ATOM 1561 N ASN A 331 14.259 68.930 50.513 1.00 30.23 A N ATOM 1562 CA ASN A 331 15.627 68.421 50.411 1.00 31.60 A C ATOM 1563 CB ASN A 331 15.610 66.949 50.002 1.00 34.66 A C ATOM 1564 CG ASN A 331 14.955 66.069 51.041 1.00 38.24 A C ATOM 1565 OD1 ASN A 331 15.440 65.949 52.165 1.00 39.85 A O ATOM 1566 ND2 ASN A 331 13.841 65.449 50.672 1.00 42.35 A N ATOM 1567 C ASN A 331 16.532 69.189 49.459 1.00 31.72 A C ATOM 1568 O ASN A 331 17.757 69.115 49.572 1.00 31.03 A O ATOM 1569 N THR A 332 15.946 69.918 48.512 1.00 31.48 A N ATOM 1570 CA THR A 332 16.756 70.684 47.566 1.00 29.77 A C ATOM 1571 CB THR A 332 16.799 70.011 46.173 1.00 28.89 A C ATOM 1572 OG1 THR A 332 15.487 70.003 45.606 1.00 29.21 A O ATOM 1573 CG2 THR A 332 17.308 68.580 46.279 1.00 27.84 A C ATOM 1574 C THR A 332 16.270 72.118 47.383 1.00 31.57 A C ATOM 1575 O THR A 332 15.093 72.433 47.603 1.00 30.47 A O ATOM 1576 N TYR A 333 17.200 72.981 46.990 1.00 30.46 A N ATOM 1577 CA TYR A 333 16.918 74.386 46.744 1.00 32.40 A C ATOM 1578 CB TYR A 333 18.187 75.094 46.254 1.00 35.27 A C ATOM 1579 CG TYR A 333 19.283 75.216 47.286 1.00 39.94 A C ATOM 1580 CD1 TYR A 333 20.620 75.025 46.934 1.00 41.64 A C ATOM 1581 CE1 TYR A 333 21.640 75.157 47.874 1.00 43.08 A C ATOM 1582 CD2 TYR A 333 18.992 75.542 48.608 1.00 40.76 A C ATOM 1583 CE2 TYR A 333 20.007 75.677 49.555 1.00 43.70 A C ATOM 1584 CZ TYR A 333 21.323 75.483 49.178 1.00 43.66 A C ATOM 1585 OH TYR A 333 22.323 75.613 50.107 1.00 47.82 A O ATOM 1586 C TYR A 333 15.842 74.529 45.671 1.00 31.07 A C ATOM 1587 O TYR A 333 14.916 75.327 45.807 1.00 31.04 A O ATOM 1588 N GLN A 334 15.991 73.754 44.601 1.00 29.99 A N ATOM 1589 CA GLN A 334 15.069 73.778 43.471 1.00 30.74 A C ATOM 1590 CB GLN A 334 15.526 72.779 42.403 1.00 33.77 A C ATOM 1591 CG GLN A 334 14.434 72.304 41.439 1.00 41.43 A C ATOM 1592 CD GLN A 334 13.963 73.367 40.443 1.00 46.44 A C ATOM 1593 OE1 GLN A 334 13.366 74.388 40.820 1.00 47.38 A O ATOM 1594 NE2 GLN A 334 14.222 73.120 39.156 1.00 47.54 A N ATOM 1595 C GLN A 334 13.639 73.480 43.878 1.00 27.78 A C ATOM 1596 O GLN A 334 12.725 74.204 43.504 1.00 26.99 A O ATOM 1597 N GLU A 335 13.448 72.412 44.641 1.00 26.65 A N ATOM 1598 CA GLU A 335 12.114 72.041 45.085 1.00 26.25 A C ATOM 1599 CB GLU A 335 12.158 70.678 45.785 1.00 29.22 A C ATOM 1600 CG GLU A 335 10.814 70.193 46.294 1.00 34.80 A C ATOM 1601 CD GLU A 335 9.755 70.092 45.197 1.00 39.80 A C ATOM 1602 OE1 GLU A 335 8.569 69.866 45.539 1.00 41.99 A O ATOM 1603 OE2 GLU A 335 10.101 70.231 43.999 1.00 40.49 A O ATOM 1604 C GLU A 335 11.502 73.108 46.005 1.00 23.81 A C ATOM 1605 O GLU A 335 10.295 73.333 45.969 1.00 22.15 A O ATOM 1606 N THR A 336 12.332 73.781 46.802 1.00 21.23 A N ATOM 1607 CA THR A 336 11.835 74.821 47.710 1.00 21.06 A C ATOM 1608 CB THR A 336 12.911 75.253 48.723 1.00 20.94 A C ATOM 1609 OG1 THR A 336 13.207 74.155 49.593 1.00 21.30 A O ATOM 1610 CG2 THR A 336 12.418 76.430 49.561 1.00 19.68 A C ATOM 1611 C THR A 336 11.375 76.036 46.920 1.00 21.05 A C ATOM 1612 O THR A 336 10.317 76.634 47.204 1.00 19.51 A O ATOM 1613 N TYR A 337 12.177 76.386 45.921 1.00 22.32 A N ATOM 1614 CA TYR A 337 11.888 77.500 45.026 1.00 23.61 A C ATOM 1615 CB TYR A 337 12.987 77.601 43.959 1.00 28.60 A C ATOM 1616 CG TYR A 337 12.727 78.643 42.890 1.00 35.53 A C ATOM 1617 CD1 TYR A 337 13.096 79.978 43.076 1.00 38.47 A C ATOM 1618 CE1 TYR A 337 12.825 80.947 42.100 1.00 41.00 A C ATOM 1619 CD2 TYR A 337 12.081 78.298 41.700 1.00 38.75 A C ATOM 1620 CE2 TYR A 337 11.803 79.251 40.722 1.00 41.63 A C ATOM 1621 CZ TYR A 337 12.177 80.573 40.927 1.00 43.73 A C ATOM 1622 OH TYR A 337 11.890 81.513 39.958 1.00 46.53 A O ATOM 1623 C TYR A 337 10.546 77.221 44.346 1.00 22.77 A C ATOM 1624 O TYR A 337 9.680 78.096 44.261 1.00 20.90 A O ATOM 1625 N LYS A 338 10.384 75.988 43.870 1.00 22.05 A N ATOM 1626 CA LYS A 338 9.163 75.578 43.183 1.00 24.06 A C ATOM 1627 CB LYS A 338 9.314 74.153 42.633 1.00 28.55 A C ATOM 1628 CG LYS A 338 8.183 73.729 41.703 1.00 35.30 A C ATOM 1629 CD LYS A 338 8.152 72.221 41.440 1.00 41.29 A C ATOM 1630 CE LYS A 338 9.451 71.691 40.831 1.00 42.96 A C ATOM 1631 NZ LYS A 338 10.551 71.612 41.836 1.00 45.52 A N ATOM 1632 C LYS A 338 7.934 75.656 44.094 1.00 22.36 A C ATOM 1633 O LYS A 338 6.894 76.160 43.686 1.00 22.23 A O ATOM 1634 N ARG A 339 8.056 75.174 45.328 1.00 20.86 A N ATOM 1635 CA ARG A 339 6.936 75.214 46.263 1.00 19.98 A C ATOM 1636 CB ARG A 339 7.252 74.388 47.506 1.00 21.06 A C ATOM 1637 CG ARG A 339 7.288 72.892 47.250 1.00 24.15 A C ATOM 1638 CD ARG A 339 7.637 72.141 48.504 1.00 25.25 A C ATOM 1639 NE ARG A 339 7.821 70.720 48.241 1.00 30.16 A N ATOM 1640 CZ ARG A 339 8.053 69.811 49.182 1.00 30.16 A C ATOM 1641 NH1 ARG A 339 8.126 70.173 50.456 1.00 31.69 A N ATOM 1642 NH2 ARG A 339 8.217 68.541 48.848 1.00 32.15 A N ATOM 1643 C ARG A 339 6.516 76.626 46.685 1.00 17.94 A C ATOM 1644 O ARG A 339 5.339 76.878 46.919 1.00 14.93 A O ATOM 1645 N ILE A 340 7.478 77.536 46.788 1.00 17.04 A N ATOM 1646 CA ILE A 340 7.187 78.908 47.175 1.00 16.76 A C ATOM 1647 CB ILE A 340 8.497 79.705 47.480 1.00 14.52 A C ATOM 1648 CG2 ILE A 340 8.203 81.199 47.598 1.00 14.90 A C ATOM 1649 CG1 ILE A 340 9.127 79.209 48.786 1.00 14.96 A C ATOM 1650 CD1 ILE A 340 10.491 79.833 49.095 1.00 16.04 A C ATOM 1651 C ILE A 340 6.433 79.573 46.030 1.00 16.16 A C ATOM 1652 O ILE A 340 5.369 80.139 46.225 1.00 16.78 A O ATOM 1653 N SER A 341 6.988 79.469 44.829 1.00 18.02 A N ATOM 1654 CA SER A 341 6.397 80.061 43.636 1.00 19.89 A C ATOM 1655 CB SER A 341 7.302 79.792 42.423 1.00 22.71 A C ATOM 1656 OG SER A 341 6.820 80.457 41.269 1.00 27.61 A O ATOM 1657 C SER A 341 4.982 79.552 43.360 1.00 19.31 A C ATOM 1658 O SER A 341 4.118 80.318 42.946 1.00 18.97 A O ATOM 1659 N ARG A 342 4.753 78.262 43.594 1.00 19.76 A N ATOM 1660 CA ARG A 342 3.443 77.658 43.382 1.00 21.30 A C ATOM 1661 CB ARG A 342 3.597 76.214 42.911 1.00 24.17 A C ATOM 1662 CG ARG A 342 4.204 76.121 41.531 1.00 26.81 A C ATOM 1663 CD ARG A 342 4.268 74.702 41.017 1.00 31.06 A C ATOM 1664 NE ARG A 342 4.686 74.692 39.617 1.00 35.62 A N ATOM 1665 CZ ARG A 342 4.769 73.601 38.868 1.00 36.48 A C ATOM 1666 NH1 ARG A 342 5.157 73.700 37.606 1.00 40.12 A N ATOM 1667 NH2 ARG A 342 4.471 72.414 39.382 1.00 38.88 A N ATOM 1668 C ARG A 342 2.580 77.690 44.634 1.00 21.34 A C ATOM 1669 O ARG A 342 1.403 77.298 44.600 1.00 21.22 A O ATOM 1670 N VAL A 343 3.173 78.165 45.729 1.00 19.64 A N ATOM 1671 CA VAL A 343 2.499 78.260 47.022 1.00 19.20 A C ATOM 1672 CB VAL A 343 1.386 79.323 47.000 1.00 18.65 A C ATOM 1673 CG1 VAL A 343 0.848 79.534 48.417 1.00 15.93 A C ATOM 1674 CG2 VAL A 343 1.920 80.622 46.410 1.00 17.93 A C ATOM 1675 C VAL A 343 1.887 76.917 47.403 1.00 19.26 A C ATOM 1676 O VAL A 343 0.667 76.793 47.569 1.00 19.70 A O ATOM 1677 N GLU A 344 2.747 75.916 47.544 1.00 17.68 A N ATOM 1678 CA GLU A 344 2.311 74.568 47.879 1.00 19.81 A C ATOM 1679 CB GLU A 344 2.860 73.584 46.830 1.00 19.99 A C ATOM 1680 CG GLU A 344 2.339 73.871 45.426 1.00 26.77 A C ATOM 1681 CD GLU A 344 3.088 73.125 44.328 1.00 29.54 A C ATOM 1682 OE1 GLU A 344 2.646 73.198 43.163 1.00 33.31 A O ATOM 1683 OE2 GLU A 344 4.115 72.476 44.619 1.00 30.95 A O ATOM 1684 C GLU A 344 2.738 74.142 49.277 1.00 19.23 A C ATOM 1685 O GLU A 344 3.928 73.915 49.529 1.00 17.01 A O ATOM 1686 N PHE A 345 1.763 74.038 50.184 1.00 18.09 A N ATOM 1687 CA PHE A 345 2.030 73.621 51.555 1.00 19.56 A C ATOM 1688 CB PHE A 345 2.529 74.811 52.410 1.00 18.38 A C ATOM 1689 CG PHE A 345 1.461 75.833 52.734 1.00 18.52 A C ATOM 1690 CD1 PHE A 345 0.592 75.644 53.810 1.00 21.05 A C ATOM 1691 CD2 PHE A 345 1.313 76.982 51.951 1.00 18.65 A C ATOM 1692 CE1 PHE A 345 −0.415 76.584 54.102 1.00 16.74 A C ATOM 1693 CE2 PHE A 345 0.310 77.925 52.235 1.00 19.55 A C ATOM 1694 CZ PHE A 345 −0.553 77.720 53.317 1.00 18.36 A C ATOM 1695 C PHE A 345 0.779 73.033 52.185 1.00 20.33 A C ATOM 1696 O PHE A 345 −0.332 73.277 51.708 1.00 20.11 A O ATOM 1697 N THR A 346 0.969 72.260 53.255 1.00 19.73 A N ATOM 1698 CA THR A 346 −0.136 71.655 53.985 1.00 19.58 A C ATOM 1699 CB THR A 346 −0.326 70.158 53.615 1.00 20.72 A C ATOM 1700 OG1 THR A 346 0.916 69.459 53.746 1.00 20.60 A O ATOM 1701 CG2 THR A 346 −0.821 70.023 52.177 1.00 20.25 A C ATOM 1702 C THR A 346 0.116 71.792 55.487 1.00 20.13 A C ATOM 1703 O THR A 346 1.232 72.103 55.902 1.00 18.25 A O ATOM 1704 N PHE A 347 −0.932 71.567 56.282 1.00 20.15 A N ATOM 1705 CA PHE A 347 −0.887 71.673 57.746 1.00 20.73 A C ATOM 1706 CB PHE A 347 −2.084 72.476 58.280 1.00 19.55 A C ATOM 1707 CG PHE A 347 −2.217 73.870 57.720 1.00 20.41 A C ATOM 1708 CD1 PHE A 347 −1.433 74.909 58.201 1.00 17.74 A C ATOM 1709 CD2 PHE A 347 −3.178 74.150 56.744 1.00 20.45 A C ATOM 1710 CE1 PHE A 347 −1.597 76.204 57.732 1.00 18.97 A C ATOM 1711 CE2 PHE A 347 −3.354 75.449 56.264 1.00 19.38 A C ATOM 1712 CZ PHE A 347 −2.566 76.476 56.757 1.00 20.54 A C ATOM 1713 C PHE A 347 −0.983 70.309 58.430 1.00 22.46 A C ATOM 1714 O PHE A 347 −1.685 69.416 57.952 1.00 21.99 A O ATOM 1715 N PRO A 348 −0.285 70.133 59.565 1.00 24.54 A N ATOM 1716 CD PRO A 348 0.801 70.979 60.093 1.00 25.31 A C ATOM 1717 CA PRO A 348 −0.354 68.854 60.286 1.00 23.76 A C ATOM 1718 CB PRO A 348 0.728 68.991 61.354 1.00 24.65 A C ATOM 1719 CG PRO A 348 1.715 69.961 60.728 1.00 26.35 A C ATOM 1720 C PRO A 348 −1.756 68.822 60.910 1.00 24.94 A C ATOM 1721 O PRO A 348 −2.389 69.868 61.056 1.00 22.13 A O ATOM 1722 N ASP A 349 −2.231 67.640 61.286 1.00 27.34 A N ATOM 1723 CA ASP A 349 −3.568 67.503 61.870 1.00 30.19 A C ATOM 1724 CB ASP A 349 −3.856 66.047 62.234 1.00 33.25 A C ATOM 1725 CG ASP A 349 −3.804 65.139 61.045 1.00 37.28 A C ATOM 1726 OD1 ASP A 349 −4.341 65.526 59.987 1.00 39.75 A O ATOM 1727 OD2 ASP A 349 −3.232 64.034 61.172 1.00 41.94 A O ATOM 1728 C ASP A 349 −3.856 68.342 63.103 1.00 30.17 A C ATOM 1729 O ASP A 349 −4.987 68.777 63.293 1.00 29.70 A O ATOM 1730 N PHE A 350 −2.855 68.565 63.949 1.00 28.31 A N ATOM 1731 CA PHE A 350 −3.100 69.334 65.160 1.00 26.49 A C ATOM 1732 CB PHE A 350 −1.977 69.094 66.184 1.00 25.79 A C ATOM 1733 CG PHE A 350 −0.600 69.470 65.705 1.00 24.86 A C ATOM 1734 CD1 PHE A 350 −0.183 70.798 65.703 1.00 27.41 A C ATOM 1735 CD2 PHE A 350 0.294 68.492 65.296 1.00 22.65 A C ATOM 1736 CE1 PHE A 350 1.112 71.143 65.302 1.00 23.41 A C ATOM 1737 CE2 PHE A 350 1.586 68.824 64.895 1.00 22.60 A C ATOM 1738 CZ PHE A 350 1.995 70.153 64.899 1.00 23.36 A C ATOM 1739 C PHE A 350 −3.349 70.830 64.963 1.00 26.28 A C ATOM 1740 O PHE A 350 −3.926 71.482 65.833 1.00 26.14 A O ATOM 1741 N VAL A 351 −2.957 71.380 63.820 1.00 24.56 A N ATOM 1742 CA VAL A 351 −3.174 72.809 63.600 1.00 23.91 A C ATOM 1743 CB VAL A 351 −2.429 73.304 62.341 1.00 21.91 A C ATOM 1744 CG1 VAL A 351 −2.624 74.803 62.184 1.00 22.59 A C ATOM 1745 CG2 VAL A 351 −0.943 72.989 62.459 1.00 19.79 A C ATOM 1746 C VAL A 351 −4.666 73.183 63.510 1.00 23.38 A C ATOM 1747 O VAL A 351 −5.408 72.635 62.707 1.00 23.52 A O ATOM 1748 N THR A 352 −5.076 74.123 64.358 1.00 23.53 A N ATOM 1749 CA THR A 352 −6.454 74.618 64.463 1.00 24.90 A C ATOM 1750 CB THR A 352 −6.561 75.531 65.724 1.00 26.17 A C ATOM 1751 OG1 THR A 352 −6.461 74.713 66.893 1.00 29.32 A O ATOM 1752 CG2 THR A 352 −7.872 76.284 65.769 1.00 31.36 A C ATOM 1753 C THR A 352 −7.013 75.350 63.230 1.00 23.73 A C ATOM 1754 O THR A 352 −6.270 75.946 62.447 1.00 23.43 A O ATOM 1755 N GLU A 353 −8.335 75.306 63.059 1.00 24.62 A N ATOM 1756 CA GLU A 353 −8.967 75.954 61.909 1.00 24.68 A C ATOM 1757 CB GLU A 353 −10.468 75.643 61.869 1.00 29.50 A C ATOM 1758 CG GLU A 353 −10.797 74.232 61.368 1.00 35.19 A C ATOM 1759 CD GLU A 353 −10.272 73.983 59.966 1.00 38.71 A C ATOM 1760 OE1 GLU A 353 −10.401 74.895 59.117 1.00 40.65 A O ATOM 1761 OE2 GLU A 353 −9.739 72.879 59.703 1.00 40.38 A O ATOM 1762 C GLU A 353 −8.752 77.464 61.858 1.00 21.70 A C ATOM 1763 O GLU A 353 −8.583 78.041 60.782 1.00 19.58 A O ATOM 1764 N GLY A 354 −8.755 78.106 63.017 1.00 19.06 A N ATOM 1765 CA GLY A 354 −8.551 79.542 63.035 1.00 17.79 A C ATOM 1766 C GLY A 354 −7.128 79.867 62.603 1.00 18.40 A C ATOM 1767 O GLY A 354 −6.878 80.874 61.930 1.00 16.97 A O ATOM 1768 N ALA A 355 −6.191 79.009 62.993 1.00 14.57 A N ATOM 1769 CA ALA A 355 −4.794 79.210 62.648 1.00 15.46 A C ATOM 1770 CB ALA A 355 −3.919 78.229 63.439 1.00 16.64 A C ATOM 1771 C ALA A 355 −4.589 79.038 61.136 1.00 14.00 A C ATOM 1772 O ALA A 355 −3.846 79.800 60.508 1.00 10.53 A O ATOM 1773 N ARG A 356 −5.269 78.043 60.565 1.00 15.01 A N ATOM 1774 CA ARG A 356 −5.199 77.759 59.133 1.00 16.46 A C ATOM 1775 CB ARG A 356 −6.010 76.503 58.799 1.00 16.70 A C ATOM 1776 CG ARG A 356 −5.460 75.229 59.389 1.00 18.49 A C ATOM 1777 CD ARG A 356 −6.495 74.120 59.378 1.00 22.62 A C ATOM 1778 NE ARG A 356 −6.108 73.006 58.518 1.00 28.84 A N ATOM 1779 CZ ARG A 356 −5.911 71.762 58.945 1.00 29.04 A C ATOM 1780 NH1 ARG A 356 −6.058 71.463 60.224 1.00 27.32 A N ATOM 1781 NH2 ARG A 356 −5.577 70.811 58.086 1.00 31.07 A N ATOM 1782 C ARG A 356 −5.758 78.941 58.350 1.00 15.08 A C ATOM 1783 O ARG A 356 −5.225 79.335 57.319 1.00 14.99 A O ATOM 1784 N ASP A 357 −6.841 79.508 58.860 1.00 18.02 A N ATOM 1785 CA ASP A 357 −7.466 80.646 58.214 1.00 18.90 A C ATOM 1786 CB ASP A 357 −8.694 81.096 58.994 1.00 18.88 A C ATOM 1787 CG ASP A 357 −9.406 82.240 58.312 1.00 22.28 A C ATOM 1788 OD1 ASP A 357 −9.966 81.992 57.235 1.00 22.61 A O ATOM 1789 OD2 ASP A 357 −9.388 83.381 58.830 1.00 24.45 A O ATOM 1790 C ASP A 357 −6.494 81.824 58.092 1.00 19.94 A C ATOM 1791 O ASP A 357 −6.289 82.342 56.998 1.00 20.32 A O ATOM 1792 N LEU A 358 −5.900 82.238 59.211 1.00 18.05 A N ATOM 1793 CA LEU A 358 −4.942 83.358 59.219 1.00 18.23 A C ATOM 1794 CB LEU A 358 −4.411 83.613 60.638 1.00 18.23 A C ATOM 1795 CG LEU A 358 −3.394 84.760 60.758 1.00 20.75 A C ATOM 1796 CD1 LEU A 358 −4.012 86.056 60.216 1.00 19.09 A C ATOM 1797 CD2 LEU A 358 −2.964 84.934 62.208 1.00 17.47 A C ATOM 1798 C LEU A 358 −3.749 83.145 58.290 1.00 16.19 A C ATOM 1799 O LEU A 358 −3.413 84.021 57.481 1.00 16.52 A O ATOM 1800 N ILE A 359 −3.119 81.983 58.415 1.00 15.38 A N ATOM 1801 CA ILE A 359 −1.956 81.629 57.613 1.00 16.57 A C ATOM 1802 CB ILE A 359 −1.329 80.296 58.114 1.00 16.35 A C ATOM 1803 CG2 ILE A 359 −0.186 79.879 57.193 1.00 13.83 A C ATOM 1804 CG1 ILE A 359 −0.825 80.469 59.553 1.00 17.25 A C ATOM 1805 CD1 ILE A 359 −0.321 79.200 60.220 1.00 14.18 A C ATOM 1806 C ILE A 359 −2.255 81.518 56.112 1.00 17.80 A C ATOM 1807 O ILE A 359 −1.398 81.829 55.294 1.00 18.14 A O ATOM 1808 N SER A 360 −3.464 81.079 55.759 1.00 19.68 A N ATOM 1809 CA SER A 360 −3.867 80.938 54.354 1.00 21.20 A C ATOM 1810 CB SER A 360 −5.153 80.099 54.233 1.00 19.64 A C ATOM 1811 OG SER A 360 −4.950 78.757 54.649 1.00 20.82 A O ATOM 1812 C SER A 360 −4.105 82.303 53.714 1.00 22.33 A C ATOM 1813 O SER A 360 −3.958 82.467 52.501 1.00 20.61 A O ATOM 1814 N ARG A 361 −4.500 83.274 54.533 1.00 23.60 A N ATOM 1815 CA ARG A 361 −4.741 84.633 54.059 1.00 23.75 A C ATOM 1816 CB ARG A 361 −5.587 85.410 55.072 1.00 28.01 A C ATOM 1817 CG ARG A 361 −7.078 85.081 55.087 1.00 32.71 A C ATOM 1818 CD ARG A 361 −7.726 85.333 53.723 1.00 39.20 A C ATOM 1819 NE ARG A 361 −7.187 86.514 53.042 1.00 44.85 A N ATOM 1820 CZ ARG A 361 −7.332 87.772 53.456 1.00 46.87 A C ATOM 1821 NH1 ARG A 361 −8.012 88.048 54.562 1.00 45.54 A N ATOM 1822 NH2 ARG A 361 −6.772 88.759 52.767 1.00 47.53 A N ATOM 1823 C ARG A 361 −3.414 85.369 53.863 1.00 21.60 A C ATOM 1824 O ARG A 361 −3.268 86.174 52.941 1.00 24.02 A O ATOM 1825 N LEU A 362 −2.450 85.078 54.730 1.00 19.99 A N ATOM 1826 CA LEU A 362 −1.139 85.730 54.683 1.00 18.01 A C ATOM 1827 CB LEU A 362 −0.431 85.627 56.042 1.00 15.49 A C ATOM 1828 CG LEU A 362 −0.993 86.459 57.207 1.00 15.69 A C ATOM 1829 CD1 LEU A 362 −0.312 86.063 58.496 1.00 10.97 A C ATOM 1830 CD2 LEU A 362 −0.801 87.948 56.941 1.00 15.65 A C ATOM 1831 C LEU A 362 −0.225 85.192 53.603 1.00 18.43 A C ATOM 1832 O LEU A 362 0.608 85.930 53.080 1.00 18.21 A O ATOM 1833 N LEU A 363 −0.362 83.911 53.271 1.00 19.92 A N ATOM 1834 CA LEU A 363 0.483 83.328 52.235 1.00 21.77 A C ATOM 1835 CB LEU A 363 0.918 81.910 52.623 1.00 21.94 A C ATOM 1836 CG LEU A 363 1.412 81.704 54.065 1.00 26.68 A C ATOM 1837 CD1 LEU A 363 2.276 80.444 54.158 1.00 23.94 A C ATOM 1838 CD2 LEU A 363 2.215 82.925 54.518 1.00 26.76 A C ATOM 1839 C LEU A 363 −0.243 83.314 50.892 1.00 22.91 A C ATOM 1840 O LEU A 363 −0.570 82.261 50.359 1.00 24.15 A O ATOM 1841 N LYS A 364 −0.505 84.508 50.370 1.00 23.56 A N ATOM 1842 CA LYS A 364 −1.180 84.691 49.090 1.00 23.34 A C ATOM 1843 CB LYS A 364 −2.211 85.818 49.181 1.00 24.62 A C ATOM 1844 CG LYS A 364 −3.545 85.423 49.806 1.00 26.87 A C ATOM 1845 CD LYS A 364 −4.289 84.446 48.912 1.00 29.10 A C ATOM 1846 CE LYS A 364 −5.713 84.208 49.392 1.00 32.69 A C ATOM 1847 NZ LYS A 364 −6.503 83.427 48.391 1.00 32.47 A N ATOM 1848 C LYS A 364 −0.144 85.052 48.032 1.00 22.89 A C ATOM 1849 O LYS A 364 0.696 85.929 48.247 1.00 23.81 A O ATOM 1850 N HIS A 365 −0.210 84.375 46.893 1.00 22.71 A N ATOM 1851 CA HIS A 365 0.717 84.624 45.797 1.00 23.97 A C ATOM 1852 CB HIS A 365 0.380 83.734 44.602 1.00 24.15 A C ATOM 1853 CG HIS A 365 1.275 83.955 43.426 1.00 25.26 A C ATOM 1854 CD2 HIS A 365 1.097 84.673 42.293 1.00 26.54 A C ATOM 1855 ND1 HIS A 365 2.563 83.470 43.372 1.00 27.83 A N ATOM 1856 CE1 HIS A 365 3.142 83.883 42.258 1.00 26.33 A C ATOM 1857 NE2 HIS A 365 2.274 84.617 41.588 1.00 26.94 A N ATOM 1858 C HIS A 365 0.703 86.085 45.354 1.00 23.66 A C ATOM 1859 O HIS A 365 1.757 86.695 45.187 1.00 24.80 A O ATOM 1860 N ASN A 366 −0.491 86.631 45.144 1.00 25.39 A N ATOM 1861 CA ASN A 366 −0.667 88.027 44.729 1.00 28.27 A C ATOM 1862 CB ASN A 366 −2.058 88.197 44.101 1.00 30.44 A C ATOM 1863 CG ASN A 366 −2.331 89.620 43.624 1.00 33.56 A C ATOM 1864 OD1 ASN A 366 −3.386 89.895 43.051 1.00 36.17 A O ATOM 1865 ND2 ASN A 366 −1.390 90.525 43.857 1.00 32.69 A N ATOM 1866 C ASN A 366 −0.526 88.926 45.965 1.00 28.67 A C ATOM 1867 O ASN A 366 −1.389 88.928 46.843 1.00 29.64 A O ATOM 1868 N PRO A 367 0.562 89.706 46.044 1.00 29.87 A N ATOM 1869 CD PRO A 367 1.612 89.829 45.019 1.00 28.83 A C ATOM 1870 CA PRO A 367 0.832 90.611 47.172 1.00 31.07 A C ATOM 1871 CB PRO A 367 2.013 91.437 46.675 1.00 30.37 A C ATOM 1872 CG PRO A 367 2.734 90.479 45.790 1.00 30.85 A C ATOM 1873 C PRO A 367 −0.328 91.496 47.624 1.00 32.07 A C ATOM 1874 O PRO A 367 −0.483 91.754 48.820 1.00 32.30 A O ATOM 1875 N SER A 368 −1.131 91.966 46.671 1.00 32.61 A N ATOM 1876 CA SER A 368 −2.261 92.834 46.987 1.00 34.50 A C ATOM 1877 CB SER A 368 −2.760 93.547 45.720 1.00 35.81 A C ATOM 1878 OG SER A 368 −3.206 92.623 44.736 1.00 36.05 A O ATOM 1879 C SER A 368 −3.413 92.088 47.656 1.00 35.02 A C ATOM 1880 O SER A 368 −4.290 92.706 48.258 1.00 37.52 A O ATOM 1881 N GLN A 369 −3.418 90.763 47.554 1.00 34.24 A N ATOM 1882 CA GLN A 369 −4.475 89.975 48.176 1.00 33.87 A C ATOM 1883 CB GLN A 369 −4.644 88.637 47.463 1.00 36.07 A C ATOM 1884 CG GLN A 369 −5.499 88.695 46.218 1.00 40.88 A C ATOM 1885 CD GLN A 369 −5.478 87.382 45.463 1.00 44.11 A C ATOM 1886 OE1 GLN A 369 −5.619 86.308 46.059 1.00 45.39 A O ATOM 1887 NE2 GLN A 369 −5.303 87.457 44.145 1.00 45.10 A N ATOM 1888 C GLN A 369 −4.214 89.721 49.653 1.00 32.42 A C ATOM 1889 O GLN A 369 −5.045 89.136 50.336 1.00 31.67 A O ATOM 1890 N ARG A 370 −3.053 90.149 50.141 1.00 31.86 A N ATOM 1891 CA ARG A 370 −2.714 89.968 51.549 1.00 30.59 A C ATOM 1892 CB ARG A 370 −1.193 89.979 51.741 1.00 27.86 A C ATOM 1893 CG ARG A 370 −0.498 88.834 51.047 1.00 27.06 A C ATOM 1894 CD ARG A 370 1.015 89.020 50.987 1.00 25.62 A C ATOM 1895 NE ARG A 370 1.552 88.214 49.901 1.00 23.24 A N ATOM 1896 CZ ARG A 370 2.744 88.385 49.344 1.00 22.14 A C ATOM 1897 NH1 ARG A 370 3.557 89.340 49.777 1.00 19.46 A N ATOM 1898 NH2 ARG A 370 3.098 87.618 48.314 1.00 20.24 A N ATOM 1899 C ARG A 370 −3.349 91.103 52.344 1.00 30.03 A C ATOM 1900 O ARG A 370 −3.380 92.244 51.887 1.00 30.03 A O ATOM 1901 N PRO A 371 −3.861 90.801 53.549 1.00 29.42 A N ATOM 1902 CD PRO A 371 −3.861 89.468 54.180 1.00 28.61 A C ATOM 1903 CA PRO A 371 −4.506 91.783 54.426 1.00 29.38 A C ATOM 1904 CB PRO A 371 −5.105 90.911 55.524 1.00 28.93 A C ATOM 1905 CG PRO A 371 −4.130 89.800 55.626 1.00 27.39 A C ATOM 1906 C PRO A 371 −3.579 92.856 54.995 1.00 30.07 A C ATOM 1907 O PRO A 371 −2.356 92.719 54.979 1.00 30.66 A O ATOM 1908 N MET A 372 −4.179 93.932 55.489 1.00 29.01 A N ATOM 1909 CA MET A 372 −3.422 95.014 56.095 1.00 28.79 A C ATOM 1910 CB MET A 372 −4.297 96.255 56.209 1.00 32.05 A C ATOM 1911 CG MET A 372 −4.983 96.641 54.909 1.00 38.91 A C ATOM 1912 SD MET A 372 −6.339 97.820 55.165 1.00 45.86 A S ATOM 1913 CE MET A 372 −5.396 99.295 55.623 1.00 43.73 A C ATOM 1914 C MET A 372 −3.050 94.511 57.484 1.00 27.02 A C ATOM 1915 O MET A 372 −3.635 93.542 57.965 1.00 25.83 A O ATOM 1916 N LEU A 373 −2.084 95.160 58.126 1.00 26.03 A N ATOM 1917 CA LEU A 373 −1.650 94.759 59.462 1.00 24.32 A C ATOM 1918 CB LEU A 373 −0.422 95.570 59.886 1.00 24.26 A C ATOM 1919 CG LEU A 373 0.874 95.259 59.134 1.00 24.53 A C ATOM 1920 CD1 LEU A 373 1.971 96.239 59.545 1.00 22.42 A C ATOM 1921 CD2 LEU A 373 1.291 93.821 59.422 1.00 22.22 A C ATOM 1922 C LEU A 373 −2.756 94.910 60.504 1.00 23.93 A C ATOM 1923 O LEU A 373 −2.789 94.181 61.488 1.00 24.38 A O ATOM 1924 N ALA A 374 −3.666 95.852 60.281 1.00 24.38 A N ATOM 1925 CA ALA A 374 −4.772 96.080 61.203 1.00 22.71 A C ATOM 1926 CB ALA A 374 −5.503 97.370 60.836 1.00 26.79 A C ATOM 1927 C ALA A 374 −5.741 94.911 61.164 1.00 23.14 A C ATOM 1928 O ALA A 374 −6.432 94.637 62.150 1.00 22.46 A O ATOM 1929 N GLU A 375 −5.798 94.227 60.022 1.00 23.02 A N ATOM 1930 CA GLU A 375 −6.694 93.084 59.875 1.00 25.10 A C ATOM 1931 CB GLU A 375 −6.908 92.745 58.398 1.00 25.81 A C ATOM 1932 CG GLU A 375 −7.552 93.858 57.593 1.00 30.24 A C ATOM 1933 CD GLU A 375 −7.814 93.459 56.151 1.00 30.04 A C ATOM 1934 OE1 GLU A 375 −8.843 92.800 55.883 1.00 33.09 A O ATOM 1935 OE2 GLU A 375 −6.984 93.796 55.289 1.00 29.56 A O ATOM 1936 C GLU A 375 −6.143 91.864 60.612 1.00 25.25 A C ATOM 1937 O GLU A 375 −6.910 91.011 61.063 1.00 27.99 A O ATOM 1938 N VAL A 376 −4.820 91.785 60.727 1.00 22.91 A N ATOM 1939 CA VAL A 376 −4.175 90.687 61.439 1.00 21.50 A C ATOM 1940 CB VAL A 376 −2.643 90.662 61.187 1.00 21.90 A C ATOM 1941 CG1 VAL A 376 −1.976 89.654 62.125 1.00 19.51 A C ATOM 1942 CG2 VAL A 376 −2.355 90.313 59.729 1.00 22.63 A C ATOM 1943 C VAL A 376 −4.405 90.862 62.944 1.00 21.43 A C ATOM 1944 O VAL A 376 −4.725 89.906 63.653 1.00 19.70 A O ATOM 1945 N LEU A 377 −4.241 92.090 63.422 1.00 19.23 A N ATOM 1946 CA LEU A 377 −4.426 92.375 64.837 1.00 22.49 A C ATOM 1947 CB LEU A 377 −4.002 93.815 65.142 1.00 22.58 A C ATOM 1948 CG LEU A 377 −2.498 94.047 64.962 1.00 22.54 A C ATOM 1949 CD1 LEU A 377 −2.172 95.525 64.951 1.00 22.51 A C ATOM 1950 CD2 LEU A 377 −1.753 93.341 66.092 1.00 22.08 A C ATOM 1951 C LEU A 377 −5.869 92.143 65.269 1.00 25.05 A C ATOM 1952 O LEU A 377 −6.141 91.905 66.443 1.00 26.04 A O ATOM 1953 N GLU A 378 −6.787 92.177 64.308 1.00 24.26 A N ATOM 1954 CA GLU A 378 −8.193 91.983 64.611 1.00 25.18 A C ATOM 1955 CB GLU A 378 −9.032 93.046 63.890 1.00 27.95 A C ATOM 1956 CG GLU A 378 −8.848 94.444 64.452 1.00 31.63 A C ATOM 1957 CD GLU A 378 −9.693 95.484 63.743 1.00 33.54 A C ATOM 1958 OE1 GLU A 378 −9.894 96.568 64.334 1.00 35.00 A O ATOM 1959 OE2 GLU A 378 −10.147 95.220 62.605 1.00 31.59 A O ATOM 1960 C GLU A 378 −8.713 90.597 64.251 1.00 24.15 A C ATOM 1961 O GLU A 378 −9.883 90.301 64.473 1.00 21.88 A O ATOM 1962 N HIS A 379 −7.860 89.742 63.702 1.00 22.41 A N ATOM 1963 CA HIS A 379 −8.322 88.410 63.337 1.00 22.38 A C ATOM 1964 CB HIS A 379 −7.200 87.624 62.665 1.00 18.92 A C ATOM 1965 CG HIS A 379 −7.650 86.333 62.050 1.00 16.62 A C ATOM 1966 CD2 HIS A 379 −7.936 86.009 60.767 1.00 15.24 A C ATOM 1967 ND1 HIS A 379 −7.834 85.181 62.786 1.00 15.11 A N ATOM 1968 CE1 HIS A 379 −8.208 84.202 61.982 1.00 16.55 A C ATOM 1969 NE2 HIS A 379 −8.278 84.678 60.751 1.00 17.07 A N ATOM 1970 C HIS A 379 −8.818 87.695 64.595 1.00 22.89 A C ATOM 1971 O HIS A 379 −8.211 87.802 65.659 1.00 24.73 A O ATOM 1972 N PRO A 380 −9.948 86.978 64.489 1.00 22.77 A N ATOM 1973 CD PRO A 380 −10.751 86.800 63.266 1.00 22.48 A C ATOM 1974 CA PRO A 380 −10.544 86.247 65.614 1.00 22.16 A C ATOM 1975 CB PRO A 380 −11.777 85.580 64.984 1.00 22.20 A C ATOM 1976 CG PRO A 380 −11.422 85.482 63.529 1.00 24.64 A C ATOM 1977 C PRO A 380 −9.633 85.256 66.351 1.00 21.00 A C ATOM 1978 O PRO A 380 −9.762 85.078 67.563 1.00 19.68 A O ATOM 1979 N TRP A 381 −8.722 84.613 65.627 1.00 19.43 A N ATOM 1980 CA TRP A 381 −7.801 83.666 66.246 1.00 18.47 A C ATOM 1981 CB TRP A 381 −7.098 82.827 65.172 1.00 17.30 A C ATOM 1982 CG TRP A 381 −6.164 81.805 65.737 1.00 19.05 A C ATOM 1983 CD2 TRP A 381 −4.733 81.895 65.800 1.00 18.83 A C ATOM 1984 CE2 TRP A 381 −4.270 80.732 66.456 1.00 19.95 A C ATOM 1985 CE3 TRP A 381 −3.800 82.846 65.366 1.00 19.48 A C ATOM 1986 CD1 TRP A 381 −6.499 80.628 66.336 1.00 18.42 A C ATOM 1987 NE1 TRP A 381 −5.368 79.975 66.771 1.00 18.35 A N ATOM 1988 CZ2 TRP A 381 −2.907 80.493 66.690 1.00 18.02 A C ATOM 1989 CZ3 TRP A 381 −2.440 82.609 65.597 1.00 19.48 A C ATOM 1990 CH2 TRP A 381 −2.011 81.439 66.254 1.00 19.82 A C ATOM 1991 C TRP A 381 −6.764 84.430 67.088 1.00 18.12 A C ATOM 1992 O TRP A 381 −6.385 83.991 68.176 1.00 18.12 A O ATOM 1993 N ILE A 382 −6.324 85.579 66.587 1.00 18.20 A N ATOM 1994 CA ILE A 382 −5.347 86.410 67.296 1.00 19.68 A C ATOM 1995 CB ILE A 382 −4.875 87.569 66.394 1.00 17.49 A C ATOM 1996 CG2 ILE A 382 −4.118 88.599 67.213 1.00 20.81 A C ATOM 1997 CG1 ILE A 382 −4.020 87.021 65.243 1.00 18.99 A C ATOM 1998 CD1 ILE A 382 −2.653 86.493 65.655 1.00 19.59 A C ATOM 1999 C ILE A 382 −5.932 86.997 68.592 1.00 22.60 A C ATOM 2000 O ILE A 382 −5.271 87.019 69.642 1.00 21.36 A O ATOM 2001 N THR A 383 −7.174 87.469 68.504 1.00 21.35 A N ATOM 2002 CA THR A 383 −7.886 88.068 69.632 1.00 22.03 A C ATOM 2003 CB THR A 383 −9.213 88.734 69.143 1.00 24.29 A C ATOM 2004 OG1 THR A 383 −8.912 89.957 68.457 1.00 28.50 A O ATOM 2005 CG2 THR A 383 −10.140 89.028 70.312 1.00 28.56 A C ATOM 2006 C THR A 383 −8.225 87.040 70.713 1.00 21.21 A C ATOM 2007 O THR A 383 −8.139 87.316 71.904 1.00 19.20 A O ATOM 2008 N ALA A 384 −8.622 85.849 70.285 1.00 21.12 A N ATOM 2009 CA ALA A 384 −8.986 84.788 71.217 1.00 19.34 A C ATOM 2010 CB ALA A 384 −9.661 83.649 70.448 1.00 16.55 A C ATOM 2011 C ALA A 384 −7.822 84.231 72.049 1.00 21.30 A C ATOM 2012 O ALA A 384 −7.980 83.995 73.259 1.00 22.43 A O ATOM 2013 N ASN A 385 −6.661 84.040 71.416 1.00 20.05 A N ATOM 2014 CA ASN A 385 −5.503 83.449 72.091 1.00 22.78 A C ATOM 2015 CB ASN A 385 −4.883 82.377 71.195 1.00 20.49 A C ATOM 2016 CG ASN A 385 −5.871 81.286 70.817 1.00 21.65 A C ATOM 2017 OD1 ASN A 385 −6.380 80.569 71.674 1.00 21.14 A O ATOM 2018 ND2 ASN A 385 −6.148 81.160 69.525 1.00 19.14 A N ATOM 2019 C ASN A 385 −4.385 84.356 72.593 1.00 25.16 A C ATOM 2020 O ASN A 385 −3.472 83.883 73.267 1.00 27.83 A O ATOM 2021 N SER A 386 −4.426 85.642 72.274 1.00 26.88 A N ATOM 2022 CA SER A 386 −3.375 86.536 72.739 1.00 29.74 A C ATOM 2023 CB SER A 386 −3.385 87.834 71.940 1.00 30.28 A C ATOM 2024 OG SER A 386 −2.391 88.717 72.419 1.00 33.08 A O ATOM 2025 C SER A 386 −3.559 86.851 74.218 1.00 32.93 A C ATOM 2026 O SER A 386 −4.677 87.088 74.676 1.00 32.42 A O ATOM 2027 N SER A 387 −2.461 86.844 74.967 1.00 34.64 A N ATOM 2028 CA SER A 387 −2.524 87.144 76.393 1.00 37.99 A C ATOM 2029 CB SER A 387 −1.376 86.454 77.141 1.00 38.92 A C ATOM 2030 OG SER A 387 −0.112 86.876 76.662 1.00 37.92 A O ATOM 2031 C SER A 387 −2.451 88.652 76.599 1.00 39.48 A C ATOM 2032 O SER A 387 −2.459 89.135 77.728 1.00 40.65 A O ATOM 2033 N LYS A 388 −2.387 89.383 75.489 1.00 41.58 A N ATOM 2034 CA LYS A 388 −2.320 90.844 75.487 1.00 43.93 A C ATOM 2035 CB LYS A 388 −3.340 91.441 76.466 1.00 43.62 A C ATOM 2036 CG LYS A 388 −4.758 90.887 76.316 1.00 43.37 A C ATOM 2037 CD LYS A 388 −5.787 91.767 77.016 1.00 43.10 A C ATOM 2038 CE LYS A 388 −6.533 92.633 75.989 1.00 43.79 A C ATOM 2039 NZ LYS A 388 −5.609 93.345 75.045 1.00 42.84 A N ATOM 2040 C LYS A 388 −0.918 91.354 75.822 1.00 45.61 A C ATOM 2041 O LYS A 388 −0.649 91.581 77.023 1.00 46.51 A O ATOM 2042 OXT LYS A 388 −0.100 91.503 74.881 1.00 46.24 A O TER 2043 LYS A 388 ATOM 2044 CB GLN B 126 10.213 7.246 17.228 1.00 52.35 B C ATOM 2045 CG GLN B 126 11.292 7.078 16.169 1.00 53.31 B C ATOM 2046 CD GLN B 126 12.534 6.382 16.706 1.00 54.51 B C ATOM 2047 OE1 GLN B 126 13.488 6.131 15.966 1.00 55.84 B O ATOM 2048 NE2 GLN B 126 12.526 6.065 17.999 1.00 53.41 B N ATOM 2049 C GLN B 126 8.987 9.170 16.193 1.00 50.24 B C ATOM 2050 O GLN B 126 8.930 9.438 14.994 1.00 50.75 B O ATOM 2051 N GLN B 126 8.388 6.816 15.605 1.00 51.32 B N ATOM 2052 CA GLN B 126 8.864 7.730 16.685 1.00 51.36 B C ATOM 2053 N TRP B 127 9.168 10.087 17.137 1.00 48.65 B N ATOM 2054 CA TRP B 127 9.279 11.516 16.855 1.00 45.05 B C ATOM 2055 CB TRP B 127 9.752 12.240 18.112 1.00 45.82 B C ATOM 2056 CG TRP B 127 8.716 12.256 19.197 1.00 48.91 B C ATOM 2057 CD2 TRP B 127 7.325 12.583 19.052 1.00 49.46 B C ATOM 2058 CE2 TRP B 127 6.741 12.502 20.336 1.00 50.15 B C ATOM 2059 CE3 TRP B 127 6.517 12.937 17.962 1.00 50.60 B C ATOM 2060 CD1 TRP B 127 8.911 11.997 20.523 1.00 49.18 B C ATOM 2061 NE1 TRP B 127 7.730 12.143 21.214 1.00 50.57 B N ATOM 2062 CZ2 TRP B 127 5.384 12.764 20.563 1.00 51.76 B C ATOM 2063 CZ3 TRP B 127 5.163 13.197 18.186 1.00 51.62 B C ATOM 2064 CH2 TRP B 127 4.613 13.108 19.479 1.00 51.32 B C ATOM 2065 C TRP B 127 10.131 11.952 15.671 1.00 42.62 B C ATOM 2066 O TRP B 127 11.322 11.660 15.593 1.00 42.25 B O ATOM 2067 N ALA B 128 9.488 12.664 14.749 1.00 39.75 B N ATOM 2068 CA ALA B 128 10.141 13.206 13.564 1.00 36.83 B C ATOM 2069 CB ALA B 128 9.858 12.342 12.342 1.00 37.27 B C ATOM 2070 C ALA B 128 9.533 14.584 13.386 1.00 33.84 B C ATOM 2071 O ALA B 128 8.469 14.862 13.929 1.00 33.46 B O ATOM 2072 N LEU B 129 10.201 15.443 12.630 1.00 32.37 B N ATOM 2073 CA LEU B 129 9.718 16.798 12.419 1.00 32.04 B C ATOM 2074 CB LEU B 129 10.708 17.570 11.548 1.00 31.51 B C ATOM 2075 CG LEU B 129 10.548 19.091 11.537 1.00 33.77 B C ATOM 2076 CD1 LEU B 129 10.560 19.625 12.968 1.00 33.40 B C ATOM 2077 CD2 LEU B 129 11.673 19.708 10.731 1.00 32.31 B C ATOM 2078 C LEU B 129 8.321 16.854 11.796 1.00 31.97 B C ATOM 2079 O LEU B 129 7.479 17.645 12.226 1.00 31.99 B O ATOM 2080 N ALA B 130 8.082 16.007 10.797 1.00 31.30 B N ATOM 2081 CA ALA B 130 6.803 15.951 10.091 1.00 31.88 B C ATOM 2082 CB ALA B 130 6.866 14.898 8.983 1.00 31.86 B C ATOM 2083 C ALA B 130 5.609 15.677 10.995 1.00 31.10 B C ATOM 2084 O ALA B 130 4.465 15.794 10.568 1.00 32.53 B O ATOM 2085 N ASP B 131 5.871 15.312 12.243 1.00 30.37 B N ATOM 2086 CA ASP B 131 4.800 15.038 13.193 1.00 30.59 B C ATOM 2087 CB ASP B 131 5.329 14.156 14.328 1.00 32.68 B C ATOM 2088 CG ASP B 131 5.607 12.727 13.884 1.00 36.29 B C ATOM 2089 OD1 ASP B 131 6.370 12.025 14.582 1.00 36.01 B O ATOM 2090 OD2 ASP B 131 5.053 12.302 12.847 1.00 36.71 B O ATOM 2091 C ASP B 131 4.197 16.309 13.796 1.00 29.73 B C ATOM 2092 O ASP B 131 3.185 16.242 14.492 1.00 30.13 B O ATOM 2093 N PHE B 132 4.800 17.462 13.512 1.00 28.26 B N ATOM 2094 CA PHE B 132 4.344 18.725 14.092 1.00 25.47 B C ATOM 2095 CB PHE B 132 5.417 19.272 15.039 1.00 25.53 B C ATOM 2096 CG PHE B 132 5.944 18.268 16.020 1.00 25.89 B C ATOM 2097 CD1 PHE B 132 5.301 18.056 17.234 1.00 27.37 B C ATOM 2098 CD2 PHE B 132 7.087 17.536 15.732 1.00 26.04 B C ATOM 2099 CE1 PHE B 132 5.791 17.130 18.144 1.00 28.04 B C ATOM 2100 CE2 PHE B 132 7.584 16.608 16.633 1.00 26.31 B C ATOM 2101 CZ PHE B 132 6.937 16.403 17.839 1.00 27.54 B C ATOM 2102 C PHE B 132 4.020 19.855 13.127 1.00 25.28 B C ATOM 2103 O PHE B 132 4.581 19.946 12.039 1.00 23.06 B O ATOM 2104 N GLU B 133 3.113 20.724 13.567 1.00 24.47 B N ATOM 2105 CA GLU B 133 2.751 21.929 12.835 1.00 24.02 B C ATOM 2106 CB GLU B 133 1.234 22.125 12.779 1.00 26.65 B C ATOM 2107 CG GLU B 133 0.586 21.444 11.597 1.00 32.34 B C ATOM 2108 CD GLU B 133 −0.806 21.962 11.312 1.00 36.67 B C ATOM 2109 OE1 GLU B 133 −1.355 21.615 10.245 1.00 38.29 B O ATOM 2110 OE2 GLU B 133 −1.348 22.715 12.151 1.00 38.65 B O ATOM 2111 C GLU B 133 3.387 23.029 13.678 1.00 22.07 B C ATOM 2112 O GLU B 133 3.123 23.122 14.873 1.00 19.84 B O ATOM 2113 N ILE B 134 4.228 23.842 13.051 1.00 22.05 B N ATOM 2114 CA ILE B 134 4.957 24.924 13.718 1.00 20.74 B C ATOM 2115 CB ILE B 134 6.356 25.077 13.065 1.00 22.02 B C ATOM 2116 CG2 ILE B 134 7.127 26.232 13.692 1.00 19.99 B C ATOM 2117 CG1 ILE B 134 7.121 23.758 13.219 1.00 22.38 B C ATOM 2118 CD1 ILE B 134 8.451 23.728 12.488 1.00 26.58 B C ATOM 2119 C ILE B 134 4.226 26.259 13.661 1.00 20.52 B C ATOM 2120 O ILE B 134 3.688 26.621 12.618 1.00 21.50 B O ATOM 2121 N GLY B 135 4.222 26.989 14.778 1.00 19.55 B N ATOM 2122 CA GLY B 135 3.547 28.282 14.846 1.00 19.33 B C ATOM 2123 C GLY B 135 4.485 29.464 15.035 1.00 19.91 B C ATOM 2124 O GLY B 135 5.614 29.435 14.563 1.00 18.49 B O ATOM 2125 N ARG B 136 4.034 30.499 15.739 1.00 21.61 B N ATOM 2126 CA ARG B 136 4.857 31.695 15.970 1.00 23.20 B C ATOM 2127 CB ARG B 136 4.014 32.824 16.570 1.00 24.31 B C ATOM 2128 CG ARG B 136 3.656 32.619 18.042 1.00 27.58 B C ATOM 2129 CD ARG B 136 2.652 33.652 18.548 1.00 28.19 B C ATOM 2130 NE ARG B 136 2.162 33.295 19.877 1.00 29.58 B N ATOM 2131 CZ ARG B 136 2.671 33.747 21.023 1.00 30.89 B C ATOM 2132 NH1 ARG B 136 3.692 34.598 21.016 1.00 28.09 B N ATOM 2133 NH2 ARG B 136 2.167 33.326 22.182 1.00 29.68 B N ATOM 2134 C ARG B 136 6.049 31.460 16.895 1.00 22.61 B C ATOM 2135 O ARG B 136 6.019 30.597 17.762 1.00 22.20 B O ATOM 2136 N PRO B 137 7.126 32.231 16.709 1.00 24.01 B N ATOM 2137 CD PRO B 137 7.425 33.170 15.611 1.00 24.72 B C ATOM 2138 CA PRO B 137 8.287 32.047 17.581 1.00 23.55 B C ATOM 2139 CB PRO B 137 9.393 32.798 16.840 1.00 26.09 B C ATOM 2140 CG PRO B 137 8.637 33.905 16.144 1.00 26.11 B C ATOM 2141 C PRO B 137 7.976 32.627 18.965 1.00 23.34 B C ATOM 2142 O PRO B 137 7.350 33.682 19.088 1.00 22.43 B O ATOM 2143 N LEU B 138 8.390 31.909 20.000 1.00 22.77 B N ATOM 2144 CA LEU B 138 8.153 32.316 21.383 1.00 25.08 B C ATOM 2145 CB LEU B 138 7.909 31.077 22.247 1.00 23.93 B C ATOM 2146 CG LEU B 138 6.501 30.564 22.574 1.00 25.09 B C ATOM 2147 CD1 LEU B 138 5.475 30.991 21.532 1.00 21.71 B C ATOM 2148 CD2 LEU B 138 6.575 29.054 22.715 1.00 22.09 B C ATOM 2149 C LEU B 138 9.361 33.076 21.908 1.00 27.37 B C ATOM 2150 O LEU B 138 9.253 33.860 22.842 1.00 29.02 B O ATOM 2151 N GLY B 139 10.511 32.831 21.292 1.00 30.52 B N ATOM 2152 CA GLY B 139 11.736 33.487 21.701 1.00 33.40 B C ATOM 2153 C GLY B 139 12.887 33.087 20.796 1.00 36.61 B C ATOM 2154 O GLY B 139 12.829 32.049 20.125 1.00 34.75 B O ATOM 2155 N ALA B 140 13.931 33.917 20.775 1.00 38.80 B N ATOM 2156 CA ALA B 140 15.111 33.669 19.952 1.00 41.45 B C ATOM 2157 CB ALA B 140 15.197 34.703 18.839 1.00 41.02 B C ATOM 2158 C ALA B 140 16.348 33.742 20.833 1.00 42.68 B C ATOM 2159 O ALA B 140 16.614 34.774 21.443 1.00 44.14 B O ATOM 2160 N ALA B 141 17.091 32.640 20.905 1.00 43.65 B N ATOM 2161 CA ALA B 141 18.295 32.567 21.728 1.00 43.81 B C ATOM 2162 CB ALA B 141 18.233 31.342 22.638 1.00 45.73 B C ATOM 2163 C ALA B 141 19.553 32.515 20.872 1.00 43.24 B C ATOM 2164 O ALA B 141 19.501 32.748 19.669 1.00 41.60 B O ATOM 2165 N ALA B 142 20.682 32.203 21.502 1.00 43.17 B N ATOM 2166 CA ALA B 142 21.956 32.136 20.794 1.00 43.89 B C ATOM 2167 CB ALA B 142 23.107 32.336 21.774 1.00 43.83 B C ATOM 2168 C ALA B 142 22.146 30.826 20.032 1.00 44.12 B C ATOM 2169 O ALA B 142 22.701 30.817 18.932 1.00 45.04 B O ATOM 2170 N PHE B 143 21.682 29.723 20.612 1.00 43.15 B N ATOM 2171 CA PHE B 143 21.829 28.421 19.973 1.00 41.85 B C ATOM 2172 CB PHE B 143 22.102 27.350 21.025 1.00 43.72 B C ATOM 2173 CG PHE B 143 23.254 27.671 21.931 1.00 47.41 B C ATOM 2174 CD1 PHE B 143 23.098 28.563 22.986 1.00 48.28 B C ATOM 2175 CD2 PHE B 143 24.496 27.079 21.733 1.00 47.70 B C ATOM 2176 CE1 PHE B 143 24.162 28.858 23.832 1.00 49.52 B C ATOM 2177 CE2 PHE B 143 25.564 27.368 22.572 1.00 48.56 B C ATOM 2178 CZ PHE B 143 25.398 28.259 23.624 1.00 48.11 B C ATOM 2179 C PHE B 143 20.625 28.002 19.127 1.00 39.85 B C ATOM 2180 O PHE B 143 20.673 26.972 18.453 1.00 37.97 B O ATOM 2181 N GLY B 144 19.554 28.792 19.164 1.00 37.20 B N ATOM 2182 CA GLY B 144 18.374 28.461 18.386 1.00 35.94 B C ATOM 2183 C GLY B 144 17.111 29.160 18.851 1.00 35.06 B C ATOM 2184 O GLY B 144 17.172 30.161 19.565 1.00 34.22 B O ATOM 2185 N ASN B 145 15.959 28.628 18.449 1.00 33.13 B N ATOM 2186 CA ASN B 145 14.682 29.228 18.826 1.00 31.01 B C ATOM 2187 CB ASN B 145 14.082 29.980 17.639 1.00 33.45 B C ATOM 2188 CG ASN B 145 15.124 30.694 16.824 1.00 36.83 B C ATOM 2189 OD1 ASN B 145 15.849 30.072 16.051 1.00 39.85 B O ATOM 2190 ND2 ASN B 145 15.220 32.010 16.999 1.00 39.53 B N ATOM 2191 C ASN B 145 13.654 28.225 19.318 1.00 27.19 B C ATOM 2192 O ASN B 145 13.751 27.026 19.053 1.00 26.12 B O ATOM 2193 N VAL B 146 12.663 28.745 20.030 1.00 23.46 B N ATOM 2194 CA VAL B 146 11.568 27.951 20.568 1.00 21.53 B C ATOM 2195 CB VAL B 146 11.382 28.182 22.086 1.00 21.61 B C ATOM 2196 CG1 VAL B 146 10.329 27.242 22.623 1.00 22.87 B C ATOM 2197 CG2 VAL B 146 12.688 27.990 22.807 1.00 26.97 B C ATOM 2198 C VAL B 146 10.307 28.447 19.865 1.00 20.89 B C ATOM 2199 O VAL B 146 10.087 29.657 19.774 1.00 18.61 B O ATOM 2200 N TYR B 147 9.489 27.518 19.379 1.00 18.85 B N ATOM 2201 CA TYR B 147 8.254 27.866 18.688 1.00 18.39 B C ATOM 2202 CB TYR B 147 8.273 27.362 17.239 1.00 17.65 B C ATOM 2203 CG TYR B 147 9.420 27.846 16.400 1.00 17.80 B C ATOM 2204 CD1 TYR B 147 10.654 27.186 16.409 1.00 19.71 B C ATOM 2205 CE1 TYR B 147 11.726 27.653 15.629 1.00 20.17 B C ATOM 2206 CD2 TYR B 147 9.281 28.976 15.598 1.00 17.79 B C ATOM 2207 CE2 TYR B 147 10.336 29.447 14.823 1.00 16.88 B C ATOM 2208 CZ TYR B 147 11.550 28.791 14.840 1.00 17.99 B C ATOM 2209 OH TYR B 147 12.582 29.292 14.078 1.00 21.66 B O ATOM 2210 C TYR B 147 7.050 27.218 19.349 1.00 17.88 B C ATOM 2211 O TYR B 147 7.180 26.186 20.000 1.00 17.17 B O ATOM 2212 N LEU B 148 5.880 27.829 19.188 1.00 17.80 B N ATOM 2213 CA LEU B 148 4.661 27.208 19.688 1.00 18.36 B C ATOM 2214 CB LEU B 148 3.478 28.172 19.616 1.00 22.50 B C ATOM 2215 CG LEU B 148 2.102 27.595 19.990 1.00 23.22 B C ATOM 2216 CD1 LEU B 148 2.017 27.353 21.494 1.00 24.62 B C ATOM 2217 CD2 LEU B 148 1.016 28.563 19.559 1.00 25.28 B C ATOM 2218 C LEU B 148 4.475 26.107 18.641 1.00 19.19 B C ATOM 2219 O LEU B 148 4.849 26.289 17.476 1.00 18.41 B O ATOM 2220 N ALA B 149 3.941 24.959 19.034 1.00 18.74 B N ATOM 2221 CA ALA B 149 3.734 23.900 18.063 1.00 21.02 B C ATOM 2222 CB ALA B 149 5.005 23.057 17.907 1.00 22.54 B C ATOM 2223 C ALA B 149 2.560 23.018 18.429 1.00 22.53 B C ATOM 2224 O ALA B 149 2.109 23.002 19.573 1.00 22.04 B O ATOM 2225 N ARG B 150 2.060 22.286 17.444 1.00 23.48 B N ATOM 2226 CA ARG B 150 0.932 21.402 17.667 1.00 26.45 B C ATOM 2227 CB ARG B 150 −0.349 22.081 17.176 1.00 27.56 B C ATOM 2228 CG ARG B 150 −1.626 21.299 17.419 1.00 31.39 B C ATOM 2229 CD ARG B 150 −2.817 22.249 17.534 1.00 33.89 B C ATOM 2230 NE ARG B 150 −2.772 23.313 16.534 1.00 37.25 B N ATOM 2231 CZ ARG B 150 −3.463 24.447 16.616 1.00 38.06 B C ATOM 2232 NH1 ARG B 150 −4.258 24.669 17.655 1.00 39.33 B N ATOM 2233 NH2 ARG B 150 −3.350 25.367 15.664 1.00 37.88 B N ATOM 2234 C ARG B 150 1.157 20.075 16.957 1.00 27.39 B C ATOM 2235 O ARG B 150 1.540 20.044 15.785 1.00 26.15 B O ATOM 2236 N GLU B 151 0.953 18.978 17.680 1.00 28.95 B N ATOM 2237 CA GLU B 151 1.130 17.657 17.092 1.00 33.02 B C ATOM 2238 CB GLU B 151 1.153 16.597 18.186 1.00 34.21 B C ATOM 2239 CG GLU B 151 1.901 15.344 17.795 1.00 39.51 B C ATOM 2240 CD GLU B 151 1.687 14.213 18.781 1.00 43.41 B C ATOM 2241 OE1 GLU B 151 1.948 14.412 19.991 1.00 44.45 B O ATOM 2242 OE2 GLU B 151 1.257 13.122 18.342 1.00 46.66 B O ATOM 2243 C GLU B 151 −0.031 17.402 16.123 1.00 33.90 B C ATOM 2244 O GLU B 151 −1.187 17.611 16.470 1.00 31.69 B O ATOM 2245 N LYS B 152 0.281 16.958 14.911 1.00 36.17 B N ATOM 2246 CA LYS B 152 −0.747 16.718 13.901 1.00 39.16 B C ATOM 2247 CB LYS B 152 −0.103 16.292 12.579 1.00 38.11 B C ATOM 2248 CG LYS B 152 0.598 17.422 11.855 1.00 37.99 B C ATOM 2249 CD LYS B 152 1.208 16.952 10.554 1.00 39.08 B C ATOM 2250 CE LYS B 152 1.924 18.091 9.855 1.00 40.02 B C ATOM 2251 NZ LYS B 152 2.654 17.635 8.642 1.00 41.02 B N ATOM 2252 C LYS B 152 −1.845 15.725 14.270 1.00 41.64 B C ATOM 2253 O LYS B 152 −3.033 16.047 14.171 1.00 41.11 B O ATOM 2254 N GLN B 153 −1.459 14.523 14.688 1.00 44.21 B N ATOM 2255 CA GLN B 153 −2.445 13.505 15.040 1.00 46.53 B C ATOM 2256 CB GLN B 153 −1.756 12.244 15.553 1.00 48.92 B C ATOM 2257 CG GLN B 153 −2.672 11.035 15.561 1.00 53.13 B C ATOM 2258 CD GLN B 153 −3.378 10.842 14.226 1.00 55.60 B C ATOM 2259 OE1 GLN B 153 −2.735 10.731 13.177 1.00 56.44 B O ATOM 2260 NE2 GLN B 153 −4.708 10.807 14.260 1.00 55.73 B N ATOM 2261 C GLN B 153 −3.427 14.022 16.082 1.00 46.20 B C ATOM 2262 O GLN B 153 −4.626 14.116 15.825 1.00 47.04 B O ATOM 2263 N SER B 154 −2.926 14.344 17.265 1.00 46.37 B N ATOM 2264 CA SER B 154 −3.791 14.879 18.305 1.00 46.19 B C ATOM 2265 CB SER B 154 −3.206 14.591 19.690 1.00 45.90 B C ATOM 2266 OG SER B 154 −1.871 15.057 19.798 1.00 45.56 B O ATOM 2267 C SER B 154 −3.847 16.379 18.046 1.00 46.16 B C ATOM 2268 O SER B 154 −3.415 16.846 16.995 1.00 47.31 B O ATOM 2269 N LYS B 155 −4.387 17.139 18.981 1.00 45.67 B N ATOM 2270 CA LYS B 155 −4.450 18.582 18.806 1.00 45.70 B C ATOM 2271 CB LYS B 155 −5.916 19.031 18.799 1.00 48.89 B C ATOM 2272 CG LYS B 155 −6.128 20.540 18.761 1.00 52.40 B C ATOM 2273 CD LYS B 155 −6.349 21.108 20.159 1.00 53.23 B C ATOM 2274 CE LYS B 155 −6.084 22.601 20.182 1.00 54.16 B C ATOM 2275 NZ LYS B 155 −4.697 22.904 19.726 1.00 53.54 B N ATOM 2276 C LYS B 155 −3.677 19.222 19.959 1.00 42.90 B C ATOM 2277 O LYS B 155 −3.770 20.423 20.207 1.00 43.52 B O ATOM 2278 N PHE B 156 −2.892 18.397 20.644 1.00 39.07 B N ATOM 2279 CA PHE B 156 −2.108 18.824 21.796 1.00 35.93 B C ATOM 2280 CB PHE B 156 −1.375 17.615 22.377 1.00 37.42 B C ATOM 2281 CG PHE B 156 −0.841 17.834 23.761 1.00 39.54 B C ATOM 2282 CD1 PHE B 156 −1.699 18.157 24.806 1.00 39.40 B C ATOM 2283 CD2 PHE B 156 0.521 17.705 24.024 1.00 40.10 B C ATOM 2284 CE1 PHE B 156 −1.209 18.351 26.099 1.00 40.25 B C ATOM 2285 CE2 PHE B 156 1.024 17.897 25.316 1.00 40.40 B C ATOM 2286 CZ PHE B 156 0.156 18.220 26.354 1.00 40.47 B C ATOM 2287 C PHE B 156 −1.111 19.943 21.487 1.00 32.41 B C ATOM 2288 O PHE B 156 −0.328 19.846 20.544 1.00 31.99 B O ATOM 2289 N ILE B 157 −1.153 20.999 22.294 1.00 28.30 B N ATOM 2290 CA ILE B 157 −0.270 22.153 22.146 1.00 27.01 B C ATOM 2291 CB ILE B 157 −0.933 23.445 22.684 1.00 28.09 B C ATOM 2292 CG2 ILE B 157 0.042 24.608 22.590 1.00 29.72 B C ATOM 2293 CG1 ILE B 157 −2.212 23.754 21.899 1.00 29.62 B C ATOM 2294 CD1 ILE B 157 −1.977 24.215 20.480 1.00 32.78 B C ATOM 2295 C ILE B 157 1.016 21.934 22.936 1.00 24.58 B C ATOM 2296 O ILE B 157 0.990 21.436 24.060 1.00 23.83 B O ATOM 2297 N LEU B 158 2.141 22.320 22.353 1.00 23.27 B N ATOM 2298 CA LEU B 158 3.426 22.158 23.020 1.00 22.00 B C ATOM 2299 CB LEU B 158 3.933 20.721 22.832 1.00 22.79 B C ATOM 2300 CG LEU B 158 3.978 20.154 21.407 1.00 26.19 B C ATOM 2301 CD1 LEU B 158 5.220 20.663 20.676 1.00 25.77 B C ATOM 2302 CD2 LEU B 158 3.991 18.632 21.463 1.00 24.53 B C ATOM 2303 C LEU B 158 4.438 23.165 22.491 1.00 20.27 B C ATOM 2304 O LEU B 158 4.118 24.000 21.648 1.00 19.23 B O ATOM 2305 N ALA B 159 5.660 23.106 23.005 1.00 18.97 B N ATOM 2306 CA ALA B 159 6.695 24.016 22.552 1.00 16.46 B C ATOM 2307 CB ALA B 159 7.183 24.864 23.705 1.00 13.97 B C ATOM 2308 C ALA B 159 7.826 23.189 21.967 1.00 16.51 B C ATOM 2309 O ALA B 159 8.214 22.169 22.536 1.00 16.62 B O ATOM 2310 N LEU B 160 8.330 23.614 20.813 1.00 16.01 B N ATOM 2311 CA LEU B 160 9.419 22.914 20.143 1.00 17.40 B C ATOM 2312 CB LEU B 160 9.002 22.524 18.712 1.00 19.02 B C ATOM 2313 CG LEU B 160 10.016 21.678 17.928 1.00 20.39 B C ATOM 2314 CD1 LEU B 160 10.062 20.269 18.520 1.00 21.64 B C ATOM 2315 CD2 LEU B 160 9.628 21.606 16.459 1.00 21.97 B C ATOM 2316 C LEU B 160 10.648 23.821 20.092 1.00 16.96 B C ATOM 2317 O LEU B 160 10.582 24.930 19.581 1.00 17.75 B O ATOM 2318 N LYS B 161 11.766 23.351 20.629 1.00 18.51 B N ATOM 2319 CA LYS B 161 13.002 24.136 20.624 1.00 19.34 B C ATOM 2320 CB LYS B 161 13.612 24.188 22.039 1.00 19.45 B C ATOM 2321 CG LYS B 161 14.832 25.113 22.166 1.00 20.17 B C ATOM 2322 CD LYS B 161 15.129 25.442 23.625 1.00 20.81 B C ATOM 2323 CE LYS B 161 16.291 26.407 23.767 1.00 22.49 B C ATOM 2324 NZ LYS B 161 16.427 26.941 25.152 1.00 23.30 B N ATOM 2325 C LYS B 161 13.987 23.520 19.637 1.00 19.59 B C ATOM 2326 O LYS B 161 14.296 22.329 19.708 1.00 20.16 B O ATOM 2327 N VAL B 162 14.471 24.336 18.709 1.00 19.67 B N ATOM 2328 CA VAL B 162 15.402 23.867 17.688 1.00 21.10 B C ATOM 2329 CB VAL B 162 14.945 24.292 16.276 1.00 22.26 B C ATOM 2330 CG1 VAL B 162 15.832 23.623 15.235 1.00 24.01 B C ATOM 2331 CG2 VAL B 162 13.465 23.934 16.058 1.00 22.27 B C ATOM 2332 C VAL B 162 16.800 24.430 17.908 1.00 21.17 B C ATOM 2333 O VAL B 162 16.993 25.642 17.848 1.00 19.86 B O ATOM 2334 N LEU B 163 17.768 23.544 18.133 1.00 21.64 B N ATOM 2335 CA LEU B 163 19.157 23.950 18.369 1.00 20.49 B C ATOM 2336 CB LEU B 163 19.651 23.326 19.670 1.00 20.44 B C ATOM 2337 CG LEU B 163 18.813 23.620 20.912 1.00 22.02 B C ATOM 2338 CD1 LEU B 163 19.087 22.573 21.978 1.00 22.74 B C ATOM 2339 CD2 LEU B 163 19.121 25.026 21.417 1.00 22.92 B C ATOM 2340 C LEU B 163 20.094 23.542 17.234 1.00 21.79 B C ATOM 2341 O LEU B 163 19.998 22.422 16.707 1.00 22.08 B O ATOM 2342 N PHE B 164 21.008 24.441 16.861 1.00 22.17 B N ATOM 2343 CA PHE B 164 21.968 24.157 15.795 1.00 22.32 B C ATOM 2344 CB PHE B 164 22.261 25.419 14.985 1.00 23.92 B C ATOM 2345 CG PHE B 164 21.063 25.946 14.256 1.00 30.95 B C ATOM 2346 CD1 PHE B 164 20.081 26.667 14.934 1.00 30.56 B C ATOM 2347 GD2 PHE B 164 20.880 25.668 12.903 1.00 31.82 B C ATOM 2348 CE1 PHE B 164 18.935 27.099 14.281 1.00 32.58 B C ATOM 2349 CE2 PHE B 164 19.733 26.096 12.238 1.00 34.84 B C ATOM 2350 CZ PHE B 164 18.758 26.813 12.930 1.00 34.24 B C ATOM 2351 C PHE B 164 23.251 23.598 16.382 1.00 22.61 B C ATOM 2352 O PHE B 164 23.925 24.261 17.176 1.00 22.86 B O ATOM 2353 N LYS B 165 23.582 22.371 15.994 1.00 22.67 B N ATOM 2354 CA LYS B 165 24.777 21.711 16.511 1.00 22.73 B C ATOM 2355 CB LYS B 165 24.982 20.360 15.827 1.00 21.42 B C ATOM 2356 CG LYS B 165 24.153 19.240 16.419 1.00 21.02 B C ATOM 2357 CD LYS B 165 24.153 18.010 15.506 1.00 22.54 B C ATOM 2358 CE LYS B 165 23.243 16.926 16.062 1.00 22.64 B C ATOM 2359 NZ LYS B 165 23.231 15.701 15.230 1.00 21.04 B N ATOM 2360 C LYS B 165 26.051 22.533 16.388 1.00 23.20 B C ATOM 2361 O LYS B 165 26.865 22.548 17.312 1.00 21.71 B O ATOM 2362 N ALA B 166 26.215 23.219 15.261 1.00 22.64 B N ATOM 2363 CA ALA B 166 27.416 24.013 15.026 1.00 24.25 B C ATOM 2364 CB ALA B 166 27.384 24.629 13.613 1.00 24.20 B C ATOM 2365 C ALA B 166 27.636 25.098 16.072 1.00 24.80 B C ATOM 2366 O ALA B 166 28.772 25.333 16.491 1.00 24.79 B O ATOM 2367 N GLN B 167 26.563 25.758 16.495 1.00 25.16 B N ATOM 2368 CA GLN B 167 26.684 26.810 17.503 1.00 26.89 B C ATOM 2369 CB GLN B 167 25.411 27.660 17.545 1.00 29.97 B C ATOM 2370 CG GLN B 167 25.203 28.462 18.834 1.00 37.08 B C ATOM 2371 CD GLN B 167 26.215 29.587 19.035 1.00 42.68 B C ATOM 2372 OE1 GLN B 167 27.425 29.351 19.185 1.00 43.86 B O ATOM 2373 NE2 GLN B 167 25.719 30.824 19.042 1.00 43.02 B N ATOM 2374 C GLN B 167 26.950 26.193 18.866 1.00 26.35 B C ATOM 2375 O GLN B 167 27.707 26.739 19.672 1.00 24.45 B O ATOM 2376 N LEU B 168 26.334 25.041 19.111 1.00 25.56 B N ATOM 2377 CA LEU B 168 26.501 24.339 20.374 1.00 24.45 B C ATOM 2378 CB LEU B 168 25.605 23.091 20.428 1.00 21.23 B C ATOM 2379 CG LEU B 168 24.076 23.257 20.548 1.00 24.32 B C ATOM 2380 CD1 LEU B 168 23.398 21.885 20.478 1.00 19.55 B C ATOM 2381 CD2 LEU B 168 23.711 23.942 21.856 1.00 19.17 B C ATOM 2382 C LEU B 168 27.951 23.931 20.610 1.00 25.52 B C ATOM 2383 O LEU B 168 28.501 24.192 21.674 1.00 23.62 B O ATOM 2384 N GLU B 169 28.577 23.303 19.623 1.00 27.52 B N ATOM 2385 CA GLU B 169 29.948 22.844 19.809 1.00 32.03 B C ATOM 2386 CB GLU B 169 30.259 21.672 18.863 1.00 32.00 B C ATOM 2387 CG GLU B 169 29.545 21.711 17.535 1.00 35.49 B C ATOM 2388 CD GLU B 169 29.317 20.317 16.954 1.00 35.75 B C ATOM 2389 OE1 GLU B 169 28.662 19.485 17.621 1.00 36.56 B O ATOM 2390 OE2 GLU B 169 29.789 20.057 15.829 1.00 34.75 B O ATOM 2391 C GLU B 169 31.007 23.924 19.703 1.00 32.42 B C ATOM 2392 O GLU B 169 32.114 23.762 20.202 1.00 34.46 B O ATOM 2393 N LYS B 170 30.659 25.034 19.071 1.00 34.54 B N ATOM 2394 CA LYS B 170 31.585 26.142 18.934 1.00 34.41 B C ATOM 2395 CB LYS B 170 31.124 27.071 17.813 1.00 37.50 B C ATOM 2396 CG LYS B 170 32.090 28.190 17.512 1.00 41.65 B C ATOM 2397 CD LYS B 170 31.700 28.922 16.240 1.00 45.85 B C ATOM 2398 CE LYS B 170 31.944 28.064 15.005 1.00 48.44 B C ATOM 2399 NZ LYS B 170 33.402 27.794 14.811 1.00 48.66 B N ATOM 2400 C LYS B 170 31.639 26.899 20.253 1.00 34.06 B C ATOM 2401 O LYS B 170 32.694 27.395 20.651 1.00 31.09 B O ATOM 2402 N ALA B 171 30.496 26.966 20.937 1.00 33.89 B N ATOM 2403 CA ALA B 171 30.394 27.671 22.212 1.00 34.35 B C ATOM 2404 CB ALA B 171 28.955 28.087 22.467 1.00 31.71 B C ATOM 2405 C ALA B 171 30.914 26.869 23.398 1.00 36.33 B C ATOM 2406 O ALA B 171 30.973 27.374 24.517 1.00 37.82 B O ATOM 2407 N GLY B 172 31.288 25.619 23.168 1.00 37.10 B N ATOM 2408 CA GLY B 172 31.796 24.824 24.265 1.00 39.08 B C ATOM 2409 C GLY B 172 31.293 23.408 24.199 1.00 41.69 B C ATOM 2410 O GLY B 172 30.945 22.814 25.231 1.00 41.29 B O ATOM 2411 N VAL B 173 31.262 22.884 22.972 1.00 44.30 B N ATOM 2412 CA VAL B 173 30.807 21.528 22.670 1.00 44.96 B C ATOM 2413 CB VAL B 173 31.989 20.572 22.425 1.00 46.41 B C ATOM 2414 CG1 VAL B 173 31.476 19.285 21.791 1.00 45.74 B C ATOM 2415 CG2 VAL B 173 33.048 21.246 21.539 1.00 44.74 B C ATOM 2416 C VAL B 173 29.984 20.983 23.817 1.00 46.17 B C ATOM 2417 O VAL B 173 30.498 20.247 24.667 1.00 46.81 B O ATOM 2418 N GLU B 174 28.705 21.352 23.842 1.00 44.84 B N ATOM 2419 CA GLU B 174 27.841 20.912 24.911 1.00 42.70 B C ATOM 2420 CB GLU B 174 26.509 21.646 24.865 1.00 43.75 B C ATOM 2421 CG GLU B 174 26.485 22.871 25.754 1.00 44.96 B C ATOM 2422 CD GLU B 174 27.483 23.929 25.329 1.00 45.73 B C ATOM 2423 OE1 GLU B 174 28.664 23.587 25.115 1.00 46.37 B O ATOM 2424 OE2 GLU B 174 27.087 25.108 25.219 1.00 45.36 B O ATOM 2425 C GLU B 174 27.611 19.420 24.997 1.00 42.19 B C ATOM 2426 O GLU B 174 26.665 18.869 24.427 1.00 39.51 B O ATOM 2427 N HIS B 175 28.522 18.781 25.719 1.00 41.13 B N ATOM 2428 CA HIS B 175 28.458 17.365 26.001 1.00 40.20 B C ATOM 2429 CB HIS B 175 29.845 16.864 26.435 1.00 44.57 B C ATOM 2430 CG HIS B 175 29.880 15.420 26.837 1.00 49.02 B C ATOM 2431 CD2 HIS B 175 30.422 14.337 26.228 1.00 50.48 B C ATOM 2432 ND1 HIS B 175 29.305 14.954 28.001 1.00 51.44 B N ATOM 2433 CE1 HIS B 175 29.490 13.648 28.091 1.00 51.08 B C ATOM 2434 NE2 HIS B 175 30.165 13.249 27.027 1.00 51.29 B N ATOM 2435 C HIS B 175 27.493 17.408 27.185 1.00 37.70 B C ATOM 2436 O HIS B 175 26.942 16.394 27.604 1.00 37.04 B O ATOM 2437 N GLN B 176 27.282 18.621 27.692 1.00 35.01 B N ATOM 2438 CA GLN B 176 26.399 18.841 28.827 1.00 36.23 B C ATOM 2439 CB GLN B 176 26.846 20.066 29.624 1.00 37.61 B C ATOM 2440 CG GLN B 176 27.133 21.297 28.819 1.00 41.69 B C ATOM 2441 CD GLN B 176 27.294 22.516 29.710 1.00 46.57 B C ATOM 2442 OE1 GLN B 176 27.841 23.549 29.298 1.00 49.05 B O ATOM 2443 NE2 GLN B 176 26.807 22.406 30.942 1.00 47.86 B N ATOM 2444 C GLN B 176 24.921 18.970 28.473 1.00 34.56 B C ATOM 2445 O GLN B 176 24.063 18.678 29.299 1.00 34.08 B O ATOM 2446 N LEU B 177 24.624 19.419 27.259 1.00 33.44 B N ATOM 2447 CA LEU B 177 23.240 19.533 26.824 1.00 32.62 B C ATOM 2448 CB LEU B 177 23.163 20.178 25.433 1.00 33.83 B C ATOM 2449 CG LEU B 177 21.829 20.192 24.665 1.00 35.49 B C ATOM 2450 CD1 LEU B 177 21.552 18.815 24.084 1.00 35.05 B C ATOM 2451 CD2 LEU B 177 20.698 20.638 25.581 1.00 33.78 B C ATOM 2452 C LEU B 177 22.728 18.102 26.776 1.00 31.62 B C ATOM 2453 O LEU B 177 21.561 17.826 27.057 1.00 30.39 B O ATOM 2454 N ARG B 178 23.624 17.188 26.425 1.00 30.82 B N ATOM 2455 CA ARG B 178 23.265 15.784 26.357 1.00 32.73 B C ATOM 2456 CB ARG B 178 24.380 14.979 25.698 1.00 33.93 B C ATOM 2457 CG ARG B 178 24.492 15.194 24.207 1.00 39.47 B C ATOM 2458 CD ARG B 178 25.654 14.398 23.658 1.00 44.54 B C ATOM 2459 NE ARG B 178 25.537 12.989 24.018 1.00 47.63 B N ATOM 2460 CZ ARG B 178 26.501 12.098 23.838 1.00 48.23 B C ATOM 2461 NH1 ARG B 178 27.651 12.476 23.302 1.00 49.75 B N ATOM 2462 NH2 ARG B 178 26.316 10.835 24.192 1.00 49.72 B N ATOM 2463 C ARG B 178 22.998 15.241 27.753 1.00 32.47 B C ATOM 2464 O ARG B 178 21.976 14.597 27.995 1.00 33.18 B O ATOM 2465 N ARG B 179 23.912 15.506 28.676 1.00 30.61 B N ATOM 2466 CA ARG B 179 23.729 15.016 30.030 1.00 31.15 B C ATOM 2467 CB ARG B 179 24.965 15.320 30.880 1.00 34.46 B C ATOM 2468 CG ARG B 179 26.228 14.641 30.359 1.00 39.50 B C ATOM 2469 CD ARG B 179 26.988 13.929 31.471 1.00 43.76 B C ATOM 2470 NE ARG B 179 26.134 13.031 32.253 1.00 49.01 B N ATOM 2471 CZ ARG B 179 25.409 12.036 31.746 1.00 49.97 B C ATOM 2472 NH1 ARG B 179 25.421 11.793 30.441 1.00 51.21 B N ATOM 2473 NH2 ARG B 179 24.668 11.280 32.547 1.00 50.28 B N ATOM 2474 C ARG B 179 22.489 15.644 30.637 1.00 27.71 B C ATOM 2475 O ARG B 179 21.776 15.006 31.394 1.00 26.64 B O ATOM 2476 N GLU B 180 22.228 16.896 30.279 1.00 27.23 B N ATOM 2477 CA GLU B 180 21.070 17.620 30.782 1.00 26.36 B C ATOM 2478 CB GLU B 180 21.163 19.080 30.346 1.00 27.40 B C ATOM 2479 CG GLU B 180 20.452 20.047 31.271 1.00 30.43 B C ATOM 2480 CD GLU B 180 20.951 19.961 32.708 1.00 33.04 B C ATOM 2481 OE1 GLU B 180 22.178 20.114 32.934 1.00 32.92 B O ATOM 2482 OE2 GLU B 180 20.114 19.739 33.613 1.00 32.02 B O ATOM 2483 C GLU B 180 19.746 16.997 30.296 1.00 25.78 B C ATOM 2484 O GLU B 180 18.796 16.863 31.063 1.00 24.13 B O ATOM 2485 N VAL B 181 19.693 16.612 29.023 1.00 25.67 B N ATOM 2486 CA VAL B 181 18.494 16.002 28.453 1.00 27.08 B C ATOM 2487 CB VAL B 181 18.693 15.717 26.936 1.00 27.03 B C ATOM 2488 CG1 VAL B 181 17.566 14.856 26.405 1.00 27.81 B C ATOM 2489 CG2 VAL B 181 18.745 17.029 26.171 1.00 22.54 B C ATOM 2490 C VAL B 181 18.155 14.703 29.188 1.00 28.77 B C ATOM 2491 O VAL B 181 17.000 14.452 29.536 1.00 30.48 B O ATOM 2492 N GLU B 182 19.175 13.887 29.433 1.00 30.16 B N ATOM 2493 CA GLU B 182 19.024 12.615 30.139 1.00 29.83 B C ATOM 2494 CB GLU B 182 20.394 11.937 30.231 1.00 34.09 B C ATOM 2495 CG GLU B 182 20.452 10.614 30.983 1.00 40.35 B C ATOM 2496 CD GLU B 182 21.884 10.092 31.105 1.00 45.37 B C ATOM 2497 OE1 GLU B 182 22.072 8.979 31.646 1.00 47.27 B O ATOM 2498 OE2 GLU B 182 22.826 10.798 30.657 1.00 47.17 B O ATOM 2499 C GLU B 182 18.445 12.843 31.534 1.00 28.60 B C ATOM 2500 O GLU B 182 17.457 12.223 31.920 1.00 28.99 B O ATOM 2501 N ILE B 183 19.060 13.741 32.290 1.00 27.98 B N ATOM 2502 CA ILE B 183 18.593 14.056 33.636 1.00 28.08 B C ATOM 2503 CB ILE B 183 19.493 15.130 34.293 1.00 28.69 B C ATOM 2504 CG2 ILE B 183 18.894 15.567 35.618 1.00 27.35 B C ATOM 2505 CG1 ILE B 183 20.910 14.586 34.484 1.00 28.95 B C ATOM 2506 CD1 ILE B 183 21.880 15.609 35.030 1.00 30.67 B C ATOM 2507 C ILE B 183 17.153 14.588 33.627 1.00 28.81 B C ATOM 2508 O ILE B 183 16.275 14.072 34.321 1.00 27.77 B O ATOM 2509 N GLN B 184 16.934 15.632 32.837 1.00 27.78 B N ATOM 2510 CA GLN B 184 15.635 16.283 32.721 1.00 29.40 B C ATOM 2511 CB GLN B 184 15.728 17.393 31.677 1.00 29.48 B C ATOM 2512 CG GLN B 184 15.084 18.695 32.085 1.00 33.57 B C ATOM 2513 CD GLN B 184 15.767 19.331 33.274 1.00 34.49 B C ATOM 2514 OE1 GLN B 184 15.177 19.449 34.344 1.00 34.49 B O ATOM 2515 NE2 GLN B 184 17.021 19.740 33.095 1.00 36.47 B N ATOM 2516 C GLN B 184 14.474 15.349 32.360 1.00 29.74 B C ATOM 2517 O GLN B 184 13.377 15.473 32.899 1.00 29.32 B O ATOM 2518 N SER B 185 14.714 14.411 31.455 1.00 30.43 B N ATOM 2519 CA SER B 185 13.659 13.497 31.024 1.00 31.44 B C ATOM 2520 CB SER B 185 14.123 12.710 29.801 1.00 29.48 B C ATOM 2521 OG SER B 185 15.188 11.853 30.147 1.00 33.05 B O ATOM 2522 C SER B 185 13.151 12.524 32.093 1.00 32.12 B C ATOM 2523 O SER B 185 12.156 11.842 31.884 1.00 31.84 B O ATOM 2524 N HIS B 186 13.818 12.463 33.237 1.00 33.65 B N ATOM 2525 CA HIS B 186 13.391 11.564 34.305 1.00 34.39 B C ATOM 2526 CB HIS B 186 14.582 10.731 34.781 1.00 36.84 B C ATOM 2527 CG HIS B 186 15.052 9.729 33.773 1.00 39.30 B C ATOM 2528 CD2 HIS B 186 14.363 8.961 32.893 1.00 40.21 B C ATOM 2529 ND1 HIS B 186 16.384 9.432 33.581 1.00 39.62 B N ATOM 2530 CE1 HIS B 186 16.497 8.528 32.623 1.00 42.04 B C ATOM 2531 NE2 HIS B 186 15.286 8.225 32.189 1.00 42.20 B N ATOM 2532 C HIS B 186 12.758 12.295 35.487 1.00 34.27 B C ATOM 2533 O HIS B 186 12.296 11.667 36.442 1.00 34.94 B O ATOM 2534 N LEU B 187 12.745 13.621 35.423 1.00 32.72 B N ATOM 2535 CA LEU B 187 12.162 14.441 36.476 1.00 31.38 B C ATOM 2536 CB LEU B 187 12.798 15.835 36.466 1.00 30.82 B C ATOM 2537 CG LEU B 187 14.074 16.108 37.274 1.00 31.43 B C ATOM 2538 CD1 LEU B 187 14.997 14.911 37.294 1.00 32.58 B C ATOM 2539 CD2 LEU B 187 14.764 17.317 36.686 1.00 31.34 B C ATOM 2540 C LEU B 187 10.659 14.569 36.248 1.00 31.86 B C ATOM 2541 O LEU B 187 10.214 14.797 35.121 1.00 30.47 B O ATOM 2542 N ALA B 188 9.881 14.413 37.316 1.00 31.25 B N ATOM 2543 CA ALA B 188 8.429 14.530 37.230 1.00 30.44 B C ATOM 2544 CB ALA B 188 7.789 13.148 37.091 1.00 29.88 B C ATOM 2545 C ALA B 188 7.912 15.237 38.481 1.00 29.21 B C ATOM 2546 O ALA B 188 7.862 14.651 39.559 1.00 28.34 B O ATOM 2547 N HIS B 189 7.538 16.504 38.319 1.00 28.72 B N ATOM 2548 CA HIS B 189 7.032 17.326 39.412 1.00 27.13 B C ATOM 2549 CB HIS B 189 8.205 17.925 40.201 1.00 27.59 B C ATOM 2550 CG HIS B 189 7.799 18.662 41.442 1.00 24.39 B C ATOM 2551 CD2 HIS B 189 7.993 18.377 42.752 1.00 25.28 B C ATOM 2552 ND1 HIS B 189 7.122 19.859 41.410 1.00 26.03 B N ATOM 2553 CE1 HIS B 189 6.919 20.283 42.646 1.00 24.93 B C ATOM 2554 NE2 HIS B 189 7.438 19.402 43.479 1.00 23.51 B N ATOM 2555 C HIS B 189 6.193 18.431 38.787 1.00 26.49 B C ATOM 2556 O HIS B 189 6.562 18.998 37.766 1.00 26.44 B O ATOM 2557 N PRO B 190 5.049 18.760 39.402 1.00 26.98 B N ATOM 2558 CD PRO B 190 4.548 18.263 40.699 1.00 25.70 B C ATOM 2559 CA PRO B 190 4.177 19.807 38.863 1.00 24.70 B C ATOM 2560 CB PRO B 190 2.998 19.811 39.846 1.00 25.70 B C ATOM 2561 CG PRO B 190 3.633 19.382 41.139 1.00 26.97 B C ATOM 2562 C PRO B 190 4.814 21.191 38.682 1.00 24.45 B C ATOM 2563 O PRO B 190 4.378 21.966 37.832 1.00 24.60 B O ATOM 2564 N ASN B 191 5.842 21.506 39.464 1.00 22.38 B N ATOM 2565 CA ASN B 191 6.481 22.809 39.346 1.00 21.54 B C ATOM 2566 CB ASN B 191 6.713 23.408 40.730 1.00 21.05 B C ATOM 2567 CG ASN B 191 5.436 23.575 41.495 1.00 19.72 B C ATOM 2568 OD1 ASN B 191 4.567 24.371 41.121 1.00 19.90 B O ATOM 2569 ND2 ASN B 191 5.299 22.815 42.571 1.00 20.48 B N ATOM 2570 C ASN B 191 7.793 22.801 38.564 1.00 21.58 B C ATOM 2571 O ASN B 191 8.627 23.699 38.720 1.00 19.27 B O ATOM 2572 N ILE B 192 7.964 21.787 37.722 1.00 20.97 B N ATOM 2573 CA ILE B 192 9.154 21.674 36.880 1.00 21.01 B C ATOM 2574 CB ILE B 192 10.064 20.494 37.331 1.00 21.26 B C ATOM 2575 CG2 ILE B 192 11.219 20.288 36.331 1.00 19.48 B C ATOM 2576 CG1 ILE B 192 10.613 20.770 38.733 1.00 21.57 B C ATOM 2577 CD1 ILE B 192 11.462 19.627 39.299 1.00 23.94 B C ATOM 2578 C ILE B 192 8.667 21.432 35.453 1.00 19.86 B C ATOM 2579 O ILE B 192 7.908 20.497 35.210 1.00 22.96 B O ATOM 2580 N LEU B 193 9.082 22.282 34.519 1.00 20.26 B N ATOM 2581 CA LEU B 193 8.669 22.142 33.124 1.00 21.42 B C ATOM 2582 CB LEU B 193 9.307 23.234 32.268 1.00 22.27 B C ATOM 2583 CG LEU B 193 8.681 23.436 30.883 1.00 23.28 B C ATOM 2584 CD1 LEU B 193 7.245 23.930 31.030 1.00 21.92 B C ATOM 2585 CD2 LEU B 193 9.495 24.445 30.101 1.00 19.52 B C ATOM 2586 C LEU B 193 9.041 20.763 32.565 1.00 21.67 B C ATOM 2587 O LEU B 193 10.199 20.350 32.598 1.00 18.44 B O ATOM 2588 N ARG B 194 8.041 20.069 32.036 1.00 21.75 B N ATOM 2589 CA ARG B 194 8.215 18.732 31.482 1.00 23.01 B C ATOM 2590 CB ARG B 194 6.841 18.096 31.268 1.00 25.81 B C ATOM 2591 CG ARG B 194 6.788 16.596 31.448 1.00 32.81 B C ATOM 2592 CD ARG B 194 6.817 16.240 32.921 1.00 37.46 B C ATOM 2593 NE ARG B 194 6.281 14.904 33.176 1.00 44.90 B N ATOM 2594 CZ ARG B 194 5.012 14.542 32.974 1.00 47.96 B C ATOM 2595 NH1 ARG B 194 4.125 15.418 32.508 1.00 48.71 B N ATOM 2596 NH2 ARG B 194 4.626 13.299 33.247 1.00 48.22 B N ATOM 2597 C ARG B 194 8.981 18.673 30.159 1.00 21.93 B C ATOM 2598 O ARG B 194 8.821 19.538 29.292 1.00 19.59 B O ATOM 2599 N LEU B 195 9.819 17.647 30.021 1.00 21.33 B N ATOM 2600 CA LEU B 195 10.567 17.403 28.788 1.00 22.76 B C ATOM 2601 CB LEU B 195 12.053 17.148 29.069 1.00 22.81 B C ATOM 2602 CG LEU B 195 13.078 17.437 27.959 1.00 24.02 B C ATOM 2603 CD1 LEU B 195 14.267 16.498 28.140 1.00 21.85 B C ATOM 2604 CD2 LEU B 195 12.483 17.251 26.563 1.00 23.51 B C ATOM 2605 C LEU B 195 9.921 16.119 28.274 1.00 22.36 B C ATOM 2606 O LEU B 195 10.110 15.056 28.861 1.00 22.57 B O ATOM 2607 N TYR B 196 9.145 16.215 27.201 1.00 22.31 B N ATOM 2608 CA TYR B 196 8.453 15.050 26.651 1.00 22.19 B C ATOM 2609 CB TYR B 196 7.281 15.490 25.768 1.00 23.58 B C ATOM 2610 CG TYR B 196 6.155 16.146 26.519 1.00 23.96 B C ATOM 2611 CD1 TYR B 196 5.772 17.460 26.238 1.00 25.04 B C ATOM 2612 CE1 TYR B 196 4.728 18.071 26.937 1.00 24.87 B C ATOM 2613 CD2 TYR B 196 5.467 15.457 27.515 1.00 25.05 B C ATOM 2614 CE2 TYR B 196 4.426 16.056 28.217 1.00 25.56 B C ATOM 2615 CZ TYR B 196 4.062 17.361 27.923 1.00 25.01 B C ATOM 2616 OH TYR B 196 3.023 17.944 28.612 1.00 29.27 B O ATOM 2617 C TYR B 196 9.333 14.108 25.851 1.00 22.57 B C ATOM 2618 O TYR B 196 9.132 12.898 25.873 1.00 23.50 B O ATOM 2619 N GLY B 197 10.294 14.663 25.124 1.00 22.59 B N ATOM 2620 CA GLY B 197 11.180 13.841 24.332 1.00 20.31 B C ATOM 2621 C GLY B 197 12.161 14.702 23.572 1.00 23.62 B C ATOM 2622 O GLY B 197 12.220 15.919 23.772 1.00 24.47 B O ATOM 2623 N TYR B 198 12.935 14.078 22.695 1.00 23.97 B N ATOM 2624 CA TYR B 198 13.903 14.810 21.900 1.00 27.71 B C ATOM 2625 CB TYR B 198 15.140 15.125 22.735 1.00 31.42 B C ATOM 2626 CG TYR B 198 15.966 13.915 23.087 1.00 36.13 B C ATOM 2627 CD1 TYR B 198 17.100 13.584 22.349 1.00 37.59 B C ATOM 2628 CE1 TYR B 198 17.863 12.466 22.667 1.00 40.01 B C ATOM 2629 CD2 TYR B 198 15.611 13.096 24.158 1.00 38.85 B C ATOM 2630 CE2 TYR B 198 16.364 11.977 24.485 1.00 40.86 B C ATOM 2631 CZ TYR B 198 17.489 11.667 23.734 1.00 41.45 B C ATOM 2632 OH TYR B 198 18.232 10.550 24.049 1.00 46.15 B O ATOM 2633 C TYR B 198 14.293 13.982 20.699 1.00 26.60 B C ATOM 2634 O TYR B 198 13.951 12.812 20.611 1.00 26.01 B O ATOM 2635 N PHE B 199 15.000 14.599 19.767 1.00 27.65 B N ATOM 2636 CA PHE B 199 15.443 13.904 18.572 1.00 27.79 B C ATOM 2637 CB PHE B 199 14.233 13.426 17.749 1.00 27.11 B C ATOM 2638 CG PHE B 199 13.388 14.540 17.161 1.00 27.89 B C ATOM 2639 CD1 PHE B 199 13.637 15.019 15.876 1.00 27.86 B C ATOM 2640 CD2 PHE B 199 12.310 15.064 17.868 1.00 27.14 B C ATOM 2641 CE1 PHE B 199 12.824 15.996 15.301 1.00 26.93 B C ATOM 2642 CE2 PHE B 199 11.492 16.040 17.303 1.00 26.16 B C ATOM 2643 CZ PHE B 199 11.750 16.505 16.015 1.00 27.17 B C ATOM 2644 C PHE B 199 16.297 14.860 17.767 1.00 28.08 B C ATOM 2645 O PHE B 199 16.345 16.049 18.073 1.00 28.24 B O ATOM 2646 N HIS B 200 16.993 14.353 16.758 1.00 27.87 B N ATOM 2647 CA HIS B 200 17.806 15.238 15.938 1.00 29.75 B C ATOM 2648 CB HIS B 200 19.100 15.594 16.681 1.00 33.26 B C ATOM 2649 CG HIS B 200 19.948 14.418 17.048 1.00 34.79 B C ATOM 2650 CD2 HIS B 200 21.287 14.230 16.965 1.00 36.25 B C ATOM 2651 ND1 HIS B 200 19.439 13.288 17.648 1.00 35.92 B N ATOM 2652 CE1 HIS B 200 20.427 12.454 17.921 1.00 37.18 B C ATOM 2653 NE2 HIS B 200 21.559 13.003 17.517 1.00 36.60 B N ATOM 2654 C HIS B 200 18.116 14.715 14.538 1.00 27.95 B C ATOM 2655 O HIS B 200 17.752 13.591 14.187 1.00 26.05 B O ATOM 2656 N ASP B 201 18.725 15.571 13.721 1.00 26.67 B N ATOM 2657 CA ASP B 201 19.138 15.186 12.377 1.00 25.20 B C ATOM 2658 CB ASP B 201 18.335 15.916 11.282 1.00 23.68 B C ATOM 2659 CG ASP B 201 18.264 17.424 11.483 1.00 25.88 B C ATOM 2660 OD1 ASP B 201 19.294 18.047 11.802 1.00 23.44 B O ATOM 2661 OD2 ASP B 201 17.166 17.998 11.290 1.00 26.10 B O ATOM 2662 C ASP B 201 20.627 15.505 12.299 1.00 24.36 B C ATOM 2663 O ASP B 201 21.263 15.653 13.339 1.00 24.08 B O ATOM 2664 N ALA B 202 21.184 15.617 11.096 1.00 22.49 B N ATOM 2665 CA ALA B 202 22.615 15.887 10.946 1.00 22.92 B C ATOM 2666 CB ALA B 202 23.038 15.661 9.485 1.00 21.85 B C ATOM 2667 C ALA B 202 23.106 17.263 11.420 1.00 22.02 B C ATOM 2668 O ALA B 202 24.289 17.437 11.710 1.00 19.11 B O ATOM 2669 N ALA B 203 22.212 18.237 11.520 1.00 21.84 B N ATOM 2670 CA ALA B 203 22.654 19.564 11.935 1.00 20.59 B C ATOM 2671 CB ALA B 203 22.661 20.502 10.718 1.00 18.98 B C ATOM 2672 C ALA B 203 21.902 20.213 13.095 1.00 17.95 B C ATOM 2673 O ALA B 203 22.321 21.262 13.583 1.00 19.24 B O ATOM 2674 N ARG B 204 20.825 19.595 13.568 1.00 17.86 B N ATOM 2675 CA ARG B 204 20.060 20.197 14.660 1.00 19.08 B C ATOM 2676 CB ARG B 204 18.849 20.964 14.111 1.00 23.11 B C ATOM 2677 CG ARG B 204 19.083 21.702 12.813 1.00 24.65 B C ATOM 2678 CD ARG B 204 17.793 22.345 12.317 1.00 31.21 B C ATOM 2679 NE ARG B 204 17.847 22.663 10.890 1.00 36.40 B N ATOM 2680 CZ ARG B 204 17.679 21.773 9.911 1.00 38.70 B C ATOM 2681 NH1 ARG B 204 17.752 22.161 8.644 1.00 41.01 B N ATOM 2682 NH2 ARG B 204 17.419 20.500 10.191 1.00 38.76 B N ATOM 2683 C ARG B 204 19.547 19.228 15.711 1.00 18.39 B C ATOM 2684 O ARG B 204 19.463 18.030 15.492 1.00 18.56 B O ATOM 2685 N VAL B 205 19.199 19.767 16.870 1.00 18.68 B N ATOM 2686 CA VAL B 205 18.649 18.958 17.949 1.00 18.67 B C ATOM 2687 CB VAL B 205 19.551 18.984 19.201 1.00 18.98 B C ATOM 2688 CG1 VAL B 205 18.933 18.135 20.301 1.00 19.79 B C ATOM 2689 CG2 VAL B 205 20.947 18.472 18.852 1.00 15.84 B C ATOM 2690 C VAL B 205 17.290 19.572 18.282 1.00 19.14 B C ATOM 2691 O VAL B 205 17.182 20.796 18.405 1.00 21.54 B O ATOM 2692 N TYR B 206 16.263 18.731 18.396 1.00 17.89 B N ATOM 2693 CA TYR B 206 14.910 19.193 18.709 1.00 19.04 B C ATOM 2694 CB TYR B 206 13.891 18.696 17.674 1.00 18.60 B C ATOM 2695 CG TYR B 206 14.228 19.017 16.240 1.00 18.39 B C ATOM 2696 CD1 TYR B 206 15.207 18.293 15.565 1.00 21.42 B C ATOM 2697 CE1 TYR B 206 15.542 18.578 14.244 1.00 21.55 B C ATOM 2698 CD2 TYR B 206 13.576 20.052 15.555 1.00 19.46 B C ATOM 2699 CE2 TYR B 206 13.907 20.352 14.216 1.00 21.97 B C ATOM 2700 CZ TYR B 206 14.898 19.602 13.573 1.00 23.91 B C ATOM 2701 OH TYR B 206 15.267 19.858 12.269 1.00 26.45 B O ATOM 2702 C TYR B 206 14.459 18.705 20.073 1.00 19.50 B C ATOM 2703 O TYR B 206 14.538 17.508 20.373 1.00 21.94 B O ATOM 2704 N LEU B 207 13.985 19.633 20.897 1.00 16.85 B N ATOM 2705 CA LEU B 207 13.491 19.291 22.224 1.00 17.98 B C ATOM 2706 CB LEU B 207 14.181 20.161 23.286 1.00 16.72 B C ATOM 2707 CG LEU B 207 15.722 20.138 23.321 1.00 19.44 B C ATOM 2708 CD1 LEU B 207 16.216 21.031 24.461 1.00 19.09 B C ATOM 2709 CD2 LEU B 207 16.226 18.707 23.519 1.00 19.58 B C ATOM 2710 C LEU B 207 11.973 19.535 22.225 1.00 17.04 B C ATOM 2711 O LEU B 207 11.513 20.588 21.803 1.00 18.06 B O ATOM 2712 N ILE B 208 11.205 18.547 22.674 1.00 18.23 B N ATOM 2713 CA ILE B 208 9.747 18.653 22.727 1.00 16.54 B C ATOM 2714 CB ILE B 208 9.093 17.336 22.272 1.00 16.55 B C ATOM 2715 CG2 ILE B 208 7.568 17.474 22.238 1.00 14.96 B C ATOM 2716 CG1 ILE B 208 9.614 16.978 20.872 1.00 20.37 B C ATOM 2717 CD1 ILE B 208 9.149 15.613 20.347 1.00 21.43 B C ATOM 2718 C ILE B 208 9.412 18.969 24.179 1.00 17.23 B C ATOM 2719 O ILE B 208 9.636 18.144 25.081 1.00 16.63 B O ATOM 2720 N LEU B 209 8.871 20.166 24.401 1.00 16.12 B N ATOM 2721 CA LEU B 209 8.577 20.630 25.752 1.00 17.56 B C ATOM 2722 CB LEU B 209 9.472 21.830 26.063 1.00 17.90 B C ATOM 2723 CG LEU B 209 10.978 21.577 25.959 1.00 19.46 B C ATOM 2724 CD1 LEU B 209 11.664 22.798 25.379 1.00 19.75 B C ATOM 2725 CD2 LEU B 209 11.525 21.215 27.336 1.00 19.17 B C ATOM 2726 C LEU B 209 7.144 21.018 26.084 1.00 18.62 B C ATOM 2727 O LEU B 209 6.348 21.346 25.202 1.00 18.84 B O ATOM 2728 N GLU B 210 6.844 20.984 27.381 1.00 16.02 B N ATOM 2729 CA GLU B 210 5.549 21.382 27.898 1.00 17.17 B C ATOM 2730 CB GLU B 210 5.496 21.128 29.409 1.00 16.24 B C ATOM 2731 CG GLU B 210 4.275 21.705 30.100 1.00 17.66 B C ATOM 2732 CD GLU B 210 4.319 21.542 31.615 1.00 19.26 B C ATOM 2733 OE1 GLU B 210 3.396 22.037 32.298 1.00 19.17 B O ATOM 2734 OE2 GLU B 210 5.273 20.919 32.126 1.00 18.51 B O ATOM 2735 C GLU B 210 5.419 22.881 27.619 1.00 17.58 B C ATOM 2736 O GLU B 210 6.386 23.640 27.787 1.00 17.15 B O ATOM 2737 N TYR B 211 4.239 23.301 27.177 1.00 17.46 B N ATOM 2738 CA TYR B 211 3.975 24.707 26.875 1.00 17.27 B C ATOM 2739 CB TYR B 211 2.915 24.830 25.771 1.00 17.32 B C ATOM 2740 CG TYR B 211 2.598 26.265 25.406 1.00 18.99 B C ATOM 2741 CD1 TYR B 211 3.601 27.115 24.953 1.00 18.89 B C ATOM 2742 CE1 TYR B 211 3.337 28.443 24.637 1.00 18.07 B C ATOM 2743 CD2 TYR B 211 1.300 26.783 25.536 1.00 19.53 B C ATOM 2744 CE2 TYR B 211 1.025 28.124 25.215 1.00 17.93 B C ATOM 2745 CZ TYR B 211 2.058 28.943 24.766 1.00 19.57 B C ATOM 2746 OH TYR B 211 1.837 30.268 24.435 1.00 21.28 B O ATOM 2747 C TYR B 211 3.488 25.437 28.119 1.00 17.08 B C ATOM 2748 O TYR B 211 2.676 24.905 28.880 1.00 20.12 B O ATOM 2749 N ALA B 212 3.977 26.657 28.315 1.00 16.19 B N ATOM 2750 CA ALA B 212 3.619 27.487 29.470 1.00 16.51 B C ATOM 2751 CB ALA B 212 4.882 27.927 30.202 1.00 15.30 B C ATOM 2752 C ALA B 212 2.856 28.705 28.952 1.00 17.50 B C ATOM 2753 O ALA B 212 3.450 29.726 28.596 1.00 18.16 B O ATOM 2754 N PRO B 213 1.520 28.618 28.925 1.00 17.93 B N ATOM 2755 CD PRO B 213 0.728 27.494 29.458 1.00 16.26 B C ATOM 2756 CA PRO B 213 0.651 29.693 28.437 1.00 18.73 B C ATOM 2757 CB PRO B 213 −0.758 29.108 28.604 1.00 17.80 B C ATOM 2758 CG PRO B 213 −0.609 28.146 29.724 1.00 19.64 B C ATOM 2759 C PRO B 213 0.761 31.115 28.984 1.00 19.83 B C ATOM 2760 O PRO B 213 0.513 32.063 28.245 1.00 20.80 B O ATOM 2761 N LEU B 214 1.128 31.288 30.250 1.00 20.66 B N ATOM 2762 CA LEU B 214 1.211 32.640 30.798 1.00 20.06 B C ATOM 2763 CB LEU B 214 0.709 32.647 32.255 1.00 19.58 B C ATOM 2764 CG LEU B 214 −0.812 32.790 32.467 1.00 22.04 B C ATOM 2765 CD1 LEU B 214 −1.576 31.829 31.576 1.00 23.11 B C ATOM 2766 CD2 LEU B 214 −1.161 32.538 33.926 1.00 22.72 B C ATOM 2767 C LEU B 214 2.572 33.346 30.686 1.00 21.48 B C ATOM 2768 O LEU B 214 2.749 34.451 31.200 1.00 23.25 B O ATOM 2769 N GLY B 215 3.533 32.724 30.013 1.00 21.00 B N ATOM 2770 CA GLY B 215 4.825 33.368 29.847 1.00 21.31 B C ATOM 2771 C GLY B 215 5.790 33.299 31.023 1.00 23.13 B C ATOM 2772 O GLY B 215 5.657 32.448 31.904 1.00 23.73 B O ATOM 2773 N THR B 216 6.758 34.214 31.042 1.00 22.29 B N ATOM 2774 CA THR B 216 7.779 34.238 32.088 1.00 23.81 B C ATOM 2775 CB THR B 216 9.127 34.692 31.517 1.00 23.63 B C ATOM 2776 OG1 THR B 216 9.090 36.102 31.277 1.00 25.10 B O ATOM 2777 CG2 THR B 216 9.409 33.987 30.199 1.00 22.17 B C ATOM 2778 C THR B 216 7.461 35.125 33.291 1.00 23.33 B C ATOM 2779 O THR B 216 6.712 36.100 33.191 1.00 20.98 B O ATOM 2780 N VAL B 217 8.036 34.774 34.435 1.00 22.90 B N ATOM 2781 CA VAL B 217 7.827 35.554 35.651 1.00 24.21 B C ATOM 2782 CB VAL B 217 8.470 34.857 36.867 1.00 23.26 B C ATOM 2783 CG1 VAL B 217 8.387 35.740 38.109 1.00 22.26 B C ATOM 2784 CG2 VAL B 217 7.763 33.552 37.110 1.00 22.25 B C ATOM 2785 C VAL B 217 8.439 36.935 35.449 1.00 23.65 B C ATOM 2786 O VAL B 217 7.922 37.933 35.932 1.00 23.81 B O ATOM 2787 N TYR B 218 9.536 36.967 34.708 1.00 25.98 B N ATOM 2788 CA TYR B 218 10.247 38.193 34.395 1.00 29.23 B C ATOM 2789 CB TYR B 218 11.395 37.865 33.437 1.00 33.60 B C ATOM 2790 CG TYR B 218 12.225 39.040 32.974 1.00 37.23 B C ATOM 2791 CD1 TYR B 218 11.965 39.661 31.753 1.00 39.24 B C ATOM 2792 CE1 TYR B 218 12.756 40.710 31.296 1.00 40.90 B C ATOM 2793 CD2 TYR B 218 13.296 39.503 33.733 1.00 39.21 B C ATOM 2794 CE2 TYR B 218 14.096 40.551 33.285 1.00 41.41 B C ATOM 2795 CZ TYR B 218 13.819 41.149 32.065 1.00 42.06 B C ATOM 2796 OH TYR B 218 14.609 42.175 31.607 1.00 43.77 B O ATOM 2797 C TYR B 218 9.302 39.228 33.788 1.00 30.16 B C ATOM 2798 O TYR B 218 9.259 40.368 34.242 1.00 31.95 B O ATOM 2799 N ALA B 219 8.540 38.831 32.770 1.00 30.65 B N ATOM 2800 CA ALA B 219 7.589 39.736 32.123 1.00 29.66 B C ATOM 2801 CB ALA B 219 6.906 39.026 30.967 1.00 28.94 B C ATOM 2802 C ALA B 219 6.542 40.257 33.118 1.00 29.78 B C ATOM 2803 O ALA B 219 6.199 41.438 33.110 1.00 28.08 B O ATOM 2804 N GLU B 220 6.027 39.371 33.964 1.00 30.79 B N ATOM 2805 CA GLU B 220 5.037 39.753 34.968 1.00 34.09 B C ATOM 2806 CB GLU B 220 4.587 38.529 35.766 1.00 36.73 B C ATOM 2807 CG GLU B 220 3.344 37.838 35.251 1.00 43.32 B C ATOM 2808 CD GLU B 220 2.073 38.618 35.542 1.00 46.85 B C ATOM 2809 OE1 GLU B 220 1.801 39.613 34.835 1.00 48.71 B O ATOM 2810 OE2 GLU B 220 1.350 38.237 36.489 1.00 48.33 B O ATOM 2811 C GLU B 220 5.618 40.785 35.934 1.00 34.92 B C ATOM 2812 O GLU B 220 4.956 41.755 36.296 1.00 36.60 B O ATOM 2813 N LEU B 221 6.858 40.569 36.356 1.00 34.26 B N ATOM 2814 CA LEU B 221 7.505 41.482 37.286 1.00 34.78 B C ATOM 2815 CB LEU B 221 8.920 40.995 37.621 1.00 33.24 B C ATOM 2816 CG LEU B 221 9.646 41.761 38.735 1.00 32.72 B C ATOM 2817 CD1 LEU B 221 8.807 41.773 40.010 1.00 30.46 B C ATOM 2818 CD2 LEU B 221 10.996 41.112 38.988 1.00 32.35 B C ATOM 2819 C LEU B 221 7.565 42.880 36.693 1.00 34.90 B C ATOM 2820 O LEU B 221 7.275 43.864 37.374 1.00 32.14 B O ATOM 2821 N GLN B 222 7.941 42.961 35.419 1.00 35.21 B N ATOM 2822 CA GLN B 222 8.026 44.241 34.735 1.00 37.12 B C ATOM 2823 CB GLN B 222 8.563 44.044 33.319 1.00 39.87 B C ATOM 2824 CG GLN B 222 9.945 43.424 33.287 1.00 44.00 B C ATOM 2825 CD GLN B 222 10.690 43.723 32.004 1.00 47.25 B C ATOM 2826 OE1 GLN B 222 10.220 43.410 30.907 1.00 49.30 B O ATOM 2827 NE2 GLN B 222 11.864 44.333 32.135 1.00 48.03 B N ATOM 2828 C GLN B 222 6.684 44.972 34.687 1.00 36.68 B C ATOM 2829 O GLN B 222 6.634 46.184 34.865 1.00 37.49 B O ATOM 2830 N LYS B 223 5.597 44.241 34.461 1.00 35.79 B N ATOM 2831 CA LYS B 223 4.277 44.859 34.406 1.00 36.52 B C ATOM 2832 CB LYS B 223 3.237 43.868 33.875 1.00 37.92 B C ATOM 2833 CG LYS B 223 3.354 43.561 32.389 1.00 39.91 B C ATOM 2834 CD LYS B 223 2.292 42.560 31.944 1.00 42.68 B C ATOM 2835 CE LYS B 223 0.886 43.140 32.033 1.00 43.66 B C ATOM 2836 NZ LYS B 223 0.693 44.275 31.079 1.00 46.03 B N ATOM 2837 C LYS B 223 3.792 45.402 35.749 1.00 36.84 B C ATOM 2838 O LYS B 223 3.357 46.550 35.833 1.00 38.21 B O ATOM 2839 N LEU B 224 3.860 44.580 36.795 1.00 35.10 B N ATOM 2840 CA LEU B 224 3.398 44.988 38.122 1.00 33.56 B C ATOM 2841 CB LEU B 224 2.929 43.762 38.913 1.00 33.55 B C ATOM 2842 CG LEU B 224 1.871 42.852 38.282 1.00 34.89 B C ATOM 2843 CD1 LEU B 224 1.619 41.658 39.189 1.00 33.24 B C ATOM 2844 CD2 LEU B 224 0.589 43.630 38.059 1.00 34.60 B C ATOM 2845 C LEU B 224 4.452 45.735 38.939 1.00 32.05 B C ATOM 2846 O LEU B 224 4.141 46.297 39.989 1.00 32.92 B O ATOM 2847 N SER B 225 5.691 45.723 38.455 1.00 30.59 B N ATOM 2848 CA SER B 225 6.826 46.380 39.112 1.00 31.41 B C ATOM 2849 CB SER B 225 6.449 47.792 39.549 1.00 32.21 B C ATOM 2850 OG SER B 225 7.615 48.537 39.843 1.00 34.55 B O ATOM 2851 C SER B 225 7.361 45.585 40.318 1.00 31.23 B C ATOM 2852 O SER B 225 8.556 45.589 40.599 1.00 30.58 B O ATOM 2853 N LYS B 226 6.466 44.921 41.035 1.00 30.59 B N ATOM 2854 CA LYS B 226 6.851 44.096 42.173 1.00 31.60 B C ATOM 2855 CB LYS B 226 7.535 44.924 43.273 1.00 32.62 B C ATOM 2856 CG LYS B 226 6.733 46.065 43.866 1.00 33.34 B C ATOM 2857 CD LYS B 226 7.482 46.606 45.085 1.00 37.58 B C ATOM 2858 CE LYS B 226 6.839 47.858 45.658 1.00 39.62 B C ATOM 2859 NZ LYS B 226 7.074 49.049 44.786 1.00 41.42 B N ATOM 2860 C LYS B 226 5.620 43.400 42.707 1.00 29.47 B C ATOM 2861 O LYS B 226 4.501 43.795 42.391 1.00 29.83 B O ATOM 2862 N PHE B 227 5.821 42.355 43.500 1.00 28.21 B N ATOM 2863 CA PHE B 227 4.702 41.597 44.039 1.00 26.85 B C ATOM 2864 CB PHE B 227 4.928 40.091 43.833 1.00 28.42 B C ATOM 2865 CG PHE B 227 5.401 39.718 42.453 1.00 27.26 B C ATOM 2866 CD1 PHE B 227 4.884 40.346 41.321 1.00 27.70 B C ATOM 2867 CD2 PHE B 227 6.352 38.712 42.286 1.00 27.41 B C ATOM 2868 CE1 PHE B 227 5.308 39.976 40.041 1.00 27.47 B C ATOM 2869 CE2 PHE B 227 6.786 38.334 41.011 1.00 27.41 B C ATOM 2870 CZ PHE B 227 6.261 38.969 39.887 1.00 27.84 B C ATOM 2871 C PHE B 227 4.453 41.850 45.525 1.00 26.66 B C ATOM 2872 O PHE B 227 5.307 42.385 46.229 1.00 25.45 B O ATOM 2873 N ASP B 228 3.273 41.442 45.983 1.00 24.91 B N ATOM 2874 CA ASP B 228 2.870 41.576 47.375 1.00 25.21 B C ATOM 2875 CB ASP B 228 1.346 41.623 47.484 1.00 25.97 B C ATOM 2876 CG ASP B 228 0.675 40.479 46.742 1.00 26.97 B C ATOM 2877 OD1 ASP B 228 0.468 40.611 45.525 1.00 33.21 B O ATOM 2878 OD2 ASP B 228 0.373 39.440 47.359 1.00 27.04 B O ATOM 2879 C ASP B 228 3.394 40.357 48.129 1.00 26.47 B C ATOM 2880 O ASP B 228 3.979 39.447 47.528 1.00 26.50 B O ATOM 2881 N GLU B 229 3.158 40.327 49.436 1.00 25.93 B N ATOM 2882 CA GLU B 229 3.627 39.234 50.275 1.00 25.05 B C ATOM 2883 CB GLU B 229 3.425 39.579 51.757 1.00 26.99 B C ATOM 2884 CG GLU B 229 4.230 40.789 52.233 1.00 30.82 B C ATOM 2885 CD GLU B 229 4.296 40.905 53.753 1.00 31.53 B C ATOM 2886 OE1 GLU B 229 3.239 41.053 54.403 1.00 32.47 B O ATOM 2887 OE2 GLU B 229 5.415 40.847 54.299 1.00 33.80 B O ATOM 2888 C GLU B 229 2.961 37.900 49.973 1.00 25.00 B C ATOM 2889 O GLU B 229 3.624 36.855 49.985 1.00 22.64 B O ATOM 2890 N GLN B 230 1.657 37.930 49.702 1.00 23.27 B N ATOM 2891 CA GLN B 230 0.925 36.698 49.420 1.00 25.73 B C ATOM 2892 CB GLN B 230 −0.577 36.990 49.254 1.00 30.97 B C ATOM 2893 CG GLN B 230 −1.443 35.736 49.099 1.00 37.32 B C ATOM 2894 CD GLN B 230 −2.902 36.043 48.773 1.00 41.26 B C ATOM 2895 OE1 GLN B 230 −3.214 36.601 47.720 1.00 43.42 B O ATOM 2896 NE2 GLN B 230 −3.800 35.673 49.679 1.00 43.12 B N ATOM 2897 C GLN B 230 1.477 36.003 48.173 1.00 22.96 B C ATOM 2898 O GLN B 230 1.779 34.811 48.203 1.00 22.41 B O ATOM 2899 N ARG B 231 1.618 36.750 47.081 1.00 21.69 B N ATOM 2900 CA ARG B 231 2.151 36.196 45.841 1.00 20.70 B C ATOM 2901 CB ARG B 231 2.067 37.237 44.720 1.00 24.11 B C ATOM 2902 CG ARG B 231 2.972 36.943 43.534 1.00 29.60 B C ATOM 2903 CD ARG B 231 2.207 36.654 42.261 1.00 32.47 B C ATOM 2904 NE ARG B 231 1.381 37.776 41.827 1.00 35.86 B N ATOM 2905 CZ ARG B 231 1.031 37.992 40.562 1.00 38.81 B C ATOM 2906 NH1 ARG B 231 0.269 39.031 40.249 1.00 39.91 B N ATOM 2907 NH2 ARG B 231 1.466 37.183 39.602 1.00 38.33 B N ATOM 2908 C ARG B 231 3.606 35.719 46.001 1.00 19.50 B C ATOM 2909 O ARG B 231 3.957 34.622 45.557 1.00 17.71 B O ATOM 2910 N THR B 232 4.441 36.538 46.635 1.00 17.49 B N ATOM 2911 CA THR B 232 5.838 36.184 46.847 1.00 16.16 B C ATOM 2912 CB THR B 232 6.612 37.312 47.576 1.00 19.54 B C ATOM 2913 OG1 THR B 232 6.597 38.504 46.782 1.00 13.78 B O ATOM 2914 CG2 THR B 232 8.082 36.879 47.834 1.00 14.78 B C ATOM 2915 C THR B 232 5.956 34.904 47.682 1.00 17.18 B C ATOM 2916 O THR B 232 6.672 33.984 47.307 1.00 15.09 B O ATOM 2917 N ALA B 233 5.243 34.852 48.807 1.00 19.12 B N ATOM 2918 CA ALA B 233 5.264 33.684 49.695 1.00 18.94 B C ATOM 2919 CB ALA B 233 4.352 33.925 50.906 1.00 17.71 B C ATOM 2920 C ALA B 233 4.828 32.407 48.966 1.00 19.02 B C ATOM 2921 O ALA B 233 5.417 31.334 49.157 1.00 18.32 B O ATOM 2922 N THR B 234 3.785 32.527 48.148 1.00 19.42 B N ATOM 2923 CA THR B 234 3.275 31.399 47.370 1.00 18.40 B C ATOM 2924 CB THR B 234 1.975 31.784 46.620 1.00 17.88 B C ATOM 2925 OG1 THR B 234 0.965 32.134 47.575 1.00 15.16 B O ATOM 2926 CG2 THR B 234 1.480 30.618 45.762 1.00 16.22 B C ATOM 2927 C THR B 234 4.329 30.932 46.364 1.00 18.28 B C ATOM 2928 O THR B 234 4.550 29.735 46.196 1.00 20.75 B O ATOM 2929 N TYR B 235 4.981 31.876 45.694 1.00 19.08 B N ATOM 2930 CA TYR B 235 6.034 31.540 44.736 1.00 18.92 B C ATOM 2931 CB TYR B 235 6.514 32.803 44.014 1.00 19.29 B C ATOM 2932 CG TYR B 235 5.661 33.258 42.851 1.00 21.57 B C ATOM 2933 CD1 TYR B 235 4.389 32.729 42.634 1.00 23.85 B C ATOM 2934 CE1 TYR B 235 3.589 33.176 41.579 1.00 24.93 B C ATOM 2935 CD2 TYR B 235 6.116 34.247 41.984 1.00 21.08 B C ATOM 2936 CE2 TYR B 235 5.325 34.705 40.926 1.00 24.94 B C ATOM 2937 CZ TYR B 235 4.063 34.168 40.728 1.00 26.16 B C ATOM 2938 OH TYR B 235 3.267 34.628 39.695 1.00 22.88 B O ATOM 2939 C TYR B 235 7.242 30.871 45.423 1.00 18.91 B C ATOM 2940 O TYR B 235 7.855 29.956 44.869 1.00 18.47 B O ATOM 2941 N ILE B 236 7.603 31.336 46.619 1.00 18.40 B N ATOM 2942 CA ILE B 236 8.745 30.741 47.321 1.00 17.73 B C ATOM 2943 CB ILE B 236 9.188 31.601 48.541 1.00 18.76 B C ATOM 2944 CG2 ILE B 236 10.387 30.945 49.254 1.00 18.52 B C ATOM 2945 CG1 ILE B 236 9.612 32.999 48.065 1.00 19.28 B C ATOM 2946 CD1 ILE B 236 10.744 32.987 47.035 1.00 16.65 B C ATOM 2947 C ILE B 236 8.407 29.322 47.781 1.00 16.37 B C ATOM 2948 O ILE B 236 9.274 28.460 47.824 1.00 15.52 B O ATOM 2949 N THR B 237 7.138 29.086 48.109 1.00 17.75 B N ATOM 2950 CA THR B 237 6.685 27.770 48.545 1.00 18.73 B C ATOM 2951 CB THR B 237 5.203 27.813 49.028 1.00 20.81 B C ATOM 2952 OG1 THR B 237 5.124 28.585 50.224 1.00 20.67 B O ATOM 2953 CG2 THR B 237 4.677 26.420 49.334 1.00 20.82 B C ATOM 2954 C THR B 237 6.818 26.764 47.410 1.00 18.80 B C ATOM 2955 O THR B 237 7.425 25.710 47.576 1.00 20.21 B O ATOM 2956 N GLU B 238 6.253 27.092 46.252 1.00 20.60 B N ATOM 2957 CA GLU B 238 6.320 26.199 45.099 1.00 19.19 B C ATOM 2958 CB GLU B 238 5.555 26.813 43.918 1.00 20.66 B C ATOM 2959 CG GLU B 238 4.036 26.779 44.100 1.00 23.37 B C ATOM 2960 CD GLU B 238 3.313 27.786 43.224 1.00 24.80 B C ATOM 2961 OE1 GLU B 238 3.581 27.842 42.009 1.00 25.78 B O ATOM 2962 OE2 GLU B 238 2.466 28.527 43.755 1.00 28.41 B O ATOM 2963 C GLU B 238 7.767 25.917 44.705 1.00 19.31 B C ATOM 2964 O GLU B 238 8.126 24.780 44.361 1.00 17.16 B O ATOM 2965 N LEU B 239 8.598 26.954 44.751 1.00 18.37 B N ATOM 2966 CA LEU B 239 10.004 26.801 44.401 1.00 17.98 B C ATOM 2967 CB LEU B 239 10.690 28.166 44.357 1.00 19.30 B C ATOM 2968 CG LEU B 239 10.569 28.862 43.002 1.00 22.62 B C ATOM 2969 CD1 LEU B 239 10.915 30.346 43.126 1.00 23.53 B C ATOM 2970 CD2 LEU B 239 11.493 28.157 42.008 1.00 23.78 B C ATOM 2971 C LEU B 239 10.746 25.877 45.362 1.00 18.38 B C ATOM 2972 O LEU B 239 11.517 25.025 44.926 1.00 18.06 B O ATOM 2973 N ALA B 240 10.514 26.047 46.665 1.00 16.60 B N ATOM 2974 CA ALA B 240 11.180 25.214 47.668 1.00 17.68 B C ATOM 2975 CB ALA B 240 10.830 25.701 49.080 1.00 16.34 B C ATOM 2976 C ALA B 240 10.777 23.750 47.496 1.00 18.39 B C ATOM 2977 O ALA B 240 11.606 22.856 47.641 1.00 16.04 B O ATOM 2978 N ASN B 241 9.502 23.518 47.179 1.00 19.07 B N ATOM 2979 CA ASN B 241 9.009 22.166 46.967 1.00 21.46 B C ATOM 2980 CB ASN B 241 7.517 22.167 46.602 1.00 23.76 B C ATOM 2981 CG ASN B 241 6.625 22.096 47.814 1.00 28.59 B C ATOM 2982 OD1 ASN B 241 6.917 21.367 48.759 1.00 31.92 B O ATOM 2983 ND2 ASN B 241 5.524 22.842 47.794 1.00 29.40 B N ATOM 2984 C ASN B 241 9.789 21.536 45.833 1.00 21.94 B C ATOM 2985 O ASN B 241 10.282 20.408 45.951 1.00 23.36 B O ATOM 2986 N ALA B 242 9.898 22.279 44.735 1.00 20.78 B N ATOM 2987 CA ALA B 242 10.614 21.816 43.553 1.00 21.85 B C ATOM 2988 CB ALA B 242 10.437 22.818 42.426 1.00 18.99 B C ATOM 2989 C ALA B 242 12.105 21.567 43.820 1.00 21.42 B C ATOM 2990 O ALA B 242 12.634 20.508 43.488 1.00 21.59 B O ATOM 2991 N LEU B 243 12.782 22.537 44.426 1.00 22.94 B N ATOM 2992 CA LEU B 243 14.209 22.383 44.730 1.00 21.96 B C ATOM 2993 CB LEU B 243 14.751 23.669 45.360 1.00 19.53 B C ATOM 2994 CG LEU B 243 14.744 24.896 44.439 1.00 20.66 B C ATOM 2995 CD1 LEU B 243 15.174 26.127 45.213 1.00 20.26 B C ATOM 2996 CD2 LEU B 243 15.674 24.656 43.266 1.00 20.88 B C ATOM 2997 C LEU B 243 14.457 21.196 45.668 1.00 21.93 B C ATOM 2998 O LEU B 243 15.449 20.469 45.535 1.00 20.07 B O ATOM 2999 N SER B 244 13.558 21.014 46.626 1.00 22.84 B N ATOM 3000 CA SER B 244 13.676 19.913 47.572 1.00 25.72 B C ATOM 3001 CB SER B 244 12.528 19.966 48.582 1.00 26.38 B C ATOM 3002 OG SER B 244 12.707 18.992 49.589 1.00 31.74 B O ATOM 3003 C SER B 244 13.646 18.594 46.800 1.00 26.65 B C ATOM 3004 O SER B 244 14.497 17.725 47.001 1.00 28.75 B O ATOM 3005 N TYR B 245 12.667 18.450 45.912 1.00 25.41 B N ATOM 3006 CA TYR B 245 12.545 17.246 45.101 1.00 26.59 B C ATOM 3007 CB TYR B 245 11.297 17.347 44.210 1.00 28.10 B C ATOM 3008 CG TYR B 245 11.234 16.369 43.050 1.00 29.48 B C ATOM 3009 CD1 TYR B 245 11.789 16.695 41.808 1.00 27.01 B C ATOM 3010 CE1 TYR B 245 11.746 15.806 40.740 1.00 25.91 B C ATOM 3011 CD2 TYR B 245 10.625 15.113 43.193 1.00 29.43 B C ATOM 3012 CE2 TYR B 245 10.576 14.210 42.124 1.00 29.19 B C ATOM 3013 CZ TYR B 245 11.144 14.568 40.900 1.00 27.94 B C ATOM 3014 OH TYR B 245 11.131 13.687 39.842 1.00 26.95 B O ATOM 3015 C TYR B 245 13.808 17.026 44.261 1.00 27.59 B C ATOM 3016 O TYR B 245 14.272 15.897 44.117 1.00 27.11 B O ATOM 3017 N CYS B 246 14.372 18.099 43.711 1.00 27.30 B N ATOM 3018 CA CYS B 246 15.586 17.965 42.907 1.00 27.67 B C ATOM 3019 CB CYS B 246 15.926 19.284 42.202 1.00 27.42 B C ATOM 3020 SG CYS B 246 14.898 19.706 40.755 1.00 29.37 B S ATOM 3021 C CYS B 246 16.787 17.518 43.753 1.00 26.99 B C ATOM 3022 O CYS B 246 17.568 16.670 43.333 1.00 24.30 B O ATOM 3023 N HIS B 247 16.938 18.097 44.940 1.00 27.86 B N ATOM 3024 CA HIS B 247 18.048 17.734 45.813 1.00 28.63 B C ATOM 3025 CB HIS B 247 18.007 18.546 47.116 1.00 27.63 B C ATOM 3026 CG HIS B 247 18.519 19.950 46.976 1.00 27.06 B C ATOM 3027 CD2 HIS B 247 18.746 20.716 45.882 1.00 26.78 B C ATOM 3028 ND1 HIS B 247 18.873 20.724 48.062 1.00 26.58 B N ATOM 3029 CE1 HIS B 247 19.299 21.902 47.643 1.00 24.28 B C ATOM 3030 NE2 HIS B 247 19.232 21.923 46.325 1.00 24.21 B N ATOM 3031 C HIS B 247 18.006 16.241 46.128 1.00 30.30 B C ATOM 3032 O HIS B 247 19.046 15.594 46.243 1.00 29.75 B O ATOM 3033 N SER B 248 16.801 15.691 46.245 1.00 31.77 B N ATOM 3034 CA SER B 248 16.641 14.275 46.550 1.00 34.48 B C ATOM 3035 CB SER B 248 15.169 13.943 46.824 1.00 34.54 B C ATOM 3036 OG SER B 248 14.419 13.874 45.621 1.00 34.42 B O ATOM 3037 C SER B 248 17.166 13.396 45.417 1.00 36.24 B C ATOM 3038 O SER B 248 17.527 12.239 45.640 1.00 39.13 B O ATOM 3039 N LYS B 249 17.206 13.937 44.205 1.00 37.49 B N ATOM 3040 CA LYS B 249 17.714 13.183 43.065 1.00 38.33 B C ATOM 3041 CB LYS B 249 16.752 13.291 41.882 1.00 39.56 B C ATOM 3042 CG LYS B 249 15.480 12.470 42.075 1.00 41.09 B C ATOM 3043 CD LYS B 249 14.692 12.348 40.783 1.00 42.87 B C ATOM 3044 CE LYS B 249 13.544 11.345 40.903 1.00 44.69 B C ATOM 3045 NZ LYS B 249 14.008 9.940 41.115 1.00 43.80 B N ATOM 3046 C LYS B 249 19.110 13.649 42.667 1.00 38.25 B C ATOM 3047 O LYS B 249 19.535 13.500 41.520 1.00 38.18 B O ATOM 3048 N ALA B 250 19.823 14.208 43.639 1.00 38.25 B N ATOM 3049 CA ALA B 250 21.180 14.693 43.429 1.00 38.88 B C ATOM 3050 CB ALA B 250 22.128 13.506 43.260 1.00 37.35 B C ATOM 3051 C ALA B 250 21.294 15.642 42.234 1.00 39.66 B C ATOM 3052 O ALA B 250 22.256 15.586 41.469 1.00 39.73 B O ATOM 3053 N VAL B 251 20.312 16.521 42.077 1.00 40.68 B N ATOM 3054 CA VAL B 251 20.331 17.475 40.976 1.00 41.44 B C ATOM 3055 CB VAL B 251 19.009 17.448 40.197 1.00 39.71 B C ATOM 3056 CG1 VAL B 251 18.996 18.543 39.156 1.00 36.93 B C ATOM 3057 CG2 VAL B 251 18.833 16.099 39.542 1.00 39.66 B C ATOM 3058 C VAL B 251 20.575 18.887 41.487 1.00 43.36 B C ATOM 3059 O VAL B 251 19.857 19.361 42.361 1.00 43.18 B O ATOM 3060 N ALA B 252 21.594 19.572 41.411 1.00 47.23 B N ATOM 3061 CA ALA B 252 21.800 20.930 41.937 1.00 51.57 B C ATOM 3062 CB ALA B 252 23.072 20.979 42.781 1.00 50.06 B C ATOM 3063 C ALA B 252 21.867 21.974 40.811 1.00 55.17 B C ATOM 3064 O ALA B 252 22.516 21.755 39.786 1.00 55.31 B O ATOM 3065 N HIS B 253 21.201 23.110 41.025 1.00 59.25 B N ATOM 3066 CA HIS B 253 21.127 24.196 40.039 1.00 62.40 B C ATOM 3067 CB HIS B 253 19.928 25.100 40.346 1.00 63.38 B C ATOM 3068 CG HIS B 253 18.626 24.569 39.838 1.00 65.58 B C ATOM 3069 CD2 HIS B 253 17.728 25.093 38.970 1.00 65.78 B C ATOM 3070 ND1 HIS B 253 18.131 23.335 40.205 1.00 66.21 B N ATOM 3071 CE1 HIS B 253 16.985 23.122 39.583 1.00 66.24 B C ATOM 3072 NE2 HIS B 253 16.718 24.173 38.828 1.00 66.35 B N ATOM 3073 C HIS B 253 22.343 25.091 39.812 1.00 64.23 B C ATOM 3074 O HIS B 253 23.157 24.827 38.924 1.00 64.24 B O ATOM 3075 N ARG B 254 22.431 26.162 40.603 1.00 66.29 B N ATOM 3076 CA ARG B 254 23.501 27.162 40.503 1.00 67.93 B C ATOM 3077 CB ARG B 254 24.829 26.507 40.106 1.00 69.34 B C ATOM 3078 CG ARG B 254 25.429 25.629 41.199 1.00 72.18 B C ATOM 3079 CD ARG B 254 26.435 24.626 40.649 1.00 73.87 B C ATOM 3080 NE ARG B 254 27.423 25.232 39.760 1.00 76.14 B N ATOM 3081 CZ ARG B 254 28.423 24.559 39.197 1.00 77.32 B C ATOM 3082 NH1 ARG B 254 28.566 23.259 39.435 1.00 77.53 B N ATOM 3083 NH2 ARG B 254 29.275 25.180 38.391 1.00 77.47 B N ATOM 3084 C ARG B 254 23.093 28.203 39.455 1.00 68.10 B C ATOM 3085 O ARG B 254 23.941 28.818 38.805 1.00 68.48 B O ATOM 3086 N ASP B 255 21.779 28.383 39.311 1.00 67.94 B N ATOM 3087 CA ASP B 255 21.181 29.321 38.358 1.00 66.09 B C ATOM 3088 CB ASP B 255 21.768 29.117 36.960 1.00 68.18 B C ATOM 3089 CG ASP B 255 20.978 29.848 35.891 1.00 70.20 B C ATOM 3090 OD1 ASP B 255 20.977 31.098 35.906 1.00 70.85 B O ATOM 3091 OD2 ASP B 255 20.346 29.176 35.045 1.00 70.61 B O ATOM 3092 C ASP B 255 19.670 29.086 38.290 1.00 64.02 B C ATOM 3093 O ASP B 255 19.224 27.980 37.966 1.00 63.85 B O ATOM 3094 N ILE B 256 18.887 30.123 38.587 1.00 60.24 B N ATOM 3095 CA ILE B 256 17.432 30.007 38.557 1.00 56.06 B C ATOM 3096 CB ILE B 256 16.938 29.251 39.813 1.00 56.48 B C ATOM 3097 CG2 ILE B 256 17.097 30.123 41.051 1.00 57.30 B C ATOM 3098 CG1 ILE B 256 15.483 28.833 39.637 1.00 56.77 B C ATOM 3099 CD1 ILE B 256 15.012 27.833 40.671 1.00 57.42 B C ATOM 3100 C ILE B 256 16.727 31.371 38.444 1.00 52.46 B C ATOM 3101 O ILE B 256 15.769 31.661 39.154 1.00 51.61 B O ATOM 3102 N LYS B 257 17.209 32.193 37.521 1.00 48.41 B N ATOM 3103 CA LYS B 257 16.684 33.536 37.258 1.00 44.89 B C ATOM 3104 CB LYS B 257 17.469 34.142 36.094 1.00 45.52 B C ATOM 3105 CG LYS B 257 18.981 34.051 36.249 1.00 48.52 B C ATOM 3106 CD LYS B 257 19.703 34.586 35.017 1.00 50.54 B C ATOM 3107 CE LYS B 257 19.499 33.695 33.791 1.00 50.70 B C ATOM 3108 NZ LYS B 257 20.251 32.406 33.875 1.00 51.10 B N ATOM 3109 C LYS B 257 15.177 33.614 36.941 1.00 40.75 B C ATOM 3110 O LYS B 257 14.548 32.614 36.614 1.00 40.52 B O ATOM 3111 N PRO B 258 14.480 34.397 36.931 1.00 37.08 B N ATOM 3112 CD PRO B 258 15.445 35.391 37.431 1.00 36.34 B C ATOM 3113 CA PRO B 258 13.167 35.015 36.690 1.00 35.17 B C ATOM 3114 CB PRO B 258 13.397 36.489 37.038 1.00 34.26 B C ATOM 3115 CG PRO B 258 14.544 36.448 38.017 1.00 33.40 B C ATOM 3116 C PRO B 258 12.770 34.825 35.227 1.00 34.61 B C ATOM 3117 O PRO B 258 11.604 34.576 34.908 1.00 31.39 B O ATOM 3118 N GLU B 259 13.757 34.954 34.346 1.00 33.54 B N ATOM 3119 CA GLU B 259 13.540 34.769 32.918 1.00 34.62 B C ATOM 3120 CB GLU B 259 14.706 35.332 32.100 1.00 37.22 B C ATOM 3121 CG GLU B 259 15.143 36.745 32.442 1.00 41.67 B C ATOM 3122 CD GLU B 259 15.934 36.826 33.735 1.00 44.39 B C ATOM 3123 OE1 GLU B 259 16.564 37.874 33.978 1.00 46.55 B O ATOM 3124 OE2 GLU B 259 15.924 35.851 34.515 1.00 46.90 B O ATOM 3125 C GLU B 259 13.469 33.265 32.678 1.00 34.06 B C ATOM 3126 O GLU B 259 13.004 32.812 31.632 1.00 34.68 B O ATOM 3127 N ASN B 260 13.943 32.492 33.652 1.00 31.75 B N ATOM 3128 CA ASN B 260 13.941 31.042 33.527 1.00 30.54 B C ATOM 3129 CB ASN B 260 15.262 30.455 34.035 1.00 34.15 B C ATOM 3130 CG ASN B 260 16.474 31.178 33.478 1.00 39.70 B C ATOM 3131 OD1 ASN B 260 16.454 31.681 32.347 1.00 41.30 B O ATOM 3132 ND2 ASN B 260 17.545 31.226 34.265 1.00 40.33 B N ATOM 3133 C ASN B 260 12.785 30.413 34.284 1.00 27.70 B C ATOM 3134 O ASN B 260 12.723 29.194 34.423 1.00 28.09 B O ATOM 3135 N LEU B 261 11.879 31.244 34.783 1.00 23.87 B N ATOM 3136 CA LEU B 261 10.715 30.748 35.511 1.00 23.63 B C ATOM 3137 CB LEU B 261 10.636 31.393 36.904 1.00 23.52 B C ATOM 3138 CG LEU B 261 11.859 31.157 37.802 1.00 23.80 B C ATOM 3139 CD1 LEU B 261 11.784 32.065 39.013 1.00 23.16 B C ATOM 3140 CD2 LEU B 261 11.918 29.696 38.233 1.00 23.15 B C ATOM 3141 C LEU B 261 9.486 31.094 34.683 1.00 22.79 B C ATOM 3142 O LEU B 261 9.248 32.259 34.360 1.00 23.35 B O ATOM 3143 N LEU B 262 8.720 30.072 34.329 1.00 21.85 B N ATOM 3144 CA LEU B 262 7.530 30.240 33.503 1.00 20.81 B C ATOM 3145 CB LEU B 262 7.583 29.241 32.338 1.00 18.28 B C ATOM 3146 CG LEU B 262 8.805 29.444 31.427 1.00 20.74 B C ATOM 3147 CD1 LEU B 262 9.022 28.247 30.528 1.00 17.18 B C ATOM 3148 CD2 LEU B 262 8.594 30.704 30.600 1.00 23.22 B C ATOM 3149 C LEU B 262 6.260 30.050 34.324 1.00 20.95 B C ATOM 3150 O LEU B 262 6.320 29.607 35.468 1.00 21.65 B O ATOM 3151 N LEU B 263 5.118 30.385 33.731 1.00 20.04 B N ATOM 3152 CA LEU B 263 3.818 30.291 34.401 1.00 19.89 B C ATOM 3153 CB LEU B 263 3.199 31.682 34.542 1.00 19.96 B C ATOM 3154 CG LEU B 263 3.895 32.673 35.485 1.00 22.61 B C ATOM 3155 CD1 LEU B 263 3.332 34.074 35.269 1.00 19.88 B C ATOM 3156 CD2 LEU B 263 3.689 32.218 36.938 1.00 19.42 B C ATOM 3157 C LEU B 263 2.828 29.405 33.667 1.00 20.69 B C ATOM 3158 O LEU B 263 2.555 29.607 32.477 1.00 19.05 B O ATOM 3159 N GLY B 264 2.285 28.434 34.390 1.00 20.39 B N ATOM 3160 CA GLY B 264 1.318 27.531 33.810 1.00 22.81 B C ATOM 3161 C GLY B 264 −0.058 28.166 33.723 1.00 23.93 B C ATOM 3162 O GLY B 264 −0.267 29.307 34.146 1.00 23.55 B O ATOM 3163 N SER B 265 −0.996 27.406 33.178 1.00 26.43 B N ATOM 3164 CA SER B 265 −2.375 27.846 33.002 1.00 29.74 B C ATOM 3165 CB SER B 265 −3.224 26.687 32.478 1.00 30.89 B C ATOM 3166 OG SER B 265 −4.593 27.054 32.458 1.00 37.32 B O ATOM 3167 C SER B 265 −3.026 28.398 34.267 1.00 30.10 B C ATOM 3168 O SER B 265 −3.786 29.356 34.203 1.00 31.27 B O ATOM 3169 N ALA B 266 −2.738 27.790 35.411 1.00 29.46 B N ATOM 3170 CA ALA B 266 −3.319 28.239 36.670 1.00 28.49 B C ATOM 3171 CB ALA B 266 −3.645 27.040 37.546 1.00 27.90 B C ATOM 3172 C ALA B 266 −2.424 29.202 37.433 1.00 27.49 B C ATOM 3173 O ALA B 266 −2.673 29.486 38.594 1.00 26.71 B O ATOM 3174 N GLY B 267 −1.380 29.704 36.785 1.00 28.52 B N ATOM 3175 CA GLY B 267 −0.485 30.630 37.458 1.00 27.29 B C ATOM 3176 C GLY B 267 0.556 29.951 38.335 1.00 26.61 B C ATOM 3177 O GLY B 267 1.155 30.591 39.203 1.00 27.45 B O ATOM 3178 N GLU B 268 0.780 28.660 38.117 1.00 25.29 B N ATOM 3179 CA GLU B 268 1.766 27.924 38.905 1.00 26.30 B C ATOM 3180 CB GLU B 268 1.409 26.433 38.967 1.00 27.43 B C ATOM 3181 CG GLU B 268 0.012 26.107 38.488 1.00 34.47 B C ATOM 3182 CD GLU B 268 −0.087 26.008 36.976 1.00 35.53 B C ATOM 3183 OE1 GLU B 268 0.297 24.958 36.423 1.00 38.92 B O ATOM 3184 OE2 GLU B 268 −0.546 26.979 36.339 1.00 38.49 B O ATOM 3185 C GLU B 268 3.154 28.083 38.287 1.00 24.38 B C ATOM 3186 O GLU B 268 3.300 28.062 37.063 1.00 21.68 B O ATOM 3187 N LEU B 269 4.171 28.250 39.129 1.00 23.82 B N ATOM 3188 CA LEU B 269 5.542 28.398 38.634 1.00 21.61 B C ATOM 3189 CB LEU B 269 6.492 28.808 39.761 1.00 24.33 B C ATOM 3190 CG LEU B 269 6.545 30.246 40.265 1.00 25.70 B C ATOM 3191 CD1 LEU B 269 7.693 30.382 41.252 1.00 24.92 B C ATOM 3192 CD2 LEU B 269 6.751 31.198 39.103 1.00 27.39 B C ATOM 3193 C LEU B 269 6.061 27.099 38.034 1.00 19.77 B C ATOM 3194 O LEU B 269 5.703 26.015 38.485 1.00 19.34 B O ATOM 3195 N LYS B 270 6.909 27.222 37.017 1.00 19.92 B N ATOM 3196 CA LYS B 270 7.525 26.074 36.356 1.00 20.30 B C ATOM 3197 CB LYS B 270 6.902 25.836 34.972 1.00 18.33 B C ATOM 3198 CG LYS B 270 5.393 25.615 34.964 1.00 18.74 B C ATOM 3199 CD LYS B 270 5.012 24.155 35.137 1.00 15.50 B C ATOM 3200 CE LYS B 270 3.491 23.994 35.128 1.00 18.10 B C ATOM 3201 NZ LYS B 270 3.046 22.575 35.077 1.00 15.24 B N ATOM 3202 C LYS B 270 9.019 26.383 36.178 1.00 20.49 B C ATOM 3203 O LYS B 270 9.373 27.374 35.550 1.00 18.08 B O ATOM 3204 N ILE B 271 9.889 25.545 36.737 1.00 21.09 B N ATOM 3205 CA ILE B 271 11.329 25.756 36.587 1.00 20.68 B C ATOM 3206 CB ILE B 271 12.133 25.016 37.674 1.00 21.21 B C ATOM 3207 CG2 ILE B 271 13.640 25.176 37.413 1.00 19.34 B C ATOM 3208 CG1 ILE B 271 11.761 25.553 39.060 1.00 23.24 B C ATOM 3209 CD1 ILE B 271 12.514 24.863 40.210 1.00 24.09 B C ATOM 3210 C ILE B 271 11.754 25.207 35.224 1.00 20.59 B C ATOM 3211 O ILE B 271 11.482 24.051 34.911 1.00 19.44 B O ATOM 3212 N ALA B 272 12.410 26.034 34.416 1.00 19.34 B N ATOM 3213 CA ALA B 272 12.858 25.598 33.095 1.00 24.16 B C ATOM 3214 CB ALA B 272 12.404 26.594 32.037 1.00 20.99 B C ATOM 3215 C ALA B 272 14.384 25.434 33.039 1.00 26.77 B C ATOM 3216 O ALA B 272 15.106 26.155 33.723 1.00 27.46 B O ATOM 3217 N ASP B 273 14.843 24.478 32.225 1.00 29.94 B N ATOM 3218 CA ASP B 273 16.265 24.150 32.014 1.00 32.45 B C ATOM 3219 CB ASP B 273 17.153 25.351 32.319 1.00 33.94 B C ATOM 3220 CG ASP B 273 17.622 26.038 31.068 1.00 38.34 B C ATOM 3221 OD1 ASP B 273 18.171 27.165 31.162 1.00 41.51 B O ATOM 3222 OD2 ASP B 273 17.439 25.436 29.986 1.00 36.50 B O ATOM 3223 C ASP B 273 16.799 22.930 32.767 1.00 34.27 B C ATOM 3224 O ASP B 273 17.928 22.472 32.518 1.00 34.48 B O ATOM 3225 N GLY B 290 22.452 32.822 36.840 1.00 57.41 B N ATOM 3226 CA GLY B 290 22.919 33.188 35.513 1.00 56.55 B C ATOM 3227 C GLY B 290 23.992 34.260 35.563 1.00 56.09 B C ATOM 3228 O GLY B 290 25.185 33.954 35.650 1.00 56.35 B O ATOM 3229 N THR B 291 23.572 35.522 35.508 1.00 54.56 B N ATOM 3230 CA THR B 291 24.511 36.633 35.555 1.00 52.44 B C ATOM 3231 CB THR B 291 23.813 37.967 35.195 1.00 53.95 B C ATOM 3232 OG1 THR B 291 22.687 38.172 36.056 1.00 54.88 B O ATOM 3233 CG2 THR B 291 23.338 37.946 33.746 1.00 55.03 B C ATOM 3234 C THR B 291 25.140 36.738 36.945 1.00 50.11 B C ATOM 3235 O THR B 291 24.840 35.940 37.840 1.00 47.96 B O ATOM 3236 N LEU B 292 26.010 37.727 37.123 1.00 47.85 B N ATOM 3237 CA LEU B 292 26.695 37.926 38.395 1.00 46.13 B C ATOM 3238 CB LEU B 292 27.664 39.109 38.280 1.00 46.70 B C ATOM 3239 CG LEU B 292 28.706 39.250 39.393 1.00 47.14 B C ATOM 3240 CD1 LEU B 292 29.422 37.921 39.596 1.00 46.68 B C ATOM 3241 CD2 LEU B 292 29.704 40.342 39.030 1.00 46.77 B C ATOM 3242 C LEU B 292 25.740 38.143 39.573 1.00 44.02 B C ATOM 3243 O LEU B 292 25.967 37.638 40.675 1.00 43.84 B O ATOM 3244 N ASP B 293 24.663 38.879 39.330 1.00 41.14 B N ATOM 3245 CA ASP B 293 23.687 39.172 40.371 1.00 40.18 B C ATOM 3246 CB ASP B 293 22.551 40.010 39.789 1.00 40.75 B C ATOM 3247 CG ASP B 293 22.969 41.428 39.508 1.00 39.93 B C ATOM 3248 OD1 ASP B 293 23.770 41.635 38.578 1.00 43.70 B O ATOM 3249 OD2 ASP B 293 22.510 42.336 40.227 1.00 42.04 B O ATOM 3250 C ASP B 293 23.084 37.986 41.124 1.00 38.77 B C ATOM 3251 O ASP B 293 22.442 38.175 42.157 1.00 36.99 B O ATOM 3252 N TYR B 294 23.288 36.770 40.628 1.00 38.33 B N ATOM 3253 CA TYR B 294 22.704 35.607 41.284 1.00 36.46 B C ATOM 3254 CB TYR B 294 21.721 34.923 40.324 1.00 37.01 B C ATOM 3255 CG TYR B 294 20.645 35.862 39.813 1.00 36.29 B C ATOM 3256 CD1 TYR B 294 20.894 36.732 38.747 1.00 36.77 B C ATOM 3257 CE1 TYR B 294 19.932 37.650 38.324 1.00 35.17 B C ATOM 3258 CD2 TYR B 294 19.405 35.931 40.440 1.00 33.86 B C ATOM 3259 CE2 TYR B 294 18.438 36.841 40.029 1.00 34.67 B C ATOM 3260 CZ TYR B 294 18.707 37.700 38.974 1.00 36.81 B C ATOM 3261 OH TYR B 294 17.747 38.614 38.586 1.00 37.64 B O ATOM 3262 C TYR B 294 23.674 34.573 41.855 1.00 35.29 B C ATOM 3263 O TYR B 294 23.241 33.612 42.482 1.00 33.83 B O ATOM 3264 N LEU B 295 24.975 34.768 41.664 1.00 34.16 B N ATOM 3265 CA LEU B 295 25.946 33.804 42.180 1.00 34.73 B C ATOM 3266 CB LEU B 295 27.191 33.790 41.287 1.00 35.44 B C ATOM 3267 CG LEU B 295 26.941 33.402 39.822 1.00 37.31 B C ATOM 3268 CD1 LEU B 295 28.232 33.537 39.015 1.00 38.09 B C ATOM 3269 CD2 LEU B 295 26.409 31.974 39.754 1.00 37.09 B C ATOM 3270 C LEU B 295 26.340 34.071 43.635 1.00 33.23 B C ATOM 3271 O LEU B 295 26.485 35.220 44.045 1.00 33.47 B O ATOM 3272 N PRO B 296 26.501 33.003 44.438 1.00 32.82 B N ATOM 3273 CD PRO B 296 26.174 31.603 44.099 1.00 32.14 B C ATOM 3274 CA PRO B 296 26.877 33.123 45.852 1.00 32.58 B C ATOM 3275 CB PRO B 296 26.408 31.796 46.442 1.00 30.74 B C ATOM 3276 CG PRO B 296 26.654 30.841 45.321 1.00 30.81 B C ATOM 3277 C PRO B 296 28.380 33.355 46.069 1.00 34.00 B C ATOM 3278 O PRO B 296 29.185 33.190 45.150 1.00 32.17 B O ATOM 3279 N PRO B 297 28.771 33.744 47.297 1.00 35.08 B N ATOM 3280 CD PRO B 297 27.894 34.068 48.438 1.00 34.25 B C ATOM 3281 CA PRO B 297 30.174 33.999 47.639 1.00 36.33 B C ATOM 3282 CB PRO B 297 30.111 34.293 49.137 1.00 34.76 B C ATOM 3283 CG PRO B 297 28.777 34.948 49.287 1.00 34.10 B C ATOM 3284 C PRO B 297 31.128 32.840 47.314 1.00 37.57 B C ATOM 3285 O PRO B 297 32.097 33.021 46.583 1.00 39.23 B O ATOM 3286 N GLU B 298 30.847 31.654 47.848 1.00 38.80 B N ATOM 3287 CA GLU B 298 31.709 30.491 47.626 1.00 40.63 B C ATOM 3288 CB GLU B 298 31.108 29.232 48.260 1.00 39.54 B C ATOM 3289 CG GLU B 298 29.823 28.761 47.590 1.00 38.57 B C ATOM 3290 CD GLU B 298 28.592 29.251 48.313 1.00 37.66 B C ATOM 3291 OE1 GLU B 298 28.601 30.406 48.795 1.00 38.14 B O ATOM 3292 OE2 GLU B 298 27.618 28.481 48.400 1.00 36.41 B O ATOM 3293 C GLU B 298 32.016 30.187 46.164 1.00 42.36 B C ATOM 3294 O GLU B 298 32.873 29.355 45.874 1.00 42.42 B O ATOM 3295 N MET B 299 31.317 30.837 45.241 1.00 44.46 B N ATOM 3296 CA MET B 299 31.572 30.589 43.830 1.00 46.93 B C ATOM 3297 CB MET B 299 30.262 30.454 43.054 1.00 47.22 B C ATOM 3298 CG MET B 299 29.494 29.190 43.410 1.00 49.38 B C ATOM 3299 SD MET B 299 28.411 28.637 42.093 1.00 51.57 B S ATOM 3300 CE MET B 299 29.502 27.513 41.247 1.00 53.08 B C ATOM 3301 C MET B 299 32.447 31.662 43.212 1.00 47.79 B C ATOM 3302 O MET B 299 33.416 31.350 42.522 1.00 48.57 B O ATOM 3303 N ILE B 300 32.118 32.926 43.457 1.00 48.73 B N ATOM 3304 CA ILE B 300 32.930 34.004 42.914 1.00 49.57 B C ATOM 3305 CB ILE B 300 32.190 35.362 42.968 1.00 49.76 B C ATOM 3306 CG2 ILE B 300 30.896 35.273 42.171 1.00 49.66 B C ATOM 3307 CG1 ILE B 300 31.904 35.761 44.416 1.00 48.39 B C ATOM 3308 CD1 ILE B 300 31.295 37.143 44.540 1.00 47.07 B C ATOM 3309 C ILE B 300 34.243 34.096 43.697 1.00 50.74 B C ATOM 3310 O ILE B 300 35.253 34.571 43.177 1.00 50.30 B O ATOM 3311 N GLU B 301 34.226 33.630 44.943 1.00 52.24 B N ATOM 3312 CA GLU B 301 35.424 33.648 45.776 1.00 54.57 B C ATOM 3313 CB GLU B 301 35.058 33.596 47.267 1.00 55.69 B C ATOM 3314 CG GLU B 301 34.210 34.770 47.737 1.00 58.62 B C ATOM 3315 CD GLU B 301 34.020 34.806 49.247 1.00 59.50 B C ATOM 3316 OE1 GLU B 301 33.827 33.731 49.855 1.00 60.80 B O ATOM 3317 OE2 GLU B 301 34.046 35.915 49.823 1.00 59.81 B O ATOM 3318 C GLU B 301 36.309 32.456 45.421 1.00 55.44 B C ATOM 3319 O GLU B 301 37.419 32.322 45.936 1.00 55.50 B O ATOM 3320 N GLY B 302 35.804 31.590 44.544 1.00 55.63 B N ATOM 3321 CA GLY B 302 36.567 30.429 44.119 1.00 56.55 B C ATOM 3322 C GLY B 302 36.457 29.193 44.995 1.00 57.16 B C ATOM 3323 O GLY B 302 36.823 28.100 44.563 1.00 57.49 B O ATOM 3324 N ARG B 303 35.966 29.359 46.221 1.00 57.72 B N ATOM 3325 CA ARG B 303 35.808 28.241 47.149 1.00 57.79 B C ATOM 3326 CB ARG B 303 35.094 28.702 48.419 1.00 58.72 B C ATOM 3327 CG ARG B 303 35.855 29.706 49.257 1.00 61.00 B C ATOM 3328 CD ARG B 303 34.963 30.239 50.366 1.00 62.94 B C ATOM 3329 NE ARG B 303 35.680 31.094 51.309 1.00 64.60 B N ATOM 3330 CZ ARG B 303 36.606 30.661 52.160 1.00 65.49 B C ATOM 3331 NH1 ARG B 303 37.203 31.514 52.982 1.00 65.70 B N ATOM 3332 NH2 ARG B 303 36.936 29.376 52.191 1.00 65.53 B N ATOM 3333 C ARG B 303 34.995 27.119 46.517 1.00 58.00 B C ATOM 3334 O ARG B 303 34.586 27.209 45.358 1.00 58.81 B O ATOM 3335 N MET B 304 34.758 26.060 47.284 1.00 57.39 B N ATOM 3336 CA MET B 304 33.974 24.934 46.792 1.00 56.99 B C ATOM 3337 CB MET B 304 34.389 23.647 47.508 1.00 59.63 B C ATOM 3338 CG MET B 304 34.471 22.435 46.594 1.00 63.14 B C ATOM 3339 SD MET B 304 32.911 22.046 45.769 1.00 67.12 B S ATOM 3340 CE MET B 304 32.278 20.749 46.851 1.00 66.78 B C ATOM 3341 C MET B 304 32.504 25.247 47.072 1.00 54.74 B C ATOM 3342 O MET B 304 32.197 26.264 47.691 1.00 53.70 B O ATOM 3343 N HIS B 305 31.600 24.382 46.618 1.00 52.40 B N ATOM 3344 CA HIS B 305 30.170 24.598 46.826 1.00 49.37 B C ATOM 3345 CB HIS B 305 29.638 25.583 45.791 1.00 49.86 B C ATOM 3346 CG HIS B 305 29.857 25.138 44.380 1.00 51.90 B C ATOM 3347 CD2 HIS B 305 28.986 24.712 43.434 1.00 52.04 B C ATOM 3348 ND1 HIS B 305 31.110 25.069 43.809 1.00 51.78 B N ATOM 3349 CE1 HIS B 305 31.000 24.619 42.571 1.00 53.53 B C ATOM 3350 NE2 HIS B 305 29.723 24.395 42.319 1.00 53.06 B N ATOM 3351 C HIS B 305 29.347 23.312 46.750 1.00 46.97 B C ATOM 3352 O HIS B 305 29.791 22.296 46.208 1.00 46.30 B O ATOM 3353 N ASP B 306 28.135 23.372 47.289 1.00 43.16 B N ATOM 3354 CA ASP B 306 27.246 22.224 47.279 1.00 40.92 B C ATOM 3355 CB ASP B 306 27.405 21.433 48.586 1.00 40.71 B C ATOM 3356 CG ASP B 306 26.952 22.210 49.805 1.00 40.75 B C ATOM 3357 OD1 ASP B 306 26.828 23.449 49.725 1.00 40.70 B O ATOM 3358 OD2 ASP B 306 26.729 21.574 50.853 1.00 42.16 B O ATOM 3359 C ASP B 306 25.797 22.670 47.077 1.00 39.86 B C ATOM 3360 O ASP B 306 25.545 23.734 46.505 1.00 39.27 B O ATOM 3361 N GLU B 307 24.851 21.858 47.542 1.00 37.39 B N ATOM 3362 CA GLU B 307 23.437 22.179 47.392 1.00 35.90 B C ATOM 3363 CB GLU B 307 22.562 21.048 47.939 1.00 37.19 B C ATOM 3364 CG GLU B 307 23.310 19.796 48.370 1.00 42.69 B C ATOM 3365 CD GLU B 307 23.978 19.942 49.723 1.00 43.86 B C ATOM 3366 OE1 GLU B 307 23.275 20.245 50.713 1.00 46.08 B O ATOM 3367 OE2 GLU B 307 25.205 19.747 49.798 1.00 45.78 B O ATOM 3368 C GLU B 307 23.049 23.484 48.083 1.00 34.05 B C ATOM 3369 O GLU B 307 21.948 24.005 47.862 1.00 30.38 B O ATOM 3370 N LYS B 308 23.953 24.017 48.905 1.00 29.97 B N ATOM 3371 CA LYS B 308 23.660 25.247 49.632 1.00 27.77 B C ATOM 3372 CB LYS B 308 24.706 25.485 50.723 1.00 29.00 B C ATOM 3373 CG LYS B 308 24.669 24.472 51.857 1.00 30.48 B C ATOM 3374 CD LYS B 308 23.346 24.521 52.605 1.00 31.68 B C ATOM 3375 CE LYS B 308 23.442 23.788 53.921 1.00 32.64 B C ATOM 3376 NZ LYS B 308 22.194 23.897 54.726 1.00 32.70 B N ATOM 3377 C LYS B 308 23.536 26.485 48.743 1.00 25.47 B C ATOM 3378 O LYS B 308 23.007 27.504 49.177 1.00 23.55 B O ATOM 3379 N VAL B 309 24.011 26.405 47.504 1.00 23.68 B N ATOM 3380 CA VAL B 309 23.894 27.549 46.612 1.00 23.94 B C ATOM 3381 CB VAL B 309 24.666 27.334 45.284 1.00 23.56 B C ATOM 3382 CG1 VAL B 309 26.147 27.135 45.572 1.00 26.07 B C ATOM 3383 CG2 VAL B 309 24.101 26.148 44.528 1.00 23.94 B C ATOM 3384 C VAL B 309 22.423 27.853 46.291 1.00 24.19 B C ATOM 3385 O VAL B 309 22.051 29.017 46.139 1.00 25.34 B O ATOM 3386 N ASP B 310 21.589 26.815 46.197 1.00 23.71 B N ATOM 3387 CA ASP B 310 20.169 27.007 45.897 1.00 22.68 B C ATOM 3388 CB ASP B 310 19.454 25.656 45.690 1.00 23.58 B C ATOM 3389 CG ASP B 310 19.924 24.934 44.434 1.00 27.55 B C ATOM 3390 OD1 ASP B 310 20.273 25.612 43.445 1.00 28.81 B O ATOM 3391 OD2 ASP B 310 19.936 23.688 44.419 1.00 31.31 B O ATOM 3392 C ASP B 310 19.466 27.816 46.983 1.00 21.05 B C ATOM 3393 O ASP B 310 18.512 28.545 46.701 1.00 20.77 B O ATOM 3394 N LEU B 311 19.935 27.690 48.222 1.00 20.13 B N ATOM 3395 CA LEU B 311 19.353 28.444 49.327 1.00 19.16 B C ATOM 3396 CB LEU B 311 19.885 27.942 50.676 1.00 19.21 B C ATOM 3397 CG LEU B 311 19.208 26.743 51.357 1.00 21.60 B C ATOM 3398 CD1 LEU B 311 17.737 27.054 51.572 1.00 20.35 B C ATOM 3399 CD2 LEU B 311 19.360 25.484 50.528 1.00 19.65 B C ATOM 3400 C LEU B 311 19.664 29.934 49.174 1.00 19.50 B C ATOM 3401 O LEU B 311 18.853 30.791 49.530 1.00 17.78 B O ATOM 3402 N TRP B 312 20.848 30.245 48.653 1.00 20.26 B N ATOM 3403 CA TRP B 312 21.226 31.634 48.452 1.00 19.28 B C ATOM 3404 CB TRP B 312 22.716 31.729 48.109 1.00 20.45 B C ATOM 3405 CG TRP B 312 23.156 33.064 47.620 1.00 18.65 B C ATOM 3406 CD2 TRP B 312 23.784 34.092 48.390 1.00 19.00 B C ATOM 3407 CE2 TRP B 312 24.034 35.176 47.515 1.00 18.21 B C ATOM 3408 CE3 TRP B 312 24.161 34.205 49.733 1.00 20.36 B C ATOM 3409 CD1 TRP B 312 23.048 33.551 46.344 1.00 20.44 B C ATOM 3410 NE1 TRP B 312 23.574 34.820 46.274 1.00 19.77 B N ATOM 3411 CZ2 TRP B 312 24.646 36.354 47.940 1.00 18.87 B C ATOM 3412 CZ3 TRP B 312 24.771 35.379 50.157 1.00 19.61 B C ATOM 3413 CH2 TRP B 312 25.007 36.438 49.260 1.00 21.25 B C ATOM 3414 C TRP B 312 20.389 32.206 47.326 1.00 20.24 B C ATOM 3415 O TRP B 312 19.903 33.334 47.408 1.00 18.37 B O ATOM 3416 N SER B 313 20.236 31.421 46.263 1.00 20.08 B N ATOM 3417 CA SER B 313 19.455 31.845 45.113 1.00 19.43 B C ATOM 3418 CB SER B 313 19.460 30.760 44.037 1.00 20.79 B C ATOM 3419 OG SER B 313 20.741 30.657 43.448 1.00 24.62 B O ATOM 3420 C SER B 313 18.024 32.156 45.502 1.00 19.39 B C ATOM 3421 O SER B 313 17.403 33.035 44.920 1.00 18.50 B O ATOM 3422 N LEU B 314 17.512 31.442 46.498 1.00 19.22 B N ATOM 3423 CA LEU B 314 16.141 31.641 46.960 1.00 19.58 B C ATOM 3424 CB LEU B 314 15.737 30.476 47.871 1.00 20.69 B C ATOM 3425 CG LEU B 314 14.276 30.024 47.987 1.00 23.50 B C ATOM 3426 CD1 LEU B 314 13.682 29.761 46.608 1.00 20.26 B C ATOM 3427 CD2 LEU B 314 14.215 28.758 48.843 1.00 20.22 B C ATOM 3428 C LEU B 314 16.021 32.976 47.693 1.00 19.00 B C ATOM 3429 O LEU B 314 14.973 33.637 47.632 1.00 20.65 B O ATOM 3430 N GLY B 315 17.097 33.372 48.375 1.00 17.95 B N ATOM 3431 CA GLY B 315 17.112 34.638 49.097 1.00 14.32 B C ATOM 3432 C GLY B 315 17.085 35.805 48.120 1.00 15.06 B C ATOM 3433 O GLY B 315 16.308 36.753 48.270 1.00 15.06 B O ATOM 3434 N VAL B 316 17.930 35.728 47.098 1.00 15.22 B N ATOM 3435 CA VAL B 316 17.996 36.775 46.090 1.00 15.50 B C ATOM 3436 CB VAL B 316 19.115 36.487 45.050 1.00 17.46 B C ATOM 3437 CG1 VAL B 316 19.005 37.470 43.858 1.00 15.92 B C ATOM 3438 CG2 VAL B 316 20.492 36.626 45.715 1.00 15.82 B C ATOM 3439 C VAL B 316 16.651 36.899 45.387 1.00 15.41 B C ATOM 3440 O VAL B 316 16.152 38.004 45.193 1.00 18.18 B O ATOM 3441 N LEU B 317 16.063 35.764 45.020 1.00 15.83 B N ATOM 3442 CA LEU B 317 14.762 35.729 44.350 1.00 17.96 B C ATOM 3443 CB LEU B 317 14.399 34.276 44.019 1.00 22.63 B C ATOM 3444 CG LEU B 317 14.200 33.825 42.569 1.00 28.46 B C ATOM 3445 CD1 LEU B 317 15.254 34.441 41.657 1.00 30.81 B C ATOM 3446 CD2 LEU B 317 14.273 32.299 42.512 1.00 30.80 B C ATOM 3447 C LEU B 317 13.653 36.359 45.204 1.00 17.12 B C ATOM 3448 O LEU B 317 12.877 37.184 44.721 1.00 17.94 B O ATOM 3449 N CYS B 318 13.575 35.961 46.472 1.00 15.77 B N ATOM 3450 CA CYS B 318 12.569 36.494 47.386 1.00 13.11 B C ATOM 3451 CB CYS B 318 12.718 35.837 48.762 1.00 12.76 B C ATOM 3452 SG CYS B 318 11.422 36.262 49.915 1.00 14.06 B S ATOM 3453 C CYS B 318 12.683 38.017 47.521 1.00 14.34 B C ATOM 3454 O CYS B 318 11.672 38.730 47.550 1.00 17.24 B O ATOM 3455 N TYR B 319 13.913 38.513 47.611 1.00 15.07 B N ATOM 3456 CA TYR B 319 14.149 39.950 47.726 1.00 15.31 B C ATOM 3457 CB TYR B 319 15.642 40.217 47.992 1.00 17.63 B C ATOM 3458 CG TYR B 319 16.029 41.679 48.141 1.00 18.67 B C ATOM 3459 CD1 TYR B 319 16.103 42.524 47.032 1.00 20.95 B C ATOM 3460 CE1 TYR B 319 16.465 43.878 47.172 1.00 22.71 B C ATOM 3461 CD2 TYR B 319 16.327 42.215 49.398 1.00 21.26 B C ATOM 3462 CE2 TYR B 319 16.687 43.560 49.552 1.00 22.44 B C ATOM 3463 CZ TYR B 319 16.752 44.384 48.436 1.00 23.40 B C ATOM 3464 OH TYR B 319 17.074 45.713 48.592 1.00 22.93 B O ATOM 3465 C TYR B 319 13.719 40.650 46.430 1.00 15.75 B C ATOM 3466 O TYR B 319 13.009 41.655 46.461 1.00 15.99 B O ATOM 3467 N GLU B 320 14.156 40.125 45.289 1.00 14.73 B N ATOM 3468 CA GLU B 320 13.782 40.736 44.021 1.00 17.64 B C ATOM 3469 CB GLU B 320 14.463 40.031 42.853 1.00 17.46 B C ATOM 3470 CG GLU B 320 14.174 40.726 41.542 1.00 22.76 B C ATOM 3471 CD GLU B 320 15.125 40.341 40.423 1.00 26.48 B C ATOM 3472 OE1 GLU B 320 15.023 40.974 39.359 1.00 28.28 B O ATOM 3473 OE2 GLU B 320 15.967 39.426 40.592 1.00 26.81 B O ATOM 3474 C GLU B 320 12.264 40.748 43.811 1.00 17.10 B C ATOM 3475 O GLU B 320 11.719 41.682 43.237 1.00 20.22 B O ATOM 3476 N PHE B 321 11.573 39.720 44.276 1.00 17.49 B N ATOM 3477 CA PHE B 321 10.126 39.703 44.121 1.00 18.22 B C ATOM 3478 CB PHE B 321 9.524 38.385 44.622 1.00 18.69 B C ATOM 3479 CG PHE B 321 9.701 37.231 43.683 1.00 21.02 B C ATOM 3480 CD1 PHE B 321 10.056 37.439 42.351 1.00 21.40 B C ATOM 3481 CD2 PHE B 321 9.498 35.930 44.126 1.00 22.14 B C ATOM 3482 CE1 PHE B 321 10.209 36.366 41.479 1.00 21.40 B C ATOM 3483 CE2 PHE B 321 9.648 34.853 43.260 1.00 23.29 B C ATOM 3484 CZ PHE B 321 10.006 35.073 41.935 1.00 22.08 B C ATOM 3485 C PHE B 321 9.469 40.841 44.887 1.00 20.00 B C ATOM 3486 O PHE B 321 8.563 41.499 44.375 1.00 19.40 B O ATOM 3487 N LEU B 322 9.919 41.057 46.123 1.00 20.34 B N ATOM 3488 CA LEU B 322 9.351 42.089 46.991 1.00 21.70 B C ATOM 3489 CB LEU B 322 9.645 41.760 48.459 1.00 20.38 B C ATOM 3490 CG LEU B 322 8.924 40.530 49.008 1.00 20.56 B C ATOM 3491 CD1 LEU B 322 9.485 40.164 50.385 1.00 21.26 B C ATOM 3492 CD2 LEU B 322 7.427 40.822 49.085 1.00 17.17 B C ATOM 3493 C LEU B 322 9.796 43.516 46.719 1.00 22.34 B C ATOM 3494 O LEU B 322 9.027 44.451 46.927 1.00 23.00 B O ATOM 3495 N VAL B 323 11.024 43.679 46.247 1.00 22.63 B N ATOM 3496 CA VAL B 323 11.571 45.006 45.994 1.00 24.72 B C ATOM 3497 CB VAL B 323 13.034 45.072 46.495 1.00 22.95 B C ATOM 3498 CG1 VAL B 323 13.655 46.414 46.172 1.00 24.04 B C ATOM 3499 CG2 VAL B 323 13.054 44.856 48.002 1.00 23.23 B C ATOM 3500 C VAL B 323 11.486 45.443 44.535 1.00 25.81 B C ATOM 3501 O VAL B 323 11.200 46.606 44.245 1.00 26.53 B O ATOM 3502 N GLY B 324 11.730 44.516 43.617 1.00 25.39 B N ATOM 3503 CA GLY B 324 11.651 44.857 42.213 1.00 25.94 B C ATOM 3504 C GLY B 324 12.980 44.762 41.508 1.00 26.51 B C ATOM 3505 O GLY B 324 13.024 44.751 40.282 1.00 27.88 B O ATOM 3506 N LYS B 325 14.062 44.709 42.281 1.00 27.18 B N ATOM 3507 CA LYS B 325 15.407 44.599 41.732 1.00 28.30 B C ATOM 3508 CB LYS B 325 16.040 45.985 41.573 1.00 32.53 B C ATOM 3509 CG LYS B 325 16.057 46.809 42.843 1.00 36.71 B C ATOM 3510 CD LYS B 325 16.678 48.183 42.605 1.00 41.59 B C ATOM 3511 CE LYS B 325 16.621 49.053 43.864 1.00 44.11 B C ATOM 3512 NZ LYS B 325 17.286 48.415 45.044 1.00 44.74 B N ATOM 3513 C LYS B 325 16.259 43.749 42.666 1.00 28.12 B C ATOM 3514 O LYS B 325 15.940 43.606 43.845 1.00 26.18 B O ATOM 3515 N PRO B 326 17.348 43.160 42.147 1.00 26.86 B N ATOM 3516 CD PRO B 326 17.790 43.134 40.742 1.00 26.79 B C ATOM 3517 CA PRO B 326 18.212 42.330 42.991 1.00 26.22 B C ATOM 3518 CB PRO B 326 19.137 41.653 41.979 1.00 27.30 B C ATOM 3519 CG PRO B 326 19.215 42.656 40.863 1.00 26.62 B C ATOM 3520 C PRO B 326 18.952 43.159 44.048 1.00 25.76 B C ATOM 3521 O PRO B 326 19.249 44.330 43.838 1.00 24.87 B O ATOM 3522 N PRO B 327 19.257 42.546 45.201 1.00 25.19 B N ATOM 3523 CD PRO B 327 19.005 41.111 45.435 1.00 24.23 B C ATOM 3524 CA PRO B 327 19.945 43.148 46.350 1.00 24.63 B C ATOM 3525 CB PRO B 327 19.864 42.046 47.407 1.00 23.95 B C ATOM 3526 CG PRO B 327 19.947 40.801 46.589 1.00 24.61 B C ATOM 3527 C PRO B 327 21.376 43.684 46.198 1.00 25.54 B C ATOM 3528 O PRO B 327 21.766 44.598 46.917 1.00 23.51 B O ATOM 3529 N PHE B 328 22.158 43.128 45.280 1.00 27.17 B N ATOM 3530 CA PHE B 328 23.540 43.572 45.107 1.00 27.57 B C ATOM 3531 CB PHE B 328 24.480 42.365 45.205 1.00 24.24 B C ATOM 3532 CG PHE B 328 24.257 41.519 46.432 1.00 23.37 B C ATOM 3533 CD1 PHE B 328 24.674 41.964 47.694 1.00 21.17 B C ATOM 3534 CD2 PHE B 328 23.609 40.286 46.334 1.00 20.04 B C ATOM 3535 CE1 PHE B 328 24.449 41.195 48.832 1.00 19.30 B C ATOM 3536 CE2 PHE B 328 23.377 39.505 47.465 1.00 21.16 B C ATOM 3537 CZ PHE B 328 23.801 39.963 48.725 1.00 21.41 B C ATOM 3538 C PHE B 328 23.778 44.306 43.786 1.00 30.91 B C ATOM 3539 O PHE B 328 24.920 44.593 43.424 1.00 29.74 B O ATOM 3540 N GLU B 329 22.699 44.617 43.073 1.00 35.49 B N ATOM 3541 CA GLU B 329 22.809 45.312 41.792 1.00 39.40 B C ATOM 3542 CB GLU B 329 21.422 45.680 41.257 1.00 40.82 B C ATOM 3543 CG GLU B 329 21.439 46.221 39.829 1.00 44.77 B C ATOM 3544 CD GLU B 329 20.104 46.816 39.401 1.00 45.81 B C ATOM 3545 OE1 GLU B 329 19.695 47.839 39.986 1.00 46.10 B O ATOM 3546 OE2 GLU B 329 19.465 46.262 38.480 1.00 47.31 B O ATOM 3547 C GLU B 329 23.643 46.579 41.920 1.00 41.08 B C ATOM 3548 O GLU B 329 23.353 47.444 42.740 1.00 40.70 B O ATOM 3549 N ALA B 330 24.686 46.678 41.106 1.00 43.84 B N ATOM 3550 CA ALA B 330 25.554 47.848 41.120 1.00 46.89 B C ATOM 3551 CB ALA B 330 26.943 47.469 41.610 1.00 45.55 B C ATOM 3552 C ALA B 330 25.633 48.417 39.709 1.00 49.66 B C ATOM 3553 O ALA B 330 25.028 47.884 38.776 1.00 50.00 B O ATOM 3554 N ASN B 331 26.382 49.500 39.556 1.00 52.10 B N ATOM 3555 CA ASN B 331 26.531 50.134 38.256 1.00 54.10 B C ATOM 3556 CB ASN B 331 26.785 51.634 38.436 1.00 55.63 B C ATOM 3557 CG ASN B 331 26.419 52.446 37.205 1.00 57.22 B C ATOM 3558 OD1 ASN B 331 26.304 53.671 37.271 1.00 57.48 B O ATOM 3559 ND2 ASN B 331 26.240 51.768 36.074 1.00 58.16 B N ATOM 3560 C ASN B 331 27.691 49.481 37.513 1.00 54.40 B C ATOM 3561 O ASN B 331 27.748 49.517 36.286 1.00 54.29 B O ATOM 3562 N THR B 332 28.602 48.867 38.266 1.00 55.19 B N ATOM 3563 CA THR B 332 29.761 48.202 37.676 1.00 55.71 B C ATOM 3564 CB THR B 332 31.056 49.020 37.908 1.00 55.73 B C ATOM 3565 OG1 THR B 332 32.189 48.248 37.491 1.00 56.87 B O ATOM 3566 CG2 THR B 332 31.210 49.385 39.371 1.00 55.37 B C ATOM 3567 C THR B 332 29.977 46.787 38.206 1.00 56.55 B C ATOM 3568 O THR B 332 29.604 46.466 39.337 1.00 57.13 B O ATOM 3569 N TYR B 333 30.587 45.945 37.377 1.00 56.97 B N ATOM 3570 CA TYR B 333 30.861 44.558 37.739 1.00 56.81 B C ATOM 3571 CB TYR B 333 31.623 43.848 36.610 1.00 58.85 B C ATOM 3572 CG TYR B 333 30.984 43.930 35.233 1.00 62.30 B C ATOM 3573 CD1 TYR B 333 31.675 43.490 34.099 1.00 62.80 B C ATOM 3574 CE1 TYR B 333 31.103 43.563 32.826 1.00 63.19 B C ATOM 3575 CD2 TYR B 333 29.695 44.446 35.057 1.00 63.26 B C ATOM 3576 CE2 TYR B 333 29.114 44.521 33.786 1.00 63.66 B C ATOM 3577 CZ TYR B 333 29.825 44.079 32.678 1.00 63.50 B C ATOM 3578 OH TYR B 333 29.257 44.153 31.425 1.00 63.78 B O ATOM 3579 C TYR B 333 31.697 44.484 39.012 1.00 55.92 B C ATOM 3580 O TYR B 333 31.351 43.770 39.950 1.00 56.04 B O ATOM 3581 N GLN B 334 32.802 45.224 39.033 1.00 55.18 B N ATOM 3582 CA GLN B 334 33.711 45.227 40.176 1.00 54.38 B C ATOM 3583 CB GLN B 334 34.871 46.203 39.925 1.00 55.19 B C ATOM 3584 CG GLN B 334 34.482 47.678 39.879 1.00 57.42 B C ATOM 3585 CD GLN B 334 35.599 48.566 39.340 1.00 59.56 B C ATOM 3586 OE1 GLN B 334 36.756 48.459 39.759 1.00 60.33 B O ATOM 3587 NE2 GLN B 334 35.253 49.454 38.409 1.00 59.33 B N ATOM 3588 C GLN B 334 32.998 45.572 41.478 1.00 53.11 B C ATOM 3589 O GLN B 334 33.352 45.067 42.544 1.00 52.68 B O ATOM 3590 N GLU B 335 31.986 46.427 41.386 1.00 51.38 B N ATOM 3591 CA GLU B 335 31.226 46.826 42.561 1.00 50.81 B C ATOM 3592 CB GLU B 335 30.428 48.098 42.257 1.00 51.54 B C ATOM 3593 CG GLU B 335 29.750 48.707 43.470 1.00 54.47 B C ATOM 3594 CD GLU B 335 30.722 48.982 44.607 1.00 56.00 B C ATOM 3595 OE1 GLU B 335 30.265 49.435 45.681 1.00 55.50 B O ATOM 3596 OE2 GLU B 335 31.939 48.745 44.429 1.00 56.77 B O ATOM 3597 C GLU B 335 30.287 45.693 42.997 1.00 49.24 B C ATOM 3598 O GLU B 335 30.247 45.321 44.171 1.00 48.26 B O ATOM 3599 N THR B 336 29.543 45.144 42.042 1.00 47.63 B N ATOM 3600 CA THR B 336 28.622 44.046 42.318 1.00 46.12 B C ATOM 3601 CB THR B 336 28.002 43.497 41.013 1.00 45.85 B C ATOM 3602 OG1 THR B 336 27.289 44.548 40.347 1.00 47.48 B O ATOM 3603 CG2 THR B 336 27.046 42.345 41.308 1.00 44.35 B C ATOM 3604 C THR B 336 29.394 42.922 43.001 1.00 45.04 B C ATOM 3605 O THR B 336 28.916 42.313 43.963 1.00 44.35 B O ATOM 3606 N TYR B 337 30.594 42.665 42.494 1.00 42.84 B N ATOM 3607 CA TYR B 337 31.465 41.625 43.025 1.00 42.44 B C ATOM 3608 CB TYR B 337 32.784 41.606 42.251 1.00 45.11 B C ATOM 3609 CG TYR B 337 33.675 40.446 42.624 1.00 47.49 B C ATOM 3610 CD1 TYR B 337 33.639 39.258 41.901 1.00 48.63 B C ATOM 3611 CE1 TYR B 337 34.421 38.166 42.273 1.00 51.33 B C ATOM 3612 CD2 TYR B 337 34.520 40.520 43.733 1.00 49.23 B C ATOM 3613 CE2 TYR B 337 35.302 39.439 44.114 1.00 50.54 B C ATOM 3614 CZ TYR B 337 35.247 38.263 43.380 1.00 51.96 B C ATOM 3615 OH TYR B 337 36.005 37.179 43.761 1.00 54.44 B O ATOM 3616 C TYR B 337 31.769 41.809 44.513 1.00 41.13 B C ATOM 3617 O TYR B 337 31.759 40.843 45.276 1.00 40.24 B O ATOM 3618 N LYS B 338 32.048 43.050 44.909 1.00 40.20 B N ATOM 3619 CA LYS B 338 32.371 43.390 46.296 1.00 38.23 B C ATOM 3620 CB LYS B 338 32.833 44.850 46.388 1.00 41.59 B C ATOM 3621 CG LYS B 338 34.123 45.176 45.644 1.00 44.66 B C ATOM 3622 CD LYS B 338 34.527 46.631 45.891 1.00 48.09 B C ATOM 3623 CE LYS B 338 35.874 46.981 45.256 1.00 48.00 B C ATOM 3624 NZ LYS B 338 35.838 46.925 43.765 1.00 51.10 B N ATOM 3625 C LYS B 338 31.205 43.191 47.262 1.00 35.20 B C ATOM 3626 O LYS B 338 31.339 42.526 48.291 1.00 32.57 B O ATOM 3627 N ARG B 339 30.063 43.783 46.923 1.00 33.78 B N ATOM 3628 CA ARG B 339 28.868 43.694 47.758 1.00 32.18 B C ATOM 3629 CB ARG B 339 27.741 44.499 47.125 1.00 34.50 B C ATOM 3630 CG ARG B 339 28.069 45.975 46.971 1.00 34.49 B C ATOM 3631 CD ARG B 339 26.849 46.753 46.513 1.00 37.43 B C ATOM 3632 NE ARG B 339 27.183 48.140 46.215 1.00 39.07 B N ATOM 3633 CZ ARG B 339 26.318 49.042 45.768 1.00 40.69 B C ATOM 3634 NH1 ARG B 339 25.052 48.714 45.563 1.00 41.15 B N ATOM 3635 NH2 ARG B 339 26.723 50.278 45.524 1.00 42.78 B N ATOM 3636 C ARG B 339 28.424 42.255 48.005 1.00 30.59 B C ATOM 3637 O ARG B 339 27.998 41.916 49.106 1.00 30.06 B O ATOM 3638 N ILE B 340 28.531 41.411 46.983 1.00 28.84 B N ATOM 3639 CA ILE B 340 28.172 40.005 47.113 1.00 28.23 B C ATOM 3640 CB ILE B 340 28.265 39.284 45.746 1.00 29.04 B C ATOM 3641 CG2 ILE B 340 28.191 37.777 45.932 1.00 27.61 B C ATOM 3642 CG1 ILE B 340 27.143 39.778 44.828 1.00 29.93 B C ATOM 3643 CD1 ILE B 340 27.294 39.344 43.379 1.00 30.36 B C ATOM 3644 C ILE B 340 29.149 39.362 48.094 1.00 28.00 B C ATOM 3645 O ILE B 340 28.746 38.760 49.092 1.00 28.08 B O ATOM 3646 N SER B 341 30.437 39.511 47.806 1.00 27.83 B N ATOM 3647 CA SER B 341 31.500 38.971 48.647 1.00 27.74 B C ATOM 3648 CB SER B 341 32.869 39.405 48.099 1.00 29.39 B C ATOM 3649 OG SER B 341 33.904 39.101 49.023 1.00 31.17 B O ATOM 3650 C SER B 341 31.390 39.394 50.115 1.00 26.62 B C ATOM 3651 O SER B 341 31.581 38.576 51.019 1.00 26.60 B O ATOM 3652 N ARG B 342 31.095 40.670 50.349 1.00 26.86 B N ATOM 3653 CA ARG B 342 30.967 41.190 51.713 1.00 27.32 B C ATOM 3654 CB ARG B 342 31.486 42.635 51.786 1.00 30.87 B C ATOM 3655 CG ARG B 342 32.988 42.792 51.559 1.00 34.75 B C ATOM 3656 CD ARG B 342 33.407 44.264 51.585 1.00 38.59 B C ATOM 3657 NE ARG B 342 34.861 44.410 51.496 1.00 44.23 B N ATOM 3658 CZ ARG B 342 35.518 45.568 51.542 1.00 45.71 B C ATOM 3659 NH1 ARG B 342 36.842 45.574 51.450 1.00 47.72 B N ATOM 3660 NH2 ARG B 342 34.862 46.717 51.678 1.00 45.74 B N ATOM 3661 C ARG B 342 29.525 41.157 52.232 1.00 26.65 B C ATOM 3662 O ARG B 342 29.249 41.651 53.324 1.00 24.28 B O ATOM 3663 N VAL B 343 28.615 40.578 51.449 1.00 25.25 B N ATOM 3664 CA VAL B 343 27.201 40.491 51.825 1.00 23.45 B C ATOM 3665 CB VAL B 343 26.964 39.453 52.942 1.00 22.70 B C ATOM 3666 CG1 VAL B 343 25.475 39.151 53.038 1.00 26.95 B C ATOM 3667 CG2 VAL B 343 27.744 38.182 52.667 1.00 24.45 B C ATOM 3668 C VAL B 343 26.667 41.834 52.319 1.00 22.20 B C ATOM 3669 O VAL B 343 26.236 41.958 53.463 1.00 22.42 B O ATOM 3670 N GLU B 344 26.702 42.841 51.461 1.00 20.93 B N ATOM 3671 CA GLU B 344 26.224 44.163 51.836 1.00 19.95 B C ATOM 3672 CB GLU B 344 27.317 45.217 51.593 1.00 21.95 B C ATOM 3673 CG GLU B 344 28.483 45.077 52.579 1.00 26.85 B C ATOM 3674 CD GLU B 344 29.731 45.844 52.177 1.00 29.55 B C ATOM 3675 OE1 GLU B 344 30.643 45.948 53.029 1.00 31.16 B O ATOM 3676 OE2 GLU B 344 29.811 46.331 51.021 1.00 29.15 B O ATOM 3677 C GLU B 344 24.970 44.500 51.054 1.00 19.08 B C ATOM 3678 O GLU B 344 25.007 44.692 49.832 1.00 15.34 B O ATOM 3679 N PHE B 345 23.859 44.555 51.778 1.00 16.62 B N ATOM 3680 CA PHE B 345 22.572 44.858 51.188 1.00 19.25 B C ATOM 3681 CB PHE B 345 21.938 43.576 50.615 1.00 17.18 B C ATOM 3682 CG PHE B 345 21.524 42.574 51.661 1.00 17.47 B C ATOM 3683 CD1 PHE B 345 20.271 42.645 52.253 1.00 18.52 B C ATOM 3684 CD2 PHE B 345 22.394 41.561 52.060 1.00 19.11 B C ATOM 3685 CE1 PHE B 345 19.884 41.725 53.225 1.00 18.14 B C ATOM 3686 CE2 PHE B 345 22.015 40.634 53.039 1.00 20.48 B C ATOM 3687 CZ PHE B 345 20.758 40.719 53.620 1.00 19.36 B C ATOM 3688 C PHE B 345 21.673 45.470 52.253 1.00 18.97 B C ATOM 3689 O PHE B 345 21.857 45.229 53.450 1.00 19.32 B O ATOM 3690 N THR B 346 20.714 46.275 51.811 1.00 19.42 B N ATOM 3691 CA THR B 346 19.775 46.917 52.715 1.00 19.27 B C ATOM 3692 CB THR B 346 20.082 48.424 52.857 1.00 19.00 B C ATOM 3693 OG1 THR B 346 20.109 49.030 51.564 1.00 20.30 B O ATOM 3694 CG2 THR B 346 21.437 48.635 53.539 1.00 18.82 B C ATOM 3695 C THR B 346 18.350 46.704 52.197 1.00 19.39 B C ATOM 3696 O THR B 346 18.163 46.200 51.095 1.00 20.35 B O ATOM 3697 N PHE B 347 17.364 47.086 53.003 1.00 20.32 B N ATOM 3698 CA PHE B 347 15.941 46.925 52.689 1.00 22.26 B C ATOM 3699 CB PHE B 347 15.239 46.134 53.801 1.00 19.26 B C ATOM 3700 CG PHE B 347 15.710 44.715 53.954 1.00 22.00 B C ATOM 3701 CD1 PHE B 347 15.318 43.731 53.050 1.00 20.34 B C ATOM 3702 CD2 PHE B 347 16.521 44.352 55.029 1.00 19.14 B C ATOM 3703 CE1 PHE B 347 15.723 42.411 53.217 1.00 18.46 B C ATOM 3704 CE2 PHE B 347 16.930 43.037 55.202 1.00 16.81 B C ATOM 3705 CZ PHE B 347 16.529 42.062 54.293 1.00 16.52 B C ATOM 3706 C PHE B 347 15.180 48.246 52.572 1.00 23.77 B C ATOM 3707 O PHE B 347 15.384 49.166 53.364 1.00 24.75 B O ATOM 3708 N PRO B 348 14.280 48.353 51.590 1.00 26.17 B N ATOM 3709 CD PRO B 348 14.032 47.471 50.438 1.00 27.03 B C ATOM 3710 CA PRO B 348 13.519 49.602 51.474 1.00 27.72 B C ATOM 3711 CB PRO B 348 12.702 49.393 50.198 1.00 28.07 B C ATOM 3712 CG PRO B 348 13.561 48.455 49.394 1.00 28.17 B C ATOM 3713 C PRO B 348 12.629 49.609 52.727 1.00 29.25 B C ATOM 3714 O PRO B 348 12.262 48.546 53.232 1.00 29.40 B O ATOM 3715 N ASP B 349 12.265 50.784 53.220 1.00 30.11 B N ATOM 3716 CA ASP B 349 11.453 50.864 54.426 1.00 30.67 B C ATOM 3717 CB ASP B 349 11.199 52.329 54.785 1.00 35.47 B C ATOM 3718 CG ASP B 349 12.486 53.141 54.863 1.00 39.29 B C ATOM 3719 OD1 ASP B 349 13.519 52.592 55.315 1.00 40.71 B O ATOM 3720 OD2 ASP B 349 12.463 54.334 54.483 1.00 42.81 B O ATOM 3721 C ASP B 349 10.127 50.105 54.428 1.00 30.99 B C ATOM 3722 O ASP B 349 9.639 49.729 55.501 1.00 31.13 B O ATOM 3723 N PHE B 350 9.539 49.858 53.256 1.00 28.24 B N ATOM 3724 CA PHE B 350 8.256 49.153 53.225 1.00 24.82 B C ATOM 3725 CB PHE B 350 7.496 49.459 51.920 1.00 21.72 B C ATOM 3726 CG PHE B 350 8.175 48.964 50.670 1.00 20.48 B C ATOM 3727 CD1 PHE B 350 8.133 47.616 50.323 1.00 20.47 B C ATOM 3728 CD2 PHE B 350 8.836 49.853 49.825 1.00 18.76 B C ATOM 3729 CE1 PHE B 350 8.741 47.156 49.145 1.00 19.61 B C ATOM 3730 CE2 PHE B 350 9.447 49.412 48.649 1.00 20.75 B C ATOM 3731 CZ PHE B 350 9.400 48.057 48.305 1.00 22.07 B C ATOM 3732 C PHE B 350 8.327 47.637 53.442 1.00 25.64 B C ATOM 3733 O PHE B 350 7.293 47.002 53.660 1.00 25.56 B O ATOM 3734 N VAL B 351 9.523 47.050 53.386 1.00 23.17 B N ATOM 3735 CA VAL B 351 9.643 45.604 53.586 1.00 21.29 B C ATOM 3736 CB VAL B 351 11.012 45.072 53.124 1.00 18.96 B C ATOM 3737 CG1 VAL B 351 11.060 43.564 53.314 1.00 18.55 B C ATOM 3738 CG2 VAL B 351 11.244 45.423 51.663 1.00 15.50 B C ATOM 3739 C VAL B 351 9.429 45.215 55.052 1.00 21.74 B C ATOM 3740 O VAL B 351 10.054 45.772 55.949 1.00 20.28 B O ATOM 3741 N THR B 352 8.535 44.254 55.273 1.00 22.77 B N ATOM 3742 CA THR B 352 8.186 43.776 56.609 1.00 23.82 B C ATOM 3743 CB THR B 352 6.918 42.899 56.523 1.00 25.23 B C ATOM 3744 OG1 THR B 352 5.829 43.705 56.054 1.00 27.41 B O ATOM 3745 CG2 THR B 352 6.555 42.331 57.872 1.00 27.51 B C ATOM 3746 C THR B 352 9.304 43.017 57.343 1.00 22.96 B C ATOM 3747 O THR B 352 10.213 42.463 56.718 1.00 23.44 B O ATOM 3748 N ALA B 353 9.228 42.998 58.674 1.00 22.56 B N ATOM 3749 CA ALA B 353 10.233 42.334 59.502 1.00 19.72 B C ATOM 3750 CB ALA B 353 10.018 42.682 60.984 1.00 21.49 B C ATOM 3751 C ALA B 353 10.230 40.825 59.305 1.00 18.37 B C ATOM 3752 O ALA B 353 11.270 40.184 59.390 1.00 17.81 B O ATOM 3753 N GLY B 354 9.061 40.252 59.043 1.00 17.83 B N ATOM 3754 CA GLY B 354 9.002 38.820 58.807 1.00 14.69 B C ATOM 3755 C GLY B 354 9.749 38.486 57.524 1.00 15.67 B C ATOM 3756 O GLY B 354 10.484 37.497 57.449 1.00 15.82 B O ATOM 3757 N ALA B 355 9.571 39.318 56.503 1.00 14.39 B N ATOM 3758 CA ALA B 355 10.241 39.091 55.227 1.00 16.28 B C ATOM 3759 CB ALA B 355 9.683 40.047 54.163 1.00 14.46 B C ATOM 3760 C ALA B 355 11.759 39.285 55.374 1.00 16.62 B C ATOM 3761 O ALA B 355 12.541 38.560 54.778 1.00 18.69 B O ATOM 3762 N ARG B 356 12.162 40.266 56.175 1.00 18.54 B N ATOM 3763 CA ARG B 356 13.571 40.558 56.397 1.00 18.70 B C ATOM 3764 CB ARG B 356 13.703 41.894 57.138 1.00 19.52 B C ATOM 3765 CG ARG B 356 13.122 43.053 56.343 1.00 21.00 B C ATOM 3766 CD ARG B 356 12.584 44.189 57.208 1.00 21.75 B C ATOM 3767 NE ARG B 356 13.576 45.223 57.463 1.00 25.09 B N ATOM 3768 CZ ARG B 356 13.435 46.503 57.130 1.00 20.74 B C ATOM 3769 NH1 ARG B 356 12.340 46.921 56.528 1.00 23.41 B N ATOM 3770 NH2 ARG B 356 14.400 47.363 57.394 1.00 19.75 B N ATOM 3771 C ARG B 356 14.266 39.436 57.168 1.00 20.44 B C ATOM 3772 O ARG B 356 15.449 39.156 56.951 1.00 21.10 B O ATOM 3773 N ASP B 357 13.546 38.786 58.076 1.00 20.86 B N ATOM 3774 CA ASP B 357 14.164 37.698 58.819 1.00 18.80 B C ATOM 3775 CB ASP B 357 13.259 37.204 59.938 1.00 20.18 B C ATOM 3776 CG ASP B 357 13.911 36.098 60.740 1.00 19.17 B C ATOM 3777 OD1 ASP B 357 14.805 36.415 61.543 1.00 20.57 B O ATOM 3778 OD2 ASP B 357 13.552 34.918 60.555 1.00 21.02 B O ATOM 3779 C ASP B 357 14.465 36.530 57.887 1.00 18.01 B C ATOM 3780 O ASP B 357 15.539 35.937 57.941 1.00 19.94 B O ATOM 3781 N LEU B 358 13.508 36.199 57.029 1.00 18.45 B N ATOM 3782 CA LEU B 358 13.696 35.101 56.087 1.00 17.99 B C ATOM 3783 CB LEU B 358 12.442 34.900 55.231 1.00 17.24 B C ATOM 3784 CG LEU B 358 12.619 33.829 54.153 1.00 18.71 B C ATOM 3785 CD1 LEU B 358 12.858 32.466 54.819 1.00 17.61 B C ATOM 3786 CD2 LEU B 358 11.396 33.791 53.254 1.00 20.87 B C ATOM 3787 C LEU B 358 14.879 35.357 55.161 1.00 17.62 B C ATOM 3788 O LEU B 358 15.745 34.499 54.986 1.00 17.62 B O ATOM 3789 N ILE B 359 14.906 36.543 54.565 1.00 16.22 B N ATOM 3790 CA ILE B 359 15.976 36.891 53.640 1.00 19.15 B C ATOM 3791 CB ILE B 359 15.684 38.236 52.940 1.00 18.39 B C ATOM 3792 CG2 ILE B 359 16.848 38.610 52.036 1.00 17.22 B C ATOM 3793 CG1 ILE B 359 14.387 38.117 52.129 1.00 20.22 B C ATOM 3794 CD1 ILE B 359 13.872 39.439 51.528 1.00 22.11 B C ATOM 3795 C ILE B 359 17.363 36.947 54.282 1.00 17.31 B C ATOM 3796 O ILE B 359 18.359 36.611 53.640 1.00 16.11 B O ATOM 3797 N SER B 360 17.433 37.364 55.543 1.00 16.97 B N ATOM 3798 CA SER B 360 18.725 37.447 56.213 1.00 18.07 B C ATOM 3799 CB SER B 360 18.615 38.316 57.466 1.00 18.16 B C ATOM 3800 OG SER B 360 18.402 39.669 57.111 1.00 17.16 B O ATOM 3801 C SER B 360 19.267 36.060 56.573 1.00 19.03 B C ATOM 3802 O SER B 360 20.480 35.874 56.711 1.00 18.93 B O ATOM 3803 N ARG B 361 18.369 35.088 56.716 1.00 19.00 B N ATOM 3804 CA ARG B 361 18.775 33.730 57.040 1.00 20.67 B C ATOM 3805 CB ARG B 361 17.630 33.003 57.742 1.00 25.65 B C ATOM 3806 CG ARG B 361 17.160 33.726 58.993 1.00 31.87 B C ATOM 3807 CD ARG B 361 16.083 32.947 59.716 1.00 38.15 B C ATOM 3808 NE ARG B 361 16.529 31.589 59.998 1.00 44.86 B N ATOM 3809 CZ ARG B 361 15.896 30.743 60.804 1.00 48.17 B C ATOM 3810 NH1 ARG B 361 14.779 31.116 61.419 1.00 47.35 B N ATOM 3811 NH2 ARG B 361 16.382 29.521 60.993 1.00 48.87 B N ATOM 3812 C ARG B 361 19.211 32.974 55.785 1.00 21.43 B C ATOM 3813 O ARG B 361 19.994 32.024 55.855 1.00 22.60 B O ATOM 3814 N LEU B 362 18.721 33.407 54.628 1.00 20.42 B N ATOM 3815 CA LEU B 362 19.087 32.763 53.375 1.00 18.53 B C ATOM 3816 CB LEU B 362 17.949 32.888 52.362 1.00 17.29 B C ATOM 3817 CG LEU B 362 16.665 32.103 52.653 1.00 15.10 B C ATOM 3818 CD1 LEU B 362 15.621 32.437 51.611 1.00 15.28 B C ATOM 3819 CD2 LEU B 362 16.961 30.596 52.650 1.00 14.06 B C ATOM 3820 C LEU B 362 20.364 33.370 52.794 1.00 20.19 B C ATOM 3821 O LEU B 362 21.117 32.695 52.090 1.00 19.39 B O ATOM 3822 N LEU B 363 20.614 34.640 53.098 1.00 19.15 B N ATOM 3823 CA LEU B 363 21.793 35.310 52.565 1.00 21.61 B C ATOM 3824 CB LEU B 363 21.421 36.728 52.121 1.00 21.25 B C ATOM 3825 CG LEU B 363 20.391 36.784 50.986 1.00 22.02 B C ATOM 3826 CD1 LEU B 363 20.063 38.228 50.677 1.00 21.41 B C ATOM 3827 CD2 LEU B 363 20.941 36.079 49.732 1.00 21.42 B C ATOM 3828 C LEU B 363 22.970 35.345 53.545 1.00 23.78 B C ATOM 3829 O LEU B 363 23.443 36.421 53.931 1.00 25.25 B O ATOM 3830 N LYS B 364 23.425 34.158 53.939 1.00 22.72 B N ATOM 3831 CA LYS B 364 24.546 34.004 54.860 1.00 25.21 B C ATOM 3832 CB LYS B 364 24.296 32.822 55.812 1.00 26.10 B C ATOM 3833 CG LYS B 364 23.328 33.116 56.964 1.00 28.20 B C ATOM 3834 CD LYS B 364 23.970 34.044 57.987 1.00 30.83 B C ATOM 3835 CE LYS B 364 22.964 34.630 58.974 1.00 33.43 B C ATOM 3836 NZ LYS B 364 22.367 33.622 59.900 1.00 36.33 B N ATOM 3837 C LYS B 364 25.831 33.766 54.062 1.00 25.33 B C ATOM 3838 O LYS B 364 25.850 32.987 53.102 1.00 24.66 B O ATOM 3839 N HIS B 365 26.904 34.444 54.455 1.00 25.93 B N ATOM 3840 CA HIS B 365 28.175 34.296 53.763 1.00 26.63 B C ATOM 3841 CB HIS B 365 29.261 35.141 54.424 1.00 25.92 B C ATOM 3842 CG HIS B 365 30.590 35.009 53.756 1.00 26.63 B C ATOM 3843 CD2 HIS B 365 31.646 34.202 54.022 1.00 25.39 B C ATOM 3844 ND1 HIS B 365 30.909 35.688 52.598 1.00 28.19 B N ATOM 3845 CE1 HIS B 365 32.103 35.303 52.179 1.00 27.11 B C ATOM 3846 NE2 HIS B 365 32.569 34.401 53.024 1.00 26.10 B N ATOM 3847 C HIS B 365 28.636 32.845 53.757 1.00 26.18 B C ATOM 3848 O HIS B 365 29.112 32.338 52.747 1.00 27.21 B O ATOM 3849 N ASN B 366 28.504 32.195 54.907 1.00 27.62 B N ATOM 3850 CA ASN B 366 28.902 30.804 55.076 1.00 29.77 B C ATOM 3851 CB ASN B 366 29.442 30.620 56.493 1.00 31.38 B C ATOM 3852 CG ASN B 366 29.794 29.190 56.802 1.00 35.31 B C ATOM 3853 OD1 ASN B 366 30.346 28.480 55.963 1.00 38.20 B O ATOM 3854 ND2 ASN B 366 29.491 28.757 58.020 1.00 37.60 B N ATOM 3855 C ASN B 366 27.716 29.862 54.805 1.00 28.07 B C ATOM 3856 O ASN B 366 26.771 29.793 55.583 1.00 26.33 B O ATOM 3857 N PRO B 367 27.765 29.121 53.690 1.00 29.03 B N ATOM 3858 CD PRO B 367 28.937 29.001 52.804 1.00 29.75 B C ATOM 3859 CA PRO B 367 26.711 28.182 53.285 1.00 29.22 B C ATOM 3860 CB PRO B 367 27.283 27.542 52.017 1.00 27.84 B C ATOM 3861 CG PRO B 367 28.755 27.619 52.224 1.00 29.93 B C ATOM 3862 C PRO B 367 26.285 27.148 54.323 1.00 29.89 B C ATOM 3863 O PRO B 367 25.132 26.715 54.332 1.00 30.60 B O ATOM 3864 N SER B 368 27.202 26.754 55.198 1.00 30.30 B N ATOM 3865 CA SER B 368 26.871 25.762 56.208 1.00 31.18 B C ATOM 3866 CB SER B 368 28.141 25.252 56.905 1.00 32.85 B C ATOM 3867 OG SER B 368 28.550 26.132 57.939 1.00 35.93 B O ATOM 3868 C SER B 368 25.907 26.345 57.233 1.00 30.31 B C ATOM 3869 O SER B 368 25.268 25.613 57.975 1.00 30.36 B O ATOM 3870 N GLN B 369 25.797 27.667 57.264 1.00 31.55 B N ATOM 3871 CA GLN B 369 24.897 28.333 58.200 1.00 32.07 B C ATOM 3872 CB GLN B 369 25.505 29.665 58.656 1.00 36.11 B C ATOM 3873 CG GLN B 369 26.848 29.518 59.359 1.00 42.42 B C ATOM 3874 CD GLN B 369 27.376 30.837 59.891 1.00 45.10 B C ATOM 3875 OE1 GLN B 369 26.768 31.454 60.766 1.00 48.57 B O ATOM 3876 NE2 GLN B 369 28.511 31.279 59.361 1.00 46.32 B N ATOM 3877 C GLN B 369 23.506 28.581 57.618 1.00 29.24 B C ATOM 3878 O GLN B 369 22.607 29.029 58.323 1.00 28.91 B O ATOM 3879 N ARG B 370 23.330 28.301 56.331 1.00 27.41 B N ATOM 3880 CA ARG B 370 22.036 28.496 55.675 1.00 25.29 B C ATOM 3881 CB ARG B 370 22.230 28.548 54.157 1.00 23.14 B C ATOM 3882 CG ARG B 370 23.078 29.715 53.698 1.00 17.66 B C ATOM 3883 CD ARG B 370 23.530 29.546 52.268 1.00 21.09 B C ATOM 3884 NE ARG B 370 24.615 30.468 51.956 1.00 20.83 B N ATOM 3885 CZ ARG B 370 25.404 30.365 50.895 1.00 22.00 B C ATOM 3886 NH1 ARG B 370 25.235 29.372 50.029 1.00 21.78 B N ATOM 3887 NH2 ARG B 370 26.365 31.262 50.698 1.00 23.58 B N ATOM 3888 C ARG B 370 21.096 27.348 56.048 1.00 24.43 B C ATOM 3889 O ARG B 370 21.533 26.214 56.209 1.00 25.53 B O ATOM 3890 N PRO B 371 19.789 27.625 56.177 1.00 25.63 B N ATOM 3891 CD PRO B 371 19.116 28.920 55.965 1.00 25.62 B C ATOM 3892 CA PRO B 371 18.816 26.584 56.538 1.00 25.56 B C ATOM 3893 CB PRO B 371 17.561 27.392 56.860 1.00 25.65 B C ATOM 3894 CG PRO B 371 17.649 28.519 55.882 1.00 24.95 B C ATOM 3895 C PRO B 371 18.551 25.529 55.461 1.00 25.92 B C ATOM 3896 O PRO B 371 18.942 25.689 54.308 1.00 27.40 B O ATOM 3897 N MET B 372 17.893 24.444 55.853 1.00 27.14 B N ATOM 3898 CA MET B 372 17.533 23.391 54.911 1.00 27.45 B C ATOM 3899 CB MET B 372 17.344 22.053 55.623 1.00 29.21 B C ATOM 3900 CG MET B 372 18.607 21.462 56.225 1.00 32.29 B C ATOM 3901 SD MET B 372 18.257 19.888 57.038 1.00 38.80 B S ATOM 3902 CE MET B 372 18.599 18.751 55.690 1.00 36.16 B C ATOM 3903 C MET B 372 16.206 23.820 54.305 1.00 26.36 B C ATOM 3904 O MET B 372 15.471 24.590 54.922 1.00 27.49 B O ATOM 3905 N LEU B 373 15.901 23.323 53.108 1.00 24.23 B N ATOM 3906 CA LEU B 373 14.657 23.663 52.423 1.00 22.39 B C ATOM 3907 CB LEU B 373 14.528 22.850 51.132 1.00 22.84 B C ATOM 3908 CG LEU B 373 15.511 23.250 50.032 1.00 24.40 B C ATOM 3909 CD1 LEU B 373 15.332 22.333 48.825 1.00 26.89 B C ATOM 3910 CD2 LEU B 373 15.282 24.716 49.638 1.00 24.98 B C ATOM 3911 C LEU B 373 13.412 23.470 53.272 1.00 20.58 B C ATOM 3912 O LEU B 373 12.488 24.280 53.212 1.00 22.00 B O ATOM 3913 N ALA B 374 13.393 22.409 54.071 1.00 21.21 B N ATOM 3914 CA ALA B 374 12.249 22.111 54.936 1.00 23.10 B C ATOM 3915 CB ALA B 374 12.423 20.733 55.580 1.00 26.30 B C ATOM 3916 C ALA B 374 12.033 23.168 56.019 1.00 23.37 B C ATOM 3917 O ALA B 374 10.916 23.353 56.496 1.00 23.95 B O ATOM 3918 N GLU B 375 13.102 23.854 56.410 1.00 22.62 B N ATOM 3919 CA GLU B 375 13.007 24.891 57.426 1.00 22.21 B C ATOM 3920 CB GLU B 375 14.394 25.218 57.984 1.00 23.52 B C ATOM 3921 CG GLU B 375 15.035 24.067 58.761 1.00 27.91 B C ATOM 3922 CD GLU B 375 16.465 24.369 59.174 1.00 29.27 B C ATOM 3923 OE1 GLU B 375 16.666 25.158 60.120 1.00 31.60 B O ATOM 3924 OE2 GLU B 375 17.389 23.826 58.538 1.00 29.51 B O ATOM 3925 C GLU B 375 12.380 26.139 56.823 1.00 22.31 B C ATOM 3926 O GLU B 375 11.661 26.874 57.497 1.00 20.94 B O ATOM 3927 N VAL B 376 12.664 26.376 55.545 1.00 21.78 B N ATOM 3928 CA VAL B 376 12.106 27.526 54.840 1.00 21.13 B C ATOM 3929 CB VAL B 376 12.666 27.613 53.394 1.00 18.71 B C ATOM 3930 CG1 VAL B 376 11.973 28.725 52.634 1.00 17.37 B C ATOM 3931 CG2 VAL B 376 14.176 27.854 53.429 1.00 15.43 B C ATOM 3932 C VAL B 376 10.582 27.378 54.777 1.00 22.45 B C ATOM 3933 O VAL B 376 9.841 28.336 55.006 1.00 22.60 B O ATOM 3934 N LEU B 377 10.133 26.163 54.478 1.00 22.30 B N ATOM 3935 CA LEU B 377 8.715 25.857 54.366 1.00 26.34 B C ATOM 3936 CB LEU B 377 8.533 24.449 53.785 1.00 26.41 B C ATOM 3937 CG LEU B 377 9.025 24.299 52.343 1.00 27.84 B C ATOM 3938 CD1 LEU B 377 9.044 22.837 51.924 1.00 27.54 B C ATOM 3939 CD2 LEU B 377 8.115 25.105 51.431 1.00 26.87 B C ATOM 3940 C LEU B 377 7.976 25.971 55.693 1.00 27.31 B C ATOM 3941 O LEU B 377 6.752 25.965 55.719 1.00 28.00 B O ATOM 3942 N GLU B 378 8.722 26.069 56.788 1.00 27.51 B N ATOM 3943 CA GLU B 378 8.126 26.189 58.113 1.00 28.70 B C ATOM 3944 CB GLU B 378 8.796 25.221 59.100 1.00 33.15 B C ATOM 3945 CG GLU B 378 8.265 23.796 59.082 1.00 39.47 B C ATOM 3946 CD GLU B 378 9.030 22.878 60.036 1.00 44.38 B C ATOM 3947 OE1 GLU B 378 8.545 21.758 60.311 1.00 47.53 B O ATOM 3948 OE2 GLU B 378 10.119 23.271 60.506 1.00 44.23 B O ATOM 3949 C GLU B 378 8.252 27.601 58.659 1.00 26.28 B C ATOM 3950 O GLU B 378 7.780 27.886 59.752 1.00 26.40 B O ATOM 3951 N HIS B 379 8.891 28.491 57.915 1.00 23.55 B N ATOM 3952 CA HIS B 379 9.045 29.852 58.405 1.00 22.18 B C ATOM 3953 CB HIS B 379 9.891 30.671 57.438 1.00 18.53 B C ATOM 3954 CG HIS B 379 10.310 31.999 57.984 1.00 20.37 B C ATOM 3955 CD2 HIS B 379 11.503 32.430 58.455 1.00 16.86 B C ATOM 3956 ND1 HIS B 379 9.437 33.058 58.121 1.00 18.83 B N ATOM 3957 CE1 HIS B 379 10.076 34.084 58.653 1.00 19.47 B C ATOM 3958 NE2 HIS B 379 11.330 33.729 58.864 1.00 20.07 B N ATOM 3959 C HIS B 379 7.672 30.488 58.604 1.00 22.39 B C ATOM 3960 O HIS B 379 6.784 30.339 57.760 1.00 24.30 B O ATOM 3961 N PRO B 380 7.477 31.199 59.734 1.00 21.58 B N ATOM 3962 CD PRO B 380 8.461 31.340 60.818 1.00 20.38 B C ATOM 3963 CA PRO B 380 6.218 31.870 60.091 1.00 20.86 B C ATOM 3964 CB PRO B 380 6.521 32.487 61.458 1.00 22.72 B C ATOM 3965 CG PRO B 380 7.574 31.573 62.013 1.00 23.24 B C ATOM 3966 C PRO B 380 5.697 32.910 59.095 1.00 21.33 B C ATOM 3967 O PRO B 380 4.483 33.127 59.013 1.00 17.95 B O ATOM 3968 N TRP B 381 6.599 33.560 58.355 1.00 19.60 B N ATOM 3969 CA TRP B 381 6.183 34.555 57.365 1.00 19.09 B C ATOM 3970 CB TRP B 381 7.373 35.392 56.893 1.00 19.18 B C ATOM 3971 CG TRP B 381 7.000 36.467 55.892 1.00 20.21 B C ATOM 3972 CD2 TRP B 381 7.254 36.450 54.478 1.00 18.07 B C ATOM 3973 CE2 TRP B 381 6.688 37.629 53.935 1.00 18.87 B C ATOM 3974 CE3 TRP B 381 7.901 35.554 53.619 1.00 19.02 B C ATOM 3975 CD1 TRP B 381 6.316 37.630 56.142 1.00 18.93 B C ATOM 3976 NE1 TRP B 381 6.126 38.331 54.970 1.00 16.23 B N ATOM 3977 CZ2 TRP B 381 6.748 37.929 52.570 1.00 16.90 B C ATOM 3978 CZ3 TRP B 381 7.962 35.855 52.251 1.00 18.05 B C ATOM 3979 CH2 TRP B 381 7.386 37.034 51.747 1.00 17.42 B C ATOM 3980 C TRP B 381 5.572 33.809 56.171 1.00 20.19 B C ATOM 3981 O TRP B 381 4.562 34.233 55.600 1.00 16.91 B O ATOM 3982 N ILE B 382 6.199 32.699 55.801 1.00 18.76 B N ATOM 3983 CA ILE B 382 5.719 31.887 54.695 1.00 22.56 B C ATOM 3984 CB ILE B 382 6.766 30.844 54.318 1.00 22.31 B C ATOM 3985 CG2 ILE B 382 6.139 29.747 53.486 1.00 22.37 B C ATOM 3986 CG1 ILE B 382 7.908 31.529 53.573 1.00 23.31 B C ATOM 3987 CD1 ILE B 382 9.066 30.636 53.321 1.00 29.66 B C ATOM 3988 C ILE B 382 4.395 31.181 55.019 1.00 24.58 B C ATOM 3989 O ILE B 382 3.447 31.210 54.230 1.00 23.86 B O ATOM 3990 N THR B 383 4.348 30.543 56.183 1.00 25.64 B N ATOM 3991 CA THR B 383 3.167 29.825 56.640 1.00 25.76 B C ATOM 3992 CB THR B 383 3.462 29.123 57.982 1.00 25.87 B C ATOM 3993 OG1 THR B 383 4.162 27.896 57.732 1.00 31.20 B O ATOM 3994 CG2 THR B 383 2.196 28.841 58.734 1.00 28.47 B C ATOM 3995 C THR B 383 1.966 30.746 56.812 1.00 26.92 B C ATOM 3996 O THR B 383 0.817 30.336 56.615 1.00 27.54 B O ATOM 3997 N ALA B 384 2.234 31.994 57.175 1.00 26.10 B N ATOM 3998 CA ALA B 384 1.170 32.961 57.396 1.00 27.17 B C ATOM 3999 CB ALA B 384 1.653 34.053 58.326 1.00 25.11 B C ATOM 4000 C ALA B 384 0.635 33.584 56.119 1.00 28.32 B C ATOM 4001 O ALA B 384 −0.550 33.900 56.022 1.00 27.86 B O ATOM 4002 N ASN B 385 1.503 33.756 55.134 1.00 29.11 B N ATOM 4003 CA ASN B 385 1.090 34.392 53.898 1.00 32.57 B C ATOM 4004 CB ASN B 385 2.128 35.451 53.541 1.00 27.65 B C ATOM 4005 CG ASN B 385 2.247 36.512 54.625 1.00 26.99 B C ATOM 4006 OD1 ASN B 385 1.328 37.303 54.829 1.00 25.20 B O ATOM 4007 ND2 ASN B 385 3.367 36.517 55.342 1.00 23.02 B N ATOM 4008 C ASN B 385 0.807 33.447 52.735 1.00 35.05 B C ATOM 4009 O ASN B 385 0.812 33.859 51.580 1.00 35.34 B O ATOM 4010 N SER B 386 0.527 32.190 53.078 1.00 40.53 B N ATOM 4011 CA SER B 386 0.201 31.117 52.138 1.00 44.93 B C ATOM 4012 CB SER B 386 −0.537 31.661 50.910 1.00 45.41 B C ATOM 4013 OG SER B 386 −0.956 30.611 50.055 1.00 45.89 B O ATOM 4014 C SER B 386 1.436 30.343 51.701 1.00 48.13 B C ATOM 4015 O SER B 386 2.357 30.904 51.108 1.00 48.75 B O ATOM 4016 N SER B 387 1.435 29.046 52.006 1.00 51.11 B N ATOM 4017 CA SER B 387 2.536 28.143 51.673 1.00 52.94 B C ATOM 4018 CB SER B 387 3.430 27.924 52.898 1.00 52.84 B C ATOM 4019 OG SER B 387 4.439 26.960 52.630 1.00 53.68 B O ATOM 4020 C SER B 387 2.022 26.788 51.181 1.00 53.55 B C ATOM 4021 O SER B 387 2.221 25.788 51.903 1.00 56.01 B O ATOM 4022 OXT SER B 387 1.426 26.735 50.087 1.00 52.55 B O TER 4023 SER B 387 ATOM 4024 C1 FRA Z 1 21.364 83.849 79.751 1.00 28.06 Z C ATOM 4025 C2 FRA Z 1 21.204 82.482 80.488 1.00 28.48 Z C ATOM 4026 C3 FRA Z 1 20.089 81.594 79.848 1.00 28.20 Z C ATOM 4027 C4 FRA Z 1 20.171 81.530 78.286 1.00 29.96 Z C ATOM 4028 C5 FRA Z 1 20.403 82.931 77.637 1.00 26.40 Z C ATOM 4029 N6 FRA Z 1 21.562 83.678 78.268 1.00 26.70 Z N ATOM 4030 C7 FRA Z 1 21.844 85.007 77.590 1.00 26.79 Z C ATOM 4031 C8 FRA Z 1 22.091 84.946 76.062 1.00 22.84 Z C ATOM 4032 C9 FRA Z 1 21.703 86.217 75.301 1.00 22.28 Z C ATOM 4033 O10 FRA Z 1 22.186 86.127 73.930 1.00 21.29 Z O ATOM 4034 C11 FRA Z 1 22.294 87.227 73.066 1.00 20.50 Z C ATOM 4035 C12 FRA Z 1 22.781 87.073 71.728 1.00 19.83 Z C ATOM 4036 C13 FRA Z 1 22.881 88.197 70.870 1.00 17.71 Z C ATOM 4037 C14 FRA Z 1 22.506 89.483 71.312 1.00 15.27 Z C ATOM 4038 C15 FRA Z 1 22.005 89.651 72.695 1.00 16.51 Z C ATOM 4039 C16 FRA Z 1 21.911 88.516 73.537 1.00 18.78 Z C ATOM 4040 N17 FRA Z 1 21.634 90.872 73.162 1.00 18.92 Z N ATOM 4041 C18 FRA Z 1 21.733 91.911 72.347 1.00 15.67 Z C ATOM 4042 N19 FRA Z 1 22.169 91.877 71.088 1.00 16.81 Z N ATOM 4043 C20 FRA Z 1 22.560 90.693 70.539 1.00 16.78 Z C ATOM 4044 N21 FRA Z 1 23.025 90.704 69.148 1.00 16.94 Z N ATOM 4045 C22 FRA Z 1 23.001 91.757 68.180 1.00 18.96 Z C ATOM 4046 C23 FRA Z 1 24.061 91.923 67.246 1.00 17.20 Z C ATOM 4047 N24 FRA Z 1 24.042 92.933 66.367 1.00 19.55 Z N ATOM 4048 C25 FRA Z 1 22.992 93.783 66.394 1.00 18.00 Z C ATOM 4049 N26 FRA Z 1 21.955 93.708 67.214 1.00 17.17 Z N ATOM 4050 C27 FRA Z 1 21.936 92.724 68.097 1.00 18.78 Z C ATOM 4051 N28 FRA Z 1 23.043 94.876 65.467 1.00 22.15 Z N ATOM 4052 C29 FRA Z 1 23.696 95.214 64.346 1.00 20.72 Z C ATOM 4053 C30 FRA Z 1 23.352 96.585 63.786 1.00 19.36 Z C ATOM 4054 C31 FRA Z 1 22.405 97.470 64.411 1.00 17.69 Z C ATOM 4055 C32 FRA Z 1 22.122 98.742 63.860 1.00 20.12 Z C ATOM 4056 C33 FRA Z 1 22.776 99.153 62.676 1.00 17.24 Z C ATOM 4057 C34 FRA Z 1 23.710 98.303 62.042 1.00 17.77 Z C ATOM 4058 C35 FRA Z 1 23.998 97.035 62.589 1.00 17.80 Z C ATOM 4059 O36 FRA Z 1 24.531 94.448 63.824 1.00 21.83 Z O ATOM 4060 O37 FRA Z 1 23.170 85.827 71.240 1.00 20.79 Z O ATOM 4061 C38 FRA Z 1 22.679 85.375 69.951 1.00 26.55 Z C ATOM 4062 O39 FRA Z 1 23.466 84.677 75.820 1.00 24.51 Z O TER 4063 FRA Z 1 ATOM 4064 C1 FRA Y 1 1.515 35.986 27.679 1.00 36.52 Y C ATOM 4065 C2 FRA Y 1 0.608 36.976 26.867 1.00 37.59 Y C ATOM 4066 C3 FRA Y 1 −0.401 36.230 25.961 1.00 36.15 Y C ATOM 4067 C4 FRA Y 1 0.319 35.193 25.054 1.00 37.83 Y C ATOM 4068 C5 FRA Y 1 1.177 34.183 25.879 1.00 36.12 Y C ATOM 4069 N6 FRA Y 1 2.132 34.827 26.897 1.00 36.16 Y N ATOM 4070 C7 FRA Y 1 3.479 35.234 26.297 1.00 37.30 Y C ATOM 4071 C8 FRA Y 1 4.332 34.189 25.489 1.00 32.04 Y C ATOM 4072 C9 FRA Y 1 4.647 32.852 26.202 1.00 29.29 Y C ATOM 4073 O10 FRA Y 1 6.097 32.795 26.275 1.00 25.58 Y O ATOM 4074 C11 FRA Y 1 6.903 31.673 26.442 1.00 20.22 Y C ATOM 4075 C12 FRA Y 1 8.327 31.834 26.469 1.00 19.90 Y C ATOM 4076 C13 FRA Y 1 9.170 30.706 26.629 1.00 18.27 Y C ATOM 4077 C14 FRA Y 1 8.622 29.412 26.769 1.00 16.62 Y C ATOM 4078 C15 FRA Y 1 7.143 29.247 26.749 1.00 16.07 Y C ATOM 4079 C16 FRA Y 1 6.320 30.391 26.580 1.00 17.70 Y C ATOM 4080 N17 FRA Y 1 6.583 28.029 26.887 1.00 17.71 Y N ATOM 4081 C18 FRA Y 1 7.389 26.981 27.040 1.00 17.21 Y C ATOM 4082 N19 FRA Y 1 8.725 27.007 27.067 1.00 17.12 Y N ATOM 4083 C20 FRA Y 1 9.371 28.193 26.934 1.00 17.89 Y C ATOM 4084 N21 FRA Y 1 10.845 28.199 26.966 1.00 19.44 Y N ATOM 4085 C22 FRA Y 1 11.804 27.160 27.225 1.00 17.92 Y C ATOM 4086 C23 FRA Y 1 13.046 27.089 26.514 1.00 17.84 Y C ATOM 4087 N24 FRA Y 1 13.927 26.091 26.750 1.00 17.67 Y N ATOM 4088 C25 FRA Y 1 13.591 25.172 27.677 1.00 19.86 Y C ATOM 4089 N26 FRA Y 1 12.465 25.164 28.390 1.00 22.22 Y N ATOM 4090 C27 FRA Y 1 11.584 26.130 28.180 1.00 20.19 Y C ATOM 4091 N28 FRA Y 1 14.520 24.102 27.878 1.00 21.17 Y N ATOM 4092 C29 FRA Y 1 15.769 23.800 27.502 1.00 20.01 Y C ATOM 4093 C30 FRA Y 1 16.310 22.465 27.980 1.00 19.29 Y C ATOM 4094 C31 FRA Y 1 15.545 21.551 28.783 1.00 19.61 Y C ATOM 4095 C32 FRA Y 1 16.081 20.315 29.195 1.00 21.23 Y C ATOM 4096 C33 FRA Y 1 17.394 19.964 28.819 1.00 18.14 Y C ATOM 4097 C34 FRA Y 1 18.172 20.843 28.033 1.00 19.61 Y C ATOM 4098 C35 FRA Y 1 17.642 22.083 27.612 1.00 19.21 Y C ATOM 4099 O36 FRA Y 1 16.421 24.575 26.797 1.00 19.90 Y O ATOM 4100 O37 FRA Y 1 8.904 33.109 26.339 1.00 21.63 Y O ATOM 4101 C38 FRA Y 1 10.186 33.273 25.678 1.00 23.16 Y C ATOM 4102 O39 FRA Y 1 3.746 33.908 24.230 1.00 36.52 Y O TER 4103 FRA Y 1 ATOM 4104 O HOH E 1 −2.816 80.929 50.812 1.00 19.03 E O ATOM 4105 O HOH E 2 3.978 72.365 54.056 1.00 19.03 E O ATOM 4106 O HOH E 3 13.505 98.252 72.880 1.00 19.36 E O ATOM 4107 O HOH E 4 28.293 104.582 83.681 1.00 21.47 E O ATOM 4108 O HOH E 6 6.360 44.178 47.881 1.00 23.42 E O ATOM 4109 O HOH E 7 1.770 73.865 68.162 1.00 20.46 E O ATOM 4110 O HOH E 8 8.297 17.524 35.431 1.00 28.17 E O ATOM 4111 O HOH E 9 4.373 82.422 53.549 1.00 66.83 E O ATOM 4112 O HOH E 10 9.876 77.587 53.891 1.00 15.33 E O ATOM 4113 O HOH E 11 13.114 23.318 30.599 1.00 23.68 E O ATOM 4114 O HOH E 12 7.067 14.767 42.081 1.00 41.33 E O ATOM 4115 O HOH E 13 15.665 28.507 29.364 1.00 35.38 E O ATOM 4116 O HOH E 14 8.724 81.834 51.911 1.00 15.54 E O ATOM 4117 O HOH E 15 21.092 27.236 30.877 1.00 29.72 E O ATOM 4118 O HOH E 16 4.235 23.958 10.152 1.00 18.27 E O ATOM 4119 O HOH E 17 21.990 41.088 42.974 1.00 32.56 E O ATOM 4120 O HOH E 18 20.666 46.477 48.657 1.00 22.11 E O ATOM 4121 O HOH E 19 12.394 30.572 26.200 1.00 25.85 E O ATOM 4122 O HOH E 20 24.458 88.275 67.914 1.00 18.95 E O ATOM 4123 O HOH E 21 16.023 94.041 76.489 1.00 18.64 E O ATOM 4124 O HOH E 22 −3.046 75.441 65.884 1.00 19.92 E O ATOM 4125 O HOH E 24 13.742 101.239 70.093 1.00 20.42 E O ATOM 4126 O HOH E 25 2.139 79.403 76.859 1.00 24.59 E O ATOM 4127 O HOH E 26 −0.923 97.738 56.694 1.00 26.97 E O ATOM 4128 O HOH E 27 27.493 25.824 48.659 1.00 25.58 E O ATOM 4129 O HOH E 28 −3.060 85.100 45.284 1.00 28.40 E O ATOM 4130 O HOH E 29 2.126 21.471 26.630 1.00 18.24 E O ATOM 4131 O HOH E 30 19.055 98.237 66.551 1.00 26.93 E O ATOM 4132 O HOH E 31 5.015 20.070 34.897 1.00 27.21 E O ATOM 4133 O HOH E 32 20.699 97.163 78.060 1.00 20.06 E O ATOM 4134 O HOH E 33 19.905 95.504 66.214 1.00 16.74 E O ATOM 4135 O HOH E 34 26.799 36.524 56.357 1.00 23.12 E O ATOM 4136 O HOH E 35 7.281 42.459 52.886 1.00 27.29 E O ATOM 4137 O HOH E 36 −5.229 82.177 76.134 1.00 17.35 E O ATOM 4138 O HOH E 37 16.156 81.681 74.210 1.00 33.58 E O ATOM 4139 O HOH E 38 17.171 26.456 35.298 1.00 26.63 E O ATOM 4140 O HOH E 41 10.220 96.211 76.240 1.00 36.39 E O ATOM 4141 O HOH E 42 21.575 87.342 80.619 1.00 26.03 E O ATOM 4142 O HOH E 43 −2.344 82.211 46.311 1.00 33.39 E O ATOM 4143 O HOH E 44 1.411 102.153 63.920 1.00 40.99 E O ATOM 4144 O HOH E 45 22.412 37.472 55.894 1.00 36.08 E O ATOM 4145 O HOH E 46 2.300 24.457 31.665 1.00 23.22 E O ATOM 4146 O HOH E 47 13.621 22.599 34.360 1.00 23.98 E O ATOM 4147 O HOH E 48 15.081 50.361 55.761 1.00 28.43 E O ATOM 4148 O HOH E 49 14.580 93.564 78.622 1.00 24.96 E O ATOM 4149 O HOH E 50 26.890 18.450 12.611 1.00 42.82 E O ATOM 4150 O HOH E 51 9.227 107.514 67.012 1.00 41.46 E O ATOM 4151 O HOH E 52 34.558 108.086 67.299 1.00 37.65 E O ATOM 4152 O HOH E 53 10.050 90.871 55.783 1.00 29.24 E O ATOM 4153 O HOH E 54 7.944 16.482 49.236 1.00 41.77 E O ATOM 4154 O HOH E 55 13.318 100.169 53.864 1.00 42.27 E O ATOM 4155 O HOH E 56 7.437 71.694 56.237 1.00 34.69 E O ATOM 4156 O HOH E 57 −0.370 31.293 25.399 1.00 22.63 E O ATOM 4157 O HOH E 58 6.282 69.233 70.952 1.00 40.32 E O ATOM 4158 O HOH E 59 16.826 72.690 51.895 1.00 39.22 E O ATOM 4159 O HOH E 60 26.960 20.330 32.431 1.00 46.00 E O ATOM 4160 O HOH E 61 24.484 34.166 17.080 1.00 57.71 E O ATOM 4161 O HOH E 62 15.070 29.732 24.722 1.00 36.63 E O ATOM 4162 O HOH E 63 2.410 82.045 76.883 1.00 31.15 E O ATOM 4163 O HOH E 64 20.509 17.863 8.881 1.00 34.06 E O ATOM 4164 O HOH E 65 9.108 18.512 47.676 1.00 36.58 E O ATOM 4165 O HOH E 66 −4.442 94.264 72.560 1.00 35.02 E O ATOM 4166 O HOH E 67 4.615 73.935 73.283 1.00 34.26 E O ATOM 4167 O HOH E 68 20.674 96.637 81.076 1.00 32.24 E O ATOM 4168 O HOH E 69 6.012 84.836 76.526 1.00 39.65 E O ATOM 4169 O HOH E 70 18.931 64.756 50.070 1.00 41.17 E O ATOM 4170 O HOH E 71 1.034 33.236 39.187 1.00 32.26 E O ATOM 4171 O HOH E 72 −3.531 21.419 23.837 1.00 33.17 E O ATOM 4172 O HOH E 73 35.386 104.215 87.572 1.00 48.96 E O ATOM 4173 O HOH E 74 17.897 25.522 63.076 1.00 45.88 E O ATOM 4174 O HOH E 75 21.283 17.561 47.461 1.00 37.66 E O ATOM 4175 O HOH E 76 −11.086 90.035 66.851 1.00 30.87 E O ATOM 4176 O HOH E 77 11.320 20.363 58.814 1.00 46.67 E O ATOM 4177 O HOH E 78 −6.338 85.994 41.967 1.00 51.31 E O ATOM 4178 O HOH E 79 3.655 87.067 43.145 1.00 39.38 E O ATOM 4179 O HOH E 81 7.253 86.756 37.906 1.00 59.51 E O ATOM 4180 O HOH E 82 23.816 46.171 47.749 1.00 28.26 E O ATOM 4181 O HOH E 83 −2.313 31.734 47.707 1.00 41.05 E O ATOM 4182 O HOH E 84 11.459 17.532 33.022 1.00 35.50 E O ATOM 4183 O HOH E 85 1.163 30.110 41.773 1.00 28.95 E O ATOM 4184 O HOH E 86 6.404 108.929 60.380 1.00 44.61 E O ATOM 4185 O HOH E 87 6.970 44.481 59.964 1.00 33.00 E O ATOM 4186 O HOH E 88 6.136 40.362 59.850 1.00 35.96 E O ATOM 4187 O HOH E 89 8.854 36.982 12.914 1.00 51.29 E O ATOM 4188 O HOH E 90 14.894 17.557 10.137 1.00 29.07 E O ATOM 4189 O HOH E 91 3.598 70.913 41.429 1.00 37.85 E O ATOM 4190 O HOH E 92 15.660 96.593 64.706 1.00 34.79 E O ATOM 4191 O HOH E 93 −1.289 22.000 25.700 1.00 53.85 E O ATOM 4192 O HOH E 94 18.658 94.873 78.816 1.00 34.79 E O ATOM 4193 O HOH E 95 24.030 37.111 44.167 1.00 31.33 E O ATOM 4194 O HOH E 96 24.327 108.825 70.586 1.00 43.44 E O ATOM 4195 O HOH E 97 17.453 29.940 39.065 1.00 62.04 E O ATOM 4196 O HOH E 98 −10.095 77.380 58.416 1.00 32.83 E O ATOM 4197 O HOH E 99 1.372 41.175 43.439 1.00 30.57 E O ATOM 4198 O HOH E 100 13.220 40.977 61.050 1.00 25.13 E O ATOM 4199 O HOH E 101 20.635 23.766 29.311 1.00 36.67 E O ATOM 4200 O HOH E 102 6.907 103.740 69.211 1.00 39.48 E O ATOM 4201 O HOH E 103 29.965 20.328 27.392 1.00 35.16 E O ATOM 4202 O HOH E 104 −5.202 80.206 74.097 1.00 29.87 E O ATOM 4203 O HOH E 105 −0.936 62.297 61.894 1.00 42.93 E O ATOM 4204 O HOH E 106 36.982 102.874 54.415 1.00 36.76 E O ATOM 4205 O HOH E 107 5.889 102.017 53.094 1.00 63.79 E O ATOM 4206 O HOH E 108 39.219 43.505 52.395 1.00 38.65 E O TER 4207 HOH E 108 END

The shape of the ATP binding pocket is defined by the atomic coordinates of the atoms in the amino-acid residues in Tables 1 and 2. Table 1 lists the atomic coordinates for [T287D] Aurora A(122–396) catalytic domain, together with the AMP-PNP molecule, in Protein Data Bank (PDB) format, as determined from the first crystalline form. Table 2-lists the atomic coordinates for the two independent molecules of the GSHM-[T287D]Aurora A (122–400) catalytic domain, together with the inhibitor of formula II, in PDB format, as determined from the second crystalline form. The atomic coordinates are listed in those lines that begin with the code ATOM or HETATM, one atom per line. Following the code are: the unique atom number; the atom name; the amino acid residue name; the protein chain identifier; the amino acid residue number; the atomic coordinates x, y, and z in orthogonal Angstrom space; the atomic occupancy factor; the atomic temperature factor; the chain identifier; and the atom type. The atomic coordinates of the ATP analogue AMP-PNP carry the residue name of -ANP. Solvent water molecules carry the residue name of HOH, and a citrate and a bound phosphate derived from the crystallisation buffer carry the residue name of FRA. In the inhibitor complex the inhibitor molecules carry the residue name of FRA.

It is possible to reproduce the shape of the [T287D]Aurora A active site binding pocket through carrying out similar structure determinations with minor variations in the experimental conditions (including variations in construct such as mutants, variants and homologues, variations in crystallisation conditions, crystal form, trial model used in molecular replacement, etc.). Different experiments may give rise to apparently different co-ordinates, but those in the art will realise that two apparently different sets of coordinates for the same or similar proteins can be shown to be equivalent by superposition of the molecules. For example, the coordinates in Tables 1 and 2 are different numerically. But following superposition they can be seen to describe the same molecule. It will be appreciated that, according to accepted practice, the atomic coordinates may vary within certain limits due to experimental variation. Such variation includes standard experimental error (coordinates determined for the same construct may vary somewhat, for example within 0.3 Å) and other variation (for example, coordinates of Aurora mutants, variants, or homologues). The co-ordinates of the active site ATP binding site may also differ upon introduction of a different small molecule inhibitor, where flexible portions of the binding site adopt a new conformation specific to a type of inhibitor. For example, following superposition, the protein coordinates in Table 1 are seen to be marginally different to those in Table 2, as a result of flexible portions of the protein being influenced by the presence of a different inhibitor. This constitutes a modification of the active site ATP binding site rather than the creation of a new site. Those in the art will realise that kinases in general have flexible active sites, and adopt a number of biologically relevant conformations related to the state of catalytic activation. Therefore, for the purposes of differentiating the shape of the active site ATP-binding pocket from that in other kinases, the binding pocket is best defined by a subset of amino acids that are least affected by flexible protein responses to inhibitor binding. Thus, a protein can be said to have the Aurora active site described here if, following superposition, the positions of all atoms in the active site residues in set B, i.e. Arg136, Leu138, Gly139, Val146, Ala159, Lys161, Leu163, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260 and Leu262 or their equivalents, are within a root mean square deviation of 1.0 Å of the coordinates of these amino acid residues given in Tables 1 and 2. An equivalent residue is an amino acid residue in any Aurora mutant, variant, or homologue that occurs at one of the amino acid sequence positions in Tables 1 or 2—if the residue is not identical, only the N, Cα, Cβ, C, O atoms may be sensibly included in the rmsd calculation. It is also understood that if equivalent residues are not present in a particular variant or homologue, then they are omitted from the calculation of the average distance.

The criterion of 1.0 Å is intended to be large enough to allow the types of variations described above, yet small enough to discriminate between the active sites of Aurora kinases and other kinases. That this criterion is reasonable is illustrated in Table 3, which compares [T287D]Aurora A to one of the most closely related kinases, PKA.

TABLE 3 rms deviations in Å between all atoms of set B amino acids in the active site. The top row refers to the PDB codes for 6 entries of a different kinase, protein kinase A (PKA). The bold numbers refer to the Tables 1 and 2 which contain Aurora coordinates. Thus, when independent structure determinations of Aurora are compared (1-2, 1-3, 2-3) the rmsd is less than 1 Å, whereas when Aurora is compared to PKA (6 independent structures) the rmsd is greater than 1 Å. 1 atp 1 13r 1 bx6 1 apm 1 ydt 1 cmk 1-2 0.85 1-PKA 1.32 1.32 1.29 1.24 1.28 1.17 1-3 0.67 2-PKA 1.19 1.14 1.08 1.13 1.13 1.13 2-3 0.42 3-PKA 1.14 1.08 1.09 1.08 1.10 1.21

Thus, according to a further aspect of the invention, we provide the shape of the active site ATP binding pocket in Aurora protein kinase as defined by the atomic coordinates given in Tables 1 and 2 or by equivalent coordinates. Equivalent coordinates are those for which the subset of least flexible residues (set B) have atomic positions on average within 1.0 Å of those in the Aurora active site ATP binding pocket as defined by the coordinates in Tables 1 and 2.

According to a further aspect of the invention we provide a method to determine or design the three-dimensional structure of a crystal form of Aurora (including Aurora A homologues, variants, mutants, and inhibitor complexes) by using a particular Aurora A catalytic domain structure. The atomic co-ordinates of an Aurora A crystal may be used to model the structure of a second Aurora crystal by difference Fourier or molecular replacement methods.

The crystal structure of the Aurora A kinase catalytic domain described herein can be used to model the three-dimensional structures of other Aurora kinases. Furthermore, alternative methods of determining three-dimensional structure that do not rely on X-ray diffraction techniques and thus do not require crystallization of the protein, such as NMR techniques, are simplified if a model of the structure is available for refinement using the additional data gathered by the alternative technique. Thus, definition of the three-dimensional structure of the catalytic domain of Aurora A kinase enables one of skill in the art to determine the structure of the catalytic domains of other Aurora kinases.

Knowledge of the three-dimensional structure of the catalytic domain of Aurora A kinase provides a means for investigating the mechanism of action of the protein and tools for identifying inhibitors of its function. Knowledge of the three-dimensional structure of the catalytic domain of Aurora A kinase allows one to design molecules capable of binding thereto, including molecules which are capable of inhibiting (partially or completely) the activity of Aurora A kinase.

Illustrative crystalline forms of polypeptides of this invention having various physicochemical characteristics are disclosed herein. Preferred crystalline forms invention are capable of diffracting x-rays to a resolution of better than about 3.5 Å, and more preferably to a resolution of 3.0 Å or better, and even more preferably to a resolution of 2.2 Å or better, and are useful for determining the three-dimensional structure of the material.

Crystalline compositions of this invention specifically include those in which the crystals comprise Aurora kinase family proteins characterized by the structural coordinates set forth in any of the accompanying tables or characterized by coordinates having a root mean square deviation therefrom, with respect to backbone atoms of amino acids given in the Tables, of 1.5 Å or less. Crystalline compositions of this invention also include those in which the crystals comprise Aurora kinase family proteins characterized by having a binding site defined by the x,y,z-coordinates of atoms in the set of amino acid residues (set A) given by the list Arg136, Leu138, Gly139, Lys140, Gly141, Val146, Lys161, Leu163, Val177, Glu180, Val181, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260, Leu262, Ala272, Asp273, Phe274, Gly275, Trp276, Ser277, Val278, and His279, the atomic coordinates being listed in Tables 1 and 2. Further, crystalline forms of polypeptides of this invention also include those in which the crystals comprise Aurora kinase family proteins in which the binding site is defined by the x,y,z-coordinates of atoms in the set of amino acid residues (set B) given by the list Arg136, Leu138, Gly139, Val146, Ala159, Lys161, Leu163, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260 and Leu262 or their equivalent, are within a root mean square deviation of 1.0 Å of the coordinates of these amino acid residues given in Tables 1 and 2.

Structural coordinates of a crystalline composition of this invention may be stored in a machine-readable form on a machine-readable storage medium, such as a computer hard drive, diskette, DAT tape, for display as a three-dimensional shape or for other uses involving computer-assisted manipulation of, or computation based on, the structural coordinates or the three-dimensional structures they define. For example, data defining the three dimensional structure of a protein of the Aurora kinase family, or portions or structurally similar homologues of such proteins, may be stored in a machine-readable storage medium and displayed as a three-dimensional representation of the protein structure, typically using a computer capable of reading the data from said storage medium and programmed with instructions for creating the representation from such data. This invention thus encompasses a machine, such as a computer, having a memory which contains data representing the structural coordinates of a crystalline composition of this invention, such as the coordinates set forth in Tables 1 and 2, together with additional optional data and instructions for manipulating such data. Such data may be used for a variety of purposes, such as the elucidation of other related structures and drug discovery.

For example, a first set of such machine readable data may be combined with a second set of machine-readable data using a machine programmed with instructions for using the first data set and the second data set to determine at least a portion of the coordinates corresponding to the second set of machine-readable data. For instance, the first set of data may comprise a Fourier transform of at least a portion of the coordinates for Aurora kinase proteins set forth in Tables 1 and 2, while the second data set may comprise X-ray diffraction data of a molecule or molecular complex.

More specifically, one of the objects of this invention is to provide three-dimensional structural information on new complexes of Aurora kinase family members (e.g., complexed with an ATP analogue or an inhibitor, such as a synthetic inhibitor), new Aurora kinase family members and variants of any of the foregoing. The structural coordinates of a crystalline composition of this invention, or portions thereof, can be used to solve, e.g. by molecular replacement, the three dimensional structure of a crystalline form of such a polypeptide or polypeptide complex. Doing so involves obtaining x-ray diffraction data for crystals of the polypeptide or polypeptide complex (e.g., in complex with an ATP analogue or an inhibitor, such as a synthetic inhibitor) for which one wishes to determine the three dimensional structure. The three-dimensional structure of that polypeptide or complex is determined by analyzing the x-ray diffraction data using molecular replacement techniques with reference to the structural coordinates provided. For example, molecular replacement can use a molecule having a known structure as a starting point to model the structure of an unknown crystalline sample. This technique is based on the principle that two molecules which have similar structures, orientations and positions in the unit cell diffract similarly. The term “molecular replacement” refers to a method that involves generating a preliminary model of a crystal whose atomic coordinates are not known, by orienting and positioning a related molecule whose atomic coordinates are known. Phases are then calculated from this model and combined with observed amplitudes to give an approximate Fourier synthesis of the structure whose coordinates are unknown. Molecular replacement involves positioning the known structure in the unit cell in the same location and orientation as the unknown structure. Once positioned, the atoms of the known structure in the unit cell are used to calculate the structure factors that would result from a hypothetical diffraction experiment. This involves rotating the known structure in the six dimensions (three angular and three spatial dimensions) until alignment of the known structure with the experimental data is achieved. This approximate structure can be refined to yield a more accurate and often higher resolution structure using various refinement techniques. For instance, the resultant model for the structure defined by the experimental data may be subjected to rigid body refinement in which the model is subjected to limited additional rotation in the six dimensions yielding positioning shifts of under about 5%. The refined model may then be further refined using other known refinement methods.

For example, one may use molecular replacement to exploit a set of coordinates such as set forth in Table 1 or Table 2 to determine the structure of the catalytic domain of Aurora kinase in complex with other than ATP-PNP or the inhibitor of formula II.

The present invention also relates to designing and, optionally producing, a homologue of Aurora kinase, such as a homologue of Aurora kinase A, that mimics the three-dimensional structure of the Aurora kinase. The method comprises:

-   -   (i) determining the three-dimensional coordinates of atoms of an         Aurora kinase;     -   (ii) providing a computer having a memory means, a data input         means, a visual display means, said memory means containing         three-dimensional molecular simulation software operable to         retrieve co-ordinate data from said memory means and to display         a three-dimensional representation of a molecule on said visual         display means and being operable to produce a modified         three-dimensional homologue representation responsive to         operator-selected changes to the structure of the Aurora kinase         and to display the three-dimensional representation of the         modified three-dimensional homologue;     -   (iii) inputting three-dimensional co-ordinate data of atoms of         Aurora kinase into the computer and storing said data in the         memory means;     -   (iv) inputting into the data input means of said computer at         least one operator-selected change in structure of the Aurora         kinase;     -   (v) executing said molecular simulation software to produce a         modified three-dimensional molecular representation of the         homologue structure;     -   (vi) displaying the three-dimensional representation of the         homologue on said visual display means, whereby changes in         three-dimensional structure of the Aurora kinase resulting from         changes on structure can be visually monitored;     -   (vii) repeating steps (iv) through (vi) to produce a         multiplicity of homologues; and     -   (viii) selecting a homologue structure represented by a         three-dimensional representation wherein the three-dimensional         configuration and spatial arrangements of the kinase catalytic         domain remain substantially preserved, thereby producing a         homologue of Aurora kinase that mimics the three-dimensional         structure of the Aurora kinase.

The present invention also relates to a method of producing a modulator of Aurora kinase (particularly inhibitors), such as a modulator of Aurora kinase A. The method comprises identifying a compound or molecule or designing a compound or molecule that fits into the active site ATP binding pocket of the Aurora kinase, wherein the ATP binding pocket is defined by (a) Arg136, Leu138, Gly139, Lys140, Gly141, Val146, Lys161, Leu163, Val177, Glu180, Val181, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260, Leu262, Ala272, Asp273, Phe274, Gly275, Trp276, Ser277, Val278, and His279, the atomic coordinates being listed in Tables 1 and 2 or (b) the x,y,z-coordinates of atoms in the set of amino acid residues (set B) given by the list Arg136, Leu138, Gly139, Val146, Ala159, Lys161, Leu163, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260 and Leu262, each having coordinates as described in Tables 1 and 2, thereby producing a modulator of Aurora kinase.

Another object of the invention is to provide a method for determining the three-dimensional structure of the catalytic domain of an Aurora kinase protein, or the catalytic domain of an Aurora kinase protein in complex with an inhibitor, using homology modeling techniques and structural coordinates for a composition of this invention. Homology modeling involves constructing a model of an unknown structure using structural coordinates of one or more related proteins, protein domains and/or subdomains. Homology modeling may be conducted by fitting common or homologous portions of the protein or peptide whose three dimensional structure is to be solved to the three dimensional structure of homologous structural elements. This approach can be used to rebuild part or all of a three dimensional structure with replacement of amino acids (or other components) by those of the related structure to be solved. For example, using the structural coordinates of the catalytic domain of an Aurora kinase in complex with AMP-PNP or the inhibitor of formula II, it is possible to determine the three dimensional structure of the catalytic domain of another Aurora kinase protein through the use of homology modeling. Those coordinates may be stored, displayed, manipulated and otherwise used in like fashion as the Aurora kinase coordinates of Tables 1–2.

Thus, crystalline compositions of this invention provide a starting material for use in solving the three-dimensional structure of other Aurora kinase polypeptides.

By way of further example, the structure defined by the machine readable data may be computationally evaluated for its ability to associate with various chemical entities. The term “chemical entity”, as used herein, refers to chemical compounds, complexes of at least two chemical compounds, and fragments of such compounds or complexes.

For instance, a first set of machine-readable data defining the three-dimensional structure of an Aurora kinase family protein, or a portion or complex thereof, is combined with a second set of machine-readable data defining the structure of a chemical entity or moiety of interest using a machine programmed with instructions for evaluating the ability of the chemical entity or moiety to associate with the Aurora kinase family protein or portion or complex thereof and/or the location and/or orientation of such association. Such methods provide insight into the location, orientation and energetics of association of the Aurora kinase family protein with such chemical entities. Chemical entities that associate or interact with an Aurora kinase may inhibit its interaction with naturally occurring ligands for the protein and may inhibit biological functions mediated by such interaction. Such chemical entities are drug candidates.

The protein structure encoded by the data may be displayed in a graphical format permitting visual inspection of the structure, as well as visual inspection of the structure's association with chemical entities. Alternatively, more quantitative or computational methods may be used. For example, one method of this invention for evaluating the ability of a chemical entity to associate with any of the molecules or molecular complexes set forth herein comprises the steps of: a) employing computational means to perform a fitting operation between the chemical entity and a binding pocket or other surface feature of the molecule or molecular complex; and b) analyzing the results of the fitting operation to quantify the association between the chemical entity and the binding pocket.

This invention further provides for the use of the structural coordinates of a crystalline composition of this invention, or portions thereof, to identify reactive amino acids, such as cysteine residues, within the three-dimensional structure, such as within or adjacent to the catalytic domain; to generate and visualize a molecular surface, such as a water-accessible surface or a surface comprising the space-filling van der Waals surface of all atoms; to calculate and visualize the size and shape of surface features of the protein or complex, e.g., ligand binding pockets; to locate potential H-bond donors and acceptors within the three-dimensional structure, preferably within or adjacent to a ligand binding site; to calculate regions of hydrophobicity and hydrophilicity within the three-dimensional structure, preferably within or adjacent to a ligand binding site; and to calculate and visualize regions on or adjacent to the protein surface of favorable interaction energies with respect to selected functional groups of interest (e.g. amino, hydroxyl, carboxyl, methylene, alkyl, alkenyl, aromatic carbon, aromatic rings, heteroaromatic rings, substituted and unsubstituted phosphates, substituted and unsubstituted phosphonates, substituted and unsubstituted fluoro and difluorophosphonates; etc.). One may use the foregoing approaches for characterizing the protein and its interactions with moieties of potential ligands to design or select compounds capable of specific covalent attachment to reactive amino acids (e.g., cysteine) and to design or select compounds of complementary characteristics (e.g., size, shape, charge, hydrophobicity/hydrophilicity, ability to participate in hydrogen bonding, etc.) to surface features of the protein, a set of which may be preselected. Using the structural coordinates, one may also predict or calculate the orientation, binding constant or relative affinity of a given ligand to the protein in the complexed state, and use that information to design or select compounds of improved affinity.

In such cases, the structural coordinates of the Aurora kinase family protein, or portion or complex thereof, are entered in machine readable form into a machine programmed with instructions for carrying out the desired operation and containing any necessary additional data (e.g. data defining structural and/or functional characteristics of a potential ligand or moiety thereof, defining molecular characteristics of the various amino acids).

One method of this invention provides for selecting from a database of chemical structures a molecular compound capable of binding to an Aurora kinase family protein (e.g., coordinates defining the three dimensional structure of an Aurora kinase family protein or a portion thereof). Points associated with the three dimensional structure (structural coordinates) of a crystalline form of Aurora A kinase catalytic domain are characterized with respect to the favorability of interactions with one or more functional groups. A database of chemical structures is then searched for candidate compounds containing one or more functional groups disposed for favorable interaction with the protein based on the prior characterization. Compounds having structures which best fit the points of favorable interaction with the three dimensional structure are thus identified.

It is often preferred, although not required, that such searching be conducted with the aid of a computer. In that case a first set of machine-readable data defining the three-dimensional structure of an Aurora kinase family protein, or a portion or complex thereof, is combined with a second set of machine readable data defining one or more moieties or functional groups of interest, using a machine programmed with instructions for identifying preferred locations for favorable interaction between the functional group(s) and atoms of the protein. A third set of data, which defines the location(s) of favorable interaction between protein and functional group(s) is generated. The third set of data is then combined with a fourth set of data defining the three-dimensional structures of one or more chemical entities using a machine programmed with instructions for identifying chemical entities containing functional groups to best fit the locations of their respective favorable interaction with the protein.

Compounds of the structures selected or designed by any of the foregoing means may be tested for their ability to bind to an Aurora kinase family protein, inhibit the binding of an Aurora kinase family protein to a natural or non-natural ligand therefor, and/or inhibit a biological function mediated by an Aurora kinase family member.

The new crystal may be a crystal of a homologue, variant, mutant, or inhibitor complex of Aurora. The shape of the Aurora active site binding pocket in the new crystal model is an equivalent shape to that of the first. The active site binding pocket of the original Aurora A crystal is defined by the amino acid residues of set A and their atomic coordinates as given in Tables 1 and 2. Equivalent shape is defined as having an rmsd of less than 1 Å upon superposition of the subset of least flexible amino acid residues (set B).

Thus, the invention provides a method to determine or design the three dimensional structure of a crystal form of Aurora by difference Fourier or Molecular Replacement, using the coordinates (Tables 1 and 2) of an Aurora A crystal to model the structure of a new Aurora crystal wherein the active site ATP binding region is equivalent to that in the first crystal. The method may be carried out as follows. An Aurora protein (wild type, mutant, variant or homologue) is purified and crystallised as a pure protein or in complex with an inhibitor compound. This crystal may have the same crystal form (same protein packing) as one of the crystal structures defined by Tables 1 and 2, or it may have a different crystal form (different protein packing). By taking diffraction measurements of the crystal and using the atomic coordinates in Tables 1 or 2 (or equivalent coordinates), it is possible to work out the structure of the crystal by the known methods of difference Fourier (same packing) or molecular replacement (different packing). This invention covers the use in drug design of the active site ATP binding pocket in any new crystal since this will be equivalent to that in the original crystal.

The invention further provides Aurora A proteins (including homologues, variants and mutants) designed by the above method. The Aurora A proteins may have identical properties to wild type Aurora A or may have one or more different properties compared to wild type Aurora A.

According to a further aspect of the invention, we provide a method to select or design chemical modulators (preferably inhibitors) of Aurora by using the Aurora A catalytic domain structure (including that of homologues, variants, mutants, and inhibitor complexes) and the shape of the active site ATP binding pocket (or an equivalent shape as previously defined). Information from the three dimensional atomic coordinates of the AMP-PNP molecule and its spatial orientation in relation to the three dimensional atomic coordinates of the Aurora A catalytic domain is used as a tool to design Aurora modulators (preferably inhibitors). In addition, information from the three dimensional atomic coordinates of the inhibitor molecule of formula II and its spatial orientation in relation to the three dimensional atomic coordinates of the Aurora A catalytic domain is used as tool to design Aurora modulators (preferably inhibitors). Small-molecule modulators of Aurora may be selected or designed to fit into the shape of the active site binding pocket.

Knowledge of the structural determinants that account for the difference in substrate specificity between Aurora A and other kinases, such as PKA, provides a foundation for the design of highly specific modulators of the Aurora A enzyme.

Structural differences at the ATP binding pocket between Aurora and other kinases (defined by differences in the atomic coordinates of residues in the ATP pocket) may be used to design selective Aurora A modulators.

According to a further aspect of the invention, use of the coordinates of the Aurora A catalytic domain (Tables 1 and 2) to locate other pockets for interaction by small molecule modulators that affect Aurora activity is claimed. Such pockets may overlap with the active site ATP binding pocket or be completely independent. The three-dimensional structure of Aurora A kinase is an essential tool in the discovery of any such pockets that provide an alternative for modulator interaction to the active site ATP binding pocket.

As described above, the Aurora A crystal structure may be used in the rational design of drugs which modulate (preferably inhibit) the action of Aurora. These Aurora modulators may be used to prevent or treat the undesirable physical and pharmacological consequences of inappropriate Aurora activity.

The present invention will now be described with reference to the following non-limiting Examples.

Definition of Terms

In the Description (including the Examples) the following terms are used:

The term “atomic co-ordinates” refers to mathematical co-ordinates corresponding to the positions of every atom derived from mathematical equations related to the diffraction patterns obtained from a monochromatic beam of X-rays illuminating a crystal. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are used to establish the positions of the individual atoms within the unit cell of the crystal. Those of skill in the art understand that a set of atomic co-ordinates determined by X-ray crystallography is not without standard error or experimental variation.

The term “unit cell” refers to the basic building block from which the entire volume of a crystal may be constructed.

The term “space group” refers to the arrangement of symmetry elements within a unit cell.

The term “molecular replacement” refers to a method that involves generating a preliminary model of a crystal whose atomic co-ordinates are not known, by orienting and positioning a related molecule whose atomic co-ordinates are known. Phases are then calculated from this model and combined with observed amplitudes to give an approximate Fourier synthesis of the structure whose co-ordinates are unknown.

EXAMPLE 1 Production of the Kinase Catalytic Domain of Aurora A Molecular Biology

In order to obtain a polypeptide (or protein) that can be utilised for determination of the three dimensional (tertiary) structure of Aurora A, DNA encoding Aurora A may be obtained by total gene synthesis or by cloning. This DNA may then be expressed in a suitable expression system to obtain a polypeptide that can be subjected to techniques to determine its three dimensional structure.

In this case, the human Aurora A gene carrying an artificially induced mutation (GAT to ACT in nucleotides 862–864, taking the A of the initial ATG in the open reading frame of the gene to be +1) encoding for a threonine to aspartate (T to D using the single letter amino acid code) mutation of amino acid 287 (taking the first amino acid immediately after the initial methionine as amino acid number one) formed the basis of the expression construct used in these studies. This [T287D]Aurora A mutant was a gift of Dr. Jim Bischoff, SUGEN Inc. Since the full length [T287D]Aurora A protein expressed in E. coli was poorly soluble and aggregated on purification, a truncated mutant form was generated. The regions encoding for amino acids 94 to the stop codon of [T287D] Aurora A was amplified using the polymerase chain reaction (PCR). The 5′ PCR primer (5′GATCGATCGGATCCACCCAAAAGAGCAAGCAGCCC 3′; SEQ ID NO.: 1) carried a spacer region (to allow efficient cleavage by restriction endonuclease), the BamH1 restriction endonuclease recognition sequence and sequence corresponding to the bases 283–301. The 3′ primer (5′ TGACGCTAGGATCCCCTAAGACTGTTTGCTAGCTGATTC 3′; SEQ ID NO.: 2) carried a spacer region, BamH1 recognition sequence and 3′ end of the Aurora A (bases 1189–1212) sequence including the stop codon. PCR products were purified and cloned in to the pCR-Script vector (Stratagene) using the pCR-Script AMP cloning kit (Stratagene. product # 211188) according to manufacturers directions. The pCR-Script vector carrying the [T287D] Aurora A (94–402) sequence was digested with BamH1, the digestion products resolved by agarose gel electrophoresis and the DNA fragment corresponding to the [T287D] Aurora A (94–402) sequence excised and purified using a Qiagen QIAquick kit (Qiagen product #28704). This fragment was then ligated into the vector pTB375NBSE, which had previously been cut with BamH1. (Details of the methods for the assembly of recombinant DNA molecules can be found in standard texts, for example Sambrook et al. 1989, Molecular Cloning—A Laboratory Manual, 2^(nd) Edition, Cold Spring hbor Laboratory Press and Ausubel et al. 1999, Current Protocols in Molecular Biology, John Wiley and Sons Inc). The pTB375NBSE vector is derived from pAT153, which is a mobilization-minus derivative of pBR322. The inserted genes were under the control of a bacteriophage T7 promoter and therefore requires expression of the T7 polymerase in trans for efficient transcription in E. coli. The plasmid encodes tetracyline resistance for selection.

The ligation reactions were transfected in-to TOP10 competent E. coli (Invitrogen product #C4040-10) and E. coli carrying the pTB375NBSE recombinant vectors identified by their ability to grow on media containing tetracycline. Plasmid DNA was extracted from these bacteria and subjected to digestion with the restriction endonuclease EcoR1 to identify those carrying the [T287D] Aurora A (94–402) sequence. The identity of the insert was then confirmed by dideoxy chain termination DNA sequencing prior to protein expression.

pTB375NBSE carries the initiation codon (ATG) 3′ to the T7 promoter and also the following sequence up to and including the BamH1 restriction endonuclease recognition site:

(SEQ ID NO.: 3) 5′ . . . ATG GGC CAT CAT CAT CAT CAT CAC GGA TCC . . . 3′

Sequences inserted into the BamH1 site “in frame” with the initiation codon will therefore be expressed as a fusion protein with the following N-terminal fusion:

(SEQ ID NO.: 4) (N-terminal) MGHHHHHHGS . . . (C-terminal)

The fusion of 6 histidines to proteins is commonly used to provide a “tag” for protein purification, usually by affinity for metal ions such as nickel. Since the [T287D] Aurora A sequence coding for amino acids 94–402 was inserted in to the BamH1 site, the plasmid encodes for the following protein (using the standard single letter amino acid code):

MGHHHHHHGSTQKSKQPLPSAPENNPEEELASKQKNEESKKRQWALEDFEIG (SEQ ID NO.: 5) RPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHL RHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELA NALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTDLCGTLD YLPPEMIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEF TFPDFVTEGARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESA SKQS.

This protein will be referred to in the text as MG-6His-GS-[T287D]Aurora A(94-402).

Based on the limited proteolysis studies (described later in Example 1), two additional truncated mutant forms of the Aurora A protein were also generated. The regions encoding for amino acids 113–400 and 122–400 of [T287D]Aurora A were amplified using the polymerase chain reaction (PCR). The 5′ PCR primers (5′CATATGCTGGCATCAAAACAGAAAAATG 3′ (SEQ ID NO.: 6) for 113–400 of [T287D]Aurora A or 5′CATATGTCAAAAAAGAGGCAGTGGGC 3′(SEQ ID NO.: 7) for 122–400 of [T287D]Aurora A) carried a Nde1 restriction endonuclease recognition sequence. A single 3′ primer (5′GGATCCTCATTTGCTAGCTGATTCTTTGTTTTGG 3′(SEQ ID NO.: 8)) was used for both constructs and carries a BamH1 recognition sequence and 3′ end of the Aurora A sequence following the stop codon. PCR products were purified and cloned into the pCR-Script vector (Stratagene) using the pCR-Script AMP cloning kit (Stratagene. product #211188) according to manufacturers instructions and transfected into the E. coli strain DH5□ (Invitrogen product #18258-012). The E. coli colonies containing the recombinant pPCR-Script [T287D]Aurora A(113–400) or pPCRscript [T287D]Aurora A(122–400) were identified by colony PCR screening using the primers T3 (5′AATTAACCCTCACTAAAGGG 3′ (SEQ ID NO.: 9)) and T7pro (5′TAATACGACTCACTATAGGG 3′ (SEQ ID NO.: 10)) hybridising specifically on either side of the pPCR script vector cloning site. The pPCR-Script vectors carrying the [T287D]Aurora A(113–400) or [T287D]Aurora A(122–400) sequence were prepared from E. coli and were digested with Nde1 and BamH1, the digestion products resolved by agarose gel electrophoresis. The fragments containing the [T287D]Aurora A(113–400) or [T287D]Aurora(122–400) were ligated into the expression vector pET28a (Novagen product #69864-3) between the Nde1 and BamH1 restriction sites. The inserted genes were cloned in frame with a sequence coding for a 6 histidine tag followed by a sequence encoding a thrombin protease cleavage site (see below for a complete description). The inserted genes are under the control of a bacteriophage T7 promoter and therefore require expression of the T7 polymerase in trans for efficient transcription in E. coli. The plasmid encodes kanamycin resistance for selection.

The ligation reactions were transfected into DH5 □ competent E. coli and the bacteria carrying the pET28a-[T287D]Aurora A(113–400) or pET28a-[T287D]Aurora A(122–400) recombinant vectors were identified by their ability to grow on media containing kanamycin. Plasmid DNAs were extracted from these bacteria and subjected to digestion with the restriction endonucleases Nde1 and BamH1 to identify those carrying the [T287D]Aurora A(113–400) or [T287D]Aurora A(122–400) sequences. The identity of the insert was then confirmed by dideoxy chain termination DNA sequencing prior to protein expression.

pET28a carries the initiation codon (ATG) 3′ to the T7 promoter and also the following sequence up to and including the Nde1 restriction endonuclease recognition site:

(SEQ ID NO.: 11) 5′ . . . ATG GGC AGC AGC CAT CAT CAT CAT CAT CAC AGC AGC GGC CTG GTG CCG CGC GGC AGC CAT ATG . . . 3′ Sequences inserted into the Nde1 site “in frame” with the initiation codon will therefore be expressed as a fusion protein with the following N-terminal fusion (using the standard single letter amino acid code):

(SEQ ID NO.: 12) (N-terminal) MGSSHHHHHHSSGLVPRGSHM . . . (C-terminal)

The fusion of 6 histidines to proteins is commonly used to provide a “tag” for protein purification, usually by affinity for metal ions such as nickel. The motif “LVPRGS” (SEQ ID NO.: 13) corresponds to a specific thrombin protease cleavage site that allows the proteolytic removal of the sequence “MGSSHHHHHHSSGLVPR” (SEQ ID NO.: 14) after incubation of the protein with thrombin. Since the [T287D]Aurora A sequences coding for amino acids 113–400 and 122–400 were inserted into the Nde 1 site, the plasmid encodes for the following protein (using the standard single letter amino acid code):

[T287D]Aurora A(113–400) MGSSHHHHHHSSGLVPRGSHMLASKQKNEESKKRQWALEDFEIGRPLGKGK (SEQ ID NO.: 15) FGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRL YGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHS KRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTDLCGTLDYLPPEMIEG RMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEG ARDLISRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASK This protein will be referred to in the text as MGSS-6His-SSGLVPRGSHM-[T287D]Aurora A(113–400)

[T287D]Aurora A(122–400) MGSSHHHHHHSSGLVPRGSHMSKKRQWALEDFEIGRPLGKGKFGNVYLARE (SEQ ID NO.: 16) KQSKFILALKVLFKAQLEKAGVEHQLRREVEIQSHLRHPNILRLYGYFHDATR VYLILEYAPLGTVYRELQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKP ENLLLGSAGELKIADFGWSVHAPSSRRTDLCGTLDYLPPEMIEGRMHDEKVD LWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLISRLLK HNPSQRPMLREVLEHPWITANSSKPSNCQNKESASK This protein will be referred to in the text as MGSS-6His-SSGLVPRGSHM-[T287D]Aurora A(122–400) Protein Expression

pTB375NBSE carrying the [T287D] Aurora A (94–402) sequence were transfected into E. coli BL21(DE3) pLys S (genotype: B F⁻ dcm ompT hsdS(r_(B) ⁻m_(B) ⁻) gal □(DE3) [pLysS Cam^(r)]). The strain was grown for 16 h (LB medium containing tetracycline (10 μg/mL) and chloramphenicol (34 μg/mL) at 30° C. in shake flasks to OD_(550nm)˜5. This culture was inoculated into high biomass medium containing tetracycline (10 μg/mL) and chloramphenicol (34 μg/mL), in a 20 L fermenter (B. Braun, Melsungen, Germany). Cells were grown aerobically in fed batch culture at 30° C., pH 6.7 with dissolved oxygen tension maintained at 50% air saturation. Expression of 6His-[T287D] Aurora A (94–402) was induced 12 hours post inoculation (OD_(550nm)˜13) with 0.40 mM isopropyl-β-D-thiogalactopyranoside (IPTG), and cells harvested 3.0 hours later (OD_(550nm)˜33) by batch centrifugation (7,000×g at 4° C. for 30 min).

pET28a carrying the [T287D]Aurora A(122–400) sequence was transfected into E coli DS410 (DE3) (a derivative of the original minicell-producing strain P678–54). The strain was grown for 30 h (M9 glucose medium containing kanamycin (25 μg/mL) at 37° C. in shake flasks to OD_(550nm)˜1.4. This culture was inoculated into high biomass medium containing kanamycin (25 μg/mL) in a 20 L fermenter (B. Braun, Melsungen, Germany). Cells were grown aerobically in fed batch culture at 30° C., pH 6.7 with dissolved oxygen tension maintained at 50% air saturation. Expression of MGSS-6His-SSGLVPRGSHM-[T287D]Aurora A(122–400) (SEQ ID NO.: 16) was induced 16 hours post inoculation (OD_(550nm)˜19) with 0.10 mM isopropyl-β-D-thiogalactopyranoside (IPTG), and cells harvested 23 hours later (OD_(550nm)˜26) by batch centrifugation (7,000×g at 4° C. for 30 min).

Definition of Kinase Domain Fragment

MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) was purified from E. coli cell paste by Ni-NTA Agarose chromatography followed by size exclusion chromatography. The solution properties of this protein were found to be unfavourable for structural studies. Limited proteolysis of MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) was used to identify fragments of the Aurora A kinase domain with superior solution properties. Aliquots of MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) were subjected to proteolytic digestion with trypsin, thermolysin or endoproteinase Glu-C (V8). Protein fragments were identified by analysis with Coomassie-stained SDS PAGE, electrospray mass spectrometry (ESMS) and N-terminal sequencing. Cleavage and purification was performed at sufficient scale to produce appropriate quantities of [T287D]Aurora A (122–396) for crystallisation, as detailed below. Characterization of these fragments of Aurora A was used to design additional constructs, including MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16). The molecular biology procedures used to generate MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) are given in the Molecular Biology section of Example 1.

Lysis of E. coli Containing MG-6His-GS-[T287D]Aurora A(94–402)

The following procedures were performed at 4° C. unless otherwise stated. E. coli cell paste (200 g) was resuspended using a Kinematica PT6000 homogeniser (Kinematica GMBH, Basel, Switzerland) in 1.01 of lysis buffer (40 mM HEPES, 200 mM NaCl, 2 mM imidazole, 2 mM 2-mercaptoethanol, 1 mM benzamidine, pH 7.4). The cells were lysed using an Avestin EmulsiFlex ñC5 (Avestin, Inc., Ottawa, Canada), using a single pass at an average pressure of 10,000 psi. The resulting lysate was centrifuged at 17,000×g (average) for 90 min before aspirating the supernatant and discarding the pellet.

Lysis of E. coli Containing MG-6His-GS-[T287D]Aurora A(94–402)

The following procedures were performed at 4° C. unless otherwise stated. E. coli cell paste (200 g) was resuspended using a Kinematica PT6000 homogeniser (Kinematica GMBH, Basel, Switzerland) in 1.01 of lysis buffer (40 mM HEPES, 200 mM NaCl, 2 mM imidazole, 2 mM 2-mercaptoethanol, 1 mM benzamidine, pH 7.4). The cells were lysed using an Avestin EmulsiFlex ñC5 (Avestin, Inc., Ottawa, Canada), using a single pass at an average pressure of 10,000 psi. The resulting lysate was centrifuged at 17,000×g (average) for 90 min before aspirating the supernatant and discarding the pellet.

The following procedures were performed at 4° C. unless otherwise stated. A 26 mm diameter chromatography column packed with 25 mL Qiagen Ni NTA-Agarose (Qiagen GMBH, Hilden, Germany) was equilibrated with 10 column volumes of lysis buffer before loading lysate supernatant containing MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) onto the column at a flow rate of 0.9 mL/min. Using a flow rate of 2.0 mL/min the column was washed with 10 column volumes of wash buffer (40 mM HEPES, 20 mM imidazole, 2 mM 2-mercaptoethanol, pH 7.5) to remove weakly bound or non-specifically bound impurities. Elution of bound protein was effected using elution buffer (40 mM HEPES, 400 mM imidazole, 2 mM 2-mercaptoethanol, pH 7.5) at 2.0 mL/min. Eluted material was flowed through a second chromatography column (26 mm diameter, packed with 25 mL Pharmacia Q Sepharose Fast Flow (Amersham Pharmacia Biotech, Uppsala, Sweden) previously equilibrated with 10 column volumes of wash buffer). Fractions of 10.0 mL were collected, and after analysis by Coomassie-stained SDS PAGE, those fractions containing significant amounts of MG-6His-GS-[T287D]Aurora A(94–402) were pooled. At this stage the pool (approximately 200 mL) was stored in an airtight container at 4° C. for up to seven days.

From this stage forward, all procedures were carried out at room temperature, unless otherwise stated. A Pharmacia HiPrep 16/60 Sephacryl S-100 pre-packed size exclusion column was equilibrated in running buffer (40 mM HEPES pH7.5, 350 mM NaCl, 2 mM dithiothreitol (DTT)). The column was run at a flowrate of 1.0 mL/min. A 10 mL sample of the MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) pool was centrifuged (31,000×g, 4° C., 60 min) and loaded onto the column. The fractions (2.0 mL) were analysed by Coomassie-stained SDS PAGE, and those containing MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4) were pooled.

Limited proteolysis at room temperature was carried out on the size exclusion chromatography-purified pool of MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4), whose concentration was 1 mg/mL. Using a mass ratio of 1 part protease to 100 parts MG-6His-GS-[T287D]Aurora A(94–402) (SEQ ID NO.: 4), endoproteinase Glu-C from Staphylococcus aureus V8 (Boehringer Mannheim UK, Lewes, Sussex, UK) was added to the pool. Proteolysis was allowed to continue for between 3 and 7 h.

A chromatography column was packed with a mixture of Pharmacia Sephacryl S-100 HR and Pharmacia Q-Sepharose high performance in the ratio of 9:1 v/v respectively (referred to as ‘the S-100/Q column’). The column volume was 130 mL. It was equilibrated and run in S-100/Q running buffer (40 mM HEPES pH7.5, 50 mM NaCl, 2 mM dithiothreitol) at a flowrate of 1.0 mL/min. A sample of the proteolysed pool (8 mL) was loaded onto the S-100/Q column and 2.0 mL fractions were collected. Fractions were analysed by Coomassie-stained SDS PAGE, and those containing significant quantities of pure [T287D]Aurora A(122–396) were pooled. A sample of the pool was analysed by LC-ESMS using a Micromass LCT in conjunction with a Waters Alliance HPLC (Micromass, Manchester, UK). A further sample of the pool was subjected to N-terminal sequencing. Once the identity of the cleaved protein had been confirmed as [T287D]Aurora A(122–396), it was submitted for crystallisation.

Preparation of GSHM-[T287D]Aurora A(122–400)

The following procedures were performed at 4° C. unless otherwise stated. A 26 mm diameter chromatography column packed with 15 mL Qiagen Ni NTA-Agarose (Qiagen GMBH, Hilden, Germany) was equilibrated with 10 column volumes of lysis buffer before loading lysate supernatant containing MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) onto the column at a flow rate of 1.0 mL/min. Using a flow rate of 2.0 mL/min the column was washed with 7 column volumes of wash buffer (40 mM HEPES, 200 mM NaCl, 10 mM MgCl₂, 20 mM imidazole, 2 mM 2-mercaptoethanol, pH 7.5) to remove weakly bound or non-specifically bound impurities. Elution of bound protein was effected using elution buffer (40 mM HEPES, 400 mM imidazole, 10 mM MgCl₂, 2 mM 2-mercaptoethanol, pH 7.5) at 2.0 mL/min. Fractions of 10.0 mL were collected, and after analysis by Coomassie-stained SDS PAGE, those fractions containing significant amounts of MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) were pooled.

From this stage in the purification onward, all procedures were carried out at room temperature unless otherwise stated. A Pharmacia HiPrep 26/10 Fast Desalting pre-packed column was equilibrated in running buffer (40 mM HEPES pH7.4, 150 mM NaCl, 2 mM 2-mercaptoethanol). The column was run at a flowrate of 3.0 mL/min. A 10 mL sample of the MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) pool was filtered (0.22 μm) and loaded onto the column. Fractions were collected, and those containing the most concentrated amounts of MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) were pooled.

Bovine thrombin (500 units, Amersham Pharmacia Biotech) was added to the pool of 50 mg (+/−20%) of purified MGSS-6His-SSGLVPRGSHM-[T287D]Aurora-A(122–400) (SEQ ID NO.: 16) whose concentration was 1 mg/mL. Specific proteolytic cleavage was allowed to proceed to completion at 4° C., producing the truncated mutant GSHM-[T287D]Aurora A(122–400).

A Pharmacia HiPrep 16/60 Sephacryl S-100 pre-packed size exclusion column was equilibrated in running buffer (40 mM HEPES pH7.4, 50 mM NaCl, 1 mM dithiothreitol). The column was run at a flowrate of 1.0 mL/min. A 10 mL sample of the GSHM-[T287D]Aurora A(122–400) pool was filtered (0.22 μm) and loaded onto the column. Fractions (2.0 mL) were analysed by Coomassie-stained SDS PAGE, and those containing GSHM-[T287D]Aurora A(122–400) were pooled, and submitted for crystallisation.

Analysis

For SDS PAGE all samples were diluted in Laemmli buffer containing □-mercaptoethanol, boiled for 2 minutes and loaded onto a 8–16% gradient, 1.5 mm thickness×10 well NOVEX gel (NOVEX, San Diego, Calif.). Gels were stained with Coomassie blue R-250. Edman degradation was carried out on a Perkin Elmer 477A peptide sequencer (Applied Biosystems, Foster City, Calif.) with on-line detection of PTH amino acids. Mass spectra were acquired using a Micromass LCT with electrospray source (Micromass, Manchester, UK) and on-line Waters 2790 Alliance delivery system (Waters, Milford, Mass.). Protein was loaded directly on to a Phenomenex Jupiter 5μ C5 300_(—)150×2.00 mm reverse phase column equilibrated in Milli Q water (Millipore, Bedford, Mass.), 2.7% acetonitrile, 0.1% trifluoroacetic acid, and the column was developed with a 2.7% to 90% acetonitrile gradient over 30 minutes at a flowrate of 80 μl/min. A fraction (approximately 25%) of the eluted proteins passed into the mass spectrometer.

EXAMPLE 2 Crystallisation of [T287D] Aurora A Catalytic Domain Constructs

The [T287D] Aurora A(122–396):AMPPNP complex was crystallized at 15° C. by the method of hanging-drop vapour diffusion. The protein [T287D] Aurora A (122–396) was concentrated to ˜10 mg/mL solution (in 40 mM HEPES pH 7.4, 2 mM DTT, 50 mM NaCl), 5 mM AMP-PNP was then added to this solution and the complex was incubated on ice for 30 minutes. Prior to setting up crystallization trials this complex solution was microfuged for 10 minutes. The drops contained a 1:1 by volume mixture of complex solution and reservoir buffer (0.2M K₂HPO₄, 1.6M NaH₂PO₄, 0.1M phosphate/citrate buffer pH 3.8) giving a final 4 μl drop volume. The [T287D] Aurora(122–396)-AMP-PNP crystals belong to space group P3₂21 with unit cell dimensions a=b=86.55 Å, c=78.34 Å, and α=β=90°, γ=120°, and contain 1 complex molecule per asymmetric unit. Before data collection, the crystals were transferred briefly (for about 20 seconds) to a cryobuffer containing 0.2M K₂HPO₄, 1.6M NaH₂PO₄, 0.1M phosphate citrate pH 3.8, 30% glycerol before being cooled to 100 K in a nitrogen gas stream.

The GSHM-[T287D] Aurora A(122–400) complex with the chemically synthesized inhibitor of formula II was crystallized as follows. Preparation of compound of formula II is described under example 19 in patent publication number WO 01/21597, publication date 29 Mar., 2001 (application number PCT/GB00/03593, international filing date 19 Sep., 2000). The compound was added at 5 mM to a solution containing protein (GSHM-[T287D] Aurora A(122–400) at 10 mg/ml, 40 mM HEPES pH7.5, 50 mM NaCl, and 1 mM 2-mercaptoethanol. Drops were formed by mixing 1:1 volumes of protein complex solution and a reservoir solution containing 22% PEG 4000 and 0.2M ammonium sulphate. Crystallisation was achieved by hanging drop vapour diffusion at 15° C. Data were collected at room temperature from a crystal mounted in a capillary. The crystal could be translated in the X-ray beam to allow multiple exposures. The Aurora A-inhibitor crystals are of space group P2₁ with unit cell dimensions a=52.6, b=88.4, c=67.8 Å, α=γ=90 and β=90.01°, and contain two complex molecules in the asymmetric unit.

EXAMPLE 3 Structure Determination of [T287D] Aurora A Catalytic Constructs

Diffraction data were collected at beamline PX9.6 at the SRS, Daresbury on an ADSC Quantum 4 CCD detector. The data were indexed and integrated with the program Mosflm and scaled with the program SCALA (CCP4). Molecular replacement and rigid body refinement to a resolution of 3.0 Å were carried out using the program AMoRe. A search model was derived from mouse PKA, truncating the model at residues 32 to 310 and replacing all non-identical residues with Ala. 5% of the data were reserved at this stage as a cross-validation set and the initial model underwent torsion angle simulated annealing in the program CNX using a maximum likelihood target and an overall anisotropic temperature factor correction. The model then underwent iterative rounds of manual rebuilding and simulated annealing until the working R-factor fell below 30%, at which point restrained isotropic individual temperature factor refinement was carried out. Concurrent building of both inhibitor complexes with the same Aurora protein in different crystal forms proved very instructive when it came to clarification of regions that were difficult to interpret. Further iterative rebuilding and addition of waters was carried out until the free R factor converged.

Crystallographic data and refinement statistics are given in tables 4 and 5.

TABLE 4 Aurora-AMPPNP complex data and refinement statistics. Space Group P3₂21 Cell constants a = b = 86.55, c = 78.34 Å α = β = 90, γ = 120° Reflections 62278 Independent 17003 Reflections R_(sym) (2.25–2.2 Å) 3.6% (32.6%) Resolution (Å) 38–2.2 I/sigI (2.25–2.2 Å) 19.3 (3.0) Completeness 97.1% (83.2%) (2.25–2.2 Å) R_((free)), R_((work)) 23%, 28% Rmsd (bond lengths) 0.006 Rmsd (bond angles) 1.2

TABLE 5 Aurora-inhibitor complex data and refinement statistics: Space Group P2₁ Cell constants a = 52.6, b = 88.4, c = 67.8 Å □ = □ = 90, β = 90.01° Reflections 36664 Independent Reflections 26294 R_(sym) (2.25–2.1 Å) 6.6% (30.5%) Resolution (Å) 52–2.1 I/sigI (2.25–2.1 Å) 7 (2.1) Completeness (2.25–2.1 Å) 72.5% (25.5%) R_((free)), R_((work)) 22%, 27% Rmsd (bond lengths) 0.019 Rmsd (bond angles) 1.8

EXAMPLE 4 Description of the Structure of Aurora A Kinase

The structure of [T287D] Aurora A (122–396) in a binary complex with the ATP analogue AMP-PNP has been solved to a resolution of 2.2 Å. The structure of GSHM-[T287D] Aurora A(122–400) in a binary complex with the synthetic inhibitor of formula II has been solved to a resolution of 2.1 Å. The structures contain the residues of the kinase catalytic domain. The kinase domain of [T287D] Aurora A shows the bilobal structure characteristic of protein kinases with the ATP and inhibitor binding site situated between the two lobes. The N-terminal domain (lobe) comprises a twisted β-sheet and a single kinked helix. The C-terminal lobe comprises mainly helices but also includes a small region of β-sheet. Parts of the polypeptide chain are disordered. In particular, the activation loop, residues 279 to 290 containing the T287D substitution, is not visible in the electron density. The disordered nature of the activation loop is a common feature in kinase crystal structures.

The structure adopts a conformation typical of catalytically inactive kinases, despite the introduction of the constitutively active mutation, T287D. It is thought that the acidic pH at which the crystallisation experiments were carried out will result in the introduced aspartate being protonated, and thus no longer able to mimic the phosphorylated threonine in the wild-type activated protein. The kinase activity of the mutant enzyme towards a peptide substrate was measured at varying pH values, as shown in FIG. 3, and indeed, activity is significantly reduced falls as the pH is lowered.

The inactive conformation seen in our [T287D] Aurora A complexes is clearly capable of binding the inhibitor of formula II and the ATP analogue, and therefore allows structure-based design, which needs to make allowances for the flexibility and conformational changes that the kinase may undergo, for example, between its active and inactive states. In the case of the inhibitor, the inactive conformation may be forced by the steric bulk of the inhibitor.

Aurora A is quite closely related to the cyclic AMP-dependent protein kinase, also known as PKA, and the structures superpose with an overall rmsd of 1.4 Å. The ATP binding cleft of Aurora A is more extended than the equivalent cleft in PKA on account of a shift in the position of a helix, formed by residues 174 to 182 in the N-terminal lobe. In the structure of [T287D] Aurora A, the helix is displaced approximately 3 Å away from the ATP binding pocket compared with the equivalent helix in PKA, thus extending the length of the cleft between the two lobes. The extended cleft can be exploited by elongated inhibitor molecules such as that of formula II and may be key to the design of specific inhibitors. The conserved DFG motif (Asp273Phe274Glu275) preceding the activation loop is apparent in the electron density. This region contains an aspartate residue necessary for catalysis. The glycine-rich loop, which is important for ATP binding in all kinases, shows good electron density throughout the main chain atoms, although the temperature factors are quite high, indicating significant mobility of the loop. However, the density for the side chains of some residues, such as Phe 143, is poor, and these are likely to adopt multiple conformations.

The AMP-PNP molecule adopts a dual conformation (FIG. 1). The adenine ring and ribose moiety in both conformations occupy similar locations with respect to the kinase molecule. Classical hydrogen-bonding interactions are made between the adenine ring and the hinge region of Aurora A. These are between N6 of the adenine ring and the main chain oxygen of Glu 210 and between N1 of the adenine ring and the main chain nitrogen of Ala 212. The differences in the two conformations arise from torsion angle differences between the ribose ring and the phosphate groups and also in torsion angles of phosphorus-oxygen bonds. In one conformation, the β-phosphate group forms a hydrogen bond to a water molecule, which, in turn, forms a hydrogen bond to Asp 273. In the other conformation, the β-phosphate forms hydrogen bonds with Ser 277 and Gin 260. In both conformations the α-phosphate forms a salt-bridge with Lys 161, and also forms a hydrogen bond with the main chain nitrogen of Val 278. No electron density for the γ-phosphate is present in either conformation suggesting a high degree of disorder. This disorder of the γ-phosphate has also been seen in other crystal structures, for example that of Checkpoint kinase.

The molecule of formula II also binds in the ATP binding site in the cleft between the two domains in the Aurora A kinase molecule. The molecule of formula II adopts an extended conformation, which demonstrates the extent of the available binding pocket (FIG. 2 b). A classical kinase (adenine-mimetic) inhibitor hydrogen bond interaction with the main chain peptides is made between N(17) in the inhibitor and the amide of amino acid residue 212. The piperidine moiety of the inhibitor extends into solvent (on the left in FIG. 2 b). At the other extreme of the inhibitor (right end in FIG. 2 b) the benzoyl moiety fits into a hydrophobic pocket formed by residues Leu163, Leu181, Leu195, Leu207 and Trp276. This inhibitor represents a more interesting start point for design than AMPPNP since protein regions more remote from the ATP location are explored, and this may help achieve specificity. 

1. A crystalline form of a human Aurora A kinase polypeptide consisting of the catalytic domain of human Aurora A kinase comprising-amino acids 22 to 296 of SEQ ID NO:16, wherein said amino acids are equivalent to amino acids 122 to 396 of full length human Aurora A kinase, which is complexed with an Aurora A kinase inhibitor, wherein the inhibitor is

and wherein the crystalline form is further characterized as having the space group of P3₂21 and comprises the unit cell dimensions of a=b=86.55 Å, c=78.34 Å, α=β=90° and γ=120°.
 2. A crystalline form of a human Aurora A kinase polypeptide consisting of the catalytic domain of human Aurora A kinase comprising-amino acids 22 to 300 of SEQ ID NO:16, wherein said amino acids are equivalent to amino acids 122 to 400 of full length human Aurora A kinase, which is complexed with an Aurora A kinase inhibitor, wherein the inhibitor is

and wherein the crystalline form is further characterized as having the space group of P2₁ and comprises the unit cell dimensions of a=52.6 Å, b=88.4 Å, c=67.8 Å, α=γ=90° and β=90.01°.
 3. A crystalline form according to claim 1 or claim 2, wherein the catalytic domain comprises a binding site, wherein the binding site is defined by the x,y,z-coordinates of atoms in the set of amino acid residues given by the list: Arg136, Leu138, Gly139, Lys140, Gly141, Val146, Ala159, Lys161, Leu163, Val177, Glu180, Val181, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260, Leu262, Ala272, Asp273, Phe274, Gly275, Trp276, Ser277, Val278, and His279, wherein the atomic coordinates are listed in Tables 1 and 2; or wherein the binding site is defined by the x,y,z-coordinates of atoms in the set of amino acid residues given by the list: Arg136, Leu138, Gly139, Val146, Ala159, Lys16l, Leu163, Ile183, Gln184, Leu193, Leu195, Leu207, Leu209, Glu210, Tyr211, Ala212, Pro213, Leu214, Gly215, Thr216, Arg219, Glu259, Asn260 and Leu262, and wherein the x,y,z-coordinates are within a root mean square deviation of not more than 1.0 Å of the coordinates listed in Tables 1 and
 2. 